Chromatin Regulation of Early Embryonic Lineage Specification (Advances in Anatomy, Embryology and Cell Biology) 1st ed. 2018 Edition

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Five leaders in the field of mammalian preimplantation embryo development provide their own perspectives on key molecular and cellular processes that mediate lineage formation during the first week of life. The first cell-fate decision involves the formation of the pluripotent inner cell mass (ICM) and extraembryonic trophectoderm (TE). The second cell-fate choice encompasses the transformation of ICM into extraembryonic primitive endoderm (PE) and pluripotent epiblast. The processes, which occur during the period of preimplantation development, serve as the foundation for subsequent developmental events such as implantation, placentation, and gastrulation. The mechanisms that regulate them are complex and involve many different factors operating spatially and temporally over several days to modulate embryonic chromatin structure, impose cellular polarity, and direct distinct gene expression programs in the first cell lineages.

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Operative Techniques in Single Incision Laparoscopic Colorectal Surgery

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The goal of this text is to expand one’s practice of minimally invasive colorectal surgery by implementation of various advanced reduced port and single techniques. The authors present a comprehensive operative technique text to teach and implement single incision and reduced port laparoscopic colorectal surgery best practices into clinical practice. The text is divided into three main sections: perioperative considerations; focused operative techniques, tips and tricks; and step-by-step details of common colorectal procedures. Each case is paired with intraoperative photos and video accompaniment to facilitate understanding the technique, reproducing the steps, and implementing single incision laparoscopic colorectal surgery. The extensive illustrations and links to video make this a truly interactive text. With the aid of this text, surgeon experienced in laparoscopy, as well as those looking to expand their minimally invasive arsenal will be able to successfully incorporate single incision laparoscopic techniques into practice

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The Physical Exam: An Innovative Approach in the Age of Imaging 1st ed. 2018 Edition

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This book invites clinicians to take a fresh look at the routine physical examination by outlining in detail how they can adapt a more efficient, regional approach to the exam activity. By adopting the systematic sequence and focus provided in this novel title, clinicians can offer a more modern physical examination, one that may prove more productive than the methods taught in the pre-imaging era.
The Physical Exam: An Innovative Approach in the Age of Imaging offers a unique, step-by-step sequence for the physical exam. The text guides the clinician through a series of steps that involve observing, touching and listening – in an organized sequence, region by region – of all organ systems. The general approach is applicable to every physical examination and can be modified when appropriate. Express pathways are provided so that the clinicians can quickly assess the general health of the patient while focusing on the presenting problem. A major contribution to the diagnostic literature, the book offers a format and level of complexity that will be of significant value to internal medicine and family physicians, emergency professionals, nurse practitioners, physician’s assistants, and medical students.

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Glaucoma Surgery: Treatment and Techniques

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About the Author

Emerging Concepts Targeting Immune Checkpoints in Cancer and Autoimmunity (Current Topics in Microbiology and Immunology) 1st ed. 2017 Edition

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This volume reviews the current state of research on immune checkpoints and offers novel concepts. It discusses the two most important immune checkpoints: T lymphocyte-associated antigen-4 (CTLA-4) and programmed cell death-1 (PD-1). It shows that antagonistic antibodies against these two molecules are highly effective in the treatment of various cancers and that PD-1 and CTLA-4 have been linked to the suppression of T-cell receptor signaling and co-stimulatory molecules. Further, the volume examines other agents, a number of cells, receptors and signaling molecules, that are also involved in the regulation of T-cell activation and extends the concept of immune checkpoints to “molecules and cells that negatively regulate T-cell activation”. Playing essential roles in immune homeostasis, they could offer new targets for cancer immunotherapy, and for the therapy of autoimmune diseases.

Written by internationally respected scientists, this book will appeal to basic scientists, clinicians, drug development researchers, and advanced students alike.

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Principles of BOI: Clinical, Scientific, and Practical Guidelines to 4-D Dental Implantology

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Basal Osseointegration as a procedure developed on the basis of disc implantology is the method most commonly used for the unilateral treatment of advanced maxillary atrophy. The method is extremely well developed, because it was refined over a period of decades exclusively by practitioners and become established independently of the universities. The treatment aim can be achieved safely, easily and at low cost. Principles of BOI is most practical and explains exactly how things work. It provides treatment plans, tricks and pitfalls and step-by step guidance.

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Management of Acute Kidney Problems

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From the Back Cover

Acute kidney failure is an important clinical area in the intensive care unit setting. An estimated 5–20% of critically ill patients experience an episode of acute kidney failure during the course of their illness, and about 5% of patients admitted to an ICU will eventually require renal replacement therapy. In these patients, in-hospital mortality is extremely high, exceeding 50%. Thus, the early detection and causal treatment of acute kidney problems is vitally important for a successful outcome. Written by internationally renowned experts, this clinical reference offers helpful advice with the most recent information on

  • definition
  • epidemiology
  • pathophysiology
  • clinical causes of acute kidney failure
  • differential diagnostic approaches for patients with acute renal failure
  • various key aspects related to the adequate delivery of acute renal replacement therapy

It also gives a detailed outline of important measures for their clinical management. This reference is intended as a helpful guide for all clinicians involved in the care of patients at risk of developing acute kidney problems.

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Manual of Pediatric Nephrology

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From the Back Cover

Management of Chronic Kidney Disease: A Clinician’s Guide

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This book presents a comprehensive and instructive management plan for physicians who care for CKD patients. Basic aspects of CKD, clinical assessment, evaluation and management of risk factors, cardiovascular disease in the context of CKD, assessment and management of CKD complications, special circumstances in CKD patients, and the path to renal replacement therapy are all thoroughly covered. Diagnostic and therapeutic approaches are presented according to the latest staging system for CKD, with patient care being discussed separately for each disease stage. The proposed management plan is both “best available evidence based” and “practice based”. The book also recognizes the needs of busy clinicians by including helpful boxes summarizing the evidence on diagnostic and therapeutic issues and practice pearls based on guidelines. The authors are recognized experts from across the world, ensuring global coverage of the problem, and most have participated in writing guidelines on CKD.

About the Author

Real-Time Monitoring of Cancer Cell Metabolism for Drug Testing 2015th Edition

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Hamed Alborzinia uses the biosensor chip to monitor the metabolic and morphological changes in cancer cell lines in real time, particularly: (i) real-time measurements of basic cancer cell metabolism of different cancer cell lines; (ii) a detailed timeline of the metabolic response to cisplatin treatment and clear detection of the time span between start of cisplatin treatment and onset of cell death, which reflects the time required for the underlying molecular mechanisms of cell fate decision; (iii) direct functional measurement of the biological activity of a key regulatory protein of cellular metabolism following the kinetic change in respiration upon SIRT3 overexpression; and (iv) the time-resolved impact of several organometallic compounds on cell metabolism and cell morphology, including unexpected and not yet understood highly significant and specific effects on cell-cell interaction and adhesion.

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