This book, now in an extensively updated and expanded third edition, offers important insights into polymyalgia rheumatica (PMR) and giant cell arteritis (GCA), providing an overview of their pathophysiology, genetics, immunology, and endocrinological mechanisms but above all presenting the state of the art in diagnosis and treatment. Both PMR and GCA are diseases of advanced age. Early diagnosis and treatment can save one of the most precious senses – vision. In this book, the role of imaging techniques is thoroughly examined, with particular attention to ultrasonography and FDG PET. All aspects of management of both diseases are discussed, including the current use of glucocorticoids, the efficacy of modern biological treatment, such as infliximab, tocilizumab, and rituximab, and the available monitoring tools. Diagnostic criteria for PMR and GCA are outlined, with discussion of differential diagnosis. Among the other topics addressed are disease classification, the histopathology of GCA, the ACR criteria for temporal arteritis, the value of temporal artery biopsy in GCA, serum cytokine profiles, chronobiology, and sine syndromes. The reader will find that the book aids in achieving early diagnosis and providing faster and more effective disease management. General readers with an interest in rheumatology, internal medicine, oftalmology and gerontology will find this book particularly valuable.
Jozef Rovenský, MD, PhD, DSc, graduated in Medicine from Masaryk University, Brno, Czech Republic in 1966 and subsequently completed specializations in Internal Medicine, Rheumatology, and Clinical Immunology at the Postgraduate Medical School, Bratislava, Slovak Republic. He was awarded his PhD from the School of Medicine (Internal Medicine), František Palacky University, Olomouc, Czech Republic and his DSc from the School of Medicine (Internal Medicine), Comenius University, Bratislava, Slovak Republic. In 1990 he was appointed Director of the Research Institute of Rheumatic Diseases, Piešťany, Slovak Republic and in 1991 became Associate Professor of Internal Medicine at Masaryk University. In 1993, Dr. Rovenský was awarded the Silver Medal of the Slovak Medical Society for contributions to medical activity and in 1995 he was appointed Professor of Internal Medicine at Masaryk University. He has served on the editorial boards of various journals, including Clinical and Experimental Rheumatology, and is a member of the Advisory Committee for Annals of Rheumatic Diseases. He is the author of more than 200 publications.