Category: Gastroenterology/Hepatology

Biomarkers in Inflammatory Bowel Diseases 1st ed

Biomarkers in Inflammatory Bowel Diseases 1st ed

This book provides a comprehensive and complete overview of biomarkers in clinical practice for inflammatory bowel disease (IBD) bringing together the literature in a clear and concise manner. The book bridges the gap between growing knowledge at the bench and current and future applications of biomarkers in clinical practice.

The central structure of the book focuses on prognostic and predictive biomarkers in IBD with an emphasis on the fields of research and scientific techniques (genomics, proteomics and metabonomics) that have led to biomarker discovery and places these biomarkers within a clinical context to help understand their utility in clinical practice.

This book will be of use to clinicians who have an interest in using biomarkers in clinical practice as well as clinician researchers and scientists involved in the biomarker research pipeline.

The author team comprises experts from around the world in order to bring together the literature in an effort to inform clinicians and researchers about the current state-of-the art in biomarker discovery.  It is intended to  assist future research efforts and indicate how biomarkers might be best applied to clinical practice both at present and in the future.

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HIV and GI Tract Complications: A Comprehensive Clinical Guide

HIV and GI Tract Complications: A Comprehensive Clinical Guide

This text provides a concise yet comprehensive review of GI tract complications of HIV infection. Beginning with an overview on the pathophysiology of HIV and its direct effect on the GI tract, the book outlines opportunistic infections, noninfectious etiologies, diagnostic testing, and therapy in relation to specific organs in the GI tract. Organs covered include the esophagus, stomach, gallbladder and biliary tract, liver, pancreas, and small and large intestines.
Written by experts in the field, HIV and GI Tract Complications: A Comprehensive Clinical Guide is a valuable resource for clinicians and researchers interested in HIV/AIDS and associated GI tract complications, that will help guide patient management and stimulate investigative efforts.

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The Internist’s Guide to Minimally Invasive Gastrointestinal Surgery (Clinical Gastroenterology) 1st ed

The Internist’s Guide to Minimally Invasive Gastrointestinal Surgery (Clinical Gastroenterology) 1st ed

This book provides a concise yet comprehensive overview of minimally invasive gastrointestinal surgery, specifically for the medical internist. Organized by organ system, the text reviews the pathophysiology, workup, treatment, and surgical options for diseases inherent to gastrointestinal surgery. The book also focuses on when and who to refer to for consultation by a minimally invasive surgeon, as well as what to expect in the immediate and long term post-operative period.
Written by experts in the field, The Internist’s Guide to Minimally Invasive Gastrointestinal Surgery is a valuable resource for medical internists on minimally invasive GI surgery and how best to care for these patients in the pre and post-operative setting.

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Fundamentals of Anorectal Surgery 3rd ed

Fundamentals of Anorectal Surgery 3rd ed

This book is a comprehensive and current guide to the diagnosis and treatment of the entire spectrum of anorectal diseases. It focuses mainly on anorectal problems, as anorectal pathology is often more complex and challenging for surgeons than colonic diseases.

The book covers anorectal anatomy, physiology, and embryology as a foundation to a detailed description of preoperative, intraoperative, and post-operative patient management. All surgical procedures are shown in step-by-step detail by leading surgeons and gastroenterologists.

This book will be relevant to general, colon, and rectal surgeons in training and practice, gastroenterologists, and other practitioners with an interest in anorectal diseases.

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Textbook of Gastroenterology, 2 Volume Set 5th Edition

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Textbook of Gastroenterology, 2 Volume Set 5th Edition

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Over the past twenty years, thousands of physicians have come to depend on Yamada’s Textbook of Gastroenterology. Its encyclopaedic discussion of the basic science underlying gastrointestinal and liver diseases as well as the many diagnostic and therapeutic modalities available to the patients who suffer from them was—and still is—beyond compare. This new edition provides the latest information on current and projected uses of major technologies in the field and a new section on diseases of the liver. Plus, it comes with a fully searchable CD ROM of the entire content.

Translational Research Methods in Diabetes, Obesity, and Nonalcoholic Fatty Liver Disease: A Focus on Early Phase Clinical Drug Development 2nd

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Translational Research Methods in Diabetes, Obesity, and Nonalcoholic Fatty Liver Disease: A Focus on Early Phase Clinical Drug Development 2nd

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This book aims to aid the selection of the most appropriate methods for use in early phase (1 and 2) clinical studies of new drugs for diabetes, obesity, non-alcoholic fatty liver disease (NAFLD) and related cardiometabolic disorders.

Clinical research methods to assess the pharmacokinetics and pharmacodynamics of new diabetes drugs, e.g. the euglycemic clamp technique, have become well-established in proof-of-mechanism studies.  However, selection of the most appropriate techniques is by no means straightforward. Moreover, the application of such methods must conform to the regulatory requirements for new drugs.

