Botulinum Toxin Treatment in Clinical Medicine: A Disease-Oriented Approach 1st ed. 2018 Edition

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Clarke’s Analysis of Drugs and Poisons, 4th Edition (Book + 1-Year Online Access Package) 4 Revised Edition

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Clarke’s Analysis of Drugs and Poisons, 4th Edition is now being offered solely as a print and online package. It is a full book & digital package, consisting of the two volume reference book in a slip case, plus one year’s individual access to the online version of Clarke’s via MedicinesComplete, with all the attendant benefits, including updating annually.

(A secure code will be included in the package enabling the end-user to access MedicinesComplete and setup their account and their 1-Year subscription)

MedicinesComplete is produced and updated by Pharmaceutical Press.

Clarke’s Analysis of Drugs and Poisons is the definitive source of analytical data for drugs and poisons. Written by over 40 international experts, the resource also boasts an editorial advisory board of over 45 world renowned scientists.

This reference work has been completely revised and updated for the new edition, and comprises two volumes.

The book is essential for all forensic and clinical toxicologists, pathologists, hospital pharmacists, pharmaceutical analysts, clinical pharmacologists, clinical and forensic laboratories, and poison information centers.

From the reviews of the previous edition

‘Some things in life are worth the wait and truly this 3rd edition of Clarke’s Analysis of Drugs and Poisons falls into this category…the quality is superb’ Australian Journal of Forensic Sciences

‘Clarke has gained an international reputation as a reliable source of information for the analyses of drugs, and this new highly-expanded edition is the 21st century’s successor.’ Veterinary and Human Toxicology

‘The content is comprehensive, absorbing and layout is well planned and executed. Without doubt, this volume will be a much well thumbed institution in any serious analytical laboratory and will assist generations of scientists in years to come.’ Pharmacy Education


Pesticide Toxicology and International Regulation (Current Toxicology) 1st Edition

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This book brings together key features of the toxicology and occupational hazards of pesticides and the way their use is regulated in the main trading regions of the world. There are chapters on each of the main groups of insecticides, namely organochlorines, anticholinesterases and pyrethrins and pyrethroids. The book also covers fungicides and herbicides, as well as more specialised agents such as microbial pesticides. The risks and hazards to humans are considered, both occupational and through the consumption of contaminated foodstuffs.  Additionally, clinical aspects of pesticide poisoning are discussed.

The possibility of harm from pesticide exposure has led to the development of national and international regulations governing the application of pesticides. The book describes the regulatory systems in three major economic areas: the North American Free Trade Area (USA, Canada and Mexico), the European Union and Japan.

This book should be of interest to all individuals working on the development and application of pesticides anywhere in the world. All those involved in the manufacture, regulation and toxicology of pesticides should also benefit from reading this book.


Alternatives for Dermal Toxicity Testing 1st ed

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Translational Toxicology and Therapeutics: Windows of Developmental Susceptibility in Reproduction and Cancer 1st Edition

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Toxic Trauma: A Basic Clinical Guide

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This book provides practical guidance to emergency personnel and others in the event of having to manage individual or mass chemical casualties as part of their work in a civilian ambulance service or hospital. The text considers the nature and basic science of the hazards faced as well as the practical management of persons exposed to chemicals and toxins (which although of biological origin behave as chemicals in terms of their effects and transmission).  

Individual chapters cover the development and classification of chemical toxic agents, how exposure can occur and how medical personnel should be involved in its management . There is also consideration of the nature of toxic trauma and the pathophysiological processes involved, together with a systematic approach to early and continuing management supported by specific examples of incidents. This guide is a useful practical resource for emergency medical and paramedical personnel involved in the management of mass chemical casualties and with ensuring safe operating procedures within potentially contaminated areas to prevent secondary casualties from a chemical release.


Bone Toxicology (Molecular and Integrative Toxicology) 1st ed. 2017 Edition

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Neurotoxicity of Metals (Advances in Neurobiology) 1st ed. 2017 Edition

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Computational Systems Pharmacology and Toxicology (Issues in Toxicology) Gld Edition

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The network approaches of systems pharmacology and toxicology serve as early predictors of the most relevant screening approach to pursue both in drug discovery and development and ecotoxicological assessments. Computational approaches have the potential to improve toxicological experimental design, enable more rapid drug efficacy and safety testing and also reduce the number of animals used in experimentation. Rapid advances in availability of computing technology hold tremendous promise for advancing applied and basic science and increasing the efficiency of risk assessment.
This book provides an understanding of the basic principles of computational toxicology and the current methods of predictive toxicology using chemical structures, toxicity-related databases, in silico chemical-protein docking, and biological pathway tools. The book begins with an introduction to systems pharmacology and toxicology and computational tools followed by a section exploring modelling adverse outcomes and events. The second part of the book covers the discovery of protein targets and the characterisation of toxicant-protein interactions. Final chapters include case studies and additionally discuss interactions between phytochemicals and Western therapeutics.
This book will be useful for scientists involved in environmental research and risk assessment. It will be a valuable resource for postgraduate students and researchers wishing to learn about key methods used in studying biological targets both from a toxicity and pharmacological activity standpoint.


Metallomics: Recent Analytical Techniques and Applications 1st ed. 2017 Edition

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This book focuses on recent topics in metallomics, a study of the metallome, or metal-containing biomolecules. Metals can induce various physiological and toxicological effects in a very small amounts, in other words, the concentrations of biometals are very low in organisms. Thus, analytical techniques for a trace amount of metal are crucial to understand the biological and toxicological functions of metals.This volume begins with an overview of metallomics including the history and development of the field. Subsequent parts provide basic and advanced techniques for metallomics. Speciation and imaging of metals are basic approaches to reveal the function of the metallome. The applications of speciation using an HPLC hyphenated with inductively coupled plasma mass spectrometry (LC-ICP-MS) and flow cytometry ICP-MS are described. As advanced approaches, the applications using a micro-flow injection-ICP-MS, an ICP-triple quadrupole mass spectrometer, an ICP-sector field mass spectrometer, and an ICP-multi-collector mass spectrometer are mentioned. For the imaging of metals, basic principles and applications of several techniques such as scanning X-ray fluorescence microscopy and ICP-MS equipped with laser ablation (LA-ICP-MS) are presented. Speciation analyses using electrospray ionization mass spectrometry (ESI-MS), X-ray Absorption Spectroscopy (XAS), and nuclear magnetic resonance spectroscopy (NMR) are also introduced. The last part highlights the medical and pharmaceutical applications of metallomics. Molecular biological approaches to reveal the effects of toxic metals, metal functions in brain and neurodegenerative diseases, and metallodrugs are explained. The topic of metal transporters is also presented.


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