Category: Hematology

Hemorrhagic Shock: Recognition, Pathophysiology and Management

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Hemorrhagic Shock: Recognition, Pathophysiology and Management

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In this first version of the book Hemorrhagic Shock: Recognition, Pathophysiology and Management, the entire spectrum of hemorrhage in various pathologic conditions is explored with a particular emphasis on bleeding from injury. World class experts have summarized their benchtop or clinical investigation of severe bleeding and the subsequent host’s response. Furthermore, contemporary content experts have been assembled to relate their own clinical expertise flanked by literature consensus in the subject. Navigation through the different chapters reveals succinct discussions about epidemiology, pathophysiology, bedside assessment and laboratory investigations. In addition, an important part of the content is practical approaches to the management and/or control of difficult hemorrhage sites including the diagnosis, management, adjunct, pharmaceutical and operative options available for the care of these patients. Additionally, separate chapters are presented for exploring areas relate

Bone Marrow Pathology 5th Edition

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Bone Marrow Pathology 5th Edition

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Bone Marrow Pathology has been extensively revised to reflect the significant advances which have occurred in the application of cytogenetics and in particular, molecular genetics in the diagnosis, classification and understanding of haematological disorders. This comprehensive book not only provides information on all common disease entities, but also covers rare disorders in which bone marrow examination is useful. It is designed as a practical resource with ‘problems and pitfalls’ highlighted throughout to aid laboratory diagnosis.

Aplastic Anemia and Other Bone Marrow Failure Syndromes

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Aplastic Anemia and Other Bone Marrow Failure Syndromes

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During the past decade, there have been numerous direct and indirect scientific contributions to both the etiology and therapy of aplastic anemia and related bone marrow failure syndromes. Clinical observations, such as autologous bone marrow recovery after conditioning with immunosup­ pressive agents for bone marrow transplantation; failure to achieve en­ graftment in some identical twins without prior immunosuppressive ther­ apy; and hematologic response to immunosuppressive agents, have led to the concept of immune-mediated etiology of acquired aplastic anemia. Such a concept was further strengthened by laboratory findings, implicat­ ing the role of activated cytotoxic T lymphocytes and abnormal produc­ tion of inhibitory lymphokines. The immunologic mechanisms may also apply to the idiosyncratic bone marrow aplasias associated with drugs, toxic chemicals, and viruses. These agents may alter normal cellular recog­ nition sites by interacting with cellular components and result in loss of self tolerance. Immunologic mechanisms have long been advocated in many other organ failures, and the hemopoietic organ is no exception. It is of interest that parallel clinical and laboratory investigations in juvenile diabetes mellitus type I and in rodent models of this disease have yielded results compatible with the same pathogenic mechanisms. The infiltration of pancreatic islets by activated T lymphocytes, functional and morphological alterations of islet cells upon incubation with lymphokines such as gamma interferon and tumor necrosis factor, and clinical response to cyclosporine are a few examples.

Anticoagulation Therapy 1st ed

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Anticoagulation Therapy 1st ed

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This book presents the latest evidence and guidelines supporting the use of anticoagulant therapy for various clinical scenarios. The field of anticoagulation therapy is evolving rapidly, particularly since the arrival and widespread adoption of direct oral anticoagulants. Organized in two parts, this book reviews the pharmacologic properties of various anticoagulants and details the clinical applications of anticoagulant therapy. Drugs such as warfarin and unfractionated heparin, as well as parenteral and direct oral anticoagulants are discussed in terms of their pharmacokinetics, drug-disease interactions, dosing strategies, and risk considerations. Clinical applications of anticoagulant therapy in disorders such as acute coronary syndromes, atrial fibrillation, and thrombophilia and in special populations such as pregnant women, the elderly, and in the patient with cancer are highlighted. Clinical vignettes, algorithms, clinical pearls, and self-assessment questions are integrated throughout the book. Featuring contributions from authorities in the field, Anticoagulation Therapy is an essential resource for cardiologists, vascular medicine specialists, hematologists, internists, and all other healthcare professionals who prescribe anticoagulants.

Recent Advances in Thrombosis and Hemostasis

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Recent Advances in Thrombosis and Hemostasis

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Now more than ever, thrombotic and thromboembolic disorders as well as related diseases such as malignancies, arteriosclerosis, diabetes mellitus, hypertension, and obesity are the leading causes of morbidity and mortality. They have become urgent medical problems with serious economic consequences in industrialized and devel- ing countries alike. At the same time, the impact of molecular biology and genetics on our understanding of thrombosis and hemostasis is rapidly growing stronger as well as our knowledge of regeneration and development of specific tissues, organs, and embryos. Researchers are also constantly learning more about cardiovascular diseases as well as regulatory mechanisms for various intrinsic and extrinsic stimuli in viable tissues. In this volume, our intention has been to present the latest relevant information in molecular biology and genetics as well as the clinical implications of a better understanding of pathophysiology, novel diagnostic methodologies, and therapeutic applications for new methods of prevention in thrombosis/hemostasis and related disorders, including atherosclerosis. The dramatic advances in knowledge of thrombosis/hemostasis and vascular biology since the first publication of Recent Advances in Thrombosis and Fibrinolysis, edited with Japanese colleagues, in 1991, have required extensive revision in order to highlight and review recent progress in the field. The editors also gratefully welcome the seven distinguished non Japanese authors, who, with their valuable contributions on subjects beyond the coverage by Japanese authors, have made this new edition truly international.

