Bone Marrow Failure (Pediatric Oncology)

Bone Marrow Failure (Pediatric Oncology)

This book presents the latest scientific knowledge on inherited and acquired bone marrow failure syndromes, describing the advances in understanding of genetics and pathophysiology that have been achieved as a result of high-throughput DNA sequencing, RNA expression studies, and modern biochemistry techniques. The full range of relevant conditions is covered, including acquired aplastic anemia, Fanconi anemia, ribosomopathies, telomeropathies, dyskeratosis congenita, Shwachman-Diamond syndrome, Diamond-Blackfan anemia, and congenital neutropenias and thrombocytopenias. In addition, it is explained how the study of these rare diseases has uncovered important new science and elucidated the pathophysiology of more common hematological and oncological diseases. A treatment-specific chapter describes options ranging from the conventional to the cutting edge. Bone Marrow Failure will be of value for both trainee and practicing hematologists and oncologists.

 

 

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Integrative Pediatric Oncology

Integrative Pediatric Oncology 

This book covers a broad spectrum of complementary and alternative medicine (CAM) practices employed in pediatric oncology worldwide, with a special focus on the methods widely used in Western countries. It is a scientifically based, practice-oriented handbook that will meet the needs of pediatric oncologists working in medical practices and hospitals. An introductory section includes a comparative overview of current CAM use in pediatric oncology in different countries. Commonly used CAM methods are then discussed in a series of chapters that provide a theoretical description of the method in question, followed by more practically oriented information, including scientific data if applicable. Special attention is paid to the issue of how to integrate each method into conventional pediatric oncology. The closing parts of the book consider aspects of CAM requiring further development, such as institutional research, and provide a road map on establishing integrative pediatric oncology worldwide.

 

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Pediatric Oncologic Pharmacy: A Complete Guide to Practice

Pediatric Oncologic Pharmacy: A Complete Guide to Practice 

There are few publications about chemotherapy in children, and none of them is a book aimed at pharmacists. Pediatric Oncology Pharmacy is an area where more and more specific knowledge is required in daily practice. Pharmacists who work in pediatric oncology area do not have a book directed at them; none of the oncopediatric books addresses topics unique to pharmacy — such as manipulation of cytotoxic drugs for children, analysis of oncopediatric prescriptions, clinical pharmacy in oncopediatrics, pharmaceutical care in oncopediatric area, and other subjects that are of exclusive interest to these professionals, but no less essential for a therapy of excellence. As for this need, the purpose of this book is to be a guideline for all subjects that pediatric oncology pharmacists need to know to work in this area. It will be an essential guide to pediatric oncology pharmacists, clinical pharmacists, pharmaceutical residents who work with drug therapy in children and pharmaceutical researchers. It will be a pocket guide to assist in daily practice, and it will be essential to Pediatric Oncology/ Hematology Institutions. The essential propose of this book is to be the first one focusing pediatric oncology for pharmacists.

 

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Pediatric Oncology Nursing: Advanced Clinical Handbook 2nd ed

Pediatric Oncology Nursing: Advanced Clinical Handbook 2nd ed

Pediatric Oncology Nursing: Advanced Clinical Hand- signs, diagnostic and laboratory procedures, tre- book is a joint effort between nurses in Canada, the ment, prognosis, and follow up care are included for United Kingdom, and the United States. This is the each of the disorders. second edition, and has been another wonderful Part III covers cancer treatment, including c- opportunity to bring together the expertise of hema- motherapy, radiation therapy, hematopoetic stem cell tology and oncology nurses from two continents. The transplantation, surgery, gene therapy, biotherapy, c- book is designed to be a comprehensive clinical hand- plimentary and alternative medicine, and clinical trials. book for nurses in advanced practice working with The principles and description of treatment, method pediatric hematology/oncology patients. Speci? c of treatment delivery, potential side effects, and special issues related to young children and adolescents with considerations for each type of treatment are discussed. cancer and hematologic disorders are discussed. Part IV focuses on the side effects of cancer Thirty-one contributors and two editors partici- treatment in relation to metabolic processes and pated in the writing of this text. Individuals in advanced gastrointestinal, hematologic, respiratory, renal, c- practice and academic roles – nurse practitioners, clin- diovascular, neurologic, musculoskeletal, integum- ical nurse specialists, nutritionists, clinical instructors, tary, endocrine, and auditory systems. The incidence, lecturers, academicians, and educators – were involved. etiology, treatment, prevention, and prognosis are One of the most appealing features of this text is the included for each side effect reviewed.

