Ultrasound in Emergency Care

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A practical guide to the use of ultrasound and how to interpret the scans, aimed specifically at emergency physicians and staff. This is recognised as an essential skill in emergency medicine, and this book will provide the means to learn it, with question led text and many illustrations of real examples. The book will include a CD Rom of video clips, showing normal and abnormal scans, approximating to the real life situation.

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Relevant Surgical Exposures First Edition

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Master Techniques in Orthopaedic Surgery: Relevant Surgical Exposures First Edition

This important new Master Techniques in Orthopaedic Surgery volume demonstrates approximately 100 of the most successful, widely used surgical exposures. World-renowned master surgeons describe their preferred surgical exposure techniques in step-by-step detail and offer pearls and tips for improving results. The book is thoroughly illustrated with full-color, sequential, surgeon’s-eye view photographs of anatomic dissections, with accompanying drawings by a noted medical illustrator to give surgeons a full understanding of what they will encounter in a patient.

Chapters cover each anatomic region of the musculoskeletal system and spine. Exposures are organized similarly to the other Master Techniques in Orthopaedic Surgery volumes.

A companion Website offers the fully searchable text and an image bank.

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Tunnel Syndromes 3rd Edition

 

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The need for a comprehensive resource with easy-to-find information has increased with the addition of nine new syndromes. Tunnel Syndromes: Peripheral Nerve Compression Syndromes provides a quick overview of tunnel syndromes including the definition, anatomy, etiology, clinical signs and symptoms, and treatment. It presents a total of 50 tunnel syndromes. Following the tradition of the first two editions, this resource continues to probe the origins of tunnel syndromes and to propose probable causes that lead to them.

All existing chapters have been updated and new chapters have been added including:

  • Spinal accessory nerve syndrome
  • Intercostobrachial nerve syndrome
  • Notalgia paresthetica
  • Medial antebrachial cutaneous nerve syndrome
  • Distal posterior interosseous nerve syndrome
  • Medial superior cluneal nerve syndrome
  • Pudendus nerve syndrome
  • Lateral plantar nerve syndrome
  • Medial plantar nerve syndromeNew in this Edition:
  • New syndromes of clinical importance
  • Improved illustrations, including new magnetic resonance images
  • Twenty-seven new drawings (graphic designs) and twenty new photos
  • Updated references with a total of more than 1,650 citations

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Antisense Therapeutics (Methods in Molecular Medicine) 1st Edition

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Leading researchers offer an authoritative survey and analysis of the latest findings on the rapid development of antisense oligonucleotides therapeutic and their application in various in vivo model systems. The book’s high-profile contributors provide timely accounts of their state-of-the-art strategies, discussing such topics as the synthesis and purification of oligonucleotides, their selection for a particular gene target, different methods of administration, and the use of various cell lines and cell culture systems. They also examine questions of cellular uptake, in vitro biological activity, in vivo biological activity, the pharmacology and pharmacokinetics of oligonucleotides, and the application of oligonucleotides to the central nervous system.

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Molecular Diagnosis of Cancer (Methods in Molecular Medicine) 1st Edition

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Leading clinicians and expert researchers bring together under one cover a comprehensive guide to the newest and most essential molecular techniques-particularly PCR-for diagnosing and monitoring hematological and solid tumors. These distinguished practitioners demonstrate step-by-step the use of PCR, FISH, CGH, Southern analysis, sequencing, and SSCP to assess cancer markers, to detect minimal disease and apoptosis, and to uncover particular translocations, mutations, and deletions. Their readily reproducible results offer physicians and scientists a promising entré into the powerful possibilities of using these techniques to improve the diagnosis, prognosis, and management of cancer.

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Herpes Simplex Virus Protocols (Methods in Molecular Medicine) 1998th Edition

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Herpes Simplex Virus Protocols comprises a wide range of experimental protocols that should be especially useful to new workers in herpes virology. Hopefully, it will also provide information for those with experience in the field, as well as those embarking on techniques that are new to them. Obviously the range of topics covered cannot be comprehensive, but we have tried to provide protocols dealing with those procedures that are most widely used; and we have selected expert authors accordingly. We have also tried to cover the range from the more biological in vivo maneuvers to purely molecular procedures, taking into account the topical interest in the potential use of HSV as a therapeutic tool. In this way there should be sufficient inf- mation for most procedures the average herpes virologist is likely to require– at least at this moment in time! Since the herpesviruses are a large family, we have largely based the protocols on the virus we know best–herpes simplex virus. With this as the prototype, it should be relatively easy to extrapolate and make the necessary modifications required for application to some of the other herpesviruses, especially members of the alpha group, such as PRV and EHV. It would have been an impossible task to include chapters covering the unique aspects of each known herpesvirus.

