Pathology of the Cervix (Essentials of Diagnostic Gynecological Pathology) 1st ed

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This is the third volume in the Essentials of Diagnostic Gynecological Pathology series sponsored by the British Association of Gynecological Pathologists. Focusing on cervical pathology, it provides an update on current diagnostic criteria, the use of biomarkers and specimen handling. It serves as a quick desktop reference facilitating accurate diagnosis, and also provides detailed descriptions and an exhaustive reference list for more in-depth study.

Sections devoted to the changing landscape of cervical screening, current management and future directions are included. Standardized terminology, the biology of HPV-related pre-invasive disease, and the staging of early cervical cancers are discussed.

As most histopathology departments receive many gynecological specimens, Pathology of the Cervix has been written to be useful diagnostically to general as well as specialist gynecological pathologists and pathologists in training. Gynecologists, oncologists, dermatologists, genitourinary physicians and cancer nurse specialists will find expert insights here that will help in treatment and counselling of their patients.​

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Changing Paradigms in the Management of Breast Cancer 1st ed

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This text is designed to present a comprehensive and state-of the-art approach to the management of breast cancer within the fields of surgery, medical oncology, and radiation oncology.  Sections address changes in these fields. These areas include breast imaging,  management of the axilla, atypical breast lesions, surgical margins, new techniques in breast reconstruction, and nipple sparing and contralateral mastectomies. Subsequent chapters focus on issues in medical oncology including,  triple negative breast cancer and metastatic breast disease. New paradigms in radiation oncology are examined.  Breast cancer treatment in the elderly and in young women, and genetic risk in breast cancer management is also be discussed. Written by experts in their field, each of these sections addresses advances and changes in the field. A brief review of the existing literature addressing the particular topic follows in each section.  The text concludes with chapters on pathological issues and advances in radiation oncology.

As access to a comprehensive multidisciplinary resource such as this is currently limited in the literature, Changing Paradigms in the Management of Breast Cancer represents the first single source to provide information on advances and outcomes for the physician caring for breast cancer patients in a multidisciplinary setting.

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The Bethesda System for Reporting Thyroid Cytopathology: Definitions, Criteria, and Explanatory Notes 2nd ed

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  The first edition of The Bethesda System for Reporting Thyroid Cytopathology was published in 2010 and has greatly influenced the practice of thyroid cytopathology. The terminology proposed and illustrated in this text has been widely adopted not only in the U.S. but also abroad. It has become an essential text for pathology trainees and practicing pathologists examining thyroid fine needle aspiration (FNA) specimens.
  Since 2010, there have been a number of important advances in the management of patients with nodular thyroid disease and in the understanding of the biology of thyroid cancer. This new edition includes these advances that impact terminology for reporting thyroid cytopathology. In particular, it incorporates a discussion of the recently implemented and now widespread use of molecular testing of thyroid FNA samples, which has transformed the management of patients with nodular thyroid disease in the U.S.. In addition, this edition accommodates the recent changes to the classification of thyroid cancer, most notably the introduction of a new thyroid diagnosis, that of “non-invasive follicular tumor with papillary-like nuclear features (NIFTP)”.
  Thoroughly revised and updated, The Bethesda System for Reporting Thyroid Cytopathology, Second Edition will provide the reader with a unified approach to diagnosing and reporting thyroid FNA interpretations. It serves as a reference guide not just for pathologists, but also endocrinologists, surgeons, and radiologists.

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Applied Cerebral Angiography: Normal Anatomy and Vascular Pathology 3rd ed. 2017 Edition

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This book offers detailed guidance on the diagnostic use of cerebral angiography based on precise description of the angiographic appearances of normal anatomy and pathological conditions. In this third edition, every chapter has been thoroughly revised and enlarged to reflect new knowledge and experiences, and more attention is paid to the correlations between anatomopathological findings and clinical manifestations. Beyond explaining the diagnostic value of cerebral angiography, a key aim is to equip readers with the precise knowledge of the anatomy of cerebral vessels required for optimal application of endovascular therapy of pathologies involving the arteries and veins of the brain. As in preceding editions, the book is divided into two parts. The first part describes the normal anatomy, with attention to morphological aspects, embryological development, function, and vascular territories. The intraorbital and extracranial vascularization is also fully considered. The knowledge provided will serve as a sound basis for the correct interpretation of pathological processes and their clinical significance, as covered in depth in the second part of the book.

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Pediatric Femur Fractures: A Practical Guide to Evaluation and Management 1st ed. 2016 Edition

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Bringing together the many considerations and complexities surrounding the management pediatric femur fractures, this up-to-date, comprehensive book discusses all aspects of these common but challenging injuries, where the treatment strategies are rapidly changing and which have the potential for complications and less than ideal outcomes. Because there may be multiple acceptable treatment approaches to a given fracture, we sought to review the full spectrum of therapeutic modalities. The entirety of the pediatric femur is considered, including femoral head and neck fractures, diaphyseal, physeal and epiphyseal fractures, and intra-articular fractures of the distal femur. Opening with chapters on development and anatomy as well as radiological evaluation, each fracture type-specific chapter discusses the indications and contra-indications, advantages and disadvantages, technical principles and published outcomes associated with each of the accepted techniques, from casting and traction to external and internal fixation. Concluding chapters discuss pathological fractures and the evaluation and management of complications. By channeling the expertise of a broad and accomplished group of authors with extensive experience in both researching and treating pediatric femur fractures, Pediatric Femur Fractures provides caregivers with the most complete and reliable resource when faced with any of the many types of this challenging injury.