 

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Radiobiology of Glioblastoma: Recent Advances and Related Pathobiology

Radiobiology of Glioblastoma: Recent Advances and Related Pathobiology

This text properly considers the most recent and relevant advances in molecular RB of GB, taking into account the related topics of pathobiology, and underscores the most promising translational perspectives from the preclinical to the clinical domain. Section I (From Bedside to Bench) discusses conditions associated with RT resistance of GB and the consequent RB hints, technology improvements intended to overcome RT-resistance of GB, mathematical modeling of RB parameters from clinical studies, the present impact of molecular prognostic factors in therapy of GB, and RT tolerance of normal brain. Section II (Preclinical Research and Pathobiology Topics) presents the traditional and mechanistic/molecular approaches to RB of GB, genetic and epigenetic studies on GB, issues of cell-death pathways, stem-like cells, invasiveness, tumor microenvironment, hypoxia, mi-RNA manipulations, and nanoparticle technology. Section III (Translational Perspectives) presents RB issues related to molecular profiling and classification of GB as frames of reference for clinical studies, translational perspectives of gene therapy, evolving protocols based on pre-clinical data and large data-bases and ontologic models.

 

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Advanced Imaging Techniques in Clinical Pathology

Advanced Imaging Techniques in Clinical Pathology

This text provides a comprehensive, state-of-the-art review of the application of image analysis focusing on the techniques which can be used in every biology and medical laboratory to automate procedures of cell analysis and to create statistics very useful for a comprehension of cell growth dynamics and the effects of drugs on them. This textbook will serve as a very useful resource for physicians and researchers dealing with, and interested in, cell analysis. It will provide a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts.  All chapters are written by experts in their fields and  include the most up-to-date scientific and clinical information. Advanced Imaging Techniques in Clinical Pathology will be of great value to clinical pathologists, biologists, biology researchers, and those working in the  clinical and biological laboratory arena.​

 

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Liquid Biopsy in Cancer Patients: The Hand Lens for Tumor Evolution

Liquid Biopsy in Cancer Patients: The Hand Lens for Tumor Evolution

This text is designed to provide readers with a useful and comprehensive resource and state-of-the-art overview about the new, growing and fast-expanding field of “liquid biopsy” for the management of cancer patients. The liquid biopsy represents an important turning point in oncology since it provides a tool for a serial monitoring of disease. Liquid biopsy is our “hand lens” to follow molecular changes that characterize tumor development and progression. The book provide a unique and valuable resource on the clinical relevance of liquid biopsy as well as on the technical aspects of liquid biopsy analysis. All invited authors are recognized experts in their field. 
Liquid Biopsy in Cancer Patients: The Hand Lens for Tumor Evolution is targeted to resident and fellows physicians, medical oncologists, molecular biologists and biotechnologists.

