Clinical Skills ⋆ Page 40 of 102 ⋆ eMEDICAL BOOKS

Inflammation and Angiogenesis 1st ed

November 12, 2017

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This book is focused on the analysis of the role played by immune cell components in the angiogenic process associated with inflammation and tumor growth. Both innate and adaptive immune cells are involved in the mechanisms of endothelial cell proliferation, migration and activation, through the production and release of a large spectrum of pro-angiogenic mediators. These may create the specific microenvironment that favors an increased rate of tissue vascularization. The link between chronic inflammation and tumorigenesis was first proposed by Rudolf Virchow in 1863 after the observation that infiltrating leukocytes are a hallmark of tumors and first established a causative connection between the lymph reticular infiltrate at sites of chronic inflammation and the development of cancer. Tumors were described as wounds that never heal and surgeons have long described the tendency of tumors to recur in healing resection margin and it has been reported that wound healing environment provides an opportunistic matrix for tumor growth. As angiogenesis is the result of a net balance between the activities exerted by positive and negative regulators, this book will also provide information on some anti-angiogenic properties of immune cells that may be utilized for a potential pharmacological use as anti-angiogenic agents in inflammation as well as in cancer. The work is written for researchers in the field and also for graduate students which approach this matter.

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Clinical Skills

Cognitive Screening Instruments: A Practical Approach 2nd ed

November 10, 2017

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“This second edition of a very useful book presents an overview as well as practical advice about the use of cognitive screening instruments in outpatient and hospital settings. … This is a useful book with practical tools and strategies for the use of cognitive screening instruments in clinical settings. Any physicians or clinicians who deal with patients with potential cognitive impairments should be aware of the tests that are referenced in this superb book.” (Michael Joel Schrift, Doody’s Book Reviews, May, 2017)

From the Back Cover

This revised and updated second edition provides a practical and structured overview of some of the most commonly used and easily available cognitive screening instruments applicable in the outpatient clinic and bedside setting. It now includes additional chapters on AD8 and also methodological aspects of systematic cognitive screening instrument assessment from the Cochrane Dementia and Cognitive Improvement Group.

Expert authors from around the world equip the reader with clear instructions on the usage of each screening instrument, its strengths and weaknesses, the time required for administration, and rules on scoring, such as how to correct for variations in the patients age or education, and suggested cutoff scores.

Cognitive Screening Instruments: A Practical Approach, Second Edition is aimed at both clinicians and professionals in disciplines allied to medicine who are called upon to assess patients with possible cognitive disorders, including neurologists, old age psychiatrists, neuropsychologists, primary care physicians, dementia support workers, and members of memory assessment teams.

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Clinical Skills

Managing Pain in Children: A Clinical Guide 1st Edition

November 9, 2017

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All children have a right to appropriate prevention, assessment and control of their pain. Managing Pain in Children is an evidence-based, practical guide to care in all areas of children’s pain management, providing nurses and other health care practitioners with the skills and expertise necessary to manage children’s pain effectively.

The text first explores the relevant anatomy and physiology of children, the latest policy guidelines surrounding pain management and ethical issues involved in managing children’s pain. It then goes on to look at the various pain assessment tools available for children and non-drug methods of pain relief. The text then goes on to apply these pain management principles to practice in relation to acute pain, chronic pain, palliative care and the management of procedural pain. Each of these chapters covers the evidence base, assessment techniques, pain relieving interventions, and guidance for best practice in both hospital and community settings.

Special features:

Practical and accessible, with ‘best practice’ points in each chapter
Written in the context of latest policy developments
Provides the necessary evidence-base for care throughout
With contributions from experts in the field

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Liquid Crystals in Biotribology: Synovial Joint Treatment (Biological and Medical Physics, Biomedical Engineering) 1st ed

November 9, 2017

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This book summarizes the theoretical and experimental studies confirming the concept of the liquid-crystalline nature of boundary lubrication in synovial joints. It is shown that cholesteric liquid crystals in the synovial liquid play a significant role in the mechanism of intra-articular friction reduction. The results of structural, rheological and tribological research of the creation of artificial synovial liquids containing cholesteric liquid crystals in natural synovial liquids are described. These liquid crystals reproduce the lubrication properties of natural synovia and provide a high chondroprotective efficiency. They were tested in osteoarthritis models and in clinical practice.

