Category: Neurology/Neurosurgery

Cell Therapy for Perinatal Brain Injury 1st ed

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This book provides a wealth of insights, advances and new perspectives on cell therapy for different types of neonatal ischemic disease, such as Hypoxic-Ischemic Encephalopathy (HIE), Periventricular Leukomalacia (PVL) and neonatal infarction.

These diseases pose serious challenges for neonatologists and neurologists, because the severe sequelae lead to decreasing QOL for patients and their families. Accordingly, new treatments for neonatal ischemic diseases are needed all over the world.

The book develops new effective therapies combined with hypothermia therapy, an established treatment for HIE. After reviewing past approaches, it presents cutting-edge topics in cell therapy, one of the most promising candidates for treating neonatal ischemic disease. Cell Therapy for Neonatal Ischemic Disease will offer readers a better understanding of the current state of the art in this field from bench to bedside, and inspire researchers and physicians to further explore this evolving therapy.

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Head and Neck Cancer: Multimodality Management 1st ed. 2016 Edition

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​This second edition ​provides a comprehensive view of consolidated and innovative concepts, in terms of both diagnosis and treatment. Written by leading international physicians and investigators, this book emphasizes the necessity of combining local and systemic treatments to achieve the objective of yielding higher cure rates and lower toxicities. Heavily updated from the previous edition, it highlights new surgery and radiotherapy techniques, disease awareness, patient quality of life, and comprehensive management.
Head-and-neck cancers are a complex clinical entity and their response to treatment is also known to vary markedly in function of host-related factors. Notwithstanding the impressive progresses observed in the field of imaging, head and neck cancers are often diagnosed at a late stage and the presence of locally advanced disease in a significant number of patients implies the use of aggressive treatments in order to both ensure local disease control and reduce distant metastasis risks.
In comparison with the first edition, Head and Neck Cancer, Second Edition provides a detailed update of innovative concepts in chemo- and bio-radiation, viral infection impact on tumor growth and response to treatment, and impact of tumor- and host-related factors on treatment outcome.

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Infant Brain Development: Formation of the Mind and the Emergence of Consciousness 1st ed. 2016 Edition

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This book discusses the main milestones of early brain development and the emergence of consciousness, within and outside the mother’s environment, with a particular focus on the preterm infant. These insights offer new perspectives on issues concerning fetal pain, awareness in newborns, and the effects of current digital media on the developing infant brain.

Among the topics covered:

·         Brain patterning, neural proliferation, and migration.

·         The stress of being born and first breaths.

·         The stream of consciousness.

·         Parenting and stimulating the brain of the child.

·         The moral status of the fetus and the infant.

Infant Brain Development is an excellent resource for researchers, clinicians and related professionals, and graduate students across a variety of disciplines including developmental psychology, pediatrics, neurobiology, neuroscience, obstetrics, nursing and medical ethics. It is written with historic and philosophical remarks of interest for a broad readership.

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“This book is a joy to read for anyone interested in understanding where biology is heading in the 21st century, and it is essential for those who work in child development.”
Eric Kandel, University Professor, Columbia University, Co-Director, Mortimer B. Zuckerman Mind Brain Behavior Institute, Nobel Laureate in Medicine 2000

“With the precision of a scientist, the depth of a philosopher, and the heart and sensitivity of a pediatrician, Hugo Lagercrantz weaves a story as readable and engrossing as any mystery novel, linking brain, genes, the environment, and behavior to explain the development of the mind of a newborn. A tour de force!”
Patricia K. Kuhl, The Bezos Family Foundation Endowed Chair in Early Childhood Learning, Co-Director, Institute for Learning & Brain Sciences, University of Washington

“This book is a noble and valiant effort by Dr. Lagercrantz to explain the immensely complex issue of normal and pathological development of the human brain in simple terms that are accessible to the general public.”
Pasko Rakic, Duberg Professor of Neuroscience and Neurology, Yale University School of Medicine

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Minimally Invasive Spine Surgery Techniques 1st ed. 2018 Edition

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About the Author

Complications in Neuroanesthesia 1st Edition

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Complications in Neuroanesthesia focuses on complications that may arise related to neuroanesthesia practice and discusses its various causes. Each complication is written as a separate chapter, and the pathophysiology and mechanisms of each complication, as well as measures for diagnosis, treatment and prevention are discussed. Towards the end of the book, several case scenarios are provided to the readers that challenge readers to diagnose the possible complication for each case. Chapters include brain and spinal cord problems, cardiovascular and hematological problems, and nerve and muscle problems.

