Category: Gastroenterology/Hepatology

Translational Research Methods in Diabetes, Obesity, and Nonalcoholic Fatty Liver Disease: A Focus on Early Phase Clinical Drug Development 2nd

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Translational Research Methods in Diabetes, Obesity, and Nonalcoholic Fatty Liver Disease: A Focus on Early Phase Clinical Drug Development 2nd

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This book aims to aid the selection of the most appropriate methods for use in early phase (1 and 2) clinical studies of new drugs for diabetes, obesity, non-alcoholic fatty liver disease (NAFLD) and related cardiometabolic disorders.

Clinical research methods to assess the pharmacokinetics and pharmacodynamics of new diabetes drugs, e.g. the euglycemic clamp technique, have become well-established in proof-of-mechanism studies.  However, selection of the most appropriate techniques is by no means straightforward. Moreover, the application of such methods must conform to the regulatory requirements for new drugs.

This book discusses the need for new pharmacotherapies for diabetes, obesity and NAFLD and the molecular targets of drugs currently in development.  Emerging technologies including functional imaging, circulating biomarkers and omics are considered together with practical and ethical issues pertaining to early phase clinical trials in subjects with cardiometabolic disorders.

Translational Research Methods in Diabetes, Obesity, and Non-Alcoholic Fatty Liver Disease is of interest to biomedical scientists, pharmacologists, academics involved in metabolic research and clinicians practicing in these specialties.

Hepatitis B and D Protocols: Volume 2: Immunology, Model Systems, and Clinical Studies

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Hepatitis B and D Protocols: Volume 2: Immunology, Model Systems, and Clinical Studies

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Despite the availability of an effective vaccine, there are still 400 million people, worldwide who are chronically infected with hepatitis B virus (HBV). For them, the vaccine, as currently applied, has no value. Given the possible consequences of HBV infection, the number of those chronically infected with HBV presents an enormous public health challenge. For example, the major etiology of hepatocellular carcinoma (HCC) is chronic infection with HBV. Although fifth in cancer incidence, worldwide, HCC/liver cancer is the third leading cause of cancer death. The high mortality as- ciated with HCC arises because the disease is often detected late and is unresponsive to treatment. The number of deaths caused by PHCC is expected to rise over the next 20 years. Those chronically infected with HBV have a life risk of death to HCC of between 10 and 25%. Even the limited efficacy of drugs for the treatment of chronic HBV helps underscore the point that this disease is responsive to therapy. Drugs that target the polymerase (e. g. , hepsera and lamivudine) and interferon alpha represent two distinct strategies and show that both conventional antiviral and immunothe- peutic approaches can be used in management. However, the current inventory of therapeutics is inadequate. Interferon alpha is of limited value, only parenterally ava- able, and fraught with adverse reactions.

Hepatitis B and D Protocols: Volume 1: Detection, Genotypes, and Characterization

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Hepatitis B and D Protocols: Volume 1: Detection, Genotypes, and Characterization

DOWNLOAD THIS MEDICAL BOOK HERE

https://upsto.re/CJYiiop

Despite the availability of an effective vaccine, there are still 400 million people, worldwide who are chronically infected with hepatitis B virus (HBV). For them, the vaccine, as currently applied, has no value. Given the possible consequences of HBV infection, the number of those chronically infected with HBV presents an enormous public health challenge. For example, the major etiology of hepatocellular carcinoma (HCC) is chronic infection with HBV. Although fifth in cancer incidence, worldwide, HCC/liver cancer is the third leading cause of cancer death. The high mortality as- ciated with HCC arises because the disease is often detected late and is unresponsive to treatment. The number of deaths caused by PHCC is expected to rise over the next 20 years. Those chronically infected with HBV have a life risk of death to HCC of between 10 and 25%. Even the limited efficacy of drugs for the treatment of chronic HBV helps underscore the point that this disease is responsive to therapy. Drugs that target the polymerase (e. g. , hepsera and lamivudine) and interferon alpha represent two distinct strategies and show that both conventional antiviral and immunothe- peutic approaches can be used in management. However, the current inventory of therapeutics is inadequate. Interferon alpha is of limited value, only parenterally ava- able, and fraught with adverse reactions.

50 Gastrointestinal Cases & Associated Imaging

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50 Gastrointestinal Cases & Associated Imaging

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Medical students and junior doctors are an integral part of the healthcare system. On an academic gastroenterology service, they often initially evaluate the patients that are then staffed by the consulting physician. Like all clinical specialties, the acquisition of medical knowledge is required to gain expertise. There are several resources such as textbooks and evidence-based articles that are …

Essential Medical Disorders of the Stomach and Small Intestine: A Clinical Casebook 1st ed

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Essential Medical Disorders of the Stomach and Small Intestine: A Clinical Casebook 1st ed

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This casebook provides a concise yet comprehensive state-of-the art review of common stomach and small intestine disorders. The casebook is divided into five parts, each of which focuses on a major disorder, symptom, or clinical scenario related to the stomach and small intestine, including dyspepsia, small bowel disorders, nausea and vomiting, chronic abdominal pain, and post-operative GI surgery challenges. Each part is comprised of cases illustrating different aspects of the subject, with each case containing sections on case presentation, objectives, epidemiology and etiology, diagnostic evaluation and treatment, case follow-up, clinical pearls, and Q&A. Some major topics presented in these cases include nausea and vomiting in the pregnant patient, gas-bloat, functional abdominal pain, post-GI surgery complications, and celiac disease and non-celiac gluten sensitivity.
Written by internationally renowned experts in the field, Essential Medical Disorders of the Stomach and Small Intestine: A Clinical Casebook is a valuable resource for clinicians and practitioners who treat patients afflicted with disorders of the stomach and small intestine.

