Carbon-Ion Radiotherapy: Principles, Practices, and Treatment Planning

Carbon-Ion Radiotherapy: Principles, Practices, and Treatment Planning

This book serves as a practical guide for the use of carbon ions in cancer radiotherapy. On the basis of clinical experience with more than 7,000 patients with various types of tumors treated over a period of nearly 20 years at the National Institute of Radiological Sciences, step-by-step procedures and technological development of this modality are highlighted. The book is divided into two sections, the first covering the underlying principles of physics and biology, and the second section is a systematic review by tumor site, concentrating on the role of therapeutic techniques and the pitfalls in treatment planning.

Readers will learn of the superior outcomes obtained with carbon-ion therapy for various types of tumors in terms of local control and toxicities. It is essential to understand that the carbon-ion beam is like a two-edged sword: unless it is used properly, it can increase the risk of severe injury to critical organs. In early series of dose-escalation studies, some patients experienced serious adverse effects such as skin ulcers, pneumonitis, intestinal ulcers, and bone necrosis, for which salvage surgery or hospitalization was required. To preclude such detrimental results, the adequacy of therapeutic techniques and dose fractionations was carefully examined in each case. In this way, significant improvements in treatment results have been achieved and major toxicities are no longer observed. With that knowledge, experts in relevant fields expand upon techniques for treatment delivery at each anatomical site, covering indications and optimal treatment planning.

With its practical focus, this book will benefit radiation oncologists, medical physicists, medical dosimetrists, radiation therapists, and senior nurses whose work involves radiation therapy, as well as medical oncologists and others who are interested in radiation therapy.

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Conventional Nuclear Medicine in Pediatrics: A Clinical Case-Based Atlas 1st ed.

Conventional Nuclear Medicine in Pediatrics: A Clinical Case-Based Atlas

This superbly illustrated book combines the systematic approach of a textbook with the simplicity of consultation of an atlas in order to provide a comprehensive guide to the applications and benefits of scintigraphic studies in children. All of the clinical scenarios in which conventional nuclear medicine techniques frequently play a role in children are covered, with explanation of imaging diagnosis, the relevance of clinical history, problem solving, and pitfalls. The images themselves are the key focus of the book, and in each setting the added value offered by scintigraphy is carefully identified. The book also describes management of the pediatric patient and addresses general considerations, including reception, interaction with parents, radiopharmaceutical administration, image acquisition, radiation exposure, and the relationship of nuclear medicine and radiology. Since the child is not a young adult, it is insufficient simply to adapt nuclear medicine procedures performed in adults to the age and size of the child. Conventional Nuclear Medicine in Pediatrics will be a rich source of information for all who perform these procedures in the pediatric setting.

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Acute Side Effects of Radiation Therapy: A Guide to Management 1st ed

Acute Side Effects of Radiation Therapy: A Guide to Management

This book provides clear guidance on how to manage a wide range of side effects frequently encountered when treating patients with radiation therapy. For each potential side effect, incidence, mechanism, symptoms, and grading are carefully described. All aspects of management are addressed, drawing on the latest available evidence and highlighting key details of importance in clinical routine.

The introduction of new radiation therapy techniques such as 3D conformal radiation therapy, intensity-modulated radiation therapy, and image-guided radiation therapy has reduced normal tissue doses and, accordingly, treatment complications. Nevertheless, a significant percentage of patients still experience acute side effects, in part because the threshold doses for these toxicities are typically lower than those for late effects. Acute toxicities may lead to interruption of treatment and be associated with an increase in late damage. A swift and effective response is therefore essential. This book will enable the reader to provide effective care for each side effect, thereby improving patient compliance with treatment and treatment outcomes.

