Breast Cancer: Carcinogenesis, Cell Growth and Signalling Pathways

This book discusses various aspects of breast cancer carcinogenesis from clinics to its hormone-based as well as genetic-based etiologies for this deadly cancer. The book will contribute to the development of novel diagnostic as well as therapeutic approaches.

Contents
Preface
Part 1 Signaling Pathways (EGFR)
1 EGFR-Ligand Signaling in Breast Cancer Metastasis: Recurring Developmental Themes
2 EGF Regulation of HRPAP20: A Role for Calmodulin and Protein Kinase C in Breast Cancer Cells
3 Endocytic Trafficking of the Epidermal Growth Factor Receptor in Transformed Cells
4 HER-2 Signaling in Human Breast Cancer
5 Brain Metastases Progression of Breast Cancer
6 Signal Transduction Pathways in Breast Cancer – Drug Targets and Challenges
7 ErbB2/HER2: Its Contribution to Basic Cancer Biology and the Development of Molecular Targeted Therapy
8 Trastuzumab-Resistance and Breast Cancer
9 Targeting HER-2 Signaling Network: Implication in Radiation Response
Part 2 Estrogen Receptors
10 The Importance of ERa/ERp Ratio in Breast Cancer: Mitochondrial Function and Oxidative Stress
11 Heterogeneity of Phenotype in Breast Cancer Cell Lines
12 Metabolomics and Transcriptional Responses in Estrogen Receptor Positive Breast Cancer Cells
13 ER-Alpha36 Mediates Non-Genomic Estrogen and Anti-Estrogen Signaling in Breast Cancer Cells
14 Estrogen-Related Receptors and Breast Cancer: A Mini Review
15 The Role of MicroRNAs in Estrogen Receptor α-Positive Human Breast Cancer
Part 3 Cell Growth Regulation, Carcinogenesis
16 Roles of SWI/SNF Complex Genes in Breast Cancer
17 p53, p63 and p73 Network in Breast Cancers
18 Role of ING Family Tumor Suppressors in Breast Cancer
19 Lipid Rafts as Master Regulators of Breast Cancer Cell Function
20 Differences in Membrane Composition and Organization of Crucial Molecules Define the Invasive Properties of MCF-7 Breast Cancer Cells
21 Adipose Tissue and Desmoplastic Response in Breast Cancer
22 Cross-Talk of Breast Cancer Cells with the Immune System
23 Engineering Transcription Factors in Breast Cancer Stem Cells
24 Breast Cancer Stem Cells – A Review
25 Potential Roles of miR-106a in Breast Cancer
26 Scleroderma and Breast Cancer
Part 4 Signaling Pathways (Others)
27 FZD7 in Triple Negative Breast Cancer Cells
28 Dysregulation of Wnt Signaling in Breast Cancer
29 Interactions of STAP-2 with BRK and STAT3/5 in Breast Cancer Cells
30 Histamine and Breast Cancer: A New Role for a Well Known Amine
31 1,25(OH)2D3 and Cyclooxygenase-2: Possible Targets for Breast Cancer?
32 Calcium, Ca2+-Sensing Receptor and Breast Cancer
33 Signal Transduction Pathways Mediated by Unsaturated Free Fatty Acids in Breast Cancer Cells
34 Adrenoceptors and Breast Cancer: Review Article
35 Steroid Receptor Coactivators and Their Expression, Regulation and Functional Role in Endocrine Responsive and Resistant Breast Cancer

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