Drug Delivery to the Brain: Physiological Concepts, Methodologies and Approaches (AAPS Advances in the Pharmaceutical Sciences Series)

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The development of new CNS drugs is notoriously difficult. Drugs must reach CNS target sites for action and these sites are protected by a number of barriers, the most important being the blood –brain barrier (BBB). Many factors are therefore critical to consider for CNS drug delivery, e.g. active/passive transport across the BBB, intra-brain distribution, and central/systemic pharmacokinetics, to name a few. Neurological disease and trauma conditions add further complexity because CNS barriers, drug distribution and pharmacokinetics are dynamic and often changed by disease/trauma. Knowledge of all these factors and their interplay in different conditions is of utmost importance for proper CNS drug development and disease treatment. In recent years much information has become available for a better understanding of the many factors important for CNS drug delivery and how they interact to affect drug action. This book describes small and large drug delivery to the brain with an emphasis on the physiology of the BBB and the principles and concepts for drug delivery across the BBB and distribution within the brain. It contains methods descriptions for studying drug delivery, routes and approaches of administering drugs into the brain, the influence of disease, and drug industry perspectives. Therewith, it contributes to an in-depth understanding of the interplay between brain (patho)-physiology and drug characteristics. Furthermore, the content is designed to be both cutting-edge and educational, so that the book can be used in high-level training of academic and industry scientists with full references to original publications.

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Evidence-Based Neurology: Management of Neurological Disorders (Evidence-Based Medicine) 2nd Edition

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From an expert editor team drawn from the Cochrane Neurological Network, Evidence-Based Neurology provides specialists and those in training with the skills and knowledge to apply evidence-based practice in the clinical setting.

  • fills the gap between guidelines and primary studies as well as between primary and secondary scientific medical literature
  • summarizes the most recent and important findings on treatments for neurological patients
  • measures the benefit and, when applicable, the risk of harm inherent in specific neurological interventions
  • now includes new non-clinical topics of interest to neurologists such as education and research

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Behavioral Neuroendocrinology 1st Edition

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Inspired by Carlos Beyer’s 50 years of pioneering research and influence on his students and colleagues, Behavioral Neuroendocrinology builds upon Beyer’s fundamental discoveries and concepts as well as their widespread implications. It presents original research and reviews on mechanisms ― genomic and non-genomic ― of steroid and protein hormone action; the role of steroid metabolism, especially aromatization, protein phosphorylation, and neurotransmitter action in mediating reproductive behavior and sexual differentiation; and brain and spinal cord mechanisms in sexual behavior and analgesia.

This book presents a rich diversity of topics ― lactation, maternal behavior, pheromone action, chronobiology, allodynia, angiogenesis, prostate physiology, sexual motivation, and specific brain systems, including vomeronasal system, cerebellum, preoptic area, hypothalamus, and spinal cord. This book brings together, in one source, an international “family” of researchers whose work has evolved in diverse but related ways from a seminal set of discoveries and concepts in behavioral neuroendocrinology.

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Neuroimaging: A Teaching File (LWW Teaching File Series) First Edition

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With 100 illustrated cases in print and an eBook containing the 100 print cases plus another200 cases, this volume in the Teaching File Series gives you ready access to actual cases culled from the teaching files of major medical centers.  Neuroradiology: A Teaching File covers a wide variety of CNS diseases that are presented as unknowns with coverage of both brain and head and neck cases.  Each case features two to four images and follows the Teaching File template:  clinical history, findings, differential diagnosis, diagnosis, discussion, questions, key issues for the report, what the clinician needs to know, and answers. It’s the next-best thing to a personal consultation with teaching hospital experts!

Key Features

  • Clear, concise discussions mimic those performed on a daily basis between residents and faculty members.
  • Cases are now randomized, to better prepare you for challenges faced in an everyday clinical setting.
  • Both brain and head and neck cases are highlighted by color perfusion, PET, and functional/MR spectroscopy images. 
  • Common neuroimaging cases are featured, including both normal anatomy and the use of advanced imaging in differential diagnosis.
  • Collaboration with clinical services and pathology provides an interdisciplinary perspective whenever possible.
  • Dozens of cases feature full-color images.
  • New softcover format for the entire series.