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Nuclear Oncology: From Pathophysiology to Clinical Applications 2nd ed. 2017 Edition

Nuclear Oncology: From Pathophysiology to Clinical Applications

This book discusses the role of nuclear medicine in the diagnosis, staging, and treatment of patients with specific cancers. It presents the incidence, pathophysiologic and clinical aspects of the disease, the use of nuclear imaging in diagnosis, staging requirements, management of specific tumors, and surveillance after primary treatment of cancers. It addresses the various diagnostic/therapeutic options that are currently available or are most likely to become available in the near future according to a prioritized approach, thereby keeping to a minimum the number of diagnostic imaging procedures the patient is expected to undergo.

Topics include basic science, clinical applications, radionuclide therapy, radioguided surgery, heart disease in the cancer patient, and adverse effects of cancer therapy. Each clinical chapter discusses the radionuclide procedures within an integrated framework, thereby identifying the information required for effective treatment of specific tumors. The book concludes with a series of cases that define and expand the didactic material in the  clinical application chapters. Thoroughly updated and revised, the second edition incorporates advances in imaging and therapy and features the  current staging guidelines of the American Joint Committee on Cancer.

With contributions from a group of internationally distinguished practitioners, Nuclear Oncology: From Pathophysiology to Clinical Applications, Second Edition, is a valuable reference for nuclear medicine physicians, radiologists, medical and surgical oncologists, and other clinicians involved in the care and management of cancer patients.

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Nuclear Medicine Technology: Review Questions for the Board Examinations 5th ed. 2018 Edition

Nuclear Medicine Technology: Review Questions for the Board Examinations

This book prepares students and technologists for registry examinations in nuclear medicine technology by providing practice questions and answers with detailed explanations, as well as a mock registry exam.  The questions are designed to test both the basic knowledge required of nuclear medicine technologists and the practical application of that knowledge.  The topics covered closely follow the content specifications and the components of preparedness as published by the certification boards.  This 5th edition includes expanded coverage of positron emission tomography, multimodality imaging, and other new procedures and practices in the field of nuclear medicine and molecular imaging.

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The Practice of Internal Dosimetry in Nuclear Medicine (Series in Medical Physics and Biomedical Engineering) 1st Edition

Written by one of the world’s leading experts in the field of nuclear medicine dosimetry, this text describes in detail the use of internal dose calculations in the practice of nuclear medicine. While radiation therapy with external sources of radiation always employs calculations of dose to optimize therapy for each patient, this is not routinely conducted in nuclear medicine therapy. As the trend towards an increasing role of dosimetry in therapy planning increases, this book reviews the available methods and technologies available to make this a more common practice.

The book begins by covering the mathematical fundamentals of internal dose calculations, and uses sample calculations to demonstrate key principles. The book then moves forward to describe anthropomorphic models, dosimetric models, and types and uses of diagnostic and therapeutic radiopharmaceuticals. The depth of coverage makes it useful reference and guide for researchers performing dose calculations and for physicians considering incorporating dose calculations into the treatment of their cancer patients.

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PET: Molecular Imaging and Its Biological Applications

This book is written as both a text and a reference book. It contains numerous images from the biological sciences and clinical practice, tables, graphs, and fig­ ures, as well as exercises that are worked out to aid the reader in understanding principles or solving problems. In some cases, derivations are placed in appen­ dices so as not to break up the flow of the subject matter in the text. The book is intended for a broad audience interested in molecular imaging with positron emission tomography (PET). It is expected that the readers will range from undergraduate, graduate, and medical students to residents, physi­ cians, and scientists with backgrounds from various physical, biological, and medical specialty areas. Each chapter presents material in a straightforward man­ ner that is well illustrated and explained. Because of the diverse audience for the book, certain chapters or sections of chapters will be of more interest than oth­ ers to certain segments of the readership. Chapter 1 introduces the fundamental physics upon which PET imaging sys­ tems is based and discusses in detail the technologies and methods used to pro­ duce PET images. The chapter starts out by reviewing the physics of positron emission and annihilation and explains how positron range and photon non­ colinearity in coincidence detection place certain limits on spatial resolution.

