Membrane Lipidomics for Personalized Health 1st Edition

Lipidomics is an important aspect of personalized medicine in relation to nutrition and metabolism. This approach has become important due to the substantial presence of nutraceuticals in the market, since it gives personalized criteria on how to choose the right nutraceutical strategy for both prevention and for quality of life.

This multi-disciplinary textbook uses a simple and practical approach to provide a comprehensive overview of lipidomics and their connection with health and nutrition. The text is divided into two parts:
–  Part 1 outlines the basics of lipidomics and focuses on the biochemical and nutritional aspects with descriptions of the analytical methods employed for the examination of cell membrane fatty acid composition.
– Part 2 familiarizes the reader with the use of membrane lipidomic diagnostics in practical health care, using health conditions as examples to introduce the concept of lipidomic profiles in different physiological and pathological situations including prevention.
Through the various properties of membrane lipidomics, readers will be able to combine the molecular status of the cell membrane with the evaluation of the subject for personalized nutritional and nutraceutical strategies.

Membrane Lipidomics for Personalized Health will be beneficial to biologists, biochemists and medical researchers, as well as health care professionals, pharmacists, and nutritionists seeking in-depth information on the topic.

 

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Peptide Chemistry and Drug Design 1st Edition

Peptide Chemistry and Drug Design 1st Edition

This book focuses on peptides as drugs, a growing area of pharmaceutical research and development. It helps readers solve problems of discovering, developing, producing, and delivering peptide-based drugs.

• Identifies promising new areas in peptide drug discovery
• Includes chapters on discovery from natural sources, metabolic modification, and drug delivery
• Overviews separation methods and techniques for analysis, bond formation, and purification
• Offers readers both a professional reference and a text or resource for graduate-level student

 

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Handbook of Otolaryngology: Head and Neck Surgery 2nd Edition

Handbook of Otolaryngology: Head and Neck Surgery 2nd Edition

Now in full color, the revised and updated second edition of David Goldenberg’s and Bradley Goldstein’s acclaimed, award-winning Handbook of Otolaryngology-Head and Neck Surgery is the GOLD standard among pocket guides for this specialty. Packed with information in an all-encompassing scope, yet conveniently portable, this book’s reader-friendly organization (and superb index) is designed for quick reference. Sections cover Otology, Rhinology, Laryngology and the Upper Aerodigestive Tract, Head and Neck Surgery, Pediatric Otolaryngology, Facial Plastic and Reconstructive Surgery, General Otolaryngology, and (new for this edition) Endocrine Surgery.

Most chapters follow a standard format, beginning with a handy list of key points, followed by epidemiology, signs and symptoms, differential diagnosis, how to best conduct the physical exam, imaging, treatment options, outcomes, and appropriate follow-up. Detailed guidance on the full continuum of patient care-from pediatric to geriatric-is provided, which is indispensable for day-to-day practice.

Key Highlights

  • Color figures explain procedures, and numerous tables facilitate learning and recall.
  • The latest TNM staging data is included within all cancer-related chapters.
  • Where applicable, each section begins with emergency situations, providing speedy access when most needed.
  • Three appendices provide basic procedures such as bronchoscopy, esophagoscopy, and tonsillectomy; illustrations of the twelve cranial nerves; and cross-referencing to help treat immediate emergencies.

This book is the essential companion for residents, fellows, and beginning clinicians in otolaryngology, and for all physicians and allied professionals in other disciplines who can use rapid and reliable guidance on ENT medicine.

 

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AUDIOLOGY Diagnosis 2nd Edition

AUDIOLOGY Diagnosis 2nd Edition

Written by the foremost authorities in the field, “Audiology: Diagnosis” presents the basic concepts and essential clinical information for diagnosing auditory disorders, otologic diseases, and vestibular dysfunction. The book provides a thorough review of fundamental principles of diagnosis, including the basic procedures, the anatomy and physiology of the auditory system, imaging techniques, instrumentation, calibration, and more. It also covers the clinical tests essential for assessing the type and degree of hearing loss and for determining the etiological factors underlying the patient’s disorder. Chapters address such important topics as ototoxicity and pharmacology in the audiology practice, and utilizing functional brain imaging and radiologic techniques.

