Pediatric Ultrasound: Requisites and Applications

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Ultrasound (US) plays an extremely important role in diagnostic imaging of neonates, infants, and children. This book systematically covers the use of US in all organ systems throughout childhood. After discussion of the basics, including physics, artifacts, and procedural details, decision making regarding the use of US is elucidated by discussing next diagnostic steps based on recommended imaging algorithms. The indications and prerequisites for a particular examination are listed, and practical tips and tricks are highlighted. The normal, age-dependent findings and typical appearances in different pathologies are then presented and illustrated by numerous high-quality images. Particular emphasis is placed on those findings that differ from the adult US appearances.

Pediatric Ultrasound will prove an indispensable source of information for radiology residents, experienced (pediatric) radiologists, sonographers, pediatricians, and all other physicians who deal with children in their daily practice.

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Metronomic Chemotherapy: Pharmacology and Clinical Applications

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This book analyzes all aspects of metronomic chemotherapy, a new approach involving low-dose, long-term, and frequently administered therapy that has preclinical and clinical activity in various tumors. After an opening section on the pharmacological bases of metronomic chemotherapy, including its antiangiogenic effects and impact on immunity, preclinical studies on various classes of drug are discussed. Clinical applications of metronomic chemotherapy in a wide variety of tumors are then addressed in detail, with description of the results of all published studies. The clinical pharmacology of metronomic chemotherapy is also considered in depth, encompassing pharmacokinetics, pharmacogenetics, pharmacoeconomics, and adverse drug reactions. The book closes by describing the role of this therapy in the veterinarian clinic.

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Core Knowledge in Critical Care Medicine

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This book provides a detailed review of state of the art knowledge on critical care topics as well as the latest research findings. It covers the core aspects in excellent detail, but is not so comprehensive as to make its daily use unfeasible. For each condition considered, discussion of the pathophysiology is integrated with observations on diagnosis and treatment in order to allow a deeper understanding. The book is scientifically based, with extensive references to published research. This will allow readers to investigate their individual interests further and will enable physicians to justify measures by providing a coherent, evidence-based strategy and relevant citations where needed. Core Knowledge in Critical Care Medicine will appeal to experienced practitioners as an aide-mémoire, but will also be of great value to a wide range of more junior staff wishing to complement their background knowledge with important facts applicable to everyday practice.

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The Flying Publisher Guide to Critical Care in Neurology

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The number of dedicated neurointensive care units is growing greatly and, now more than ever, physicians need to learn how to take care of neurocritical patients. Critical Care in Neurology addresses the day-to-day management of patients in neurointensive care units, and in particular the clinical approach to common neurocritical conditions.

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Multimodal Treatment of Recurrent Pelvic Colorectal Cancer (Updates in Surgery) 1st ed

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This book analyzes all aspects of modern multimodal treatment of locally recurrent rectal cancer in the pelvis in order to offer a panoramic overview of the different therapeutic options and enable the reader to balance their benefits and drawbacks. Indications for surgery and the surgical techniques themselves, including reconstruction techniques after major exenterative surgery, are clearly described and evaluated. The role of new imaging tools, such as MRI and PET-CT, in staging recurrences and guiding therapy is assessed and detailed consideration is given to the use of neoadjuvant and iterative radiotherapy and the indications for systemic chemotherapy. Morbidity, mortality, oncologic outcomes, and quality of life issues are carefully analyzed and options for pain control and palliation are examined. Finally, a national survey is presented on the state of the art in the surgical treatment of locally recurrent rectal cancer in Italy. While there has been a dramatic fall in the incidence of local pelvic recurrences, their treatment remains a major clinical challenge which requires a multidisciplinary approach and careful selection of the most appropriate strategy in each case. This book will aid practitioners in making the correct decisions in individual patients.

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Radiation Dose from Multidetector CT (Medical Radiology) 2nd ed

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Computed tomography (CT) is a powerful technique providing precise and confident diagnoses. The burgeoning use of CT has resulted in an exponential increase in collective radiation dose to the population. Despite investigations supporting the use of lower radiation doses, surveys highlight the lack of proper understanding of CT parameters that affect radiation dose. Dynamic advances in CT technology also make it important to explain the latest dose-saving strategies in an easy-to-comprehend manner. This book aims to review all aspects of the radiation dose from CT and to provide simple rules and tricks for radiologists and radiographers that will assist in the appropriate use of CT technique. The second edition includes a number of new chapters on the most up-to-date strategies and technologies for radiation dose reduction while updating the outstanding contents of the first edition. Vendor perspectives are included, and an online image gallery will also be available to readers.

