Mechanisms of Vascular Defects in Diabetes Mellitus (Advances in Biochemistry in Health and Disease) 1st ed

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Mechanisms of Vascular Defects in Diabetes Mellitus (Advances in Biochemistry in Health and Disease) 1st ed

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This book intends to bring together, a panel of renowned experts in the field of vascular biology and diabetology, to integrate the current understanding of the pathogenesis and pathophysiology of vascular diseases in diabetes mellitus. This attempt is significant given the increasing interest in this area as the prevalence of vascular diseases continues to escalate globally. Patients with diabetes are at a higher risk of structural and functional changes in all vessel walls of the human body. Vascular complications of diabetes are leading causes for both morbidity and mortality.
In recent years, several articles have focused on advancing our knowledge on the profound effect of hyperglycemia and insulin resistance on building up vascular wall inflammation leading to endothelial dysfunction in patients with diabetes mellitus  Other reports have elaborated on the various disorders, hyperglycemia can lead to, their therapies, adverse effects and complications. There are also studies that highlight the role of factors that induce vascular wall alterations in hyperglycemia.
In this book, we attempt to discuss vascular disease progression in diabetes with a unique approach. We attempt to provide a complete perspective of the pathophysiology of vascular complications and then dissect each of the factors that play a key role in accelerating vascular wall alterations in diabetes. Each of these factors has been adversely implicated in the initiation and progression of disease to a large extent. In this collection for the first time all these factors would be described under a common canopy. Further, the text would emphasize on pathogenesis of micro vascular complications of diabetes, such as retinopathy, neuropathy and nephropathy. Pharmacological therapies for treating vascular dysfunction in diabetes mellitus would also be reviewed. This compendium hopefully would be an invaluable replacement to scores of literature on diabetic vascular disease and would be of great interest to clinicians, academicians, medical students and researchers.
The book will be divided into seven sections, each emphasizing a common incentive to development of vascular disease in diabetes. Section I deals with pathophysiology of diabetic vascular disease, beginning with an update on the global burden of diabetes mellitus and its vascular complications. The pathophysiology and pathogenesis of diabetes associated macrovasculopathy, how hyperglycemia functions as an atherogenic factor, effects of hyperglycemia on smooth muscle accumulation in vascular lesions and genetic susceptibility for increased risk of vascular disease in diabetes will be discussed in the following chapters of this section.
The next section (Section II) surveys the process of endothelial dysfunction under hyperglycaemia and hyperinsulinemia and their effects on angiogenesis, vascular remodeling and wound healing. A chapter is also dedicated to the endothelial progenitor cell population and its dysfunction during development of vascular complications in diabetes.
Section III will highlight the molecular mechanisms underlying endothelial dysfunction, various pathways such as nitric oxide synthase pathway, oxidative stress pathway, renin – angiotensin system and increased vascular superoxide production in the initiation and progression of vascular disease in diabetes. This section also covers role of endothelin, monocyte derived cytokines, peroxynitrate and adipokines in macrovascular complications of diabetes.
Metabolic factors such as advanced glycation end products, atherogenic dyslipoproteinaemia, and homocysteine will be reviewed in Section IV, whereas an overview of the hemostatic factors such as platelet dysfunction, hyperglycaemia induced thrombin formation and aberrant clot lysis will be dwelled upon in Section V.

Section VI includes chapters on microvascular complications of diabetes which encompasses long term complications of diabetes affecting small blood vessels of the eye, kidneys and nervous system. The pathogenesis and mechanisms of these complications would be detailed here.

The final section (Section VII) of the book will consider mechanism of action of drugs for treating endothelial dysfunction in diabetes mellitus which would elaborate on lipid regulating therapies such as statins, as well as other therapies such as ACE inhibitors, Angiotensin II receptors, insulin, metformin and their effects on enhancing vascular function in diabetes.
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We intend to invite authors who symbolize a multidisciplinary approach to this complicated disease. The proposed authors include clinicians who understand the trend of vascular complications in their long term clientele, epidemiologists with a holistic view, basic and experimental researchers with years of experience in dissecting the factors leading to endothelial dysfunction and clinical researchers with the skill of translating bench work to the bedside. We expect this book will be of significant value and interest to the same group of clinicians, researchers, post doctoral fellows and medical and non medical graduate students. The novel assimilated insights could stimulate development of mechanism based prevention and therapeutic strategies providing a promising option to limit cardiovascular complications in diabetes mellitus.