Highlights: New information on effective methods for neonatal hearing screening, assessment of vestibular disorders, the genetics of hearing loss, and recent advances in testing for auditory processing disorders in children and adults Chapter outlines to rapidly acquaint reader with topics to be discussed Pearls, pitfalls, controversial points, and special considerations providing recommendations and comments on key aspects of patient care

“Audiology: Diagnosis” is one part of a three-volume series, which is completed by “Audiology: Treatment” and “Audiology: Practice Management.” Together these books provide audiologists and students in graduate programs with an invaluable resource for each stage of management.

 

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Time and Life Management for Medical Students and Residents 1st Edition

Time and Life Management for Medical Students and Residents 1st Edition

As grueling as medical studies and training are, with appropriate discipline and time management it is possible to stay afloat, maintain one’s sanity, achieve one’s goals, and still enjoy a fulfilling life. It is the purpose of this book to stimulate thought processes that nurture a healthy attitude toward organizing one’s time and life so as to improve one’s own quality of life as well as the patient’s well-being.

Topics include:

  • The macro-perspective: goals, roles, regeneration
  • The micro-perspective: from goal to action
  • Planning your week
  • Acute disaster management: three major points
  • Anxiety management and the “power of now”
  • Networking; finding and working with mentors; reevaluating; learning from errors

Junior residents and interns will benefit greatly from this handy guide, as will medical students in their rotations.

 

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Training for Change: Transforming Systems to be Trauma-Informed, Culturally Responsive, and Neuroscientifically Focused

Training for Change: Transforming Systems to be Trauma-Informed, Culturally Responsive, and Neuroscientifically Focused

This book offers an integrated training and coaching system to facilitate change in systems that serve youth (education, healthcare, and juvenile justice). The integrated training and coaching system combines brain development, cultural responsivity, and trauma-informed practices. The book provides a comprehensive overview of the neurobiology of fear, brain development, trauma, substance use, and mental health, structural bias and environmental factors that pose a threat to healthy brain development. The book employs practical applications/recommendations and case examples that help solidify understanding of key concepts. Each chapter begins with a set of objectives and interactive exercises that builds on the next, thoughtfully challenging the reader (and giving specific, practical ways for the reader) to apply the information presented with the goal of “change”. The text is written from the perspective of a trauma-informed addiction psychiatrist who has effectively facilitated systems change.

Topics featured in this book include:

  • Common threats to healthy brain development.
  • The neurobiology of trauma.
  • Applying trauma-informed practices and approaches.
  • Cannabis and its impact on the brain.
  • Labeling theory and implicit bias.
  • Exploring the connection between fear and trauma.
  • Rehabilitation versus habilitation.
  • Managing stress through mindfulness.

Training for Change will be of interest to graduate and advanced undergraduate students and researchers in the fields of cognitive psychology, criminology, public health, and child and adolescent development as well as parents, teachers, judges, attorneys, preventative medicine and pediatric providers.

 

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Maternal Drug Use and Infant Congenital Malformations 1st ed

Maternal Drug Use and Infant Congenital Malformations 1st ed

This book is the combination of the literature on maternal drug use and birth defects with a set of new data on most types of drugs.

In this book, for each group of drugs the relevant scientific literature on drug teratogenicity is presented, with consideration of possible sources of error and also what the findings may mean from a practical point of view. The book also adds data from the Swedish health registers for 1996-2013 based on more than 1.7 million early-pregnancy midwife interviews.

Maternal Drug Use and Infant Congenital Malformations will find an engaged audience among people working within the field, and will be of interest to healthcare providers, especially obstetricians and other clinicians who treat women of childbearing age.

Targeted Therapies for Lung Cancer (Current Cancer Research)

Targeted Therapies for Lung Cancer (Current Cancer Research)

This book contextualizes translational research and provides an up to date progress report on therapies that are currently being targeted in lung cancer. It is now well established that there is tremendous heterogeneity among cancer cells both at the inter- and intra-tumoral level. Further, a growing body of work highlights the importance of targeted therapies and personalized medicine in treating cancer patients. In contrast to conventional therapies that are typically administered to the average patient regardless of the patient’s genotype, targeted therapies are tailored to patients with specific traits. Nonetheless, such genetic changes can be disease-specific and/or target specific; thus, the book addresses these issues manifested in the somatically acquired genetic changes of the targeted gene. Each chapter is written by a leading medical oncologist who specializes in thoracic oncology and is devoted to a particular target in a specific indication. Contributors provide an in-depth review of the literature covering the mechanisms underlying signaling, potential cross talk between the target and downstream signaling, and potential emergence of drug resistance.