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Orthopedic Nuclear Medicine 2nd ed. 2017 Edition

This book, now in a revised and updated second edition, offers a comprehensive overview of the state of the art in orthopedic nuclear medicine, including the impressive recent advances in the field and the diagnosis of under-recognized conditions on the basis of their imaging patterns. The opening chapters acquaint the reader briefly with anatomic, physiologic, pathologic, and technical concepts crucial to a sound understanding of orthopedic nuclear medicine and its utilization in clinical practice. The imaging diagnosis of skeletal infections, trauma, vascular disorders, metabolic and neoplastic bone diseases, soft tissue calcifications, and joint disorders is then explained in detail. Two entirely new chapters, on bone marrow imaging and hybrid imaging of bone diseases, have been added to this edition.  A separate chapter is devoted to the use of radionuclides for the treatment of bone and joint disorders. The book is richly illustrated and amply documents the effectiveness of nuclear medicine in diagnosing bone disease. It will prove invaluable to all with an interest in diagnostic and therapeutic orthopedics, including orthopedists, radiologists, rheumatologists, pediatricians, podiatrists, other clinicians, and all nuclear and molecular imaging professionals.

“..it is one of the best nuclear medicine textbooks and the most complete presentation of the role of nuclear medicine in orthopedics …This book addresses a difficult topic in nuclear imaging that is often insufficiently covered ba many general textbooks in the field. ..a must have book for all professionals dealing with orthopedic problems….(Michael J. Blend, Radiology, Vol. 239, April 2006).

“This is a fine book that encompasses every aspect of bone physiopathology related to nuclear medicine in orthopaedic surgery. Nicely illustrated and well presented, this book offers comfortable and interesting reading and brings an in-depth insight on the mechanisms of action, the pathology and the pharmacology of the imaging molecules. … This volume should be available to every orthopaedic surgeon and trainee.” (C. Delloye, Acta Orthopaedica Belgica, Vol. 70(6), 2004)

“Despite the emergence of new imaging methods, nuclear medicine and in particular, osseous scintigraphy, preserves a very particular place in osteoarticular exploration. A.H. Elgazzar performs an update of the various applications in this field. … the author has the requisite merit to produce a synthetic work on the entire gamut of nuclear medicine applications in osteoarticular pathology, intended for a large audience from the point of view of specialists as well as those with some experience.” (L. Balabaud, European Journal of Orthopaedic Surgery & Traumatology, Vol. 16, 2006)

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Hybrid PET/CT and SPECT/CT Imaging: A Teaching File

Hybrid PET/CT and SPECT/CT Imaging: A Teaching File presents a complete book on state-of-the-art integrated PET/CT and SPECT/CT imaging systems. Edited by Drs. Dominique Delbeke and Ora Israel, this practical guide includes in-depth cases that will advance the skills of nuclear physicians and radiologists while also preparing residents for the field of nuclear medicine and radiology. Internationally-recognized contributors provide the reader with chapters covering the technical and clinical aspects of hybrid imaging, including basic principles, physics and instrumentation, the normal distribution of radiopharmaceuticals, and protocols critical to the field. A comprehensive review of nuclear oncology cases found in everyday practice are addressed, including among other clinical applications head and neck tumors, breast cancer, lung neoplasms, colorectal cancer, pancreatic cancer, and genitourinary tumors. Additional chapters examine the use of these modalities in pediatric patients, benign bone diseases and infection, and cardiac hybrid imaging. A wealth of illustrations reinforces the key teaching points discussed throughout the book.

A beneficial feature is the accompanying CD-ROM containing DICOM images from selected cases showing views in all planes, including the fusion images, which simulates an actual workstation used in a clinical scenario. The CD-ROM has been provided by Hermes Medical Solutions, Inc.

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PET/CT in Hepatobiliary and Pancreatic Malignancies (Clinicians’ Guides to Radionuclide Hybrid Imaging) 1st ed

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