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Clinical Skills

Mesenchymal Stem Cells – Basics and Clinical Application II (Advances in Biochemical Engineering/Biotechnology)

November 7, 2017

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Engineered MSCs from Patient-Specific iPS Cells, by Irina Eberle, Mohsen Moslem, Reinhard Henschler, Tobias Cantz

Fate of Intravenously Injected Mesenchymal Stem Cells and Significance for Clinical Application, by Beate Wagner, Reinhard Henschler

The Implications of Stem Cell Applications for Diseases of the Respiratory System, by Mei Ling Lim, Philipp Jungebluth, Paolo Macchiarini

Potential of Mesenchymal Stem Cell Applications in Plastic and Reconstructive Surgery, by Birgit Weyand, Peter M. Vogt

General Principles for the Regeneration of Bone and Cartilage, by Michael Jagodzinski, C. Haasper

Adult Mesenchymal Stem Cells Explored in the Dental Field, by K. M. Fawzy El-Sayed, C. Dörfer, F. Fändrich, F. Gieseler, M. H. Moustafa, H. Ungefroren

Mesenchymal Stem Cell Therapy and Lung Diseases, by Khondoker M. Akram, Sohel Samad, Monica Spiteri, Nicholas R. Forsyth

Mesenchymal Stem Cells as Cellular Immunotherapeutics in Allogeneic Hematopoietic Stem Cell Transplantation, by Claudia Papewalis, Daniela Topolar, Barbara Götz, Stefan Schönberger, Dagmar Dilloo

New Cell-Based Therapy Paradigm: Induction of Bone Marrow-Derived Multipotent Mesenchymal Stromal Cells into Pro-Inflammatory MSC1 and Anti-inflammatory MSC2 Phenotypes, by Aline M. Betancourt

Interactions Between Mesenchymal Stem Cells and Dendritic Cells, by Grazia Maria Spaggiari, Lorenzo Moretta

MSC and Tumors: Homing, Differentiation, and Secretion Influence Therapeutic Potential, by Naomi D’souza, Jorge Sans Burns, Giulia Grisendi, Olivia Candini, Elena Veronesi, Serena Piccinno, Edwin M. Horwitz, Paolo Paolucci, Pierfranco Conte, Massimo Dominici

Sources of Mesenchymal Stem Cells: Current and Future Clinical Use, by Michela Pozzobon, Martina Piccoli, Paolo De Coppi

Role of the EU Framework in Regulation of Stem Cell-Based Products, by Giovanni Migliaccio, Cristina Pintus

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Current Treatment Options for Fuchs Endothelial Dystrophy 1st ed. 2017 Edition

November 7, 2017

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This book provides state of the art information on modern minimally invasive lamellar transplant techniques for Fuchs endothelial dystrophy (FED), such as Descemet stripping automated endothelial keratoplasty (DSAEK) and Descemet membrane endothelial keratoplasty (DMEK). In addition to clear step-by-step descriptions of procedures, guidance is offered on donor tissue preparation, potential intra- and postoperative complications, and complication management. Future treatment options in the form of medical, cell-based approaches are also discussed. To complete the picture, relevant information is included on the pathophysiology, clinical features, and differential diagnosis of FED. This book will be of interest to all who wish to learn about the dramatic developments in corneal transplantation and medical treatment that are transforming the management of FED.

About the Author

Claus Cursiefen, MD, PhD, is Chairman and Professor in the Department of Ophthalmology at the University of Cologne, Germany and Adjunct Associate Scientist with the Schepens Eye Research Institute/Harvard Medical School, Boston. After completing his MD thesis at the Department of Anatomy, University of Würzburg, Dr. Cursiefen undertook a residency in the Department of Ophthalmology, Erlangen and a postdoctoral fellowship at the Schepens Eye Research Institute in Boston, MA. His clinical focus encompasses modern lamellar corneal transplant techniques (DMEK, DALK, DSAEK), artificial cornea, ocular surface reconstruction, cataract and glaucoma surgery, curative and refractive laser surgery, and ophthalmo-oncology. Dr. Cursiefen’s research has concentrated especially on mechanisms of corneal hem- and lymphangiogenesis and their implications for corneal transplant immunology. He is the author of more than 250 publications in the field, including in PNAS, Journal of Experimental Medicine, Journal of Clinical Investigation, and Nature Medicine.

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Pediatric Vaccines and Vaccinations: A European Textbook 1st ed. 2017 Edition

November 7, 2017

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This graduate textbook serves as a highly readable guide on vaccines and vaccination in infants, children and adolescents from an European perspective. The first part of the book is dedicated to childhood and adolescent vaccine schedules, maternal and neonatal immunization and safety of vaccines. In a second part we focus on viral and bacterial vaccines. Further chapters discuss pediatric travel vaccines, vaccines in the pipeline and the European registration process. This book is intended to be a reference textbook and will help to standardize the information on vaccines and immunization program in the WHO European Region.

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ADHD: A Guide to Understanding Symptoms, Causes, Diagnosis, Treatment, and Changes Over Time in Children, Adolescents, and Adults 5th Edition

November 5, 2017

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Drawing on over forty years of clinical and research experience, Paul Wender and new coauthor David A. Tomb have created a classic, definitive model for identifying and treating children and adults who have Attention-Deficit Hyperactivity Disorder (ADHD).

