Corneal Collagen Cross Linking 1st ed

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This book provides comprehensive coverage of corneal collagen cross-linking (CXL), a major management modality for keratoconus and ectatic corneal disorders. All aspects are covered, including refractive and non-refractive surgery indications, models of application, safety, efficacy, performance, outcome measures, evidence of CXL, complications, contraindications, use in children, and controversies. The discussion reflects the considerable progress that has been made in understanding of the modality since its development in the late 1990s. Detailed attention is paid to new concepts, changing surgical techniques and indications, the latest evidence-based science and research, and the future of CXL. Guidance is also provided on the use of CXL in combination with other modalities, such as LASIK, PRK, intracorneal ring implantation and others. The text is accompanied by numerous high-quality color illustrations. Corneal Collagen Cross Linking will provide the reader with a sound grasp of the technique and its use and will hopefully also serve as a stimulus to further research and advances.

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Joint Preservation in the Adult Knee 1st ed

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This book offers a comprehensive overview of the basic science and clinical evidence for non-arthroplasty interventions in the adult knee. It aims to cover all aspects of joint-preserving knee surgery, from injectable therapies such as platelet-rich plasma and stem cell therapies to surgical interventions such as meniscal repair and replacement, ligament reconstructions, and osteotomies. Following discussion of clinical assessment and imaging, individual chapters focus on specific clinical problems, including patellofemoral joint disorders, chondral injuries, and bone tumors. For each condition, a thorough overview is provided, describing clinical assessment, management (including surgical and non-surgical methods), and novel therapies. The contributors are experts in their fields from across Europe and are drawn from the worlds of clinical and academic orthopedic surgery. This book is unique in its coverage of the entire span of non-arthroplasty knee surgery and its focus on both clinical and basic science aspects. It will be helpful for knee surgeons and those engaged in research on knee-related topics, but also for students and other physicians involved in the care of patients with disorders of the knee.

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Complications in Acute Care Surgery: The Management of Difficult Clinical Scenarios 1st ed

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This text provides the reader a starting point for the most difficult and uncommon complications in acute care surgery. It is designed to provide options to that ubiquitous intra-operative or bedside question “Well, now what do we do with this?” The topics have been chosen for the extreme difficulty of management and the surprising regularity that they present and the lack of large volume of accumulated evidence, where expert experience remains vital. The volume editors present a list of clinical scenario’s, intra-operative findings, and ethical circumstances that few general surgeons in their career will see in their career. The authors represent the most prolific surgeons in practice today. They present how they wound manage these challenging acute care surgery problems based on their vast clinical experience. Here, these surgeons share their personal experience with the most difficult cases. The text is divided into 4 parts. The first part is “Global Patient Issues” when a singular surgical problem presents itself in a very complicated patient with an extensive list of unstable co-morbid diseases. The second part is “Specific Disease Issues”. This is a surgical text and as such each issue is an unexpected intra-operative finding and expert management. The third part is “Post-Operative Issues” and as any seasoned surgeon knows, is the most critical part of managing a complicated surgical case. The last section is “Challenging Ethical Scenarios.” The text is designed to provide the surgeon in training or the seasoned general surgeon unique clinical or operative options for the care of their patients.

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Clinical Guide to Accelerated Orthodontics: With a Focus on Micro-Osteoperforations 1st ed

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This book is a complete reference for all clinicians who are interested in incorporating into their daily practice the techniques available to reduce the duration of orthodontic treatment and to overcome other treatment limitations. It focuses especially on micro-osteoperforations (MOPs) as the most conservative, efficient, and versatile approach to increase the rate of tooth movement. The opening chapters describe the biological principles of current accelerated techniques at the molecular and cellular levels and introduce guidelines on how to select the best acceleration approach based on each patient’s needs. Clinicians are then guided step by step through the application of MOPs, case selection, and treatment planning. It is explained how MOPs can be incorporated into daily mechanotherapy for the treatment of different malocclusions and how to take advantage of the catabolic and anabolic effects of the procedure to expand the boundary of orthodontic and orthopaedic corrections. The book is written in a simple and clear language with many illustrations and clinical examples to facilitate understanding of concepts and procedures. In addition, it is a rich source for academicians and researchers interested in a comprehensive and updated review on theories of tooth movement and accelerated orthodontic techniques.

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Quick Guide to Good Clinical Practice: How to Meet International Quality Standard in Clinical Research 1st ed

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This brand-new book offers a reference guide to understanding and applying the rules for properly conducting clinical trials to meet the international quality standard – Good Clinical Practice – provided by the International Conference on Harmonization (ICH).

The work offers an updated perspective on the clinical research landscape within the context of the clinical trial regulatory frameworks in Europe and the USA. In addition to providing a historical review and a detailed definition of GPC regulations, it includes step-by-step explanations of all the requirements that researchers should bear in mind when designing and performing new trials. Further topics covered include: ethics of clinical research; the drug development process and evolution of regulations; investigator and sponsor responsibilities; and clinical trial protocols.

