The Therapeutic Use of N-Acetylcysteine (NAC) in Medicine

The Therapeutic Use of N-Acetylcysteine (NAC) in Medicine

Focusing on the practical use of N-Acetyl-Cysteine (NAC) in medicine, this book provides a comprehensive review of the basic biological and clinical studies documenting its benefits in treating medical disease. NAC is perhaps best known as an antidote for acetaminophen, but its therapeutic effect in a wide range of medical diseases has recently been realized. In addition to its well recognized use in radiological contrast prophylaxis for renal disease and pulmonary disorders, studies have suggested significant promise in psychiatric and neurological disorders such as addiction, Alzheimer’s disease, ataxia, autism, bipolar disorder, depression, epilepsy, neuropathy, obsessive-compulsive disorder, schizophrenia, traumatic brain injury and trichotillomania in addition to promising studies in audiology, cardiology, exercise physiology, gastroenterology, hematology, infectious disease, infertility and ophthalmology. Given the promising studies for a wide range of medical conditions, coupled with a excellent safety profile, the potential for NAC in the treatment of human disease appears considerable.

Dr Leonore A Herzenberg from Stanford University, a pioneer of redox physiology and the use of NAC, provides a succinct history of the development of the therapeutic use of NAC for medical disease. This is followed by a series of basic science chapters outlining the role of NAC in important physiological processes, including modulation of dopamine and glutamate neurotransmitter systems, redox and mitochondrial metabolism, apoptosis and inflammation.

The last section of the book is dedicated to clinically oriented chapters that comprehensively review the literature on medical disorders in which NAC has been found to be effective, including toxicity and cardiovascular, gastrointestinal, neurological, psychiatric, pulmonary and renal disorders. Each chapter reviews the theoretical biological mechanisms of NAC for the specific diseases reviewed, rates the clinical studies using a standardized criteria in order to provide an objective level of evidence and grade of recommendation for the use of NAC for specific medical conditions and outlines the ongoing clinical trials examining NAC for the treatment of specific diseases. Final chapters review the clinical evidence verifying that specific theoretical biological mechanisms are actually being targeted by NAC in medical disease. Studies on the pharmacology, formulation and potential adverse effects of NAC are also reviewed. A final chapter synthesizes the clinical studies to suggest that the effectiveness of NAC may signal a new basic physiological disorder, glutathione deficiency, which may be an important pathophysiological mechanism of many diseases.

 

 

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Interventions in Pulmonary Medicine 2nd ed

Interventions in Pulmonary Medicine 2nd ed

This new edition offers comprehensive coverage of all areas of interventional pulmonology, a minimally invasive endoscopic method for diagnosing and treating lung disorders. The text is divided into eight sections on the major areas of interventional pulmonology, including basic endoscopy, lung cancer staging, and interventional bronschoscopy in asthma and emphysema. Chapters then explore specific procedures and techniques, including medical thoracoscopy, flexible and rigid bronchoscopy, endobronchial ultrasound, and electromagnetical navigation with coverage of history, indications and contraindications, and up-to-date evidence-based reviews. In recent years there have been many advances in interventional pulmonology, the most significant relating to lung cancer early diagnosis and late-stage treatment. Two new chapters on lung cancer epidemiologic changes and personalized lung cancer treatment explore new methods for maximizing patient care for an increasingly prevalent disease. This inclusive volume concludes with a look towards the future of interventional pulmonology and experimental techniques currently being tested. Interventions in Pulmonary Medicine, Second Edition, is a must have for pulmonologists, endoscopists, pulmonary oncologists, ENT physicians, thoracic surgeons, anesthesiologists, and intensive care specialists and their teams.

