Innate Antiviral Immunity: Methods and Protocols (Methods in Molecular Biology) 1st ed. 2017 Edition

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This book explores methods to study the complex and evolving interplay between a virus and its host that range from model systems to the detection of chemical molecules. The collection starts with the application of humanized mice and zebrafish as model organisms to study virus-host interactions and induction of innate immune responses. Subsequent chapters outline diverse methods to detect small interfering RNAs, microRNAs, and virus-derived dsRNA from a variety of cells, tissues, and organisms, as well as to interrogating the cytosolic RNA and DNA sensing pathways, including using RNA PAMPs as molecular tools, purification of cGAMP from virus particles and infected cells, and mechanisms to visualize the subcellular localization and activation of the adaptor proteins MAVS and STING. Cutting-edge methods, including high-throughput and genome-wide CRISPR/Cas9 screens, chromosome conformation capture, and whole-exome sequencing, are described to identify novel mediators, pathways, and variants underlying host susceptibility. Given the importance of studying these pathways and players under physiologic conditions, methods describing the isolation of primary mouse sensory neurons and group 2 innate lymphoid cells are also provided. Finally, this collection comes full circle back to the whole organism level and concludes with epidemiological methods to investigate virus-host interactions and the induction of innate immunity. Written for the Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Authoritative and practical, Innate Antiviral Immunity: Methods and Protocols spans a diverse array of approaches to study and elucidate the intricacies of this vital area of study.

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The Wills Eye Manual: Office and Emergency Room Diagnosis and Treatment of Eye Disease Seventh Edition

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Publisher’s Note:   Products purchased from 3rd Party sellers are not guaranteed by the Publisher for quality, authenticity, or access to any online entitlements included with the product.

For more than 25 years, The Wills Eye Manual has been a best-selling source of authoritative guidance on treating ocular disorders in an office, emergency room, or hospital setting.  The 7th Edition introduces exciting new changes to bring this pocket-sized reference thoroughly up to date – including extensive multimedia content – while retaining the features that have made it so useful in daily practice.

New to this edition:

  • Recent major clinical trials data
  • Expertly produced videos depicting a wide range of common procedures with step-by-step narration, carefully selected to complement key techniques
  • Changing trends in trauma, oculoplastics, cornea, pediatrics, neuro-ophthalmology, uveitis, and more

Outstanding features you’ve come to expect from the Wills Eye Manual:

  • The most accurate and current information on more than 200 ophthalmic conditions
  • Effective clinical recommendations for evaluation, diagnosis, management, and treatment
  • Concise outline format for portability and quick reference
  • All chapters written and edited by the residents and attending ophthalmologists at one of busiest and largest eye hospitals in the country

It’s everything you wanted to know and nothing more.

Now with the print edition, enjoy the bundled interactive eBook edition, which can be downloaded to your tablet and smartphone or accessed online and includes features like:

  • Complete content with enhanced navigation
  • Powerful search tools and smart navigation cross-links that pull results from content in the book, your notes, and even the web
  • Cross-linked pages, references, and more for easy navigation
  • Highlighting tool for easier reference of key content throughout the text
  • Ability to take and share notes with friends and colleagues
  • Quick reference tabbing to save your favorite content for future use

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The Education of a Coroner: Lessons in Investigating Death

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In the vein of Dr. Judy Melinek’s Working Stiff, an account of the hair-raising and heartbreaking cases handled by the coroner of Marin County, California throughout his four decades on the job—from high-profile deaths to serial killers, to Golden Gate Bridge suicides.

Marin County, California is a study in contradictions. Its natural beauty attracts thousands of visitors every year, yet the county also is home to San Quentin Prison, one of the oldest and largest penitentiaries in the country. Marin ranks in the top one percent of counties nationwide in terms of affluence and overall health, yet it is far above the norm in drug overdoses and alcoholism, and comprises a large percentage of suicides from the Golden Gate Bridge.