Written by clinicians for clinicians, the book represents a valuable read also for researchers, pharmacists and all professionals involved in applications to the ethic committees, whose approval is required for new clinical studies.

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Asthma: Targeted Biological Therapies 1st ed

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This book focuses on the fundamentals of the use of biologics in asthma, describing the rationale, principles, mechanisms of action, and indications. It offers an excellent balance between basic science and the analysis of clinical trials, updating readers with new developments that are changing the global scenario for targeted biological anti-asthma therapies, especially with regard to more severe disease. A range of therapies are considered, from the humanized monoclonal anti-IgE antibody omalizumab, widely approved as add-on treatment for inadequately controlled disease, through to emerging biologics for which evidence supportive of efficacy is accumulating, including anti-IL-5, anti-IL-4, and anti-IL-13 therapies. One aspect to emerge is the variability in individual response, which suggests a need for characterization of different asthma subtypes to permit the effective implementation of phenotype-targeted treatments. This book will be of interest for pulmonologists, clinical immunologists, and physicians seeking sound information on these therapies, but also for scientists and pharmacologists wishing to enhance their knowledge of the therapeutic implications of the cellular and molecular mechanisms that underlie severe, uncontrolled asthma.

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Bacterial Infections and the Kidney 1st ed

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This text is designed to present a comprehensive and state-of the-art but practical approach to the diagnosis and management of bacterial infection associated renal disease.  The chapters address the different types of glomerular, tubulointerstitial and vascular diseases, associated with bacterial infections, describe diagnostic pitfalls, provide differential diagnosis and discuss treatment and management. Easy to follow diagnostic algorithms and tables are included for practical usefulness. The text provides a large number of color microphotographs, illustrations and each chapter refers to the most important up to date literature in the area. All chapters are written by experts in the field and will include the most up-to-date clinical information. A comprehensive but user friendly resource on renal complications of bacterial infection, such as this book, is overdue, particularly now in the era of staphylococcus epidemic and emerging new resistant bacterial strains. Bacterial Infections and the Kidney will be an important resource for pathologists, nephrologists, general internists, infectious disease specialists, and urologists. Transplant surgeons may find the chapter on transplant pyelonephritis very useful.

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Nuclear Endocrinology 2nd ed

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This well-illustrated book, now in a revised and updated second edition, is an up-to-date practical guide to the integration of nuclear medicine into the daily practice of endocrinologists, endocrine surgeons, oncologists, and other professionals involved in the diagnosis and treatment of endocrine disorders. The new edition includes information on novel tracers and procedures as well as updates on management guidelines and protocols. The focus is especially on the contributions of SPECT/CT, PET/CT, and PET/MRI in endocrinology. An opening section discusses general aspects of nuclear medicine, such as dosimetry, radiation protection, and choice of radiopharmaceutical. The role of nuclear endocrinology in diagnosis and treatment of different pathologies is then addressed in a series of chapters focusing on the thyroid, parathyroid, adrenal, and pituitary glands, the ovaries and testes, and neuroendocrine tumors. An important feature is the inclusion of informative clinical cases that highlight key aspects of practice. The book amply demonstrates the ability of modern nuclear medicine procedures to improve the care of patients with endocrine disease.

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Phosphodiesterases: CNS Functions and Diseases (Advances in Neurobiology) 1st ed

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PDEs are a family of enzymes that catalyze the hydrolysis of intracellular cyclic nucleotides. They are implicated in a number of disorders and dysfunctions and PDE inhibitors have already proven to be effective therapies for erectile dysfunction, COPD, and psoriatic arthritis.  This family of enzymes also plays a role in diseases and disorders of the CNS such as depression, anxiety, schizophrenia, and Alzheimer’s Disease. Unfortunately no effective PDE inhibitors have been developed for the treatment of these diseases.  The proposed book will be a comprehensive overview of the current state of basic and translational research on PDE inhibitors written by internationally recognized experts. Authors will also discuss potential PDE subtypes and splice variants in the hopes that this will spur more creative approaches to PDE targeting drugs.

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Cleft Lip and Palate Treatment: A Comprehensive Guide 1st ed. 2018 Edition

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The aim of this book is to discuss cleft lip and palate deformities in a comprehensive way, presenting it from the basics to the most clinically and surgically relevant issues. First, the basic concepts of embryology and pathogenesis of the facial deformities will be discussed. Special attention will be paid to the genetics underlying this condition. Following that, basic principles of surgical treatment through the most recent advances in the field will be presented, along with most important evidences from the literature and the personal experience of the editors and authors.

Cleft Lip and Palate Treatment presents the state of the art and advances in the field and is intended to serve as a comprehensive guide for a broad audience. All the specialties involved in the comprehensive care of these craniofacial deformities will be presented in this book.

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