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Helicobacter pylori Protocols (Methods in Molecular Medicine) 1997th Edition

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Helicobacter pylori Protocols offers an outstanding collection of state-of-the-art protocols for the identification and molecular manipulation of H. pylori. The authoritative contributors supply detailed and readily reproducible protocols for the culturing of H. pylori, for the isolation and restriction endonuclease digestion of H. pylori chromosomal DNA, and for the transformation and insertional mutagenesis of H. pylori. They also provide molecular epidemiological techniques, including ribotyping, PCR-RFLP, and RAPD-PCR. These procedures have been developed by leading practitioners to solve the difficult technical problems created by the application of the powerful bacterial genetic and molecular cloning techniques to H. pylori.

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Cytotoxic Drug Resistance Mechanisms (Methods in Molecular Medicine) 1999th Edition

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There is now a range of cytotoxic drugs that have considerable clinical usefulness in producing responses in tumors and even, in a small proportion of cases, cure. However, the acquisition of drug resistance is a major clinical problem and is perhaps the main limiting factor in successful treatment of cancer. Thus, a tumor initially sensitive to chemotherapy will, in the majority of cases, eventually recur as a resistant tumor, which will then progress. Much of our understanding of drug resistance mechanisms comes from the study of tumor cell lines grown in tissue culture. We now understand many of the – lecular mechanisms that can lead to a cell acquiring resistance to antic- cer drugs; however, we still do not know which mechanism(s) are those most relevant to the problem of clinical drug resistance. Indeed, given that many of the cytotoxic anticancer drugs were discovered by random screening, it is – clear what features give a clinically useful anticancer drug a sufficient the- peutic index to be of value. The aim of Cytotoxic Drug Resistance Mechanisms is to provide pro- cols that are appropriate for examining the mechanisms of cellular resistance to anticancer cytotoxics in human tumor samples. Tumor cell lines have been enormously useful as experimental models of drug resistance mechanisms, however they have limitations and we need to address the relevance of such mechanisms in patients’ tumors. Examining drug resistance in tumors is much more problematic than in cell lines.

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Encyclopedia of Adolescence 2nd ed. 2018 Edition

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The second edition of this encyclopedia continues to break new ground as an important resource for the study of adolescence. Comprehensive in breath and textbook in depth, the second edition – with entries presented in easy-to-access A to Z format – serves as a reference repository of knowledge in the field as well as a frequently updated conduit of new research and knowledge long before such information trickles down to standard textbooks. This updated and expanded major reference work advances the field by pushing and creating new boundaries and areas of study that further our understanding of adolescents and their place in society. In addition to the original 730 entries, the new edition adds more than 200 new essays as well as updates to many other entries. Substantively, the second edition continues to draw from four major areas of research relating to adolescence:

  • The first broad area includes research relating to “Self, Identity and Development in Adolescence”
  • The second broad area centers on “Adolescents’ Social and Personal Relationships”.
  • The third area examines “Adolescents in Social Institutions”.
  • “Adolescent Mental Health” constitutes the last major area of research.
    This unique, comprehensive second edition of the Encyclopedia of Adolescence is an essential reference for advanced undergraduate and graduate students as well as researchers, professors, clinicians, and other practitioners across such related disciplines as developmental psychology, criminology and criminal Justice, adolescent psychiatry, child and school psychology, family, and public health.

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Molecular Analysis of Cancer (Methods in Molecular Medicine) 2002nd Edition

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Over the past 20 years, technological advances in molecular biology have proven invaluable to the understanding of the pathogenesis of human cancer. The application of molecular technology to the study of cancer has not only led to advances in tumor diagnosis, but has also provided markers for the assessment of prognosis and disease progression. The aim of Molecular Ana- sis of Cancer is to provide a comprehensive collection of the most up-to-date techniques for the detection of molecular changes in human cancer. Leading researchers in the field have contributed chapters detailing practical pro- dures for a wide range of state-of-the-art techniques. Molecular Analysis of Cancer includes chapters describing techniques for the identification of chromosomal abnormalities and comprising: fluor- cent in situ hybridization (FISH), spectral karyotyping (SKY), comparative genomic hybridization (CGH), and microsatellite analysis. FISH has a pro- nent role in the molecular analysis of cancer and can be used for the detection of numerical and structural chromosomal abnormalities. The recently described SKY, in which all human metaphase chromosomes are visualized in specific colors, allows for the definition of all chromosomal rearrangements and marker chromosomes in a tumor cell. Protocols for the detection of chromosomal re- rangements by PCR and RT-PCR are described, as well as the technique of DNA fingerprinting, a powerful tool for studying somatic genetic alterations in tumorigenesis.

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