Category: Oncology

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A simple introduction explaining the broad principles underlying chemotherapy, this book gives trainees a framework within which they can place the specific aspects of cancer chemotherapy they encounter in their everyday experience. The first part of this book is unique in explaining the recent developments in the field in terms of their point of action in the natural history of cancer. The second and third sections contain a more straightforward description of practical aspects of chemotherapy, and the current place of drug treatment in everyday cancer management, including the outcomes of that treatment.

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The only self–contained guide for practicing oncologists who treat patients with rare or infrequently encountered malignancies, this up–to–date resource offers a balanced, authoritative approach to the management of uncommon cancers. Now in its fourth edition, the book is thoroughly revised, including new material as well as new focus on evidence–based research and clinical practice throughout. Clinicians will find guidelines for addressing management issues, gain insight into real–world clinical decision–making, and save umpteen hours of research through the use of this widely acclaimed, comprehensive guide.

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The “cancer stem cell” hypothesis postulates that cancer arises from a subpopulation of tumor-initiating cells or cancer stem cells (CSCs). While the idea of cancer stem cells has been around for more than a hundred years, evidence from the fields of hematology and cancer biology has now demonstrated the critical role of stem cells in hematological malignancies and suggested that these same mechanisms are also central to the initiation, progression, and treatment of solid cancers. Clinical and experimental studies have shown that CSCs exhibit many classical properties of normal stem cells, including a high self-renewal capacity and the ability to generate heterogeneous lineages; the requirement for a specific “niche”/microenvironment to grow; and an increased capacity for self-protection against harsh environments, toxins, and drugs.

Cancer Stem Cells in Solid Tumors represents a detailed overview of cancer stem cells and their role in solid cancers. Comprised of 24 chapters, this volume will provide readers with a comprehensive understanding of this important and evolving field.

Topics covered include:

• Introduction of the CSC hypothesis
• Historical perspectives and the contributing lessons from leukemia
• Current knowledge regarding the identification and role of CSCs in various forms of solid cancer including breast, brain, colorectal, pancreatic, prostate, melanoma, lung, ovarian, hepatocellular, and head and neck cancer
• Molecular pathways involved in driving CSC function, with a particular focus on the novel convergence of embryonic and tumorigenic signaling pathways
• In vitro and in vivo assays, model systems, and imaging modalities for studying CSCs
• The clinical importance of CSCs for cancer management and treatment, including important implications for prognosis, prediction, and treatment resistance
• Consideration of the controversy surrounding the CSC hypothesis and important unanswered questions in this field

This collective work was written by a group of prominent international experts in cancer biology, oncology, and/or stem cell biology. It will serve as a valuable resource for established researchers, professors, health care professionals, and students in the medical and scientific community who are investigating stem cells and/or oncology.

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This book collates past and current research on one of the most promising emerging modalities for breast cancer detection. Readers will discover how, as a standalone technology or in conjunction with another modality, microwave imaging has the potential to provide reliable, safe and comfortable breast exams at low cost. Current breast imaging modalities include X- ray, Ultrasound, Magnetic Resonance Imaging, and Positron Emission Tomography. Each of these methods suffers from limitations, including poor sensitivity or specificity, high cost, patient discomfort, and exposure to potentially harmful ionising radiation. Microwave breast imaging is based on a contrast in the dielectric properties of breast tissue that exists at microwave frequencies.

The book begins by considering the anatomy and dielectric properties of the breast, contrasting historical and recent studies. Next, radar-based breast imaging algorithms are discussed, encompassing both early-stage artefact removal, and data independent and adaptive beamforming algorithms. In a similar fashion, microwave tomographic reconstruction algorithms are reviewed in the following chapter, introducing the reader to both the fundamental and more advanced algorithms. Apart from imaging, the book also reviews research efforts in extracting clinically useful information from the Radar Target Signature of breast tumours, which is used to classify tumours as either benign or malignant. Finally, the book concludes by describing the current state of the art in terms of prototype microwave breast imaging systems, with a particular emphasis on those which have progressed to the clinical evaluation stage.

This work is motivated by the fact that breast cancer is one of the leading causes of death amongst women in Europe and the US, and the second most common cancer in the world today. Such an important area of research will appeal to many scholars and practitioners

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Written and edited by internationally recognized leaders in the field, the new edition of the Oxford Textbook of Oncology has been fully revised and updated, taking into consideration the advancements in each of the major therapeutic areas, and representing the multidisciplinary management of cancer.

Structured in six sections, the book provides an accessible scientific basis to the key topics of oncology, examining how cancer cells grow and function, as well as discussing the aetiology of cancer, and the general principles governing modern approaches to oncology treatment. The book examines the challenges presented by the treatment of cancer on a larger scale within population groups, and the importance of recognising and supporting the needs of individual patients, both during and after treatment.

A series of disease-oriented, case-based chapters, ranging from acute leukaemia to colon cancer, highlight the various approaches available for managing the cancer patient, including the translational application of cancer science in order to personalise treatment. The advice imparted in these cases has relevance worldwide, and reflects a modern approach to cancer care.

The Oxford Textbook of Oncology provides a comprehensive account of the multiple aspects of best practice in the discipline, making it an indispensable resource for oncologists of all grades and subspecialty interests.

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