Next-Generation Therapies and Technologies for Immune-Mediated Inflammatory Diseases (Progress in Inflammation Research) 1st ed. 2017 Edition

[amazon template=iframe image2&asin=3319422510]

As our understanding of immune mediated chronic inflammatory diseases (IMIDs) grows, it becomes more and more clear that these conditions result from the convergence of a multitude of pathogenic mechanisms whose relative individual contribution is different in different patient subsets.

Promising new technologies have been conceived that address the hypotheses that targeting multiple pathways simultaneously, selectively delivering therapeutics to areas of inflammation and/or resetting the immune system, could take efficacy to new levels. However, we have long waited for the arrival of some of these technologies to the bedside, or even far enough in the drug development process in spite of the initial enthusiasm. Some of the examples covered in this book include bispecific antibodies and genomic medicines, microparticles and targeted delivery of drugs to inflamed vasculature.

Most published reviews and book chapters on novel therapies for inflammatory diseases describe positive attributes of molecules or technologies under investigation and the rationale for developing them into therapeutics. The originality and potential value of this book is not in the description of these targets or technologies from the point of view of their structure or mechanism of action exclusively, but rather, in making an effort to critically address the question of what is needed to move these technologies into the clinic. Has the technology not made it past the preclinical stage and why? Has it already been tested in humans and failed? What are the potential reasons behind those failures? What do experts in each field believe can be done better to increase the probabilities of success?

In addition, the authors address the competitive landscape and summarize clinical studies that have failed in the respective area. They talk about the patient populations that would be required for the successful conduction of a clinical trial to test certain molecules, and they proactively share their views regarding both the potential and the drawbacks of targets or methodologies.

DOWNLOAD THIS BOOK FREE HERE

http://upsto.re/FdaPx9u

Endodontic Prognosis: Clinical Guide for Optimal Treatment Outcome 1st ed. 2017 Edition

[amazon template=iframe image2&asin=3319424106]

From the Back Cover

About the Author

Nadia Chugal, MPH, DDS, MS, is Clinical Professor at the University of California, Section of Endodontics, Los Angeles, where she is Program Director of the Postdoctoral Endodontic Program. Dr. Chugal is a Diplomate of the American Board of Endodontics. She gained her MPH, DDS, and MS from University of California Los Angeles School of Dentistry in 1984, 1988 and 1990, respectively, and completed the endodontic residency at the University of Connecticut.. She joined the UCLA’s Section of Endodontics in 1997 as faculty and has also worked in private practice, limited to endodontics, since that year. Dr. Chugal has been a member of various national committees, including, currently, the Joint Commission on National Dental Examinations and the Commission on Dental Accreditation, and is a past president of the Southern California Academy of Endodontics. She serves on the advisory board of the Journal of Endodontics and acts as a reviewer for several leading journals in the field of endodontics. The main focus of Dr. Chugal’s research has been endodontic prognosis and she is the author of award-winning articles on this subject. Her current research includes the study of new imaging technologies for endodontic diagnosis and treatment planning with the aim of developing more effective therapies and improving prognosis, as well as a translational study that deals with novel approaches in studying microbiology of the infected root canals.

Louis M. Lin, BDS, PhD, DMD, is Professor in the Department of Endodontics at New York University College of Dentistry, having previously held chairs at the School of Dentistry, University of California, Los Angeles (2000-2002) and the Department of Endodontics, UMDNJ – New Jersey Dental School (1989-2000). Dr. Lin is a Diplomate of the American Board of Endodontics. He gained his BDS from the School of Dentistry, Chung Shan Medical University in 1964, his DMD from New Jersey Medical School in 1976 and his PhD in Pathology from University of Oklahoma Medical Center in 1972. Dr. Lin completed specialty training in Oral Surgery at National Tokyo University Hospital, Tokyo, Japan, Oral Pathology at Louisiana State University Medical Center, and Endodontics at the School of Dental Medicine, University Connecticut Health Center. He also engaged in private practice before joining UMDNJ – New Jersey Dental School in 1983. Dr. Lin has won various awards, including the Modern Chinese Outstanding Achievement Award, and has been listed in Outstanding Dentists in America and Who’s Who in Frontier Science and Technology. He is a member of the editorial board of several journals, including the Journal of Endodontics and the International Journal of Dentistry, and he has published numerous articles in peer-reviewed journals.

DOWNLOAD THIS BOOK FREE HERE

http://upsto.re/FdafFaf

Autism Spectrum Disorders in Adults 1st ed. 2017 Edition

[amazon template=iframe image2&asin=3319427113]

In this book a group of international experts guide the reader through the clinical features of adults with autism spectrum disorders, describe the care needs of patients and their families, explain the evolution of the disorders into old age, and highlight what can be done to help. Detailed attention is paid to the medical and psychiatric problems of adults with these disorders and the approach to their education and professional integration. In addition, expert neuroscientists summarize current views on the neurobiology of autism.

