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This book comprising 24 chapters is devoted to the mechanisms for the pathogenesis of the spectrum of vascular diseases in diabetes. Cellular events and molecular pathways that regulate the structure and function of both small and large arteries, the dysregulation in these vessels caused by hyperglycemia, oxidative stress, metabolic and haemostatic derangements secondary to diabetes, are discussed. Mechanisms of vascular remodelling and rupture of atherosclerotic plaques in diabetes are also covered. Several of the reviews also discuss therapeutic targets and drugs employed to reduce endothelial dysfunction and vascular inflammation in diabetes. All articles are authored by experts in their respective research fields.
This compendium will be of interest to both basic scientists and clinicians in the pursuit of unravelling the molecular basis of vascular diseases and also to those who seek to identify targets for therapy of vascular complications of diabetes.
About the Author
Dr. Chandrasekharan C. Kartha is an Honorary Distinguished Professor in the Division of Cardiovascular Diseases and Diabetes Biology at Rajiv Gandhi Center for Biotechnology at Thiruvananthapuram, India. He is a pathologist by training and has made significant contributions to the understanding of the cellular and molecular mechanisms of vascular diseases and endomyocardial fibrosis, a tropical cardiomyopathy. He is an elected fellow of Royal College of Physicians (London), International Academy of Cardiovascular Sciences, National Academy of Medical Sciences (India) National Academy of Sciences (India) and Indian Academy of sciences. He has served on the editorial boards of several journals and in grant review committees of several India government agencies funding medical research and science and technology activities. He has organized several national and international conferences on cardiovascular themes and has been an invited speaker at several national and international meetings. He has published more than 120 papers in refereed journals, 15 chapters in books and edited 5 books. He is the current President of Academy of Cardiovascular Sciences, the India section of International Academy of Cardiovascular Sciences.
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