Category: Nuclear Medicine

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This book serves as a practical guide for the use of stereotactic body radiation therapy in clinics. On the basis of more than 10 years of clinical experience with lung cancer, liver cancer and other cancers, a remarkable volume of knowledge has been accumulated. At the same time, great progress in techniques has been achieved. Various new fixing apparatuses, new respiratory regulation techniques, new dose fractionation schedules and new image-guided radiation therapy machines have been developed. This book reviews the history of those developments and reports on various types of toxicities. Review of recent clinical studies is also included. The authors were key members of the JCOG 0403 clinical trials on stereotactic body radiation therapy (SBRT) for both inoperable and operableT1N0M0 primary lung cancer. Readers will learn of the superior outcomes obtained with SBRT for lung cancer and other cancers in terms of local control and toxicities. With its practical focus, this book will benefit radiation oncologists, medical physicists, medical dosimetrists, radiation therapists and senior nurses as well as medical oncologists and surgical oncologists who are interested in radiotherapy.

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This book is devoted to sharing the knowledge and experience of expert radiation therapy (RT) for extranodal lymphomas. For that purpose, the authors provide clinical-pathological information, precise RT techniques, and treatment results, i.e., disease control and survival, of all extranodal lymphomas.

Over the past 10 years, specific techniques have been updated, from 3-dimensional conformal RT to intensity modulated RT / volumetric-modulated arc therapy. Precise targeting such as image-guided RT and active breathing control are now capable of treating lymphoma lesions that shift with respiration or peristalsis.

This book, serving as a guide, provides the necessary knowledge for radiation oncology, practice, and planning involving the RT techniques of treating extranodal lymphomas. In addition, it equips oncologists, hematologists, and medical oncologists to refer patients with extranodal lymphomas to radiation oncologists for appropriate treatment in a timely manner. Therefore this volume will greatly benefit all oncologists, including radiation and medical oncologists, as well as hematologists.

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“Nuclear envelope (NE) defects have been linked to cancer biology since the mid-1800s, but it was not until the last few years that we have begun to understand these historical links and to realize that there are myriad ways that the NE impacts on tumorigenesis. The NE  is a complex double membrane system that encloses the genome while providing structural support through the intermediate filament lamin polymer and regulating protein/ mRNA trafficking and signaling between the nucleus and cytoplasm via the nuclear pore complexes (NPCs). These functions already provide some mechanisms for NE influences on cancer biology but work in the past few years has elucidated many others. Lamins and many recently identified NE transmembrane proteins (NETs) have been now shown to function in DNA repair, regulation of cell cycle and signaling, apoptosis, cell migration in metastasis and nuclear architecture and morphology. This volume presents a comprehensive overview of the wide range of functions recently identified for NE proteins and their relevance in cancer biology, providing molecular mechanisms and evidence of their value as prognostic and diagnostic markers and suggesting new avenues for the treatment of cancer. Indeed some of these recent links are already yielding promising therapies, such as the current clinical trial of selective inhibitors of the nuclear export factor exportin in certain types of leukemia, melanoma and kidney cancer.”

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