 

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Fleisher & Ludwig’s Textbook of Pediatric Emergency Medicine Seventh Edition

Fleisher & Ludwig’s Textbook of Pediatric Emergency Medicine Seventh Edition

Fleisher & Ludwig’s Textbook of Pediatric Emergency Medicine has long been acknowledged as the indispensible comprehensive clinical reference on diagnosing and managing emergent health issues in children. Now, a new editorial team and an all-star collection of contributing authorities have meticulously updated this essential work, bringing you all of the most recent approaches to virtually any pediatric emergency you are likely to encounter in practice.

  • A multitude of new chapters and comprehensive updates put the latest know-how at your fingertips, helping you to optimally manage young patients.
  • A reorganized, streamlined table of contents and refined chapter template for medical emergencies, trauma, surgical emergencies, and behavioral health emergencies approaches pediatric emergencies the way you engage with them in practice.
  • New clinical pathways section provide key steps for managing critical patients
  • New related chapters feature in most chapters enables you to easily cross-reference content across chapters.
  • New colorful design

Now with the print edition, enjoy the bundled interactive eBook edition , which can be downloaded to your tablet and smartphone or accessed online and includes features like:

  • Complete content with enhanced navigation
  • A powerful search that pulls results from content in the book, your notes, and even the web
  • Cross-linked pages , references, and more for easy navigation
  • Highlighting tool for easier reference of key content throughout the text
  • Ability to take and share notes with friends and colleagues
  • Quick reference tabbing to save your favorite content for future use
  • Online-only content includes e-figures, e-tables and additional resources

 

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Dysphagia Evaluation and Treatment: From the Perspective of Rehabilitation Medicine 1st ed

Dysphagia Evaluation and Treatment: From the Perspective of Rehabilitation Medicine 1st ed

This book presents a comprehensive approach to treating dysphagia that has been successfully applied in actual rehabilitation settings. Its main purposes are firstly to equip readers with a strong conceptual understanding of swallowing evaluation and treatment, secondly to provide guidance on the procedure of practical comprehensive dysphagia rehabilitation in real-world settings, and thirdly to update readers on the latest diagnostic and treatment technologies. To do so, it employs the concept of swallowing rehabilitation pioneered at Fujita Health University Rehabilitation.
The book is divided into 4 major sections, the first of which introduces readers to the general aspects and the principle of deglutition. In turn, Part II offers clinical approaches to both non-instrumental and instrumental evaluation of swallowing. Part III addresses treatment options in swallowing rehabilitation, especially exercises based on motor learning. Lastly, Part IV highlights three clinical cases demonstrating clinical approaches in dysphagic patients.
Readers will find this text useful both as an initial guide and a reference work for assisting clinicians, allowing them to further expand swallowing assessment and treatment, and facilitating the development of swallowing rehabilitation in real-world settings in education and rehabilitation.

 

 

 

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Electron Spin Resonance Spectroscopy in Medicine 1st ed

Electron Spin Resonance Spectroscopy in Medicine 1st ed

This book examines various applications of electron spin resonance spectroscopy (ESR) in medicine, covering topics such as interactions between blood and nanoparticles, physical intricacy of HbNO complexes, parasitic diseases, oxidative stress measurement, polymerization of resinous materials used in dentistry, tooth dosimetry and dermatological applications.

Instead of providing mathematical details, it focuses on the applications and data interpretation of ESR as an emerging tool.

This book is intended for students and researchers interested in the field of ESR applications in translational research and medicine.

 

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Clinical Regenerative Medicine in Urology 1st ed

Clinical Regenerative Medicine in Urology 1st ed

This multidisciplinary book provides up-to-date information on clinical approaches that combine stem or progenitor cells, biomaterials and scaffolds, growth factors, and other bioactive agents in order to offer improved treatment of urologic disorders including lower urinary tract dysfunction, urinary incontinence, neurogenic bladder, and erectile dysfunction. In providing clinicians and researchers with a broad perspective on the development of regenerative medicine technologies, it will assist in the dissemination of both regenerative medicine principles and a variety of exciting therapeutic options. After an opening section addressing current developments and future perspectives in tissue engineering and regenerative medicine, fundamentals such as cell technologies, biomaterials, bioreactors, bioprinting, and decellularization are covered in detail. The remainder of the book is devoted to the description and evaluation of a range of cell and tissue applications, with individual chapters focusing on the kidney, bladder, urethra, urethral sphincter, and penis and testis.

