Jasper’s Basic Mechanisms of the Epilepsies (Contemporary Neurology Series) 4th Edition

H.H. Jasper, A.A. Ward, A. Pope and H.H. Merritt, chair of the Public Health Service Advisory Committee on the Epilepsies, National Institutes of Health, published the first volume on Basic Mechanisms of the Epilepsies (BME) in 1969. Their ultimate goal was to search for a “better understanding of the epilepsies and seek more rational methods of their prevention and treatment.” Since then, basic and clinical researchers in epilepsy have gathered together every decade and a half with these goals in mind — assessing where epilepsy research has been, what it has accomplished, and where it should go. In 1999, the third volume of BME was named in honor of H.H. Jasper. In line with the enormous expansion in the understanding of basic epilepsy mechanisms over the past four decades, this fourth edition of Jasper’s BME is the most ambitious yet. In 90 chapters, the book considers the role of interactions between neurons, synapses, and glia in the initiation, spread and arrest of seizures. It examines mechanisms of excitability, synchronization, seizure susceptibility, and ultimately epileptogenesis. It provides a framework for expanding the epilepsy genome and understanding the complex heredity responsible for common epilepsies as it explores disease mechanisms of ion channelopathies and developmental epilepsy genes. It considers the mechanisms of conditions of epilepsy comorbidities. And, for the first time, this 4th edition describes the current efforts to translate the discoveries in epilepsy disease mechanisms into new therapeutic strategies. This book, considered the ‘bible’ of basic epilepsy research, is essential for the student, the clinician scientist and all research scientists who conduct laboratory-based experimental epilepsy research using cellular, brain slice and animal models, as well as for those interested in related disciplines of neuronal oscillations, network plasticity, and signaling in brain strucutres that include the cortex, hippocampus, and thalamus. In keeping with the 1969 goals, the book is now of practical importance to the clinical neurologist and epileptologist as the progress of research in molecular genetics and modern efforts to design antiepileptic drugs, cures and repairs in the epilepsies converge and impact clinical care.

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Hyperkinetic Movement Disorders (Contemporary Neurology Series) 1st Edition

Hyperkinetic Movement Disorders the latest edition to the Contemporary Neurology Series, will cover the signs, the pathophysiology, the genetics (where applicable), and the treatment options of each form of hyperkinetic movement disorder. There is a presentation of clinically-focused information regarding the full spectrum of neurological and psychiatric conditions characterized by involuntary movements.

With Parkinson’s disease as the most common hypokinetic movement disorder, the book expands on other hyperkinetic movement disorders where substantial progress has been made in the understanding of the role of the basal ganglia in the pathophysiology of these hyperkinesia disorders and in motor control, muscle tone, posture, and cognitive processes. Although therapies that target pathogenesis are still lacking, effective management of hyperkinetic movement disorders demands that physicians are knowledgeable about current and novel pharmacological and surgical approaches.
Following background information about how to approach hyperkinetic movement disorders and the neural circuitry underlying them, there are individual chapters that cover tremor, dystonia, Huntington’s disease (and other choreas, athetosis, ballism), Tourette’s syndrome (and other tic disorders), habits, mannerisms, compulsions, stereotypies, myoclonus, drug-induced disorders, Wilson’s disease, hyperkinetic movement disorders with a peripheral trigger and those of unclear origin, and psychogenic movement disorders. Chapters include sections on clinical phenomenology, etiology and pathogenesis and therapy. There are also on-line resources for clinicians and patients to refer to as well.

The experienced authors have specifically selected scientific and other published information that best helps clinicians understand, diagnose and optimally treat hyperkinetic movement disorders. The authors’ approach is comprehensive yet focused and practical with an emphasis on clinical care.

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Pretest Neurology 10th edition

Ace Your Clerkship and Shelf Exam!

PreTest® is a name you can trust for exam review. Neurology: PreTest® is the perfect way to assess your knowledge for the neurology shelf exam and the USMLE Step 2 CK exam. You’ll find hundreds of Board questions and answers that address the clerkship’s core competencies, along with detailed explanations of both correct and incorrect answers. All questions have been reviewed by students who completed their clerkships and passed the USMLE Step 2 CK exam―and know what it takes to succeed.

• Hundreds of practice questions and answers, reflecting the content and terminology you’ll see on your exams
• For common neurologic conditions, pathophysiologic explanations have been added, as well as diagnostic pearls and management strategies
• Fully updated to include the latest AAN treatment guidelines, neurologic therapeutics and neurologic electrodiagnostic and imaging techniques
• Detailed explanations for right and wrong answers
• Targets what you need to know for exam success
• Student tested and reviewed

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Dopaminergic System Function and Dysfunction: Experimental Approaches (Neuromethods Book 193) 

This volume provides a variety of technical approaches to study dopamine system function and dysfunction. Chapters guide readers through dopamine release in ex vivo and freely moving animals, multi-recording devices for in vivo simultaneous single cell and population activity, in silico modeling of dopamine neurons activity, neuroanatomical approaches, unbiased stereology, ultrastructural analyses of dopaminergic neurons, and axonal innervation. Additionally, chapters also incorporate pharmacological tools to model neuropsychiatric diseases, novel behavioral paradigms to dissect dopamine’s role in behavior, and functional imaging to follow human dopamine system development. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory.

Comprehensive and cutting-edge, Dopamine Neurotransmission aims to be a valuable resource for researchers in various disciplines.

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Oxford Textbook of Neurorehabilitation (OTs in Clinical Neurology) (Oxford Textbooks in Clinical Neurology) 1st Edition

Neurorehabilitation is an expanding field with an increasing clinical impact because of an ageing population. During the last 20 years neurorehabilitation has developed from a discipline with little scientific background, separated from other medical centers, to a medical entity largely based
on the principles of ‘evidenced based medicine’ with strong ties to basic research and clinical neurology. Today neurorehabilitation is still a ‘work in progress’ and treatment standards are not yet established for all aspects of neurorehabilitation. There are very few books that address
contemporary neurorehabilitation from this perspective.

This volume moves the reader from theory to practice. It provides the reader with an understanding of the theoretical underpinnings of neurorehabilitation, as well as a clear idea about how (and why) to approach treatment decisions in individual patients. These clinical recommendations are based on
a mix of established evidence and clinical experience that the authors bring to bear on their topics.

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