Translational Toxicology and Therapeutics: Windows of Developmental Susceptibility in Reproduction and Cancer 1st Edition

Translational Toxicology and Therapeutics: Windows of Developmental Susceptibility in Reproduction and Cancer

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Toxic Trauma: A Basic Clinical Guide

Toxic Trauma: A Basic Clinical Guide

This book provides practical guidance to emergency personnel and others in the event of having to manage individual or mass chemical casualties as part of their work in a civilian ambulance service or hospital. The text considers the nature and basic science of the hazards faced as well as the practical management of persons exposed to chemicals and toxins (which although of biological origin behave as chemicals in terms of their effects and transmission).  

Individual chapters cover the development and classification of chemical toxic agents, how exposure can occur and how medical personnel should be involved in its management . There is also consideration of the nature of toxic trauma and the pathophysiological processes involved, together with a systematic approach to early and continuing management supported by specific examples of incidents. This guide is a useful practical resource for emergency medical and paramedical personnel involved in the management of mass chemical casualties and with ensuring safe operating procedures within potentially contaminated areas to prevent secondary casualties from a chemical release.

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Bone Toxicology (Molecular and Integrative Toxicology) 1st ed. 2017 Edition

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Neurotoxicity of Metals (Advances in Neurobiology) 1st ed. 2017 Edition

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Computational Systems Pharmacology and Toxicology (Issues in Toxicology) Gld Edition

The network approaches of systems pharmacology and toxicology serve as early predictors of the most relevant screening approach to pursue both in drug discovery and development and ecotoxicological assessments. Computational approaches have the potential to improve toxicological experimental design, enable more rapid drug efficacy and safety testing and also reduce the number of animals used in experimentation. Rapid advances in availability of computing technology hold tremendous promise for advancing applied and basic science and increasing the efficiency of risk assessment.
This book provides an understanding of the basic principles of computational toxicology and the current methods of predictive toxicology using chemical structures, toxicity-related databases, in silico chemical-protein docking, and biological pathway tools. The book begins with an introduction to systems pharmacology and toxicology and computational tools followed by a section exploring modelling adverse outcomes and events. The second part of the book covers the discovery of protein targets and the characterisation of toxicant-protein interactions. Final chapters include case studies and additionally discuss interactions between phytochemicals and Western therapeutics.
This book will be useful for scientists involved in environmental research and risk assessment. It will be a valuable resource for postgraduate students and researchers wishing to learn about key methods used in studying biological targets both from a toxicity and pharmacological activity standpoint.

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Metallomics: Recent Analytical Techniques and Applications 1st ed. 2017 Edition

This book focuses on recent topics in metallomics, a study of the metallome, or metal-containing biomolecules. Metals can induce various physiological and toxicological effects in a very small amounts, in other words, the concentrations of biometals are very low in organisms. Thus, analytical techniques for a trace amount of metal are crucial to understand the biological and toxicological functions of metals.This volume begins with an overview of metallomics including the history and development of the field. Subsequent parts provide basic and advanced techniques for metallomics. Speciation and imaging of metals are basic approaches to reveal the function of the metallome. The applications of speciation using an HPLC hyphenated with inductively coupled plasma mass spectrometry (LC-ICP-MS) and flow cytometry ICP-MS are described. As advanced approaches, the applications using a micro-flow injection-ICP-MS, an ICP-triple quadrupole mass spectrometer, an ICP-sector field mass spectrometer, and an ICP-multi-collector mass spectrometer are mentioned. For the imaging of metals, basic principles and applications of several techniques such as scanning X-ray fluorescence microscopy and ICP-MS equipped with laser ablation (LA-ICP-MS) are presented. Speciation analyses using electrospray ionization mass spectrometry (ESI-MS), X-ray Absorption Spectroscopy (XAS), and nuclear magnetic resonance spectroscopy (NMR) are also introduced. The last part highlights the medical and pharmaceutical applications of metallomics. Molecular biological approaches to reveal the effects of toxic metals, metal functions in brain and neurodegenerative diseases, and metallodrugs are explained. The topic of metal transporters is also presented.

