Resistance to Tyrosine Kinase Inhibitors (Resistance to Targeted Anti-Cancer Therapeutics) 1st ed

April 26, 2018 Leave a comment

Resistance to Tyrosine Kinase Inhibitors (Resistance to Targeted Anti-Cancer Therapeutics)

Price: $199.99

The volume will serve as a primer on tyrosine kinase signaling and its importance in cancer. The volume will first introduce the common denominators of small-molecule and antibody-derived inhibitors, as well as the general phenomenon of resistance. The volume will then detail resistance to the most commonly used classes of tyrosine kinase inhibitors, and will focus specific chapters on resistance to BCR-ABL1, FLT3, angiokinase family members, and ALK inhibitors.

About the Author

Dr.Daniele Focosi was born in Lucca (Italy) in 1980. He graduated in Medicine with full grades in 2005 at the University of Pisa, and completed specialization in hematology in 2009. He achieved a Ph.D. degree in Clinical and Fundamental Virology in 2014, and a master degree in Clinical Trials in Oncology-Hematology in 2014.

He has authored 106 peer-reviewed manuscripts indexed on PubMed, for a total h-index of 16 and an overall impact factor of over 1400 points. He has been a fellow of the International Centre for Genetic Engineering and Biotechnology (ICGEB) in Trieste, and of the Collegio Ghislieri in Pavia, Italy. He is currently employed full-time at the Pisa University Hospital, where he is also a member of the Faculty of the PhD School in Clinical and Translational Sciences at University of Pisa.

He has given 37 oral and 47 poster presentations at international medical congresses, and is member of the editorial board of 17 peer-reviewed journals.He has received awards from the European Federation of Immunogenetics, the European Society for Organ Transplantation, the Italian Society for Hematology, the Italian Interregional Transplant Association, the Italian Bone Marrow Donor Association, the Italian Society for Experimental Hematology, the Italian Society against Leukemia/Lymphoma/Myeloma.

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Imaging and Intervention in Urinary Tract Infections and Urosepsis 1st ed. 2018 Edition

March 2, 2018 Leave a comment

Aimed at practicing clinicians and radiologists, this volume provides up-to-date, detailed information on potentially severe urinary tract infections (UTIs), which frequently require intensive in-patient antibiotic therapy, percutaneous or surgical treatment. UTIs are the most prevalent infectious illness, and account for hundreds of thousands of emergency and hospital admissions yearly. Furthermore, UTIs are the most common (almost 40%) type of hospital-acquired infections, with bladder catheterisation being the key risk factor. According to the European Association of Urology guidelines, complicated urinary tract infections (C-UTIs) are those associated with structural or functional genitourinary abnormalities or with conditions that impair the host’s defence mechanisms, leading to an increased risk of acquiring infection or therapy failure.

Besides offering current perspectives from urologists, nephrologists, and specialists in infectious diseases, the book presents the techniques and highlights the role of ultrasound and contrast-enhanced ultrasound, nuclear medicine, multidetector computed tomography (CT) and magnetic resonance imaging (MRI) in providing comprehensive investigations of upper and lower tract UTIs, and of systemic infections from unknown sources. Cross-sectional imaging is currently recommended to confirm UTI, to assess severity and look for underlying treatable structural or functional abnormalities, in order to provide a consistent basis for a correct therapeutic choice.

Furthermore, dedicated chapters illustrate the current status of UTI imaging in children and the expanding role and possibilities of interventional radiology in the treatment of severe urinary tract infections.

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Philosophy of Medicine: An Introduction 1st Edition

February 15, 2018 Leave a comment

What kind of knowledge is medical knowledge? Can medicine be explained scientifically? Is disease a scientific concept, or do explanations of disease depend on values? What is “evidence-based” medicine? Are advances in neuroscience bringing us closer to a scientific understanding of the mind?

The nature of medicine raises fundamental questions about explanation, causation, knowledge and ontology – questions that are central to philosophy as well as medicine. This book introduces the fundamental issues in philosophy of medicine for those coming to the subject for the first time, including:

• understanding the physician–patient relationship: the phenomenology of the medical encounter.

• Models and theories in biology and medicine: what role do theories play in medicine? Are they similar to scientific theories?

• Randomised controlled trials: can scientific experiments be replicated in clinical medicine? What are the philosophical criticisms levelled at RCTs?

• The concept of evidence in medical research: what do we mean by “evidence-based medicine”? Should all medicine be based on evidence?

• Causation in medicine.

• What do advances in neuroscience reveal about the relationship between mind and body?

• Defining health and disease: are explanations of disease objective or do they depend on values?

• Evolutionary medicine: what is the role of evolutionary biology in understanding medicine? Is it relevant?

Extensive use of empirical examples and case studies are included throughout, including debates about smoking and cancer, the use of placebos in randomised controlled trials, controversies about PSA testing and research into the causes of HIV. This is an indispensable introduction to those teaching philosophy of medicine and philosophy of science.