 

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The Mediastinal Mass: A Multidisciplinary Approach

The Mediastinal Mass: A Multidisciplinary Approach

Tumors of the mediastinum are usually diagnosed in young patients, but they can develop at any age and form any tissue that exists in or passes through the chest cavity. The diagnosis and the accurate assessment of the mediastinum masses represents a challenge, given their clinical variability from asymptomatic to producing symptoms of cough, chest pain, and dyspnea. Mediastinal tumors encompass a wide range of various neoplasms. The localization of mediastinal masses is critical in the diagnosis: the anterior mediastinal masses are generally thymomas, teratomas, substernal thyroid/parathyroid tissue, or lymphomas; the middle mediastinum massess are typically pericardial and bronchogenic cysts; the posterior mediastinum  masses are often neurogenic tumors and esophageal cysts. The wide variety of different entities demonstrates a heterogeneous spectrum of clinical and pathologic features, suggesting that a uniform “standard” management of these patients is not appropriate.
In this context, the proposed book will provide a comprehensive review of the mediastinal tumors according to different sites of the diseases, including the masses of anterior, middle and posterior mediastinum. The handling of these tumors requires a multidisciplinary approach due to the complex anatomy of the mediastinum as well as the different clinical, radiographic, and prognostic features. This book has risen from the desire to provide to the specialists in the field an easy, updated and practical guidelines title to facilitate the clinical practice of mediastinic masses. This book will be a comprehensive guide to clinical best practices developed through the opinions of experts in the field.

 

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Cardiovascular Complications in Cancer Therapy

Cardiovascular Complications in Cancer Therapy

This proposed text is designed to provide a useful and comprehensive resource and state-of-the-art overview to readers about vascular damage  potentially induced by antineoplastic drugs. Thanks to more and more effective antineoplastic treatments the survival of cancer patients is enormously increasing, but at the same time it is increasing the burden of related cardiovascular complications that affect morbidity and mortality. On this basis a new branch of cardiology has been developed, that is Cardio-Oncology. The aim is to prevent cardiovascular complications related to cancer therapy and to facilitate and avoid interruption of antineoplastic drugs due to the occurrence of cardiovascular damage. An increasing attention has been given to cardiac damage, while, until today, vascular complications have been poorly evaluated. The aim of this book is to focus on vascular complications related to cancer treatment, to guide the clinician at facing, during his every day practice, cardiovascular toxicity in cancer and hematologic patients. The proposed sections of the book have been structured to review the molecular mechanisms underlying vascular damage induced by new and old treatments, to describe the various manifestations of vascular disease that may range from artery to venous disease (including coronary artery disease, peripheral arterial disease, venous thromboembolism and pulmonary hypertension), and to provide advice to monitor patients undergoing onco-hematologic treatments in order to prevent and eventually manage vascular damage.This book will address resident and fellow physicians, medical oncologists, cardiologists, general practitioners and all those who take care of these patients.All invited authors will be recognized experts in their field, and leading international researchers on these topics. The editor has worked with these expert colleagues on a variety of other projects. The authors will provide their manuscript according to current literature and clinical research studies. The book does not seek to duplicate or replace other current resources. Rather, it will create a comprehensive yet concise resource on this emerging topic that is not adequately covered by any current literature.

 

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Diagnosis of Liver Disease 2nd Edition

Diagnosis of Liver Disease 2nd Edition

This book guides practitioners in the assessment of patients with a liver problem. The emphasis is on the role of macro- and microscopic pathology in elucidating pathogenesis as well as identifying confounding features of image findings that may lead to a more elaborate differential diagnosis. If appropriate, the role of light and electron microscopic examination, along with the role of specific stains and molecular techniques, is illustrated. In addition, the concept of each liver disease is summarized briefly and its up-to-data is provided, and unresolved problems in diagnosis, treatment, and pathogenesis are clearly described.
The approach in this book is a practical one with a focus on the evaluation of illustrative cases, simultaneously demonstrating cross-sectional images (ultrasonography, computed tomography, magnetic resonance imaging, and angiography), pathological findings, and peritoneoscopic images. The diagnosis and therapy are summed up in helpful tables, and association of clinical manifestations with image analysis and pathological findings is shown to be important in differential diagnosis and treatment. With the authors comprising internationally renowned experts, this book will serve as a useful source of information for medical students, physicians, internists, hepatologists, gastroenterologists, radiologists, and pathologists worldwide.

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