THE RECEPTORS GABA B

An up-to-date comprehensive overview of the GABA B receptor system with a particular focus on the most recent therapeutic applications and potential. This receptor system has recently been implicated in several diseases and disorders including gastroesophageal reflux disease, epilepsy, mood disorders, depression, and alcohol and substance use disorder. The authors, leading researchers in the field, explore a number of approaches, including medicinal chemistry, molecular biology, physiology, and preclinical and clinical pharmacology. This overview provides a translational perspective on the potential of the GABA B receptor pharmacology.

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Antibiotic Resistance: Implications for Global Health and Novel Intervention Strategies: Workshop Summary

Years of using, misusing, and overusing antibiotics and other antimicrobial drugs has led to the emergence of multidrug-resistant ‘superbugs.’ The IOM’s Forum on Microbial Threats held a public workshop April 6-7 to discuss the nature and sources of drug-resistant pathogens, the implications for global health, and the strategies to lessen the current and future impact of these superbugs

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Metallotherapeutic Drugs and Metal-Based Diagnostic Agents: The Use of Metals in Medicine 1st Edition

There are an astonishing number and variety of roles that metals play in contemporary medicine. This book contains information on the medicinal uses of inorganics, that is, of elements such as boron, lithium, selenium, to name a few, as well as metal-containing species.

In keeping with the notion that healthy mammals rely on (bio-essential) metals for the normal functioning of approximately a third of their proteins and enzymes, a large number of drugs are metal-based and considerable effort is being devoted to developing both second- and third-generation drugs as well as generating novel metal-based drugs. While there is no doubt that there is an emphasis on ‘Metallotherapeutics’ throughout the volume, the use of metals in medicine is not restricted to metal-based drugs. The following are also covered:

  • non-invasive radiopharmaceuticals
  • Magnetic Resonance Imaging (MRI)
  • mineral supplements

From the foregoing and, more importantly, from the contents of the various Chapters, the reader will gain an appreciation of the very real role metal-based drugs play in modern medicine and of the considerable effort being devoted to the development of novel complexes with greater efficacy as therapeutic and diagnostic agents.

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Method Validation in Pharmaceutical Analysis: A Guide to Best Practice 2nd Edition

This second edition of a global bestseller has been completely redesigned and extensively rewritten to take into account the new Quality by Design (QbD) and lifecycle concepts in pharmaceutical manufacturing.

As in the first edition, the fundamental requirements for analytical method validation are covered, but the second edition describes how these are applied systematically throughout the entire analytical lifecycle. QbD principles require adoption of a systematic approach to development and validation that begin with predefined objectives. For analytical methods these predefined objectives are established as an Analytical Target Profile (ATP). The book chapters are aligned with recently introduced standards and guidelines for manufacturing processes validation and follow the three stages of the analytical lifecycle: Method Design, Method Performance Qualification, and Continued Method Performance Verification. Case studies and examples from the pharmaceutical industry illustrate the concepts and guidelines presented, and the standards and regulations from the US (FDA), European (EMA) and global (ICH) regulatory authorities are considered throughout.

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Fragment-Based Drug Discovery: Lessons and Outlook (Methods and Principles in Medicinal Chemistry)

From its origins as a niche technique more than 15 years ago, fragment–based approaches have become a major tool for drug and ligand discovery, often yielding results where other methods have failed. Written by the pioneers in the field, this book provides a comprehensive overview of current methods and applications of fragment–based discovery, as well as an outlook on where the field is headed.

The first part discusses basic considerations of when to use fragment–based methods, how to select targets, and how to build libraries in the chemical fragment space. The second part describes established, novel and emerging methods for fragment screening, including empirical as well as computational approaches. Special cases of fragment–based screening, e. g. for complex target systems and for covalent inhibitors are also discussed. The third part presents several case studies from recent and on–going drug discovery projects for a variety of target classes, from kinases and phosphatases to targeting protein–protein interaction and epigenetic targets.

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Textbook of Drug Design and Discovery, Fifth Edition 5th Edition

Building on the success of the previous editions, the Textbook of Drug Design and Discovery, Fifth Edition, has been thoroughly revised and updated to provide a complete source of information on all facets of drug design and discovery for students of chemistry, pharmacy, pharmacology, biochemistry, and medicine. The information is presented in an up-to-date review form with an underlying and fundamental focus on the educational aspects.

