Primary Immunodeficiency Diseases: A Molecular and Genetic Approach 3rd Edition

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Primary immunodeficiency diseases, first recognized 60 years ago, are inherited disorders that affect human adaptive and innate immunity. In most cases, affected individuals experience recurrent infections, but they may also suffer from autoimmune diseases and malignancies.

This third edition of Primary Immunodeficiency Diseases provides readers with the historic and scientific background, clinical presentations, immunologic characteristics, and the molecular/genetic underpinnings of this rapidly enlarging class of diseases. With up-to-date diagnostic tools and therapeutic options — from prophylactic anti-infective measures to hematopoietic stem cell transplantation and gene therapy — this volume will remain an authoritative resource on this increasingly important area.

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Antimicrobial Resistance and Implications for the 21st Century (Emerging Infectious Diseases of the 21st Century)

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This comprehensive, up-to-date volume defines the issues and offers potential solutions to the challenges of antimicrobial resistance. The chapter authors are leading international experts on antimicrobial resistance among a variety of bacteria, viruses including HIV and herpes, parasites and fungi. The chapters explore the molecular mechanisms of drug resistance, the immunology and epidemiology of resistance strains, clinical implications and implications on research and lack thereof, and prevention and future directions.

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Fundamental Medical Mycology 1st Edition

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Medical mycology deals with those infections in humans, and animals resulting from pathogenic fungi. As a separate discipline, the concepts, methods, diagnosis, and treatment of fungal diseases of humans are specific. Incorporating the very latest information concerning this area of vital interest to research and clinical microbiologists,Fundamental Medical Mycology balances clinical and laboratory knowledge to provide clinical laboratory scientists, medical students, interns, residents, and fellows with in-depth coverage of each fungal disease and its etiologic agents from both the laboratory and clinical perspective. Richly illustrated throughout, the book includes numerous case presentations.

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Infection Prevention and Control: Theory and Practice for Healthcare Professionals 1st Edition

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This book provides the reader with all of the background information necessary to enhance their understanding of the rationale behind the basic principles of infection control and how to apply them in every day situations; how specific bacteria interact with the host and cause infection; the background to each of the bacteria/infections described within the text, and, evidence based recommendations on the infection control management of these.

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Non-Neoplastic Hematopathology and Infections 1st Edition

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Most books on hematopathology are neoplastic in scope and offer little non-neoplastic content. In Non-Neoplastic Hematopathology and Infections, the authors fully describe the hematologic manifestations in tissue and blood of infectious agents, including many rare and exotic diseases found in both Western and Eastern hemispheres, in order to assist pathologists and medical laboratory professionals all over the world in better diagnosing and treating such infections.

Thoroughly illustrated with photographs, tables and text, this book features a wide range of non-neoplastic hematologic disorders, as well as reactive patterns of non-infectious and infectious agents. Comprehensive and state-of-the-art diagnostic materials are described, as are the epidemiology, pathobiology, clinical and pathologic manifestations in blood and lymphatic organs—as well as the approaches to treatment.

In addition, Non-Neoplastic Hematopathology and Infections:

  • Contains detailed information on the pathology and patterns of blood, lymph node, and a number of bone marrow and splenic infections and infectious agent manifestations
  • Thoroughly updates the classic pathology of reactive lymphadenopathies and extends this pattern-based approach to tropical and emergent infections
  • Promotes the multidisciplinary integration of hematopathologists and microbiologists in the analysis and diagnostic work-up of tissue and blood
  • Complements current major treatises on such tropical diseases as Manson’s, Ashworth’s, and Doerr’s and updates the classic tomes of William St. Clair Symmers and current texts on neoplastic hematopathology

Non-Neoplastic Hematopathology and Infections is an important book for any medical professional interested in non-neoplastic hematology, infections and tissue hematopathology, infectious diseases and tropical medicine, and tropical hematopathology.

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Infectious Diseases: A Geographic Guide 1st Edition

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This concise and practical guide describes infections in geographical areas and provides information on disease risk, concomitant infections (such as co-prevalence of HIV and tuberculosis) and emerging bacterial, viral and parasitic infections in a given geographical area of the world.

Infectious Diseases: A Geographic Guide is divided according to United Nations world regions and addresses geographic disease profiles, presenting symptoms and incubation periods of infections. Each chapter contains a section on the coverage of the childhood vaccination programs in the countries included in that region. Chapters also include descriptions of infectious disease risk and problems with resistant bacteria in each region (e.g. antibiotic resistance in Salmonella infections in Southeast Asia).

