Clinical Guide to Accelerated Orthodontics: With a Focus on Micro-Osteoperforations 1st ed

This book is a complete reference for all clinicians who are interested in incorporating into their daily practice the techniques available to reduce the duration of orthodontic treatment and to overcome other treatment limitations. It focuses especially on micro-osteoperforations (MOPs) as the most conservative, efficient, and versatile approach to increase the rate of tooth movement. The opening chapters describe the biological principles of current accelerated techniques at the molecular and cellular levels and introduce guidelines on how to select the best acceleration approach based on each patient’s needs. Clinicians are then guided step by step through the application of MOPs, case selection, and treatment planning. It is explained how MOPs can be incorporated into daily mechanotherapy for the treatment of different malocclusions and how to take advantage of the catabolic and anabolic effects of the procedure to expand the boundary of orthodontic and orthopaedic corrections. The book is written in a simple and clear language with many illustrations and clinical examples to facilitate understanding of concepts and procedures. In addition, it is a rich source for academicians and researchers interested in a comprehensive and updated review on theories of tooth movement and accelerated orthodontic techniques.


Quick Guide to Good Clinical Practice: How to Meet International Quality Standard in Clinical Research 1st ed

This brand-new book offers a reference guide to understanding and applying the rules for properly conducting clinical trials to meet the international quality standard – Good Clinical Practice – provided by the International Conference on Harmonization (ICH).

The work offers an updated perspective on the clinical research landscape within the context of the clinical trial regulatory frameworks in Europe and the USA. In addition to providing a historical review and a detailed definition of GPC regulations, it includes step-by-step explanations of all the requirements that researchers should bear in mind when designing and performing new trials. Further topics covered include: ethics of clinical research; the drug development process and evolution of regulations; investigator and sponsor responsibilities; and clinical trial protocols.

Written by clinicians for clinicians, the book represents a valuable read also for researchers, pharmacists and all professionals involved in applications to the ethic committees, whose approval is required for new clinical studies.


Cleft Lip and Palate Treatment: A Comprehensive Guide 1st ed. 2018 Edition

The aim of this book is to discuss cleft lip and palate deformities in a comprehensive way, presenting it from the basics to the most clinically and surgically relevant issues. First, the basic concepts of embryology and pathogenesis of the facial deformities will be discussed. Special attention will be paid to the genetics underlying this condition. Following that, basic principles of surgical treatment through the most recent advances in the field will be presented, along with most important evidences from the literature and the personal experience of the editors and authors.

Cleft Lip and Palate Treatment presents the state of the art and advances in the field and is intended to serve as a comprehensive guide for a broad audience. All the specialties involved in the comprehensive care of these craniofacial deformities will be presented in this book.


Drug Design: Principles and Applications 1st ed. 2017 Edition

This book offers an in-depth discussion of the latest strategies in the field of drug design and their applications in various disorders, in order to encourage readers to undertake their own projects.It also includes the contemporary application of drug-designing methodologies to inspire others to further expand the utility of this field in other diseases.It is intended for advanced undergraduate and graduate students, postdocs, researchers, lecturers and professors in bioinformatics, computational biology, medicine, pharmaceutics and other related fields.


Greenman’s Principles of Manual Medicine (Point (Lippincott Williams & Wilkins)) Fourth Edition

Greenman’s Principles of Manual Medicine has been fully updated and expanded for its Fourth Edition. This practical guide covers the foundations of manual medicine as well as specific techniques for diagnosing and treating musculoskeletal pain. More than 1,000 photographs combined with detailed instructions for each technique make this an invaluable clinical reference. Practitioners can keep up to date with expanded chapters on increasingly popular soft tissue techniques and new techniques for the treatment of closed head injuries. Adjunctive techniques and the use of exercise to prevent and treat disease are also covered.


Oral Mucosa in Health and Disease: A Concise Handbook 1st ed. 2018 Edition

This book is designed to re-establish the position of the oral cavity and its mucosa at the forefront of defence and maintenance of homeostatic mechanisms that protect against disease not just locally but also systemically. The oral mucosa is a unique collection of tissues that constitutes a highly active environment with its own unique microflora and homeostatic interaction with the innate and adaptive immune responses. As an immune tissue the oral mucosa was somewhat neglected in the past owing to the tendency to assume similarity to the gut mucosa. More recently it has become apparent that the oral mucosa is a complex environment and, like the esophageal mucosa, has more in common with vaginal tissue than with the gut. Furthermore, the ability of the oral mucosa to act as an immune inductive site has made it an attractive area of research in terms of desensitization for allergic reactions and possibly autoimmune responses. In this book, recognized experts in the field provide up-to-date coverage of all aspects of the structure and function of the oral mucosa, reflecting important recent advances in knowledge, including at the molecular level.


Moral Distress in the Health Professions

This is the first book on the market or within academia dedicated solely to moral distress among health professionals. It aims to bring conceptual clarity about moral distress and distinguish it from related concepts. Explicit attention is given to the voices and experiences of health care professionals from multiple disciplines and many parts of the world.  Contributors explain the evolution of the concept of moral distress, sources of moral distress including those that arise at the unit/team and organization/system level, and possible solutions to address moral distress at every level. A liberal use of case studies will make the phenomenon palpable to readers.

This volume provides information not only for academia and educational initiatives, but also for practitioners and the research community, and will serve as a professional resource for courses in health professional schools, bioethics, and business, as well as in the hospital wards, intensive care units, long-term care facilities, hospice, and ambulatory practice sites in which moral distress originates.


Chronic Illness Care: Principles and Practice 1st ed. 2018 Edition

This book offers a comprehensive overview to chronic illness care, which is the coordinated, comprehensive, and sustained response to chronic diseases and conditions by a range of health care providers, formal and informal caregivers, healthcare systems, and community-based resources. Using an ecological framework, which looks at the interdependent influences between individuals and their larger environment, this unique text examines chronic illness care at multiple levels and includes  sections on the individual influences on chronic illness, the role of family and social networks, and how chronic care is provided across the spectrum of health care settings; from home to clinic to the emergency department to hospital and residential care facilities.  The book describes the organizational frameworks and strategies that are needed to provide quality care for chronically ill patients, including behavioral health, care management, transitions of care, and health information technology. The book also addresses the changing workforce needs in health care, and the fiscal models and policies that will be required to meet the needs of this population, with a focus on sustaining the ongoing transformation in health care.  This book acts as a major reference for practitioners and students in medicine, nursing, social work, allied health, and behavioral medicine, as well as stakeholders in public health, health policy, and population health.


The Plasticity of Skeletal Muscle: From Molecular Mechanism to Clinical Applications 1st ed

This book discusses recent advances and various topics in plasticity of skeletal muscle from the perspectives of morphology, biological function, and clinical applications. Skeletal muscle is a highly plastic organ to adapt to environmental various demands, appears to endocrine various myokines, which flow into blood to protect the recognizing function of brain and inhibit the appearance of several cancer tumorigenesis.

The book deals with current stem-cell based, pharmacological, and nutritional therapies for muscle wasting (sarcopenia, cachexia, and muscular dystrophy). It also explains the roles of biological mediators such as PGC-1, transient receptor potential cation channels (TRPC), and AMPK in modulating muscle function. The functional roles of ubiquitin-proteasome system, autophagy-dependent signaling in muscle homeostasis, ribosome biogenesis, and redox regulation of mechanotransduction to modulate skeletal muscle mass are also covered.

It is an essential resource for physicians, researchers, post-docs as well as graduate students in the field of sports science including rehabilitation therapy, exercise physiology, exercise biochemistry, and molecular biology dealing with skeletal muscle.


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