 

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The Therapeutic Use of N-Acetylcysteine (NAC) in Medicine

The Therapeutic Use of N-Acetylcysteine (NAC) in Medicine

Focusing on the practical use of N-Acetyl-Cysteine (NAC) in medicine, this book provides a comprehensive review of the basic biological and clinical studies documenting its benefits in treating medical disease. NAC is perhaps best known as an antidote for acetaminophen, but its therapeutic effect in a wide range of medical diseases has recently been realized. In addition to its well recognized use in radiological contrast prophylaxis for renal disease and pulmonary disorders, studies have suggested significant promise in psychiatric and neurological disorders such as addiction, Alzheimer’s disease, ataxia, autism, bipolar disorder, depression, epilepsy, neuropathy, obsessive-compulsive disorder, schizophrenia, traumatic brain injury and trichotillomania in addition to promising studies in audiology, cardiology, exercise physiology, gastroenterology, hematology, infectious disease, infertility and ophthalmology. Given the promising studies for a wide range of medical conditions, coupled with a excellent safety profile, the potential for NAC in the treatment of human disease appears considerable.

Dr Leonore A Herzenberg from Stanford University, a pioneer of redox physiology and the use of NAC, provides a succinct history of the development of the therapeutic use of NAC for medical disease. This is followed by a series of basic science chapters outlining the role of NAC in important physiological processes, including modulation of dopamine and glutamate neurotransmitter systems, redox and mitochondrial metabolism, apoptosis and inflammation.

The last section of the book is dedicated to clinically oriented chapters that comprehensively review the literature on medical disorders in which NAC has been found to be effective, including toxicity and cardiovascular, gastrointestinal, neurological, psychiatric, pulmonary and renal disorders. Each chapter reviews the theoretical biological mechanisms of NAC for the specific diseases reviewed, rates the clinical studies using a standardized criteria in order to provide an objective level of evidence and grade of recommendation for the use of NAC for specific medical conditions and outlines the ongoing clinical trials examining NAC for the treatment of specific diseases. Final chapters review the clinical evidence verifying that specific theoretical biological mechanisms are actually being targeted by NAC in medical disease. Studies on the pharmacology, formulation and potential adverse effects of NAC are also reviewed. A final chapter synthesizes the clinical studies to suggest that the effectiveness of NAC may signal a new basic physiological disorder, glutathione deficiency, which may be an important pathophysiological mechanism of many diseases.

 

 

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Dysphagia Evaluation and Treatment: From the Perspective of Rehabilitation Medicine 1st ed

Dysphagia Evaluation and Treatment: From the Perspective of Rehabilitation Medicine 1st ed

This book presents a comprehensive approach to treating dysphagia that has been successfully applied in actual rehabilitation settings. Its main purposes are firstly to equip readers with a strong conceptual understanding of swallowing evaluation and treatment, secondly to provide guidance on the procedure of practical comprehensive dysphagia rehabilitation in real-world settings, and thirdly to update readers on the latest diagnostic and treatment technologies. To do so, it employs the concept of swallowing rehabilitation pioneered at Fujita Health University Rehabilitation.
The book is divided into 4 major sections, the first of which introduces readers to the general aspects and the principle of deglutition. In turn, Part II offers clinical approaches to both non-instrumental and instrumental evaluation of swallowing. Part III addresses treatment options in swallowing rehabilitation, especially exercises based on motor learning. Lastly, Part IV highlights three clinical cases demonstrating clinical approaches in dysphagic patients.
Readers will find this text useful both as an initial guide and a reference work for assisting clinicians, allowing them to further expand swallowing assessment and treatment, and facilitating the development of swallowing rehabilitation in real-world settings in education and rehabilitation.

 

 

 

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