Autism spectrum disorders are devastating neurodevelopmental disorders. Although diagnosis and therapeutic interventions usually take place in infancy, they are chronic lifelong conditions. Surprisingly, the literature on autism spectrum disorders in adults is scarce. Moreover, most mental health professionals working with adults have little training in autism, and adult mental health services around the world are rarely prepared to address the needs of these patients, which tend to increase with age. This book therefore fills a crucial gap in the literature and will prove useful for all who care for and deal with adults in the Autistic Spectrum.

DOWNLOAD THIS BOOK FREE HERE

http://upsto.re/Fda58br

Principles of Coding and Reimbursement for Surgeons 1st ed. 2017 Edition

[amazon template=iframe image2&asin=3319435930]

This text provides the in-depth understanding of the mechanisms that guide coding and reimbursement. The text is meant to be useful to surgeons in practice, both in general surgery and in surgical subspecialties; practice management teams of surgical practices and to resident physicians in surgery. Part 1 of the text addresses the CPT coding process, the relative valuation system (RVU), the ICD-9 and ICD-10 systems of classification, Medicare Part B payment rules for physicians, the DRG system and Medicare Part A payment for hospitals, alternative payment models, and the myriad of quality measures of importance to surgeons. Part 2 of the text addresses specific coding in areas where surgeons historically have had the most difficulty. This is not meant to substitute for the available texts, software or courses on coding, but to provide the historical background and rationale for the specific coding rules. Principles of Coding and Reimbursement for Surgeons will be of great value to general surgeons and surgical subspecialists in private practice, academic institutions, and employed positions. It will provide direction to management teams from practice and institutional levels. It is also of use to surgical trainees and to researchers in health policy issues.

DOWNLOAD THIS BOOK FREE HERE

http://upsto.re/FdayQnt

The Blood Brain Barrier and Inflammation (Progress in Inflammation Research) 1st ed. 2017 Edition

[amazon template=iframe image2&asin=3319455125]

About the Author

Atlas of Cardiac Innervation 1st ed. 2017 Edition

[amazon template=iframe image2&asin=3319457985]

This atlas elucidates the role of the neuronal component in normal cardiovascular function and cardiac disorders and discusses the currently available imaging targets and probes. It provides a foundation in cardiac neuronal imaging and image processing and serves as a guide in the effective utilization of these techniques in clinical and research settings. The atlas discusses the principles of autonomic control in the regulation of cardiac function and disease; chemistry and biology of radiotracers designed to target changes in the myocardial sympathetic and parasympathetic innervation as a function of disease or treatment; neuronal imaging in heart failure and reverse remodeling and the use of PET imaging in quantification of cardiac innervation; cardiac sympathetic innervation in ventricular arrhythmias and device therapy; conditions that affect the autonomic nervous system; and the role of myocardial blood flow and cardiac neuronal imaging in denervation and reinnervation in cardiac transplant recipients. Featuring full-color illustrations, schematic diagrams, and diagnostic algorithms, Atlas of Cardiac Innervation is a valuable resource for cardiologists, radiologists, nuclear medicine physicians, and electrophysiologists.

DOWNLOAD THIS BOOK FREE HERE

http://upsto.re/FdoHzsB

Operative Atlas of Laparoscopic and Robotic Reconstructive Urology: Second Edition 2nd ed. 2017 Edition

[amazon template=iframe image2&asin=3319332295]

From the Back Cover

About the Author

Vascular Diseases for the Non-Specialist: An Evidence-Based Guide 1st ed. 2017 Edition

[amazon template=iframe image2&asin=3319460579]

From the Back Cover

About the Author

Nitrite and Nitrate in Human Health and Disease (Nutrition and Health) 2nd ed. 2017 Edition

[amazon template=iframe image2&asin=3319461877]

This fully revised and updated new edition provides a comprehensive look at nitrite and nitrate and their effect on human health and disease. The first section describes the biochemical analysis of nitrite and nitrate and its role in human physiology. The book then shifts to sources of human exposure of nitrite and nitrate, including environmental and dietary. Finally, the last section discusses nitric oxide-based therapeutics and how nitrite and nitrate biochemistry can be safely harnessed to improve human health. Each chapter provides a balanced, evidence-based view and heavily cites the most recent published literature. They follow a strict chapter format which includes keywords, key points, a conclusion highlighting major findings, and extensive references.

The second edition contains new chapters on nitrite and nitrate in age medicine, nitrite and nitrate as a treatment for hypertension, and nitrite and nitrate in exercise performance. Additionally, the editors have expanded the biochemistry section to include chapters on nitrate reducing oral bacteria, nitrite mediated S-Nitrosation, epigenetics and the regulation of nitric oxide, and nitrite control of mitochondrial function.

Nitrate and Nitrite in Human Health and Disease, 2e, will be of interest to health professionals, nutritionists, dieticians, biomedical scientists, and food scientists.

DOWNLOAD THIS BOOK FREE HERE

http://upsto.re/F2soJmu

Failed Anti-Reflux Therapy: Analysis of Causes and Principles of Treatment 2nd ed. 2017 Edition

[amazon template=iframe image2&asin=3319468847]

From the Back Cover

About the Author

1 … 590 591 592 593 594 … 904