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Atlas of Neurosurgical Techniques: Spine and Peripheral Nerves 2nd Edition

November 26, 2017 Leave a comment

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“The editors have succeeded in creating a formidable atlas…Its presentation is generally concise. Technical details are presented succinctly and with large, lucid diagrams. Although the text is organized in a practical manner that allows for quick consultation, it also succeeds in supplying the detailed information found in general neurosurgical texts. In short, the editors have successfully created a first-line resource for all clinicians. Many substantial and diverse topics have been successfully corralled into a useful and readily accessible reference source. Given its scope and depth of information, “Atlas of Neurosurgical Techniques: Spine and Peripheral Nerves” is reasonably priced. In the opinion of this reviewer, it would be beneficial to any clinician or resident as an operative resource.”–Journal of Neurosurgery

“Much more than an atlas…a prime composition of leading authors…the illustrations are superb, the text easy to read, the quality impeccable, and the price

The editors have succeeded in creating a formidable atlas…Its presentation is generally concise. Technical details are presented succinctly and with large, lucid diagrams. Although the text is organized in a practical manner that allows for quick consultation, it also succeeds in supplying the detailed information found in general neurosurgical texts. In short, the editors have successfully created a first-line resource for all clinicians. Many substantial and diverse topics have been successfully corralled into a useful and readily accessible reference source. Given its scope and depth of information, “Atlas of Neurosurgical Techniques: Spine and Peripheral Nerves” is reasonably priced. In the opinion of this reviewer, it would be beneficial to any clinician or resident as an operative resource.–Journal of NeurosurgeryMuch more than an atlas…a prime composition of leading authors…the illustrations are superb, the text easy to read, the quality impeccable, and the price appropriate…a must for most neurosurgical libraries.–Doody’s Review”Volume 1: Brain” and “Volume 2: Spine,” lays out in artist’s color drawings, line diagrams, intraoperative photographs, radiographs, and in an easily digestible written format the breadth and scope of virtually every neurosurgical procedure…both volumes can help fill a need for practicing neuroradiology and in training programs in neuroradiology…with [“Spine”] as a reference, an understanding of the surgical management of intracranial and intraspinal abnormalities can be appreciated…this text borders on being mandatory in any neuroradiology library, particularly where fellows and residents are being trained…highly recommended as an addition to a department’s collection of important clinical textbooks.–American Journal of Neuroradiology

From the Back Cover

Winner of Association of American Publishers Best Book in Clinical Medicine, 2006 Highly Commended in Surgery by British Medical Association, 2007

Here is complete coverage of state-of-the-art surgical techniques for the spine and peripheral nerves. This atlas engages the full range of approaches — anterior, antero-lateral, posterior, and postero-lateral — for operations on peripheral nerves and in every area of the spine.

Each of the seven sections of the atlas opens with in-depth discussion of pathology, etiology and differential diagnosis conveying the underlying scientific principles of diseases and conditions of the spine and peripheral nerves. The authors then present technique-oriented chapters containing step-by-step descriptions of surgical procedures. These chapters delineate the goals, indications, contraindications, anesthesia considerations, positions, as well as the advantages and disadvantages of each technique in a concise manner, ideal for the busy practitioner seeking review.

Beautifully illustrated with more than 1,200 images, including 811 full-color drawings, this authoritative text covers all of the critical issues involved in surgeries for the spine and peripheral nerves. It will be an invaluable asset to neurosurgeons, orthopedic surgeons and residents seeking a carefully edited, didactic atlas.

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Penetrating Trauma: A Practical Guide on Operative Technique and Peri-Operative Management 2nd ed. 2017 Edition

October 1, 2017 Leave a comment

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“The editors have expanded their focus on surgical techniques to include a more holistic assessment of patient care, with several areas of interest to anesthesiologists. … We highly recommend that anesthesiologists with responsibility for trauma patients read and utilize this book frequently. Velmahos, Degiannis, and Doll are giants in trauma surgery, and their surgical insight on evidencebased approaches to care of the patient with penetrating trauma will prove valuable to anesthesiologists caring for such patients.” (Markus M. Luedi and Richard P. Dutton, Anesthesia & Analgesia, Vol. 124 (3), March, 2017)

“This is the second edition of a comprehensive textbook of trauma care with a focus on the patient suffering penetrating injury. … Resuscitation and operative management are appropriately emphasized, but the scope of the chapters spans the full spectrum of trauma care from field assessment and resuscitation through rehabilitation. Senior surgical trainees and practicing surgeons, particularly those with only occasional contact with patients with penetrating injury, will benefit from this book, originating from an international group of authors.” (David J. Dries, Doody’s Book Reviews, December, 2016)

From the Back Cover

This book provides clear practical guidance on all aspects of the surgical treatment of penetrating trauma and aims to foster the type of strategic thinking that can save patients’ lives. The coverage encompasses prehospital care, penetrating injuries to various body regions and specific organs, orthopedic injuries, peripheral arterial injuries, injuries to special groups of patients, including children and the elderly, military injuries, and a range of other topics. Based on their extensive personal experience, expert authors provide step-by-step instructions on evaluation, surgical techniques, and management of perioperative problems. Tips and tricks and technical pearls are highlighted and each chapter includes a list of the most important points to observe.

