Category: Miscellaneous Medical Books

The approach to drug discovery from natural sources has yielded many important new pharmaceuticals inaccessible by other routes. In many cases the isolated natural product may not be an effective drug for any of several reasons, but it nevertheless may become a drug through chemical modification or have a novel pharmacophore for future drug design. In summarizing the status of natural products as cancer chemotherapeutics, Anticancer Agents from Natural Products, Second Edition covers the:

• History of each covered drug―a discussion of its mechanism on action, medicinal chemistry, synthesis, and clinical applications
• Potential for novel drug discovery through the use of genome mining as well as future developments in anticancer drug discovery
• Important biosynthetic approaches to “unnatural” natural products

Anticancer Agents from Natural Products, Second Edition discusses how complex target-oriented synthesis―enabled by historic advances in methodology―has enormously expanded the scope of the possible. This book covers the current clinically used anticancer agents that are either natural products or are clearly derived from natural product leads. It also reviews drug candidates currently in clinical development since many of these will be clinically used drugs in the future.

Examples include the drugs etoposide and teniposide derived from the lead compound podophyllotoxin; numerous analogs derived from taxol; topotecan, derived from camptothecin; and the synthetic clinical candidates, E7389 and HTI-286, developed from the marine leads, halichondrin B and hemiasterlin.

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“Health care is not failing but succeeding, expensively, and we don’t want to pay for it. So the administrations, public and private alike, intervene to cut costs, and herein lies the failure.”

In this sure-to-be-controversial book, leading management thinker Henry Mintzberg turns his attention to reframing the management and organization of health care.

The problem is not management per se but a form of remote-control management detached from the operations yet determined to control them. It reorganizes relentlessly, measures like mad, promotes a heroic form of leadership, favors competition where the need is for cooperation, and pretends that the calling of health care should be managed like a business.

“Management in health care should be about dedicated
and continuous care more than interventionist and episodic cures.”

This professional form of organizing is the source of health care’s great strength as well as its debilitating weakness. In its administration, as in its operations, it categorizes whatever it can to apply standardized practices whose results can be measured. When the categories fit, this works wonderfully well. The physician diagnoses appendicitis and operates; some administrator ticks the appropriate box and pays. But what happens when the fit fails—when patients fall outside the categories or across several categories or need to be treated as people beneath the categories or when the managers and professionals pass each other like ships in the night?

To cope with all this, Mintzberg says that we need to reorganize our heads instead of our institutions. He discusses how we can think differently about systems and strategies, sectors and scale, measurement and management, leadership and organization, competition and collaboration.

“Market control of health care is crass, state control is crude, professional control is closed. We need all three—in their place.”

The overall message of Mintzberg’s masterful analysis is that care, cure, control, and community have to work together, within health-care institutions and across them, to deliver quantity, quality, and equality simultaneously.

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…one of the best scientific references available for acupuncture faculty and students….the author is able to effectively and efficiently bridge different approaches to auricular acupuncture as practiced in the western world for the past 50 years. — Doody’s Book Review (starred review)

The updated Second Edition of this outstanding reference guide and textbook provides a comprehensive review of both the French (after Nogier) and Chinese schools of acupuncture. The book offers a detailed description of the anatomy and morphology of the ear, acupoints on the ear and their localizations, as well as specific points for ear acupuncture. Dr. Rubach, with many years’ experience as a practitioner and teacher, provides valuable information in an easy-to-read, helpful format. You will learn how to use ear acupuncture safely and effectively. Large-format, graphic images are used to clearly show the location of points and the methods of auriculotherapy. The book includes answers to important everyday questions and is a treasury of practical information.

Special features of Principles of Ear Acupuncture, Second Edition:

• A critical review of different methods of stimulation
• A practical compendium of the therapeutic point combinations
• Quick reference section on acupoints and localization
• A question and answer section for instant review
• Now includes over 30 interesting indications

The book includes special sections on the use of acupuncture in pregnancy, obstetrics, gynecology, and dentistry. Filled with tips for daily practice and an excellent reference guide, this book is a must for students and ear acupuncturists.

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About the Author

About the Author

Through its use of real clinical examples, this book provides an explanation of the project management process tailored for nurses. It first describes, in detail, the project management process along with its relationship to the phases of the project life cycle. Coverage includes the tools available to successfully complete each phase of the project management process and advance the project life cycle. With the aid of case studies and project examples, the book then examines how to apply these principles in the day-to-day work of the nurse, whether manager, staff nurse, educator, researcher, or informatician.

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This volume focuses on the relationship between the regulation of signal transduction and disease mechanisms, and discusses how the dysregulation of intracellular signals cause diseases, cell death, carcinogenesis, and other disorders.

Growth, survival, transformation, and metabolic activities at the cellular level are regulated by various intracellular signal transduction pathways. Sources that stimulate intracellular signals include intracellular stresses and signal regulators/modulators, as well as extracellular growth factors. Recent studies on signal transduction analysis using animal and human cell lines have revealed how the intracellular signals are regulated and why their dysregulation leads to pathological states such as tumorigenesis, metabolic diseases, cell death, and so on.

This book highlights several important key molecules and intracellular signaling pathways such as microRNA, the TGF-beta signaling pathway, the Wnt signaling pathway and MET signaling pathway as topical and highly relevant issues in human cell research related to signal transduction. In addition to assessing the pathogenic role of these signaling pathways, it focuses on the molecular design of small molecule regulators/inhibitors of said pathways, one of the most important approaches in this area.

This book offers a valuable guide, helping not only research scientists but also clinicians to understand how the dysregulation of intracellular signals leads to diseases.

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Rates of organ donation lag far behind the increasing need. At the start of 2006, more than 90,000 people were waiting to receive a solid organ (kidney, liver, lung, pancreas, heart, or intestine). Organ Donation examines a wide range of proposals to increase organ donation, including policies that presume consent for donation as well as the use of financial incentives such as direct payments, coverage of funeral expenses, and charitable contributions. This book urges federal agencies, nonprofit groups, and others to boost opportunities for people to record their decisions to donate, strengthen efforts to educate the public about the benefits of organ donation, and continue to improve donation systems. Organ Donation also supports initiatives to increase donations from people whose deaths are the result of irreversible cardiac failure. This book emphasizes that all members of society have a stake in an adequate supply of organs for patients in need, because each individual is a potential recipient as well as a potential donor.

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Validation describes the procedures used to analyze pharmaceutical products so that the data generated will comply with the requirements of regulatory bodies of the US, Canada, Europe and Japan. Calibration of Instruments describes the process of fixing, checking or correcting the graduations of instruments so that they comply with those regulatory bodies. This book provides a thorough explanation of both the fundamental and practical aspects of biopharmaceutical and bioanalytical methods validation. It teaches the proper procedures for using the tools and analysis methods in a regulated lab setting. Readers will learn the appropriate procedures for calibration of laboratory instrumentation and validation of analytical methods of analysis. These procedures must be executed properly in all regulated laboratories, including pharmaceutical and biopharmaceutical laboratories, clinical testing laboratories (hospitals, medical offices) and in food and cosmetic testing laboratories.

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There are scattered reports in the published literature citing relationships between actin, actin-binding proteins and disease. This volume brings this information together for the first time, with a focus on human disorders. The volume is relevant to a wide readership including cell biologists interested in understanding how structural and functional changes in proteins impact on the organism as a whole.

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https://upsto.re/FVNYCvX