Managing Gastrointestinal Complications of Diabetes 1st ed. 2017 Edition

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An ideal clinical handbook for medical professionals that regularly treat patients with diabetes and comorbid gastrointestinal complications. The concise format provides evidence-based content with a targeted emphasis on diagnosis, as up to 75% of patients visiting diabetes clinics report significant gastrointestinal symptoms. Includes guidelines for complication prevention, treatment, and long-term disease management.

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Neuropharmacology of New Psychoactive Substances (NPS): The Science Behind the Headlines (Current Topics in Behavioral Neurosciences) 1st ed. 2017 Edition

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Designer drugs, or new psychoactive substances (NPS), are synthetic chemicals that mimic the effects of classic drugs of abuse. There has been an alarming worldwide increase in the abuse of NPS in recent years. NPS are cheap, easy to obtain, and often legally available. In this volume, leading experts summarize the latest studies regarding the molecular mechanisms of action, behavioral effects, and adverse consequences of popular NPS. Specific chapters clarify the differences between various types of NPS, namely: stimulants, cannabinoids and hallucinogens. Thus, this volume broadens our understanding of NPS and provides insight into the rapidly evolving “new drug” phenomenon.

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Surgical Aspects of Peritoneal Dialysis 1st ed. 2017 Edition

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This book aims to educate general and vascular surgeons on all pertinent aspects of peritoneal dialysis (PD). Most surgeons get very little training in residency on this topic, and the use of PD is growing around the world. Much of the book will focus on implantation techniques, especially laparoscopic insertions. The authors will describe the known adjunct procedures that have been shown to decrease dysfunction rates.

The aim is to provide greater patient autonomy, a better quality of life, preservation of residual renal function and a higher survival advantage.

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Asymmetric Cell Division in Development, Differentiation and Cancer (Results and Problems in Cell Differentiation) 1st ed. 2017 Edition

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This book provides readers with an overview of the frequent occurrence of asymmetric cell division. Employing a broad range of examples, it highlights how this mode of cell division constitutes the basis of multicellular organism development and how its misregulation can lead to cancer.

To underline such developmental correlations, readers will for example gain insights into stem cell fate and tumor growth. In turn, subsequent chapters include descriptions of asymmetric cell division from unicellular organisms to humans in both physiological and pathological conditions. The book also illustrates the importance of this process for evolution and our need to understand the background mechanisms, offering a valuable guide not only for students in the field of developmental biology but also for experienced researchers from neighboring fields.

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Pediatric Bone and Soft Tissue Sarcomas (Pediatric Oncology)

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The purpose of this book is to integrate the most re- butions and support of my colleagues and friends cent advances in the diagnosis and treatment of pedi- at The University of Texas Southwestern Medical atric bone and soft tissue sarcomas. The book is di- School, St. Jude Children s Research Hospital, and the vided into two major sections, the ?rst of which pres- Hospital for Sick Children in Toronto. In particular, I ents salient concepts in epidemiology, the impact of would like to thank Drs. George Buchanan, Charles novel tools in imaging and molecular biology, and the Pratt, William Crist, David Parham, Jim Anderson, underlying principles for continued drug develop- and Larry Kun for their friendship, mentorship, and ment. In the second section, the book embarks on an wisdom. Their teachings will continue to be an e- up-to-date survey of the diagnosis and treatment of less source of passion and inspiration. It is my wish each speci?c disease, with particular emphasis on the that this book will provide answers, guidance and need for an integrative, multidisciplinary approach hope to medical professionals, children, and their to diagnosis and treatment. families. I am indebted to my colleagues and collaborators who have contributed their ideas, time, and kno- edge to this project. I am also grateful for the contri- Alberto Pappo, MD IX Contents 1 Epidemiology of Bone 3 Diagnostic Imaging of Pediatric Bone and Soft Tissue Sarcomas and Soft Tissue Sarcomas Logan G. Spector, Julie A. Ross, Thomas D. Henry, Mary E. McCarville, Rajaram Nagarajan

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Pediatric Infectious Diseases Revisited (Birkhäuser Advances in Infectious Diseases)

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Starting with historical, epidemiological and sociocultural issues, this book presents clinical and molecular biological aspects of pediatric infectious diseases. The text offers new insights into the pathogenesis of infection, and updates on diagnostics, prevention and treatment of pediatric viral, fungal and bacterial diseases, as well as emerging new pathogens. The book will interest an interdisciplinary audience of clinicians and non-clinicians: pediatricians, infectious disease researchers, virologists, microbiologists and more.

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Bariatric and Metabolic Surgery: Indications, Complications and Revisional Procedures (Updates in Surgery) 1st ed. 2017 Edition

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This book describes the surgical bariatric procedures most frequently performed worldwide and examines their evolution in recent years both within Italy and internationally. For each operation, indications, the surgical technique, potential complications, and the outcomes with respect to weight and obesity-associated comorbidities are presented. In view of the significant failure rate revealed by studies on the long-term results of bariatric surgery, the problem of weight regain and revision surgery are also discussed in detail, covering the different types of revision, conversion to other procedures, and the main outcomes. In addition, individual chapters focus on selected topics of importance. The role of bariatric surgery in the cure of type 2 diabetes (“diabetes surgery”) is discussed and the debate over the significance of gastroesophageal reflux disease and hiatal hernia for choice of procedure is summarized. Finally, the most common endoluminal procedures, which have been gaining in importance, are described and other bariatric operations, outlined.