This second edition of Penetrating Trauma has been extensively revised and updated – with inclusion of some entirely new chapters – to take into account the most recent trends in resuscitation, diagnostics, and treatment. It will be an ideal resource for those looking for practical solutions on how to treat injuries surgically.

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Heart and Coronary Arteries: An Anatomical Atlas for Clinical Diagnosis, Radiological Investigation, and Surgical Treatment

October 1, 2017 Leave a comment

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The magnificent anatomic presentation in this book “The Heart and Cor onary Arteries” has a unique importance for surgeons. It is a fundamental contribution to the anatomy of the heart and great arteries as well, because of the analytical, detailed, and imaginative anatomic approach of the author. While surgery from time to time is influenced by the development of new physiologic principles and techniques, methods of intra- and post-operative support, and new diagnostic methodology, the excellence of its results con tinues to be related primarily to the precision and perfection of the opera tive procedure itself. The operative procedure can be precise and perfect only if it is based upon the surgeon’s profound knowledge of normal anatomy, his understanding of the alterations in this normal anatomy by the pathol ogy with which he is dealing, and his ability to use this anatomic informa tion in organizing and effecting his surgical procedure. The cardiac sur geon, therefore, will find great rewards from intense study of this anatomic atlas. The cardiologist, the pediatric cardiologist, the anatomist, the pathol ogist, and students interested in cardiac disease will benefit to almost the same degree from a careful study of this work. May 1975 JOHN W. KIRKLIN, M. D.

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Oxford Case Histories in Sleep Medicine by Himender Makker (26-May-2015) Paperback

September 3, 2017 Leave a comment

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PET/CT in Prostate Cancer (Clinicians’ Guides to Radionuclide Hybrid Imaging) 1st ed. 2017 Edition

August 17, 2017 Leave a comment

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This pocket book explains the significant and well-documented impact that PET/CT can have on the management of prostate cancer through the provision of high-quality evidence regarding function and structure. Up-to-date information is supplied on the relevance of PET/CT to diagnosis, treatment planning, and therapy, including the emerging role of PET/CT with PSMA. Readers will also find clear explanation of the relation of the clinical and pathological background to imaging and the value of PET/CT compared with conventional radiological imaging. The book will be an excellent asset for referring clinicians, nuclear medicine/radiology physicians, radiographers/technologists, and nurses who routinely work in nuclear medicine and participate in multidisciplinary meetings. It is published within the Springer series Clinicians’ Guides to Radionuclide Hybrid Imaging, which presents contributions from professionals worldwide who share a common purpose in promoting nuclear medicine as an important imaging specialty for the diagnosis and management of oncological and non-oncological conditions.

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Advances in Laparoscopy of the Abdominal Wall Hernia

August 10, 2017 Leave a comment

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“The purpose is to provide the available literature to general and laparoscopic surgeons interested in perfecting or improving current techniques in laparoscopic repair of the various hernias of the abdominal wall. … The book is targeted at general surgical residents, laparoscopic fellows or practicing general or minimally invasive surgeons. … This is a good, easy to read reference about the latest techniques in laparoscopic abdominal wall hernia for surgeons in training or advanced laparoscopists wishing to try new approaches.” (Jessica K. Smith, Doody’s Book Reviews, August, 2014)

From the Back Cover

With an increase in the use of laparoscopic techniques for the treatment of abdominal wall hernias, this comprehensive book provides a detailed description of the most up-to-date techniques used in the laparoscopic repair of inguinal and ventral incisional hernias. Advances in Laparoscopy of the Abdominal Wall Hernia takes the reader step-by-step through two laparoscopic techniques used in inguinal hernia correction: Extraperitoneal (TEP) and Transabdominal (TAPP), and guides the reader through the fundamentals of ventral hernia repair. The authors aim to show methods of dealing with rarer hernias and those of atypical location. This book will also inform the reader of the various kinds of meshes used and provides knowledge on how to fix them, as well as the advantages, disadvantages and indications of this type of prosthesis.

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Key Concepts and Issues in Nursing Ethics 1st ed. 2017 Edition

August 6, 2017 Leave a comment

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Short case studies, based on real stories from the health care arena, ensure that each chapter of this book is rooted in descriptions of nursing practise that are grounded, salient narratives of nursing care. The reader is assisted to explore the ethical dimension of nursing practice: what it is and how it can be portrayed, discussed, and analysed within a variety of practice and theoretical contexts. One of the unique contributions of this book is to consider nursing not only in the context of the individual nurse – patient relationship but also as a social good that is of necessity limited, due to the ultimate limits on the nursing and health care resource. This book will help the reader consider what good nursing looks like, both within the context of limitations on resources and under conditions of scarcity.

Indeed, any discussion of ethical issues in nursing should be well grounded in a conceptualisation of nursing that nursing students and practising nursing can recognise, accept and engage with. Nursing, like medicine, social work and teaching has a clear moral aim – to do good. In the case of nursing to do good for the patient. However it is vital that in the pressurised, constrained health service of the 21st century, we help nurses explore what this might mean for nursing practice and what can reasonably be expected of the individual nurse in terms of good nursing care.

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