The Diabetic Foot: Medical and Surgical Management (Contemporary Diabetes) 4th ed. 2018 Edition

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The Diabetic Foot: Medical and Surgical Management (Contemporary Diabetes) 4th ed. 2018 Edition

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In the fourth edition of this gold-standard title, a distinguished panel of experts provides a thorough update of the significant improvements in our understanding of diabetic foot physiology and its clinical management.  Divided into three sections, the first part focuses on clinical features and diagnosis; the second on pathophysiology; and the third on the management of diabetic foot problems. In addition to updating all previous chapters, several new contributions have been added, reflecting advances in our understanding of the causes of diabetic foot ulcers and efforts to develop new and more effective therapies.  The authors, many practicing at the famous Joslin-Beth Israel Deaconess Foot Center, again illuminate the successful new multidisciplinary approach now clearly required for successful treatment of the diabetic foot.  Drawing on the experiences of diabetologists, podiatrists, vascular surgeons, infectious disease specialists, orthotists, plastic and orthopedic surgeons, The Diabetic Foot: Medical and Surgical Management, 4th Edition expertly describes standard techniques and current methods derived from the most recent data. This updated edition will be of significant value to all physicians and researchers with interest in a state-of-the-art understanding of the diabetic foot.

Primary, Secondary and Tertiary Hyperparathyroidism: Diagnostic and Therapeutic Updates (Updates in Surgery)

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Primary, Secondary and Tertiary Hyperparathyroidism: Diagnostic and Therapeutic Updates (Updates in Surgery)

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This practice-oriented book provides a comprehensive and up-to-date review of the history, surgical anatomy, etiology, pathogenesis, clinical presentation and treatment of primary, secondary, and tertiary hyperparathyroidism. The coverage is wide ranging, encompassing, for example, innovations in both medical and surgical treatment, current indications for parathyroidectomy, the role and performance of minimally invasive surgery, the value of intraoperative parathyroid hormone monitoring and guidance on reoperations. Individual chapters are devoted to particular conditions and disease settings, including multiple endocrine neoplasia types 1 and 2 and parathyroid carcinoma, with provision of information on genetic testing, clinical manifestations and therapy. All aspects of secondary hyperparathyroidism in predialysis and dialysis patients are discussed. The book is endorsed by the Italian Society of Surgery. It will be of great value for endocrine surgeons and endocrinologists and will also be of interest to specialists in internal medicine, nephrologists, urologists, gynecologists and radiologists.

Management of Thyroid Nodules and Differentiated Thyroid Cancer: A Practical Guide 1st ed

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This book provides a comprehensive, state-of-the art review of this field, and will serve as a valuable resource for clinicians and researchers with an interest in the management of thyroid nodules and cancer, including both surgeons and endocrinologists.  The book reviews new data about risk factors for nodular disease and cancer, details the management of toxic and non-toxic benign thyroid nodular disease, discusses controversies in the management of indeterminate thyroid nodules and cancer, and reviews the latest data on use of molecular testing for diagnosis and prognosis.  Lastly, the book reviews the management of difficult-to-treat thyroid cancers.
Management of Thyroid Nodules and Differentiated Thyroid Cancer: A Practical Guide will serve as a useful resource for physicians and researchers dealing with, and interested in thyroid nodular disease and cancer.  It will provide a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts.  All chapters are written by experts in their fields and include the most up to date scientific and clinical information.

Operative Techniques in Gynecologic Surgery: REI: Reproductive, Endocrinology and Infertility 1st Edition

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Publisher’s Note: Products purchased from 3rd Party sellers are not guaranteed by the Publisher for quality, authenticity, or access to any online entitlements included with the product.

Second in a new four-volume series, Operative Techniques in Gynecologic Surgery: Reproductive Endocrinology and Infertility provides superbly illustrated, authoritative guidance on operative techniques along with a thorough understanding of how to select the best procedure, how to avoid complications, and what outcomes to expect. Easy to follow, up to date, and highly visual, this step-by-step reference covers the most common operations in gynecology and is ideal for residents and physicians in daily practice.