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The Breathless Heart: Apneas in Heart Failure 1st ed. 2017 Edition

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This book systematically focuses on central sleep apneas, analyzing their relationship especially with heart failure and discussing recent research results and emerging treatment strategies based on feedback modulation. The opening chapters present historical background information on Cheyne-Stokes respiration (CSR), clarify terminology, and explain the mechanics and chemistry of respiration. Following a description of the physiology of respiration, the pathophysiology underlying central apneas in different disorders and particularly in heart failure is discussed. The similarities and differences of obstructive and central apneas are then considered. The book looks beyond the concept of sleep apnea to daytime CSR and periodic breathing during effort and contrasts the opposing views of CSR as a compensatory phenomenon or as detrimental to the failing heart. The diagnostic tools currently in use for the detection of CSR are thoroughly reviewed, with guidance on interpretation of findings. The book concludes by describing the various forms of treatment that are available for CSR and by explaining how to select patients for treatment.

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Musculoskeletal Ultrasound in Rheumatology Review 1st ed

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This book provides a comprehensive clinical review of diagnostic and interventional applications of musculoskeletal ultrasound at the point-of-care. As more rheumatologists and other musculoskeletal providers in training and in practice learn the skill of musculoskeletal ultrasound, an increasing number of them will seek study materials for exam preparation and practical knowledge that apply to their clinical practice. Each chapter covers a standardized protocol of joint images with probe placement, and includes numerous examples of common ultrasound pathologies, clearly addressing what kind of pathology to look for with specific ultrasound image views. Review topics are emphasized, and study tools such as key-concept overviews, lists of important studies in the field, and extensive questions for self-assessment are included throughout. Because ultrasound training is moving toward becoming a mandatory part of rheumatology fellowship and has become mandatory in physical medicine and rehabilitation residencies, this book is a valuable educational resource for rheumatologists, physiatrists, and musculoskeletal providers seeking a practical review guide for preparation of certification exams and use in clinical practice.

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Vascular Surgery: A Global Perspective 1st ed. 2017 Edition

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Vascular surgery has experienced remarkable growth and diversification in the last decade, especially with its embracing the disruptive endovascular technological revolution.  Vascular surgeons remain the only group of specialists capable of total treatment of patients with vascular disease, providing medical, minimally invasive, and surgical therapy.  Although vascular surgeons practice in all areas of the world, practice patterns in different areas naturally have both similarities and differences that reflect both regional patterns of disease, genetic characteristics of local peoples, cultural preferences for treatment, local political and economic situations, different access to resources and devices, as well as different training paradigms. Thus, the practice of vascular surgery has diversified and evolved in parallel in many areas, converging and diverging in many ways. Vascular Surgery: A Global Perspective provides the first review and comparison of the diversity of vascular surgery practice around the world. The book is grouped according to common vascular diseases such as aneurysmal and occlusive arterial disease, as well as venous and lymphatic disease and dialysis access. Each major disease topic includes multiple chapters written by expert specialists from around the world, each discussing their local approach to the disease and its treatment. Similarly, the status of vascular surgery practice is addressed, including discussion of the influence of payment systems on practice, patient access to the internet for information, training paradigms, and the legal system including malpractice. This textbook provides the first worldwide summary of the care of patients with vascular disease and will be of interest to a wide audience including vascular surgeons, vascular medical specialists, cardiologists, radiologists, internists, and family practice physicians.

Vascular Surgery: A Global Perspective provides the first review and comparison of the diversity of vascular surgery practice around the world. The book is grouped according to common vascular diseases such as aneurysmal and occlusive arterial disease, as well as venous and lymphatic disease and dialysis access. Each major disease topic includes multiple chapters written by expert specialists from around the world, each discussing their local approach to the disease and its treatment. Similarly, the status of vascular surgery practice is addressed, including discussion of the influence of payment systems on practice, patient access to the internet for information, training paradigms, and the legal system including malpractice. This textbook provides the first worldwide summary of the care of patients with vascular disease and will be of interest to a wide audience including vascular surgeons, vascular medical specialists, cardiologists, radiologists, internists, and family practice physicians.

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Translational Neuropsychopharmacology (Current Topics in Behavioral Neurosciences) 1st ed. 2016 Edition

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This book covers wide areas of animal and human psychopharmacology with clinical utility in the treatment of psychiatric and neurological (e.g Alzheimer’s disease) disorders. The main theme is to develop a new paradigm for drug discovery that questions the claim that animal models or assays fail adequately to predict Phase 3 clinical trials. A new paradigm is advocated that stresses the importance of intermediate staging points between these extremes that depend on suitable translation of findings from animal studies to Phase 1 or Phase 2 studies utilising experimental medicine.

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Genome Editing 1st ed. 2016 Edition

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This timely volume explores the use of CRISPR-Cas9 for genome editing, presenting cutting-edge techniques and their applications in treatment of disease. The chapters describe latest methods such as use of targetable nucleases, investigation of the non-coding genome, mouse genome editing, increasing of knock-in efficiency in mouse zygotes, and generation of reporter stem cells; the text contextualizes these methods in treatment of cardiovascular disease, diabetes mellitus, retinitis pigmentosa, and others. The final chapters round out the book with a discussion of controversies and future directions.
Genome Editing is an essential, of-the-moment contribution to this rapidly growing field. Drawing from a wealth of international perspectives, it presents novel techniques and applications for the engineering of the human genome. This book is essential reading for all clinicians and researchers in stem cells, regenerative medicine, genomics, biochemical and biomedical engineering- especially those interested in learning more about genome editing and applying it in a targeted, specific way.

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