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Transsphenoidal Surgery: Complication Avoidance and Management Techniques 1st ed. 2017 Edition

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This work details contemporary clinical knowledge on the multidisciplinary management of pituitary and other sellar/parasellar tumors, with a focus on surgical techniques and a particular emphasis on complication avoidance and management. International experts provide guidance on natural history, radiologic and clinical aspects, surgical indications, and resection techniques.In addition, case presentations and clinical photographs help the reader reduce the risk of error and advance their own surgical skills. Readers also have access online to streaming videos of key procedures to help them provide the best possible outcomes for every patient.

Transsphenoidal Surgery: Complication Avoidance and Management Techniques will be of great value to Neurosurgeons, Otolaryngologists, Endocrinologists, Radiation Oncologists, and residents and fellows in these specialties.

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Comprehensive Quality by Design for Pharmaceutical Product Development and Manufacture 1st Edition

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Covers a widespread view of Quality by Design (QbD) encompassing the many stages involved in the development of a new drug product.

The book provides a broad view of Quality by Design (QbD) and shows how QbD concepts and analysis facilitate the development and manufacture of high quality products. QbD is seen as a framework for building process understanding, for implementing robust and effective manufacturing processes and provides the underpinnings for a science-based regulation of the pharmaceutical industry.

Edited by the three renowned researchers in the field, Comprehensive Quality by Design for Pharmaceutical Product Development and Manufacture guides pharmaceutical engineers and scientists involved in product and process development, as well as teachers, on how to utilize QbD practices and applications effectively while complying with government regulations. The material is divided into three main sections: the first six chapters address the role of key technologies, including process modeling, process analytical technology, automated process control and statistical methodology in supporting QbD and establishing the associated design space. The second section consisting of seven chapters present a range of thoroughly developed case studies in which the tools and methodologies discussed in the first section are used to support specific drug substance and drug-product QbD related developments. The last section discussed the needs for integrated tools and reviews the status of information technology tools available for systematic data and knowledge management to support QbD and related activities.

Highlights

  • Demonstrates Quality by Design (QbD) concepts through concrete detailed industrial case studies involving of the use of best practices and assessment of regulatory implications
  • Chapters are devoted to applications of QbD methodology in three main processing sectors—drug substance process development, oral drug product manufacture, parenteral product processing, and solid-liquid processing
  • Reviews the spectrum of process model types and their relevance, the range of state-of-the-art real-time monitoring tools and chemometrics, and alternative automatic process control strategies and methods for both batch and continuous processes
  • The role of the design space is demonstrated through specific examples and the importance of understanding the risk management aspects of design space definition is highlighted

Comprehensive Quality by Design for Pharmaceutical Product Development and Manufacture is an ideal book for practitioners, researchers, and graduate students involved in the development, research, or studying of a new drug and its associated manufacturing process.

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Understanding Host-Microbiome Interactions – An Omics Approach: Omics of Host-Microbiome Association 1st ed. 2017 Edition

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This book offers up-to-date information on different microbiomes, their community composition and interactive functions with the host, bringing together information from diverse research reports to provide an overview of the rapid developments in meta-omics technologies.

It is a valuable resource for scientists, researchers, postgraduate and graduate students interested in understanding the impact and importance of next generation sequencing technologies on different hosts and their microbiomes.

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Urothelial Carcinoma: Methods and Protocols (Methods in Molecular Biology) 1st ed. 2018 Edition

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This volume details standard techniques for the characterization of urothelial carcinoma as well as methods to investigate mechanisms of carcinogenesis.  Chapters guide readers on cellular and animal models for urothelial carcinoma and related diseases, molecular analyses from body fluids, and new approaches to therapy. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Authoritative and practical, Urothelial Carcinoma: Methods and Protocols hopes that the techniques described in this volume will contribute to the current upturn in research on urothelial carcinoma and to the application of its results in clinical practice.

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