Written in a standard format, Complications in Neuroanesthesia provides quick and easy access to understanding problems in neuroanesthesia. It provides insight into all possible complications occurring during perioperative management of neurosurgical and neurologic patients. It is useful for trainees, clinicians, and researchers in the fields of neurosurgery, neurocritical care, and neurology by providing an understanding of preventable mishaps that may occur in neurosurgical or neurologic patients.

  • Quick and easy reference for understanding problems in neuroanesthesia
  • Provides comprehensive insights into all possible complications occurring during perioperative management of neurosurgical and neurologic patients
  • Includes useful section with clinical case studies of complications in neuroanesthesia

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Essentials of Neuroanesthesia 1st Edition

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Essentials of Neuroanesthesia offers useful insights on the anesthetic management of neurosurgical and neurologic patients. This book covers all topics related to neuroanesthesia, providing essential knowledge on the brain and spinal cord. Sections include chapters on anatomy, physiology, and pharmacology, along with specific chapters related to various neurosurgical and neurological problems and their anesthetic management.

This book provides an understanding of related issues, such as palliative care, evidence based practice of neuroanesthesia, sterilization techniques, biostatistics, and ethical issues, and is useful for trainees, clinicians, and researchers in the fields of neurosurgery, neurocritical care, neuroanesthesia, and neurology.

  • Offers useful insights on the anesthetic management of neurosurgical and neurologic patients
  • Discusses related issues, such as palliative care, evidence based practice of neuroanesthesia, sterilization techniques, biostatistics, and ethical issues
  • Useful for trainees, clinicians, and researchers in the fields of neurosurgery, neurocritical care, neuroanesthesia, and neurology

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Intracranial Tumors: Diagnosis and Treatment

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Brain tumors have a longstanding reputation for being intractable to therapy, and with evidence suggesting that the incidence of some brain tumors is increasing, this has become the most feared cancer. However, with improvements in imaging technologies, radiation therapy and chemotherapy , as well as a greater knowledge of the genetic causes of brain tumors, better diagnosis and treatment is available, providing a more optimistic outlook for patients. This book, written by leading professionals in the field of neuro-oncology, provides a valuable overview and presentation of the most up-to-date ideas in the diagnosis, treatment and management of intracranial tumors. Covering the most current diagnostic and therapeutic tools available including MRI, stereotactic needle biopsy, functional MRI, 3D conformal radiotherapy, radiosurgery, fractionated stereotactic radiotherapy, new chemotherapy agents and novel regimens, gene therapy and anti-angiogenesis factors, it will be of great interest to all.

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Phosphodiesterases: CNS Functions and Diseases (Advances in Neurobiology) 1st ed

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PDEs are a family of enzymes that catalyze the hydrolysis of intracellular cyclic nucleotides. They are implicated in a number of disorders and dysfunctions and PDE inhibitors have already proven to be effective therapies for erectile dysfunction, COPD, and psoriatic arthritis.  This family of enzymes also plays a role in diseases and disorders of the CNS such as depression, anxiety, schizophrenia, and Alzheimer’s Disease. Unfortunately no effective PDE inhibitors have been developed for the treatment of these diseases.  The proposed book will be a comprehensive overview of the current state of basic and translational research on PDE inhibitors written by internationally recognized experts. Authors will also discuss potential PDE subtypes and splice variants in the hopes that this will spur more creative approaches to PDE targeting drugs.

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Neuroimaging Diagnosis for Alzheimer’s Disease and Other Dementias 1st ed.

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This book describes the latest modalities such as tau PET imaging for diagnosis of Alzheimer’s disease and other dementias, and also provides information on handling and analyzing imaging data that is not found in other books. In addition, it introduces routine imaging studies in the management of dementia in Japan. The prevalence of dementia has increased over the past few decades, either because of greater awareness and more accurate diagnosis, or because increased longevity has created a larger population of the elderly, the age group most commonly affected. Although only clinical assessment can lead to a diagnosis of dementia, neuroimaging in dementia is recommended by most clinical guidelines, and its adjunct role has traditionally been to exclude a mass lesion rather than to support a specific diagnosis. Neuroimaging may be also helpful for developing new strategies to achieve diagnoses as early as possible for therapies aimed at slowing the progression of neurodegenerative diseases manifesting dementia. Under these conditions, all clinicians and researchers who are involved in neuroimaging for dementia should decide which patients to scan, when imaging patients is most useful, which modality to use, how to handle imaging data from many institutions, and which analytical tool to use. This edition comprises contributions from leading Japanese experts in their fields.

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