Evidence-based Gastroenterology and Hepatology (Evidence-Based Medicine) 4th Edition

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Evidence-based Gastroenterology and Hepatology (Evidence-Based Medicine) 4th Edition

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The revised fourth edition of Evidence-Based Gastroenterology and Hepatology continues to provide the most current, evidence-based information for determining the appropriate medical and surgical options for screening for, diagnosing, and treating gastrointestinal conditions. With contributions from an international team of leading experts in the field, this edition includes practical recommendations for the care of individual patients based on the latest scientific evidence.

The text offers a unique resource that takes a completely evidence-based approach, and is designed to be an essential tool for gastroenterologists at all levels to consult frequently to improve the management of their time. Chapters review the clinical questions most often encountered by gastroenterologists in their daily practise. The text’s evidence (randomized controlled trials, systematic reviews or lower quality trials) and treatment recommendations are rated for quality using the respected GRADE framework. This newly revised edition:

  • Offers seven new chapters on the latest topics relevant to gastroenterology and hepatology
  • Provides a guide to patient management regimens that are supported by evidence
  • Includes a consistent rating of evidence quality using GRADE framework
  • Contains contributions from an acclaimed, international editorial team
  • Puts the focus on the most patient-important, clinical questions likely to be encountered

Written for gastroenterologists, hepatologists and specialty trainees in gastroenterology/hepatology, the revised edition of Evidence-Based Gastroenterology and Hepatology offers an evidence-based resource that appraises the evidence for the diagnostic tests and treatment regimens for gastrointestinal and hepatic diseases.

Diseases of the Liver and Biliary System in Children

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Diseases of the Liver and Biliary System in Children

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An extremely practical text, this new edition of Diseases of the Liver and Biliary System in Children covers the essentials of paediatric hepatology. The range of material is wide and has been revised and updated to include the latest advances. Many helpful algorithms and tables are included and the references at the end of each chapter have been carefully selected so as to provide the most up-to-date information available. A concluding section comprising some 100 carefully annotated plates, completes this text.

Containing the contributions of 23 internationally acclaimed authorities, active both clinically and in research, the book provides an essential guide to the diagnosis and management of paediatric liver diseases, both common and uncommon for all those involved in the care of the child with liver disease. Diseases of the Liver and Biliary System in Children has become THE REFERENCE of choice for the paediatric gastroenterologist, hepatologist and surgeon.

Atlas of Gastrointestinal Pathology: A Pattern Based Approach to Non-Neoplastic Biopsies First Edition

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Atlas of Gastrointestinal Pathology: A Pattern Based Approach to Non-Neoplastic Biopsies First Edition

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Effectively evaluate challenging GI biopsies with Atlas of Gastrointestinal Pathology: A Pattern Based Approach to Non-Neoplastic Biopsies! Presented in a format that closely mirrors the daily sign-out process, this one-of-a-kind resource helps you interpret challenging cases by highlighting red flags in the clinical chart and locating hidden clues in the slides. You’ll be able to reach confident diagnoses efficiently with this patterns based “scope-side guide”.Key Features

  • More than 1,100 images illustrate the full morphologic spectrum of the major patterns of non-neoplastic GI tract pathology – providing abundant and varied examples of each diagnosis.
  • The corresponding text details how to recognize the relevant pattern, arrive at a specific diagnosis, and avoid diagnostic pitfalls.
  • Key structural elements help you to quickly zero in on specific patterns of injury, link the injury patterns with particular etiologies, and master important diagnostic nuances.
  • A high-yield format , replete with checklists, key features, diagnostic pearls and pitfalls, frequently asked questions, and sample notes, provides all the assistance you need to enhance your diagnostic skills

Now with the print edition, enjoy the bundled interactive eBook edition , offering tablet, smartphone, or online access to:

  • An online review quiz for each chapter helps you test your understanding of vital concepts and prepare for examinations
  • Complete content with enhanced navigation
  • A powerful search that pulls results from content in the book, your notes, and even the web
  • Cross-linked pages , references, and more for easy navigation
  • Highlighting tool for easier reference of key content throughout the text
  • Ability to take and share notes with friends and colleagues
  • Quick reference tabbing to save your favorite content for future use

Pediatric Liver Intensive Care 1st ed

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Pediatric Liver Intensive Care 1st ed

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Acute management of children with liver disease and liver transplantation has rapidly evolved over the last two decades due to worldwide availability of complex liver surgery and liver transplantation. This book edited by Prof Dhawan and Dr Shanmugam, who have hands on experience in managing children with complex liver disease, its complications and liver transplant recepients, provides to a very practical approach to all the team members involved in paediatric transplantation like ; Hepatologists, anaesthetists, surgeons, intensivists, transplant coordinators, nurses and trainees at all levels and specialities. Topics covered include management of common liver problems, liver based metabolic disorders and peri-operative care protocols in paediatric liver transplantation. It also provides up to date information on drug dosage and infusion calculations for common drugs used in liver disease.

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