Ken Holmes worked in the Marin County Coroner’s Office for thirty-six years, starting as a death investigator and ending as the three-term, elected coroner. As he grew into the job—which is different from what is depicted on television—Holmes learned a variety of skills, from finding hidden clues at death scenes, interviewing witnesses effectively, managing bystanders and reporters, preparing testimony for court to notifying families of a death with sensitivity and compassion. He also learned about different kinds of firearms, all types of drugs—prescription and illegal—and about certain unexpected and potentially fatal phenomena such as autoeroticism.

Complete with poignant anecdotes, The Education of a Coroner provides a firsthand and fascinating glimpse into the daily life of a public servant whose work is dark and mysterious yet necessary for society to function.

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Comprehensive Cleft Care: Family Edition Pap/Psc Edition

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For parents, learning that their newest family member may bring some unexpected challenges along with the blessing of his or her arrival can take a bit of adjustment. They have questions and need a trusted source of information to allay their fears. You are that source. However, most of the time, parents receive almost too much information to take in all at once, and questions arise as they digest the information. The parents of your patients may wonder: Did I hear that right? What does that term mean? What should I do next? What is in store for my family?

From diagnosis to treatment options, Comprehensive Cleft Care: A Family Edition provides families with important information to help them fully understand their child’s condition and its treatment. Authored by parents and professionals, this unique work was written with real-life challenges in mind. Two of the book’s editors have raised cleft-affected children. As a result, the information provided is not only informative and helpful, but also personal, readily accessible, and relevant from a parent’s perspective.

This book enables parents and families to play a central role in navigating their child’s care while working alongside the rest of the care team. Written in easy-to-read language, it contains over two dozen short chapters that mirror topics discussed in the corresponding text written for health care professionals, Comprehensive Cleft Care, Second Edition. Topics covered include the fundamentals of care, psychosocial and educational aspects, cleft lip and palate repair, speech and hearing, airway and breathing issues, dental and orthodontic principles, and more.

By providing up-to-date information in a clear and concise format, this book can help to educate parents and to alleviate much of the anxiety they have regarding their child’s condition and its treatment. Published with a complimentary eBook, this guide is an invaluable resource for families seeking to help their cleft-affected child reach his or her full potential.

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ASEP’s Exercise Medicine-Text for Exercise Physiologists

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Watching TV, surfing the Internet, and sitting for long hours have replaced more active pursuits. Millions of Americans are simply not moving enough to meet the minimum threshold for good health and longevity. Exercise physiologists have researched and highlighted this fact for decades. That is why they emphasize the importance of regular exercise in the prevention of chronic diseases associated with physical inactivity and a sedentary lifestyle. Heart disease, obesity, type 2 diabetes, high blood pressure, stroke, peripheral arterial disease, depression, several types of cancers, and osteoporosis can be treated or even prevented with properly prescribed exercise. There is a need for integrating exercise physiology knowledge and rehabilitation programs as a continuous part of the healthcare profession. This opens up the opportunity for new approaches to manage patients suffering from chronic diseases and disabilities. ASEP’s Exercise Medicine Text for Exercise Physiologists is designed to educate exercise physiologists about the significance of professionalism in exercise physiology, exercise medicine, and entrepreneurship opportunities. It combines scientific principles with cardiovascular calculation steps that support its use in the development of safe, well-rounded, and individualized exercise programs to help clients and patients sleep better, reduce stress, maintain a healthy body weight, keep bones strong and joints healthy, decrease the risk for colon cancer, and improve mental function. This textbook demonstrates the importance of exercise medicine, and will familiarize readers with ASEP guidelines. Exercise physiologists in training will, therefore, be prepared for contributing a meaningful role in the healthcare services sector.

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After a Stroke: 500 Tips for Living Well 2nd Edition

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An essential resource for all stroke survivors and their families and caregivers.

Updated and expanded new edition of the popular resource written by a stroke survivor who has spent 24 years helping other survivors live life to the fullest potential. After a Stroke: 500 Tips for Living Well is filled with practical tips and support to help you cope with the lifestyle changes that come in the wake of a stroke. This book will show you how to:

  • Get the medical care you need
  • Integrate robotics and other modern tools to help prevent spasticity and make daily life easier
  • Navigate personal relationships as one partner becomes a survivor and another a caregiver
  • Incorporate alternative and integrative therapies into your recovery
  • Connect with organizations and outreach centers for stroke patients
  • Get the most out of home care
  • Cut through rhetoric with frank, candid, and truthful answers to Frequently Asked Questions

The second edition includes three totally new chapters, over 200 more tips, and covers the latest in stroke prevention, medical treatment, and rehabilitation to help survivors transition from being a patient to returning to a life well-lived.