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Regulatory Toxicology

Franz-Xaver Reichl studied Microbiology and Medicine in Munich, Germany. He is Head of the Department of Dental Toxicology at the Department of Operative/Restorative Dentistry, Periodontology and Pedodontics, LMU Munich and Head of the International Advisory Centre for the toxicology and biocompatibility of dental materials. His field of research cover studies on cytotoxic, mutagenic, carcinogenic and embryotoxic effects of chemical compounds (e.g. dental materials) in human and animal cells, abrasion of composites and elution of dental composite components during the chewing situation in the chewing simulator MUC/3 and in vitro- and in vivo studies on toxicokinetic and toxicodynamic effects of chemical compounds (e.g. dental materials). He also work on studies on the pathways and on the analysis of intermediates in the metabolism of dental composite components in biological systems and risk assessments of xenobiotics (e.g. dental materials). Michael Schwenk studied Biochemistry and Medicine in Tuebingen, Germany. He then qualifiedas a toxicologist and pharmacologist and worked in universities, industry and a health agency. He initially focused on experimental cell toxicology, but later shifted to the measurement of chemical residues in humans and to study the health effects of such exposures in different populations. He was active in various national regulatory committees, advised the colleagues of the public health service of Baden-Württemberg and received practical experience in all major areas of regulatory toxicology.

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Postmortem Toxicology of Abused Drugs 1st Edition

Extracted from the Drug Abuse Handbook, 2nd edition, to give you just the information you need at an affordable price.

Postmortem Toxicology of Abused Drugs considers the role of toxicology in the investigation of homicide, suicide, accident, natural death, and overdose. It gives practical insights and case reviews on conducting toxicology tests and completing toxicology reports. It explains chain of custody; specimen collection and security; sampling of blood, urine, bile, and vitreous humor; and the selection of post-mortem specimens. Analyzing various testing procedures, the book covers simple chemical tests, microdiffusion tests, chromatography, spectroscopy, and more. It also discusses methods and strategies for analysis; and covers quality assurance protocols and controls. To help avoid common pitfalls, the text demonstrates the proper interpretation of postmortem drug levels based on knowledge of pharmacokinetics, metabolism, and pharmacogenetics; post-mortem redistribution and diffusion; and other considerations such as synergistic toxicity, and drug instability. Heavily referenced and containing several tables, figures, and useful appendices, this book is a handy reference for forensic scientists and medical examiners involved with death investigation.

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Toxins and Drug Discovery (Toxinology) 1st ed. 2017 Edition

This volume deals mainly with the specialized aspect of toxins and drug discovery. Man has been using natural resources especially plants to treat diseases from very early times in history of mankind. Although many drugs derived from plants and microbes have been discovered and being used in clinical practice, not many drugs have been developed from venoms and toxins although many laboratories worldwide are actively working on it. This volume describe some of the recent developments in this research area, such as snake venoms, conotoxins , bioinformatics in drug discovery from peptide toxins.

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Practical Toxicology: Evaluation, Prediction, and Risk, Third Edition 3rd Edition

Practical Toxicology: Evaluation, Prediction, and Risk, Third Edition shows how to conduct a program of safety evaluation and testing and then to interpret and apply the resulting data and information in the real world, beginning with the basic concepts in toxicology and progressing to the interpretation of the resulting data. Revised and updated chapters on risk assessment guide the reader to setting the foundations necessary for submission to regulatory authorities. In addition, a new chapter in the book reviews the errors in toxicology, mistakes, misuse, mismanagement, and misunderstanding with a view to avoiding these in the future.

New Chapters in the Third Edition:

    • Toxicology in silico

  • Errors in Toxicology
  • Safety Assessment of Extractables and Leachables.

This new edition follows a practical sequence from introducing the basics of toxicology (including the vital concept of normality in controls) to describing a test program and then interpreting the data and translating that to risk assessment that can be used in a number of real world situations where safety and secure risk assessment are essential. Although written primarily from the perspective of pharmaceutical development, the test designs and toxicological problems encountered in that field are entirely relevant to those with other classes of chemicals, the only difference being the regulatory context. Toxicology is an international discipline and the book has been written to take into account some of the differences in regulatory nuance between the main regions of the world.

Completely revised and written in an easily accessible style, the text address several audiences―from students and post-graduates coming to the subject for the first time to established professionals who find themselves needing to learn about toxicology, toxicity testing, interpretation of the results, and risk assessment. It is intended primarily as a textbook, with case studies and information on where to go to ask questions, but can also be used as a practical reference book. It covers all the basics of toxicology and the main aspects of safety evaluation testing and risk assessment while reviewing critically the current state of the discipline. It also provides a foundation for those seeking registration or certification.

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