Key Features:

  • Succinct text, bulleted points, and quick-reference tables allow you to review information quickly and understand best practices and potential problems for each procedure.
  • Hundreds of full-color intraoperative photographs and illustrations, as well as numerous high-quality videos, capture procedures step by step and help you immediately apply your knowledge.
  • Each clinical problem is discussed in the same templated format: general principles, anatomy and differential diagnosis, imaging and other diagnostics, preoperative planning, surgical management, procedures and techniques, pearls and pitfalls, postoperative care, outcomes, and complications.
  • Coverage includes fertility operations (vaginal, cervical, uterine, tubal, ovarian, and peritoneal), assisted reproductive technological procedures, and office procedures including imaging of reproductive organs and assessment of the endometrial cavity.
  • Perfect for a quick preoperative review of the steps of a procedure.
  • Volume editors and contributors are thought leaders in their respective subspecialties and are known for their surgical expertise.

Look for other volumes in the Operative Techniques in Gynecology series:

  • Gynecology
  • Urogynecology and Pelvic Reconstructive Surgery
  • Gynecologic Oncology

Your book purchase includes a complimentary download of the enhanced eBook for iOS, Android, PC & Mac. Take advantage of these practical features that will improve your eBook experience:

  • The ability to download the eBook on multiple devices at one time — providing a seamless reading experience online or offline
  • Powerful search tools and smart navigation cross-links that allow you to search within this book, or across your entire library of VitalSource eBooks
  • Multiple viewing options that enable you to scale images and text to any size without losing page clarity as well as responsive design
  • The ability to highlight text and add notes with one click

Yen & Jaffe’s Reproductive Endocrinology: Physiology, Pathophysiology, and Clinical Management, 8e 8th Edition

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Now celebrating its 40th anniversary, Yen & Jaffe’s Reproductive Endocrinology, 8th Edition, by Drs. Jerome F. Strauss III, Robert L. Barbieri, and Antonio R. Gargiulo, keeps you up to date with the latest information on the diagnosis and management of the full range of female and male reproductive disorders. This cornerstone text thoroughly covers both basic science and clinical practice, making it a one-stop reference for all reproductive issues, including impaired fertility, infertility, recurrent pregnancy loss, problems of sexual development, menstrual disturbances, fibroids, endometriosis, female and male reproductive aging, fertility preservation, assisted reproduction technologies including ovarian stimulation and ovulation induction, transgender hormonal treatment, and contraception. Every chapter has been completely revised and updated to reflect important changes in this fast-moving field.

  • Covers key topics such as the role of genetics in reproductive endocrinology, environmental factors in reproductive endocrinology, and recent advances in surgical procedures.
  • Features full-color, high-quality illustrations that clearly depict basic anatomic structures, endocrine processes, and cell function and dysfunction.
    • Provides the knowledge and expertise of global experts who draw on the latest developments in the field to keep you abreast of current science and practice in endocrinology. Coverage includes molecular, cellular, and genetic concepts and their relevance to pathophysiology, diagnosis, and therapy.
    • Features new bulleted lists under major headings in each chapter for quick, at-a-glance summaries of every section.
    • Includes a new online video library that highlights surgical procedures, diagnostic imaging, and functional ultrasound imaging. Videos cover Disorders of Sex Development, Endometriosis, Benign Uterine Disorders, Gamete and Embryo Manipulation, and Fertility Preservation.

 

  • Expert Consult™ eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

Pediatric Endocrinology and Inborn Errors of Metabolism, Second Edition 2nd Edition

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The acclaimed clinical guide to managing both pediatric endocrine disorders and inborn errors of metabolism

No other text so skillfully blends the disciplines of endocrinology and inborn metabolic disorders into one clinically focused, highly visual resource as Pediatric Endocrinology and Inborn Errors of Metabolism, Second Edition.

In this practical, user-friendly tutorial, a team of international contributors delivers the latest information and clinical insights clinicians need to confidently diagnose and manage pediatric patients. This full-color resource guides you through the etiology, pathophysiology, presenting signs and symptoms, diagnostic laboratory examinations, and treatments regimens of each disorder. Pediatric Endocrinology and Inborn Errors of Metabolism, Second Edition successfully balances authority and comprehensiveness with a strong clinical, practical approach that delivers an unmatched integrated discussion of the fields.

Features:

• Full-color presentation with numerous photos, illustrations, diagnostic algorithms, tables, and text boxes that summarize key concepts and assist in the decision-making process
• At-a-Glance feature beginning each disease-based chapter summarizes all the clinical information you need to differentiate between disorder sub-types in one easy-to-find place
• All-inclusive coverage encompasses the full spectrum of critical topics
• Emergency assessment and treatment chapter gives you fast, clear guidance on acute presentations of endocrine and metabolic disorders
• Chapter on newborn screening walks you through an abnormal screening result to follow-up diagnostic testing
• Complete and detailed information on all laboratory and radiographic testing used to diagnose disorders in both disciplines

If you’re in need of a clinically focused learning tool that bridges the gap between endocrinology and inborn metabolic disorders, your search ends here.