Beginning with an introduction to drug design and discovery, the first eight chapters cover molecular recognition, ligand-based drug design, and biostructure-based drug design. The authors also discuss drug-like properties and decision making in medicinal chemistry, chemical biology, natural products in drug discovery, and in vivo imaging in drug discovery.

The middle six chapters provide an overview of peptide and protein drug design, prodrugs in drug design and development, and enzyme inhibitors. The authors also go through receptors (structure, function, and pharmacology), ion channels (structure and function), and neurotransmitter transporters (structure, function, and drug binding).

The following chapters address important neurotransmitter systems, GABA and glutamic acid receptors and transporter ligands, acetylcholine, histamine, dopamine and serotonin, and opioid and cannabinoid receptors. The book concludes with an examination of neglected diseases, anticancer agents, tyrosine kinase receptors, and antibiotics.

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Clinical Physiology and Pharmacology: The Essentials 1st Edition

This book is an accessible collection of case study scenarios ideal for physiology and pharmacology revision for pharmacy, medical, biomedical science, clinical science and healthcare students.

Clearly structured and organized by major organ system, the book emphasises ways in which key signs and symptoms of disease inform diagnosis and the choice of treatment, together with the relevant pharmacological mechanisms. Each chapter has a clinical focus and includes clear learning outcomes, key points and model answers with detailed explanations designed to enhance students’ understanding of the physiology and pharmacology underpinning each case study scenario.

50 topics are covered and the cases presented include an extensive range of psychological, neurological, endocrine, cardiovascular, respiratory, renal, gastrointestinal and reproductive disorders, their symptoms, complications and usual treatment along with the actions and uses of some widely- used drugs.

  • An essential revision text designed to help students apply their theoretical knowledge to real-life cases
  • Realistic case studies focusing on commonly occurring conditions and diseases
  • Model answers throughout
  • Learning outcomes provided at the beginning of each chapter
  • Key learning points presented in the cases follow each model answer
  • Helps students to understand the relevance and clinical implications of the topics studied in physiology and pharmacology courses
  • Reinforces  major concepts and definitions
  • Includes a glossary with a full list of drugs and disorders to support the text
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Pharmacy Technician Certification Exam Review (Delmar’s Pharmacy Technician Certification Exam Review) 3rd Edition

PHARMACY TECHNICIAN CERTIFICATION EXAM REVIEW, 3E is a comprehensive, all inclusive study tool to help prepare your students to become certified pharmacy technicians on a national level. This book mirrors content covered on the Pharmacy Technician Certification Exam (PTCE) and provides both exam content review and practice opportunities in a variety of formats. Ideal for review courses and for individual study, this book is a must-have tool for anyone preparing to take the PTCB and ExCPT exams. Sections are structured to help your students focus on critical topic areas outlined by the Pharmacy Technician Certification Board; including 14 chapters specifically on mathematics with examples and end-of-chapter review questions. This new edition also includes greatly expanded chapters on pharmacology, updated end-of-chapter practice questions, two cumulative tests at the end of the book, and solutions to all chapter review questions and practice exams. For even more practice, the back-of-book CD offers 600 additional review questions to create timed exams that simulate the actual PTCE!

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Pharmaceutical Process Scale-Up, Third Edition (Drugs and the Pharmaceutical Sciences) 3rd Edition

The third edition of Pharmaceutical Process Scale-Up deals with the theory and practice of scale-up in the pharmaceutical industry. This thoroughly revised edition reflects the rapid changes in the field and includes:

  • New material on tableting scale-up and compaction.
  • Regulatory appendices that cover FDA and EU Guidelines.
  • New chapters on risk evaluation and validation as related to scale-up.
  • Practical advice on scale-up solutions from world renowned experts in the field.

Pharmaceutical Process Scale-Up, Third Edition will provide an excellent insight in to the practical aspects of the process scale-up and will be an invaluable source of information on batch enlargement techniques for formulators, process engineers, validation specialists and quality assurance personnel, as well as production managers. It will also provide interesting reading material for anyone involved in Process Analytical Technology (PAT), technology transfer and product globalization.

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Drug Use and Abuse 5th Edition

DRUG USE AND ABUSE takes an interdisciplinary approach in its coverage of current drug issues. It weaves psychological, historical, cultural, social, biological, and medical perspectives — emphasizing the idea that a drug’s effects depend not only on its properties, but also on the biological and psychological characteristics of its user. This theme is highlighted throughout, and is prominent in discussions of the individual classes of drugs, as well as in the chapters on pharmacology and psychopharmacology.

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