For the clinician, this book is a tool to generate differential diagnoses by considering the geographical history, as well the presenting symptoms and duration of illness. For the travel medicine specialist, this book provides information on risks of different diseases at various destinations and is particularly useful in advising long-term travelers.

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Sexually Transmitted Diseases 1st Edition

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Sexually Transmitted Diseases present a major public health challenge. Over 25 diseases can be transmitted through sexual activity, and effective treatment, especially where long term infection can lead to further health problems, and in women infertility, requires good diagnostic skills and understanding of the best treatment methods. This book aims to give a practical guide to diagnosis and treamtent in a patient-centred framework, with care at the heart of the book.

The aim of the Gynecology in Practice Series is to provide a clinical ‘in the office’ or ‘at the bedside’ guide to effective patient care for gynecologists. The tone will be practical, not academic. The working assumption is that readers want to know what (and what not) might or should be done, without over emphasis on the why. That said, it is important to review the crucial basic science necessary for effective diagnosis and management, and to provide reminders in the context of the practical chapters.

The books will not be heavily referenced, in line with a more practical approach. This allows for smoother reading (and also relieves the burden of comprehensive citing from authors). Key evidence (clinical trials, Cochrane or other meta analyses) should be summarized in ‘Evidence at a Glance’ boxes and key references such as reviews, major papers can be provided in the ‘selected bibliography’ at the end of each chapter.

Practical guidance will be provided through:

  • the use of algorithms and guidelines where they are appropriate
  • ‘Tips and Tricks’ boxes – hints on improving outcomes perhaps via practical technique, patient questioning etc
  • ‘Caution’ warning boxes – hints on avoiding problems, perhaps via contraindications
  • ‘Science Revisited’ – quick reminder of the basic science principles necessary for understanding

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Antibacterial Agents: Chemistry, Mode of Action, Mechanisms of Resistance and Clinical Applications 1st Edition

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Antibacterial agents act against bacterial infection either by killing the bacterium or by arresting its growth. They do this by targeting bacterial DNA and its associated processes, attacking bacterial metabolic processes including protein synthesis, or interfering with bacterial cell wall synthesis and function.

Antibacterial Agents is an essential guide to this important class of chemotherapeutic drugs. Compounds are organised according to their target, which helps the reader understand the mechanism of action of these drugs and how resistance can arise. The book uses an integrated “lab-to-clinic” approach which covers drug discovery, source or synthesis, mode of action, mechanisms of resistance, clinical aspects (including links to current guidelines, significant drug interactions, cautions and contraindications), prodrugs and future improvements.

Agents covered include:

  • agents targeting DNA – quinolone, rifamycin, and nitroimidazole antibacterial agents
  • agents targeting metabolic processes –  sulfonamide antibacterial agents and trimethoprim
  • agents targeting protein synthesis – aminoglycoside, macrolide and tetracycline antibiotics, chloramphenicol, and oxazolidinones
  • agents targeting cell wall synthesis – β-Lactam and glycopeptide antibiotics, cycloserine, isonaizid, and daptomycin

Antibacterial Agents will find a place on the bookshelves of students of pharmacy, pharmacology, pharmaceutical sciences, drug design/discovery, and medicinal chemistry, and as a bench reference for pharmacists and pharmaceutical researchers in academia and industry.

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Principles and Practice of Clinical Virology 5th Edition

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The knowledge and practice of clinical virology continues to expand. This new fifth edition has thirty-six comprehensive chapters, each of which has been extensively revised or rewritten, with the addition of new colour plates.

This updated version takes into account knowledge accumulated in molecular biology with its applications for laboratory diagnosis, immunisation and antiviral chemotherapy. Each chapter highlights the clinical features and epidemiological patterns of infection. Similarly, in response to the global concern of the threat posed by new viruses, a new chapter on Emerging Infections is included.

There is also new material on Hospital Acquired Infections, including some advice relating to SARS, that will be of benefit to those dealing with the day-to-day management of patients in hospital.

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Clinical and Diagnostic Virology (Cambridge Clinical Guides) 1st Edition

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This basic but comprehensive text is aimed at all healthcare professionals who need a clear understanding of medical virology. Written by two highly experienced virologists, the book is divided into five sections: 1) Individual viruses; 2) Other related agents; 3) Clinical syndromes; 4) Diagnostic techniques; 5) Patient management. The individual virus chapters provide information on incubation period, infectivity, control of infection and management. The clinical syndrome chapters provide information on the clinical presentation of disease, thus enabling the reader to search according to patient symptoms rather than referring to several individual virus chapters. The standard chapter formats, simple language and liberal use of tables, figures and algorithms enable quick access to key information, and the comprehensive coverage of all viral agents is unique in a practical guide of this size.

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