Now with the print edition, enjoy the bundled interactive eBook edition, offering tablet, smartphone, or online access to:

  • 300  cases, including 200 eBook only cases
  • Complete content with enhanced navigation.
  • Powerful search tools and smart navigation cross-links that pull results from content in the book, your notes, and even the web.
  • Cross-linked pages, references, and more for easy navigation.
  • Highlighting tool for easier reference of key content throughout the text.
  • Ability to take and share notes with friends and colleagues.
  • Quick reference tabbing to save your favorite content for future use.

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A Dictionary of Neurological Signs 4th ed. 2016 Edition

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This updated and expanded Fourth Edition is an alphabetical listing of commonly presenting neurological signs designed to guide the physician toward the correct clinical diagnosis. The dictionary is focused, problem-based and concise.

The structured entries in this practical, clinical resource provide summaries of a wide range of neurological signs. Each entry includes: a definition of the sign; a brief account of the clinical technique required to elicit the sign; a description of the other signs which may accompany the index sign; an explanation of pathophysiological and/or pharmacological background; differential diagnosis; brief treatment details; and where known, the neuroanatomical basis of the sign.

A Dictionary of Neurological Signs, Fourth Edition, is an indispensable reference for all students, trainees, and clinicians who care for patients with neurological disorders, and could also be used in preparation for exams, since each entry is a snapshot of a specific disorder or disease.

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Metabolic Syndrome and Neurological Disorders 1st Edition

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Metabolic Syndrome and Neurological Disorders brings together information on the cluster of common pathologies which cause metabolic syndrome – abdominal obesity linked to an excess of visceral fat, insulin resistance, dyslipidemia and hypertension – to provide a comprehensive and cutting edge exploration of the link between metabolic syndrome and neurological disorders.

Metabolic syndrome is recognized to play a role in neurological disorders such as stroke, Alzheimer’s disease, and depression. For the first time in book form, Metabolic Syndrome and Neurological Disorders covers the molecular mechanisms thought to underlie this mirror relationship, as well as how lifestyle and other factors such as oxidative stress and inflammation may play a role in the disease. Grounded in a series of epidemiological studies of metabolic-cognitive syndrome, this book will be a valuable reference for researchers, dietitians, nutritionists, and physicians.

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Surgical Anatomy and Techniques to the Spine Book + Image bank CD-ROM

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Written by three neurosurgeons and an orthopedic surgeon, this comprehensive reference’s multidisciplinary approach makes it relevant and informative to all surgeons regardless of their specialty or level of surgical experience. After thoroughly reviewing the anatomy and approaches to the spine, the authors lead you through a full range of state-of-the-art techniques in spine surgery, including those procedures commonly performed for degenerative disease, trauma, scoliosis, tumor, and infection. Abundant full-color illustrations, three-dimensional images and cadaver dissection photos walk you through both simple and complex spinal surgical procedures. The bonus CD-ROM contains all the images from the book, including some of the most sought-after anatomic photographs and radiographic images in neurosurgery, brought together for the first time uniquely for this volume.

  • Multiple-viewpoint, full-color photographs and illustrations provide a thorough presentation of procedures and relevant anatomy.
  • Concise, atlas-style format makes techniques easy to understand and reproduce.
  • The Bonus CD-ROM includes all the images from the book in an easily searchable format for use in electronic presentations.
  • Multidisciplinary coverage makes the book relevant and informative to all spine surgeons.
  • Facilitates diagnosis and complication avoidance with clinical pearls and hints..

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Atlas of Regional Anatomy of the Brain Using MRI: With Functional Correlations

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A unique review of the essential topographical anatomy of the brain from an MRI perspective, correlating high-quality anatomical plates with high-resolution MRI images. The book includes a historical review of brain mapping and an analysis of the essential reference planes used. It provides a detailed review of the sulcal and the gyral anatomy of the human cortex, guiding readers through an interpretation of the individual brain atlas provided by high-resolution MRI. The relationship between brain structure and function is approached in a topographical fashion with an analysis of the necessary imaging methodology and displayed anatomy. An extensive coronal atlas rounds off the book.

