Biomaterials for 3D Tumor Modeling (Materials Today) 1st Edition

Biomaterials for 3D Tumor Modeling (Materials Today) 1st Edition

Biomaterials for 3D Tumor Modeling reviews the fundamentals and most relevant areas of the latest advances of research of 3D cancer models, focusing on biomaterials science, tissue engineering, drug delivery and screening aspects. The book reviews advanced fundamental topics, including the causes of cancer, existing cancer models, angiogenesis and inflammation during cancer progression, and metastasis in 3D biomaterials. Then, the most relevant biomaterials are reviewed, including methods for engineering and fabrication of biomaterials. 3D models for key biological systems and types of cancer are also discussed, including lung, liver, oral, prostate, pancreatic, ovarian, bone and pediatric cancer.
This book is suitable for those working in the disciplines of materials science, biochemistry, genetics, molecular biology, drug delivery and regenerative medicine.

– Reviews key biomaterials topics, including synthetic biomaterials, hydrogels, e-spun materials and nanoparticles
– Provides a comprehensive overview of 3D cancer models for key biological systems and cancer types
– Includes an overview of advanced fundamental concepts for an interdisciplinary audience in materials science, biochemistry, regenerative medicine and drug delivery

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Monte Carlo in Heavy Charged Particle Therapy: New Challenges in Ion Therapy (ISSN) 1st Edition

Monte Carlo in Heavy Charged Particle Therapy: New Challenges in Ion Therapy (ISSN) 1st Edition

This book explores the current difficulties and unsolved problems in the field of particle therapy and, after analysing them, discusses how (and if) innovative Monte Carlo approaches can be used to solve them.

Each book chapter is dedicated to a different sub-discipline, including multi-ion treatments, flash-radiotherapy, laser-accelerated beams, nanoparticles effects, binary reactions to enhance radiobiology, and space-related issues. This is the first book able to provide a comprehensive insight into this exciting field and the growing use of Monte Carlo in medical physics.

It will be of interest to graduate students in medicine and medical physics, in addition to researchers and clinical staff.

Key Features:

  • Explores the exciting and interdisciplinary topic of Monte Carlo in particle therapy and medicine
  • Addresses common challenges in the field
  • Edited by an authority on the subject, with chapter contributions from specialists

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Systems Biology of Cell Signaling: Recurring Themes and Quantitative Models 1st Edition

Systems Biology of Cell Signaling: Recurring Themes and Quantitative Models 1st Edition

How can we understand the complexity of genes, RNAs, and proteins and the associated regulatory networks? One approach is to look for recurring types of dynamical behavior. Mathematical models prove to be useful, especially models coming from theories of biochemical reactions such as ordinary differential equation models. Clever, careful experiments test these models and their basis in specific theories. This textbook aims to provide advanced students with the tools and insights needed to carry out studies of signal transduction drawing on modeling, theory, and experimentation. Early chapters summarize the basic building blocks of signaling systems: binding/dissociation, synthesis/destruction, and activation/inactivation. Subsequent chapters introduce various basic circuit devices: amplifiers, stabilizers, pulse generators, switches, stochastic spike generators, and oscillators. All chapters consistently use approaches and concepts from chemical kinetics and nonlinear dynamics, including rate-balance analysis, phase plane analysis, nullclines, linear stability analysis, stable nodes, saddles, unstable nodes, stable and unstable spirals, and bifurcations. This textbook seeks to provide quantitatively inclined biologists and biologically inclined physicists with the tools and insights needed to apply modeling and theory to interesting biological processes.

Key Features:

  • Full-color illustration program with diagrams to help illuminate the concepts
  • Enables the reader to apply modeling and theory to the biological processes
  • Further Reading for each chapter
  • High-quality figures available for instructors to download

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Directed Evolution: Methods and Protocols (Methods in Molecular Biology Book 2461)

Directed Evolution: Methods and Protocols (Methods in Molecular Biology Book 2461)

This volume explores the latest techniques used by researchers to study directed evolution (DE) at each stage of the Design-Build-Test-Learn cycle. Chapters in this book cover topics such as designing overlap extension PCR primers for protein mutagenesis; antha-guided automation of Darwin assembly for the construction of bespoke gene libraries; rapid cloning of random mutagenesis libraries using PTO-Quickstep; and DE of glycosyltransferases by a single-cell screening method. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. 

Cutting-edge and comprehensive, 
Directed Evolution: Methods and Protocols is a valuable resource for scientists and researchers who are interested in learning more about this field and incorporating these studies into new experimental workflows.

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Practical Skills in Biomolecular Science 5th Edition

Practical Skills in Biomolecular Science 5th Edition

If you are studying the biomolecular sciences – including biochemistry, biomedical sciences, biotechnology, genetics, microbiology and molecular biology – then this book will be an indispensable companion throughout the whole of your degree programme. It provides effective explanation and support for the development of a wide range of laboratory and data analysis skills that you will use time and again during the practical aspects of your studies. This book also gives you a solid grounding in the broader transferable skills, which are increasingly necessary to achieve a high level of academic success.

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Bone, Biomaterials & Beyond

Bone, Biomaterials & Beyond

The introduction of osseointegrated dental implants soon 50 years ago has indeed revolutionized dentistry. The scientific evaluation of their use has shown good and increasingly successful treatment outcomes. A prerequisite though is the availability of sufficient bone volumes to ensure integration and acceptable aesthetic results.
In this book various surgical techniques, using different augmentation materials, are described and explained. The aim has been to highlight minimally invasive surgical techniques, which leads to less risk of morbidity and reduces treatment time.
Readers will enjoy a comprehensive atlas providing some practical advices for every day surgical practice based on solid scientific evidence.