Diabetes Mellitus (Methods in Molecular Medicine) 2003rd Edition

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Diabetes mellitus is the collective name for a group of diseases associated with hyperglycemia (high levels of blood glucose) caused by defects in insulin p- duction, insulin action, or both. About 6. 2% of the US population (17 million people) have diabetes mellitus. It is the leading cause of kidney failure, bli- ness, and amputations. It is also a major risk factor for heart diseases, stroke, and birth defects. Diabetes Mellitus: Methods and Protocols provides a state-of-the-art account of the experimental methodology for studying the molecular defects leading to diabetes mellitus, both at the molecular and biochemical levels. The chapters cover a wide range of topics written by experts in their respective fields and are organized in two sections: Insulin Production and Insulin Action. The detailed experimental protocols presented, including the notes of interest, provide a very useful tool for basic researchers and clinicians for investigating and treating this disease. Each chapter starts with an introduction to a specific technique and explains its application in the field of diabetes research. Following the list of materials, a detailed description of the technique is presented in the methods section in a way that enables the successful execution of the protocol. The “Notes” section at the end discusses the pitfalls of the technique and alternative approaches. I am grateful to the numerous scientists who have contributed to this volume by writing both highly detailed and understandable chapters.

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Medullary Thyroid Cancer 1st ed

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This text provides a comprehensive, contemporary review of this disease and serves as an important resource for clinicians and researchers with an interest in medullary thyroid cancer. The book reviews the initial management of the patient with thyroid nodules, including risk factors, appropriate genetic evaluation of suspected/known medullary thyroid cancer, and appropriate screening for diseases associated with inherited forms of medullary thyroid cancer, including primary hyperparathyroidism and pheochromocytomas. It includes an in-depth discussion of the optimal surgical management of patients with sporadic and inherited disease, those with locoregional metastases, distant metastases, and recurrent medullary thyroid cancer. The long-term follow-up and management of patients with medullary thyroid cancer is highlighted.

Medullary Thyroid Cancer will serve as a useful resource for all providers and researchers interested in this relatively rare and challenging malignancy. It highlights recent guidelines for the management of patients with medullary thyroid cancer and discusses controversies within the literature. All chapters are written by experts in the field and incorporate multiple disciplines, including Surgery (Endocrine Surgery, General Surgery, and Otolaryngology), Endocrinology, Radiology, Medical Oncology and Genetic Counseling.

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Endocrine and Metabolic Medical Emergencies: A Clinician’s Guide (Wiley-Endocrine Society) 2nd Edition

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The Essential Guide to Recognizing and Treating Acute Endocrine and Metabolic Illness

Endocrinology covers some of the most common conditions and serious public health challenges facing medicine today, and endocrine and metabolic emergencies constitute a large proportion of the clinical workload. Endocrine and Metabolic Medical Emergencies: A Clinician’s Guide provides a singular reference to help endocrinologists, acute and general medicine clinicians, hospitalists and critical care physicians, and general practitioners recognize the symptoms of endocrine emergencies and provide the highest standards of care. Already the definitive and most comprehensive guide to endocrine emergency care, this new second edition: provides acute care guidance for a range of both common and unusual endocrine emergencies; details the effects of acute medical and critical illness on metabolic and endocrine systems, and their impacts on endocrine investigations; discusses special patient populations, including the impacts of aging, pregnancy, transplantation, late-effects, perioperative, inherited metabolic disorders and HIV/AIDS on presentation and management; and features detailed coverage of disorders by system, as well as, metabolic bone diseases, neuroendocrine tumors, and more.

Packed with case studies, images, and chapters written by distinguished authors, this guide is designed for both quick reference and study. Coverage includes the presentation, diagnosis, management, and treatment of endocrine and metabolic disorders in an acute care setting, as well as the most up-to-date guidance on issues including clinical lipidology, glucose, sodium, calcium and phosphate, and more.

Blending the latest science with clinical and practical advice, this invaluable resource helps clinicians stay up to date with the field’s relevant body of knowledge while providing the practical, clinical insight they need in order to provide their patients with the utmost level of care.

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