 

 

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Mechanical Ventilation in Emergency Medicine 1st ed

Mechanical Ventilation in Emergency Medicine 1st ed

This book discusses mechanical ventilation in emergency settings, covering the management of patients from the time of intubation until transfer to the ICU. It provides an introduction to key concepts of physiology pertinent to mechanical ventilation as well as a review of the core evidence-based principles of ventilation. The text highlights the management of mechanical ventilation for critically ill patients with several conditions commonly encountered in EM practice, including acute respiratory distress syndrome, asthma, chronic obstructive pulmonary disease, and traumatic brain injury. It begins by reviewing terminology and definitions as well as pathophysiology and physiology. It then addresses the use of ventilators including modes of ventilation, pressures on the ventilators, understanding the screens, the variety of settings, and troubleshooting. It concludes with a series of case studies from emergency settings and a review of key concepts. Mechanical Ventilation in Emergency Medicine is an essential resource for emergency medicine clinicians including experienced physicians, EM residents, physician assistants, nurse practitioners, nurses, and medical students rotating in the ED as well as professionals who provide emergency care for ventilated patients outside the emergency department, including paramedics, critical care transport nurses, and hospitalists.

 

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Predictive Biomarkers in Oncology: Applications in Precision Medicine

Predictive Biomarkers in Oncology: Applications in Precision Medicine

This book provides a collection of ingeniously organized, well-illustrated and up-to-date authoritative chapters divided into five sections that are clear and easy to understand. Section one provides an overview of biomarkers, introduces the basic terminologies, definitions, technologies, tools and concepts associated with this subject in the form of illustrations/graphics, photographs and concise texts. Several recent biomarker endeavors that have been initiated and funded by the National Cancer Institute, National Institutes of Health, FDA and other International organizations are presented. Section two involves the signaling pathways controlling cell growth and differentiation altered in cancer. This section analyzes how predictive biomarkers are altered (expressed or amplified) across cancer types. Section three explores how predictive biomarkers play a role in patient stratification and tailored treatment in relationship to specific cancers. In addition, it includes discussion on the various precision medicine initiatives that are going on across the globe (e.g. TARGET, NCI-MATCH, BATTLE, SHIVA, etc.). Section four discusses: (a) how pharmaceutical companies validate predictive biomarker assays and accompanying companion diagnostics either internally or externally with partner companies such as central laboratories or clinical research organizations, and (b) how predictive biomarker tests fall under the oversight of US FDA, Centers for Medicare & Medicaid Services (CMS) and state laws. Section five wraps up novel agents and targets that are being used as targets for cancer therapeutics. The biomarkers associated with these protocols will also be presented. Throughout the book, sidebars, special interest boxes and illustrations are used to explain terms that are either newly introduced, uncommon, or specialized.

 

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Quick Hits for Pediatric Emergency Medicine

Quick Hits for Pediatric Emergency Medicine

This book covers essential information necessary in diagnosing and treating pediatric patients in the emergency room. Emergencies require quick and precise decision making that does not allow for extended reading or fact-checking to ensure all factors are considered. This pocket guide addresses that need by placing vital clinical management and algorithms into a quick and simple guidebook that can be accessed within moments from a scrub pocket or white coat. It is an easy, quick access reference that can be used for those facts that are absolutely essential, but are often difficult to remember. Color images and flow charts allow doctors to grasp the essentials quickly, while more detailed explanations are included alongside for trainees. Quick Hits for Pediatric Emergency Medicine uses tips, caveats, drug dosing, and pearls to assist the provider who may not be familiar with all of the unique nuances of the pediatric population. This is ideal for emergency department physicians, nurses, and trainees including students, residents, and fellows.

 

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