Platelets in Hematologic and Cardiovascular Disorders: A Clinical Handbook 1st Edition

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Platelets in Hematologic and Cardiovascular Disorders: A Clinical Handbook 1st Edition

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A rapid increase in our understanding of the biology of platelets and their role in disease in recent years has been paralleled by increasing successes with established platelet-modifying therapies in many clinical conditions. This text focuses on the clinical role of platelets in a wide variety of hematologic, cardiovascular and other disorders, providing a practical, clinically relevant handbook for all clinicians and researchers interested in platelets and their role in disease. Covering platelet physiology, bleeding disorders, thrombotic disorders and antithrombotic therapy. Chapters cover all the conventional and less conventional aspects of platelet involvement in disease, with an emphasis on recent clinical developments. Clear take home messages have been included in each chapter to aid clinical practice. With contributions from leading experts across three continents, Platelets in Hematologic and Cardiovascular Disorders is an up-to-date, well illustrated, practical resource for everyone involved in clinical practice with platelet disorders.

Concise Guide to Hematology 2nd ed

Concise Guide to Hematology 2nd ed
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This text provides a comprehensive overview of the essential concepts and malignancies of hematology. Now in its second edition, the book reviews every major hematologic disorder and disease entity in thorough detail, from incidence and prevalence to patient and treatment-related issues. Formatted in an organized and easy-to-read outline style to facilitate rapid learning and information processing, the book allows readers to easily locate topics of immediate interest without wading through entire sections to obtain the desired data.
Written by a diverse range of experts in the field, Concise Guide to Hematology, Second Edition is a valuable resource for clinicians, residents, trainees, and entry-level fellows who work in or are just entering the field of hematology.

Consultative Hemostasis and Thrombosis (2018)

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Consultative Hemostasis and Thrombosis (2018)

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With authoritative coverage of rare and common hemostatic disorders, Consultative Hemostasis and Thrombosis, 4th Edition, keeps you both up to date with all that’s new in this fast-moving field as well as reviewing background and development and citing pertinent classical literature. Broad differential diagnoses are provided, underscoring the editors’ position that correct treatment begins with correct diagnosis. This trusted resource by Drs. Craig S. Kitchens, Craig M. Kessler, Barbara A. Konkle, Michael B. Streiff, and David A. Garcia is designed for rapid reference and critical decision making at the point of care.

  • Emphasizes real-world problems and solutions, with quick access to concise descriptions of each condition, associated symptoms, laboratory findings, differential diagnosis, and treatment.
  • Features a user-friendly design, full-color format, abundant laboratory protocols, and at-a-glance tables and charts throughout.
    • Provides thorough updates on core information on hemostasis and thrombosis, including deep venous thrombosis (DVT), pulmonary embolisms, hypercoagulability, thrombocytopenia, von Willenbrand disease, and more.
    • Covers new treatment information on hemophilia A and B.
    • Contains new chapters on hereditary hemorrhagic telangiectasia, hemolytic uremic syndrome, and paroxymal nocturnal hemoglobinuria.
    • Two new editors, Dr. Michael B. Streiff and Dr. David A. Garcia, offer fresh perspectives and valuable experience.

  • Expert Consult™ eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

Atlas of Hematopathology 2nd Edition

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Atlas of Hematopathology: Morphology, Immunophenotype, Cytogenetics, and Molecular Approaches 2nd Edition

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Atlas of Hematopathology: Morphology, Immunophenotype, Cytogenetics, and Molecular Approaches, Second Edition, will appeal to both a wide range of people undergoing training in a variety of medical fields and practicing non-hematopathologists. For clinicians, fellows and residents, correct diagnosis (and therefore correct treatment) of diseases depends on a strong understanding of the molecular basis for the disease, making this book a crucial resource. This atlas contains hundreds of high-quality color images that mirror the findings that fellows and clinicians encounter in practice. In addition, it provides information in a quick, simple and user-friendly manner, attracting both those in training and non- experts.

Residents, fellows, practicing clinicians, and researchers in pathology, hematology and hematology/oncology will find this a useful resource.

  • Covers both non-neoplastic hematopathology and neoplastic hematopathology in all organs and tissues
  • Demonstrates results of important complementary diagnostic tests, such as immunophenotyping (immunohistochemical stains and flow cytometry), karyotyping, FISH and DNA/molecular studies
  • Provides tables to summarize the most important clinicopathological features
  • Saves clinicians and researchers time in quickly accessing the very latest details on the diverse clinical and scientific aspects of hematopathology

Concise Manual of Hematology and Oncology

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Concise Manual of Hematology and Oncology

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A real boon for medical practitioners from a number of disciplines, this is a practice-oriented manual of medical oncology and hematology for day-to-day use in caring for patients’ hematologic and neoplastic diseases. It is founded on the longstanding experience of a large specialized university department accustomed to having to provide reliable advice in a broad range of circumstances. The authors have chosen not to give a comprehensive review of the various subjects but have instead focused on practical methods which have proven to be useful in their experience, with special emphasis on standardizing chemotherapy protocols.

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