This book discusses the need for new pharmacotherapies for diabetes, obesity and NAFLD and the molecular targets of drugs currently in development.  Emerging technologies including functional imaging, circulating biomarkers and omics are considered together with practical and ethical issues pertaining to early phase clinical trials in subjects with cardiometabolic disorders.

Translational Research Methods in Diabetes, Obesity, and Non-Alcoholic Fatty Liver Disease is of interest to biomedical scientists, pharmacologists, academics involved in metabolic research and clinicians practicing in these specialties.

Hepatitis B and D Protocols: Volume 2: Immunology, Model Systems, and Clinical Studies

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Hepatitis B and D Protocols: Volume 2: Immunology, Model Systems, and Clinical Studies

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Despite the availability of an effective vaccine, there are still 400 million people, worldwide who are chronically infected with hepatitis B virus (HBV). For them, the vaccine, as currently applied, has no value. Given the possible consequences of HBV infection, the number of those chronically infected with HBV presents an enormous public health challenge. For example, the major etiology of hepatocellular carcinoma (HCC) is chronic infection with HBV. Although fifth in cancer incidence, worldwide, HCC/liver cancer is the third leading cause of cancer death. The high mortality as- ciated with HCC arises because the disease is often detected late and is unresponsive to treatment. The number of deaths caused by PHCC is expected to rise over the next 20 years. Those chronically infected with HBV have a life risk of death to HCC of between 10 and 25%. Even the limited efficacy of drugs for the treatment of chronic HBV helps underscore the point that this disease is responsive to therapy. Drugs that target the polymerase (e. g. , hepsera and lamivudine) and interferon alpha represent two distinct strategies and show that both conventional antiviral and immunothe- peutic approaches can be used in management. However, the current inventory of therapeutics is inadequate. Interferon alpha is of limited value, only parenterally ava- able, and fraught with adverse reactions.

Hepatitis B and D Protocols: Volume 1: Detection, Genotypes, and Characterization

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Hepatitis B and D Protocols: Volume 1: Detection, Genotypes, and Characterization

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Despite the availability of an effective vaccine, there are still 400 million people, worldwide who are chronically infected with hepatitis B virus (HBV). For them, the vaccine, as currently applied, has no value. Given the possible consequences of HBV infection, the number of those chronically infected with HBV presents an enormous public health challenge. For example, the major etiology of hepatocellular carcinoma (HCC) is chronic infection with HBV. Although fifth in cancer incidence, worldwide, HCC/liver cancer is the third leading cause of cancer death. The high mortality as- ciated with HCC arises because the disease is often detected late and is unresponsive to treatment. The number of deaths caused by PHCC is expected to rise over the next 20 years. Those chronically infected with HBV have a life risk of death to HCC of between 10 and 25%. Even the limited efficacy of drugs for the treatment of chronic HBV helps underscore the point that this disease is responsive to therapy. Drugs that target the polymerase (e. g. , hepsera and lamivudine) and interferon alpha represent two distinct strategies and show that both conventional antiviral and immunothe- peutic approaches can be used in management. However, the current inventory of therapeutics is inadequate. Interferon alpha is of limited value, only parenterally ava- able, and fraught with adverse reactions.

50 Gastrointestinal Cases & Associated Imaging

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50 Gastrointestinal Cases & Associated Imaging

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Medical students and junior doctors are an integral part of the healthcare system. On an academic gastroenterology service, they often initially evaluate the patients that are then staffed by the consulting physician. Like all clinical specialties, the acquisition of medical knowledge is required to gain expertise. There are several resources such as textbooks and evidence-based articles that are …

Essential Medical Disorders of the Stomach and Small Intestine: A Clinical Casebook 1st ed

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Essential Medical Disorders of the Stomach and Small Intestine: A Clinical Casebook 1st ed

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This casebook provides a concise yet comprehensive state-of-the art review of common stomach and small intestine disorders. The casebook is divided into five parts, each of which focuses on a major disorder, symptom, or clinical scenario related to the stomach and small intestine, including dyspepsia, small bowel disorders, nausea and vomiting, chronic abdominal pain, and post-operative GI surgery challenges. Each part is comprised of cases illustrating different aspects of the subject, with each case containing sections on case presentation, objectives, epidemiology and etiology, diagnostic evaluation and treatment, case follow-up, clinical pearls, and Q&A. Some major topics presented in these cases include nausea and vomiting in the pregnant patient, gas-bloat, functional abdominal pain, post-GI surgery complications, and celiac disease and non-celiac gluten sensitivity.
Written by internationally renowned experts in the field, Essential Medical Disorders of the Stomach and Small Intestine: A Clinical Casebook is a valuable resource for clinicians and practitioners who treat patients afflicted with disorders of the stomach and small intestine.
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