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Hearing Science Fundamentals, Second Edition 2nd Edition

Hearing Science Fundamentals, Second Edition 2nd Edition

NOTE: This book comes with supplementary content on a PluralPlus companion website. If you purchase or rent a used copy of the printed book, the code to access the website printed inside the book may have been previously redeemed/used or be incorrect and you will not be able to use it. To guarantee access to the website, it is recommended you purchase a new copy of this book.

Hearing Science Fundamentals, Second Edition maintains the straightforward style of the previous edition, introducing the basic concepts in hearing science in an easy-to-understand format. With a wide variety of student-friendly features and instructor resources, this comprehensive textbook facilitates the absorption of technical material by both undergraduate and graduate students.

The text is divided into four clear sections to cover everything from the physics of sound to the anatomy and physiology of the auditory pathway and beyond. The textbook begins by delving into the basics of acoustics and digital signal processing (DSP). In the next section, readers will find full coverage of the basic anatomy and physiology of the auditory mechanism. The third section contains eight chapters on psychoacoustics and how sound is perceived via the auditory pathways. The book wraps up with a brand-new section devoted to pathologies of the auditory mechanisms.

New to the Second Edition

  • New coauthor, Jeremy J. Donai, AuD, PhD, brings his extensive clinical and research experience to the concepts discussed

Nine new chapters, including

  • Review of Speech Acoustics (Chapter 2)
  • Digital Signal Processing (Chapter 3)
  • Binaural Processing (Chapter 8)
  • Temporal Processing (Chapter 10)
  • Signal Detection Theory (Chapter 13)
  • Auditory Perception and Hearing Impairment (Chapter 14)
  • Separate and expanded chapters for Pathologies of the Auditory Mechanism (Chapter 9) from first edition.
    • Pathologies of the Conductive Auditory Mechanism (Chapter 15)

    • Pathologies of the Sensory Auditory Mechanism (Chapter 16)

    • Pathologies of the Central Auditory Mechanism (Chapter 17)

  • Clinical Notes intended to bridge the gap from classroom to hearing clinic have been added throughout the text
  • Vocabulary Checks throughout all the chapters
  • Evidence-based information incorporated throughout the text
  • Updated Recommended Readings list
  • Ancillary materials accessible on a PluralPlus companion website: a sample syllabus, test bank, and PowerPoint lecture slides for instructors, and practice quizzes, word-building and anatomy-labelling exercises, audio examples, and overview lecture videos for students

Key Features

  • Learning objectives and key terms at the beginning of each chapter prepare the student for the chapter contents
  • Two-color anatomical and line illustrations aid understanding of important technical concepts
  • Q & A boxes reinforce important information presented in the text
  • A glossary of important terms

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Multiple Sclerosis Therapeutics 4th Edition

Multiple Sclerosis Therapeutics 4th Edition

This book comprehensively reviews the current state of clinical trial methods in multiple sclerosis treatment, providing investigators, sponsors and specialists with current knowledge of outcome measures and study designs for disease and symptom management. The status of the rapidly evolving field of disease-modifying drugs is presented, with emphasis on the most promising therapies currently being tested. Experts discuss disease and symptom management for MS subtypes, including neuromyelitis optica and pediatric MS. In addition, key scientific advances in MS pathology, genetics, immunology and epidemiology are presented. The fourth edition has been extensively revised, featuring more than 50% new material. All chapters have been substantially updated to provide current information on rapidly evolving topics and this volume contains 15 new chapters, reflecting the growth of the field in recent years. This book is an essential reference for practitioners caring for MS patients, investigators planning or conducting clinical trials, and clinical trial sponsors.

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How to request a test: A clinician’s guide to the interpretation and evaluation of medical tests

How to request a test: A clinician’s guide to the interpretation and evaluation of medical tests

Medical tests consume considerable resources and yet making requests is often left to the most junior members of the team. Medical schools often under prepare junior doctors for these tasks so they tend to request large numbers of tests to make sure ‘all bases are covered’ by the time a more senior colleague attends to the patient.

Beginning with naïve questions such as ‘what is a medical test?’ and ‘why do we perform tests?’, the book also covers the evaluation of tests from a public health perspective and helps the readers to determine whether a test should be introduced into clinical care. By describing the basics of medical decision making based on probability thresholds, students will learn how to avoid unnecessary testing when results are unlikely to influence patient relevant decisions, and the pros and cons of using metrics such as sensitivity, specificity, and predictive values.

Illustrated throughout with real life examples from multiple medical and surgical specialties, it concludes with a novel checklist for doctors to consider every time they think of requesting a test.

Written by a clinician for clinicians, this book is ideal for medical students and junior doctors. It provides everything they need to know to become experts at requesting tests. It will support them in requesting the most appropriate and effective tests, and inform them on how to interpret results, improving patients’ outcomes.

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Comprehensive Textbook on Vitiligo 1st Edition

Comprehensive Textbook on Vitiligo 1st Edition

Vitiligo is a disorder having a significant impact in dark-skinned individuals. Along with the historical, cultural, and psychological aspects of the disease the multifactorial pathogenesis of this disorder is discussed in detail with special emphasis on the newer hypotheses proposed in the causation. Descriptions of the clinical aspects of the disease are supplemented with clinical photographs covering the latest therapeutic and surgical treatment options. Nonconventional treatments such as cosmetic camouflage and tattooing are also discussed. Topics of controversy such as the role of diet, patient selection for surgery, and so on, are covered in depth.

Key Features

  • Discusses the recent advances in treatment

  • Evidence-based approach

  • Quality of life and psychological aspects covered

  • Nonconventional treatment options included with practical tips on vitiligo surgery

  • Controversial topics covered

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