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Brain and Spine Surgery in the Elderly 1st ed. 2017 Edition

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About the Author

Textbook of Hernia 1st ed. 2017 Edition

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This textbook provides a comprehensive, state-of-the art review of the field of hernia surgery, and will serve as a valuable resource for clinicians, surgeons and researchers with an interest in both inguinal and ventral/incisional hernia. This book provides an overview of the current understanding of the biologic basis of hernia formation as well as laying the foundation for the importance of hernia research and evaluating outcomes in hernia repair. Diagnosis and management strategies for inguinal and ventral hernia are discussed in detail with separate techniques sections for the most widely used procedures in this field as well as emerging technologies such a robotic and single incision surgery. Pertinent associated topics to inguinal hernia surgery such as chronic groin and athletic pubalgia are covered in detail. For incisional hernias, associated topics such as hernia prevention and enhanced recovery protocols are discussed. For both inguinal and ventral/incisional hernias mesh choices and available mesh technologies are discussed in detail as this remains an often confusing matter for the general surgery. When appropriate, chapters to highlight controversies in care are featured such as the use of synthetic mesh in contaminated surgery and laparoscopic closure of defects in laparoscopic ventral hernia repair. Current recommendations and outcomes data are highlighted when available for each technique.
Textbook of Surgery will serve as a very useful resource for physicians and researchers dealing with, and interested in, abdominal wall hernias.  It will provide a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts.

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Osteoporosis Rehabilitation: A Practical Approach 1st ed. 2017 Edition

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About the Author

Tutorials in Patellofemoral Disorders 1st ed. 2017 Edition

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About the Author

Simon Donell, BSc, MB BS, FRCS(Orth), MD, is a Consultant Orthopaedic Surgeon at the Norfolk and Norwich University NHS Foundation Trust, Norwich, United Kingdom and Honorary Professor at the University of East Anglia. His specialist interest is the patellofemoral joint, and he has an international reputation in this field. Professor Donell is immediate Past President of the British Association for Surgery of the Knee (BASK) and a Trustee of the British Orthopaedic Association. He is also an Honorary Fellow of both the Paraguayan Orthopaedic Association and the Deutschen Kniegesellschaft (German Knee Society). He is an active member of ESSKA, serving on their Education Committee and the ESSKA Academy Editorial Board. Professor Donell is an Assessor for the Royal College of Surgeons of England and has in the past acted as a Specialist Advisor to the National Institute for Health & Clinical Excellence (Interventional Procedures Programme). He has delivered numerous invited lectures around the world and has participated in many training programmes.
Iain McNamara, BM BCh (Cantab), MRCS Eng, MRCP, FRCS (Trauma and Orthopaedics), MD (Cantab) is a Consultant Trauma and Orthopaedic Surgeon at the Norfolk and Norwich University NHS Foundation Trust, Norwich, United Kingdom and Honorary Professor at the University of East Anglia. In 2011, he received the Raymond Horton-Smith Prize,  awarded by the School of Clinical Medicine, University of Cambridge for the best thesis presented for the MD degree during the academic year. Dr. McNamara served as a board member and trustee of the British Orthopaedic Research Society from 2011 to 2015, and was Secretary of the organization from 2011 to 2013. He is also a past Secretary of the British Orthopaedic Trainees Association (BOTA) (2007–9) and past board member of The Federation of Orthopaedic Trainees in Europe. In 2015, Dr. McNamara acted as Principal Investigator on the Warwick Hip Trauma Evaluation Study (WHiTE), an NIHR multiple embedded randomized controlled trial cohort study of patients with a fracture of the proximal femur. He has fulfilled various consultancy roles and has acted as a reviewer for several leading journals in the field, including the American Journal of Sports Medicine.

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