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Multidisciplinary Management of Liver Metastases in Colorectal Cancer: Early Diagnosis and Treatment 1st ed. 2017 Edition

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This book focuses on early diagnosis and multidisciplinary treatment, which is the key to preventing the occurrence of the liver metastases in colorectal cancer, and to increasing the resection rate of the liver metastasis foci and the 5-year survival after surgery.

This book is divided into five parts: the introduction, basics, diagnosis, treatment and prevention. It has 20 chapters in total, covering the latest advances in colorectal cancer liver metastases epidemiology, pathogenesis, molecular diagnostics, marker screening, imaging technology, surgery, chemotherapy and prevention, etc. It provides professionals with up-to-date and comprehensive information on colorectal liver metastases. This book is relevant for senior surgeons and physicians working in oncology, general surgery, chemotherapy, digestive medicine, liver medicine and hepatic surgery.

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Molecular Targeted Therapy of Lung Cancer 1st ed. 2017 Edition

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This book discusses the latest molecular targeted therapy of lung cancer including its evaluation and future directions. It clearly illustrates the initial dramatic effectiveness of molecular targeted therapy, recurrence of the disease, overcoming the wide variety of resistance mechanisms using new-generation molecular targeted agents and potential novel approaches. It also outlines the increasing necessity for new diagnostic technology and strategies for managing different adverse effects and novel methods for evaluating effectiveness and safety.
Edited and authored by opinion leaders, Molecular Targeted Therapy of Lung Cancer provides a comprehensive overview of the disease and its treatments. It is a valuable resource for graduate students, post-doctoral fellows and faculty staff, as well as researchers involved in clinical and translational research on lung cancer, helping promote new ideas for further advances.

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Breast Cancer: Carcinogenesis, Cell Growth and Signalling Pathways

This book discusses various aspects of breast cancer carcinogenesis from clinics to its hormone-based as well as genetic-based etiologies for this deadly cancer. The book will contribute to the development of novel diagnostic as well as therapeutic approaches.

Contents
Preface
Part 1 Signaling Pathways (EGFR)
1 EGFR-Ligand Signaling in Breast Cancer Metastasis: Recurring Developmental Themes
2 EGF Regulation of HRPAP20: A Role for Calmodulin and Protein Kinase C in Breast Cancer Cells
3 Endocytic Trafficking of the Epidermal Growth Factor Receptor in Transformed Cells
4 HER-2 Signaling in Human Breast Cancer
5 Brain Metastases Progression of Breast Cancer
6 Signal Transduction Pathways in Breast Cancer – Drug Targets and Challenges
7 ErbB2/HER2: Its Contribution to Basic Cancer Biology and the Development of Molecular Targeted Therapy
8 Trastuzumab-Resistance and Breast Cancer
9 Targeting HER-2 Signaling Network: Implication in Radiation Response
Part 2 Estrogen Receptors
10 The Importance of ERa/ERp Ratio in Breast Cancer: Mitochondrial Function and Oxidative Stress
11 Heterogeneity of Phenotype in Breast Cancer Cell Lines
12 Metabolomics and Transcriptional Responses in Estrogen Receptor Positive Breast Cancer Cells
13 ER-Alpha36 Mediates Non-Genomic Estrogen and Anti-Estrogen Signaling in Breast Cancer Cells
14 Estrogen-Related Receptors and Breast Cancer: A Mini Review
15 The Role of MicroRNAs in Estrogen Receptor α-Positive Human Breast Cancer
Part 3 Cell Growth Regulation, Carcinogenesis
16 Roles of SWI/SNF Complex Genes in Breast Cancer
17 p53, p63 and p73 Network in Breast Cancers
18 Role of ING Family Tumor Suppressors in Breast Cancer
19 Lipid Rafts as Master Regulators of Breast Cancer Cell Function
20 Differences in Membrane Composition and Organization of Crucial Molecules Define the Invasive Properties of MCF-7 Breast Cancer Cells
21 Adipose Tissue and Desmoplastic Response in Breast Cancer
22 Cross-Talk of Breast Cancer Cells with the Immune System
23 Engineering Transcription Factors in Breast Cancer Stem Cells
24 Breast Cancer Stem Cells – A Review
25 Potential Roles of miR-106a in Breast Cancer
26 Scleroderma and Breast Cancer
Part 4 Signaling Pathways (Others)
27 FZD7 in Triple Negative Breast Cancer Cells
28 Dysregulation of Wnt Signaling in Breast Cancer
29 Interactions of STAP-2 with BRK and STAT3/5 in Breast Cancer Cells
30 Histamine and Breast Cancer: A New Role for a Well Known Amine
31 1,25(OH)2D3 and Cyclooxygenase-2: Possible Targets for Breast Cancer?
32 Calcium, Ca2+-Sensing Receptor and Breast Cancer
33 Signal Transduction Pathways Mediated by Unsaturated Free Fatty Acids in Breast Cancer Cells
34 Adrenoceptors and Breast Cancer: Review Article
35 Steroid Receptor Coactivators and Their Expression, Regulation and Functional Role in Endocrine Responsive and Resistant Breast Cancer

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