From the Back Cover

The volume provides a unique review of the essential topographical anatomy of the brain from an MRI perspective, correlating high-quality anatomical plates with the corresponding high-resolution MRI images. The book includes a historical review of brain mapping and an analysis of the essential reference planes used for the study of the human brain. Subsequent chapters provide a detailed review of the sulcal and the gyral anatomy of the human cortex, guiding the reader through an interpretation of the individual brain atlas provided by high-resolution MRI. The relationship between brain structure and function is approached in a topographical fashion with analysis of the necessary imaging methodology and displayed anatomy. The central, perisylvian, mesial temporal and occipital areas receive special attention. Imaging of the core brain structures is included. An extensive coronal atlas concludes the book. Neuroscientists, neuroradiologists, neurologists, neurosurgeons and students of human behavior should find this book useful guiding them to a better understanding of the localization of brain function.

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Neuromuscular Disorders 1st Edition

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Everything you need to know about neuromuscular disease–in one concise, full-color volume

“…this book will become an indispensable resource for clinicians involved in the diagnosis and management of patients with neuromuscular diseases, as well as for scientists working on the nature and pathogenesis of these disorders. It is a much-needed and welcome addition to the neurological literature and will rapidly gain acceptance as a standard work of reference.”–Michael J. Aminoff, MD, DSc, FRCP, (from the foreword)

Neuromuscular Disorders is comprehensive in scope, yet concise enough to serve as a valuable point-of-care guide for your day-to-day clinical practice. Grounded by numerous reference sources and enhanced by the experience of two seasoned clinicians, this text provides a pragmatic approach to the evaluation and management of neuromuscular disease. Here, in a single source, you’ll get an insightful look at both nerve and muscle conditions, ranging from motor neuron diseases to neuropathies, neuromuscular junction disorders, and myopathies.

The book opens with the clinical and laboratory approach to patients with neuromuscular disease, covering electrodiagnostic testing, nerve conduction studies, and muscle and nerve histopathology. With an emphasis on effective diagnosis and treatment, the substance of the text examines the full spectrum of specific neuromuscular diseases, giving you the “big picture” of the discipline in a way that no other text can match.

FEATURES:

  • Convenient coverage of both nerve, muscle and neuromuscular transmission disorders–both primary and secondary neuromuscular diseases
  • Specific disease sections encompass the range of conditions likely to be encountered in clinical practice, including amyotrophic lateral sclerosis, myasthenia gravis, radiculopathies and plexopathies, mononeuropathies, various polyneuropathies, toxic myopathies, and dozens more
  • The very latest diagnosis and treatment recommendations and protocols based on the most recent clinical literature and research
  • Well-illustrated with EMGs, histopathology, and clinical photos

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Neurovascular Anatomy in Interventional Neuroradiology: A Case-Based Approach 1st Edition

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This case-based book presents detailed information on neurovascular anatomy in concise, easily digestible chapters that focus on the importance of understanding anatomy when performing neurointerventional procedures. The case discussions include modern examples of invasive and non-invasive angiographic techniques that are relevant for general radiologists and diagnostic neuroradiologists as well as interventionalists. This book gives readers the detailed knowledge of neurovascular anatomy that allows them to anticipate and avoid potential complications.

Key Features: Cases are enhanced by more than 1,000 high-quality radiographs covering the full range of neurovascular anatomyContent focuses on the practical relevance of the anatomical features encountered while performing everyday neurovascular proceduresAnatomy and embryology are explained together, enabling readers to fully comprehend the vascular anatomy and its many variantsPearls and pitfalls are provided at the end of each chapter, highlighting the critical anatomy points presented

All neuroradiologists, interventionalists, general radiologists, and diagnostic neuroradiologists, as well as residents and fellows in these specialties, will read this book cover to cover and frequently consult it for a quick review before performing procedures.

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