ADHD: Attention-Deficit Hyperactivity Disorder in Children and Adults, Fifth Edition offers insights into the progression of ADHD to those at any age and describes the best treatment. Wender and Tomb stress that drug therapy remains the most effective in treating the disorder, but psychological techniques, when combined with medication, can produce further improvement. In addition, extensive first-hand accounts from men, women, and children offer dramatic insight into what it feels like to have, and to receive medical treatment for, ADHD. Throughout, the book contains valuable information on where to seek help and what kinds of diagnostic tests exist and how reliable they are, as well as comprehensive instructions and rating scales to help parents best help their child and to help adults self-screen for the disorder.

This concise and fully revised volume is a practical tool for individuals at any age, parents and teachers of children with ADHD, and clinicians.

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Stroke Genetics 2nd ed

November 4, 2017

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“This text reviews genetics of cerebrovascular diseases … . It covers the pathophysiology of occlusive small vessel disease and arteriopathies. It covers Fabry’s Disease, Amyloidosis, MELAS, etc., etc. It covers the imaging, pathophysiology, treatment, and complications for ischemia and hemorrhaging. I recommend this text for neurosurgeons, neurologists, physiologists, genetic investigators, and those with an interest in vascular diseases affecting the cerebrum.” (Joseph J. Grenier, Amazon.com, May, 2014) –This text refers to the Paperback edition.

From the Back Cover

This revised, expanded second edition updates the reader on this fast moving field as well providing an overall understanding of the genetics of complex diseases by using stroke as a paradigm. The reader will gain a comprehensive understanding of cerebrovascular genetics including the epidemiological evidence for the genetic basis of ischemic and hemorrhagic stroke, knowledge of its molecular basis from association, linkage and recent genomewide studies, and also monogenic disorders. Finally, the legal and ethical complexities in dealing with these issues are discussed.

Stroke Genetics is a valuable resource for neurologists, stroke physicians, hypertension specialists, internists, clinical pharmacologists and those in training, as well as researchers in the field of disease genetics.

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Haploidentical Stem Cell Transplantation: An Emerging Treatment Modality (Stem Cell Biology and Regenerative Medicine) 1st ed. 2017 Edition

November 4, 2017

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This book discusses the aspects of haploidentical transplants and will shed light on the debates and questions on this burgeoning field and timely topic. Donor selection, graft failure, minimal CD34+ cell requirement, and conditioning regimens used for haploidentical transplants will be written by expert authors dealing with this type of transplants. Approximately one third of the books’ chapters cover logic and basic aspects; the remaining two thirds of the book discuss clinical aspects, outcomes, and future perspectives, thus providing a comphrensive discussion of the topic. Haploidentical transplantation is extremely timely, rapidly-changing area and increasing its use will decrease the need for time-consuming, expensive, unrelated donor search. Moreover, Haploidentical Stem Cell Transplantation brings a set of clear answers to questions of feasibility, advantages over unrelated transplants, cost effectivity and outcome..

About the Author

Dr. Taner Demirer, MD, FACP, graduated from Ankara University Medical School in Turkey in 1984 and was trained in the USA through 1987-1997. He completed his Internal Medicine residency at the Medical College of Wisconsin in 1989-1992 and hematology/oncology and bone marrow transplant fellowship at the University of Washington, Fred Hutchinson Cancer Research Center (FHCRC) in Seattle, in 1992-1997. He was trained under Professors Don Thomas (Nobel laureate), Dean Buckner, Frederick Appelbaum and Rainer Storb in the clinical division of FHCRC. He is a diplomate of the American Board of Internal Medicine and Board certified in Internal Medicine and Medical Oncology. He was given the title of ‘Fellow of American College of Physicians (FACP) by ACP in July 1996. He has conducted many clinical studies at the FHCRC as principal investigator or co-investigator mainly related to peripheral blood stem cell (PBSC) mobilization and high-dose chemotherapy (HDC) as well as autologous or allogeneic stem cell transplantations (SCT) in patients with solid tumors and hematologic malignancies. During his career he has written many papers in the respected medical journals and books in regard to PBSC mobilization kinetics, factors influencing the PBSC collection and engraftment and allogeneic as well as autologous SCT in patients with hematologic malignancies and solid tumors. He was chairman of the EBMT Solid Tumors Working Party (STWP) in between 2001-2007. He has conducted, chaired and published studies in related to HDC in patients with solid tumors at the EBMT STWP. He was also board member of the Federation of the European Cancer Societies (FECS) on behalf of the EBMT through 2001-2007. He was the president of the 29th and 41st EBMT Annual Meetings which were held in Istanbul in 2003 and 2015. He has been member of the editorial board of several international journals. Dr. Demirer is ,currently, a professor of medicine and hematology/oncology at the Ankara University Medical School in Ankara, Turkey, and a full member of the Turkish Academy of Sciences as well as the European Academy of Sciences and Arts (EASA).

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