Category: Neurology/Neurosurgery

Multiscale Models of Brain Disorders

Multiscale Models of Brain Disorders

This book focuses on our current understanding of brain dynamics in various brain disorders (e.g. epilepsy, Alzheimer’s and Parkinson’s disease) and how the multi-scale, multi-level tools of computational neuroscience can enhance this understanding. In recent years, there have been significant advances in the study of the dynamics of the disordered brain at both the microscopic and the macroscopic levels. This understanding can be furthered by the application of multi-scale computational models as integrative principles that may link single neuron dynamics and the dynamics of local and distant brain regions observed using human EEG, ERPs, MEG, LFPs and fMRI. Focusing on the computational models that are used to study movement, memory and cognitive disorders as well as epilepsy and consciousness related diseases, the book brings together physiologists and anatomists investigating cortical circuits; cognitive neuroscientists studying brain dynamics and behavior by means of EEG and functional magnetic resonance imaging (fMRI); and computational neuroscientists using neural modeling techniques to explore local and large-scale disordered brain dynamics.

 

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Imaging of Brain Tumors with Histological Correlations 2nd Edition

Imaging of Brain Tumors with Histological Correlations 2nd Edition

This volume provides a deeper understanding of the diagnosis of brain tumors by correlating radiographic imaging features with the underlying pathological abnormalities. All modern imaging modalities are used to complete a diagnostic overview of brain tumors with emphasis on recent advances in diagnostic neuroradiology. High-quality illustrations depicting common and uncommon imaging characteristics of a wide range of brain tumors are presented and analysed, drawing attention to the ways in which these characteristics reflect different aspects of pathology. Important theoretical considerations are also discussed. Since the first edition, chapters have been revised and updated and new material has been added, including detailed information on the clinical application of functional MRI and diffusion tensor imaging. Radiologists and other clinicians interested in the current diagnostic approach to brain tumors will find this book to be an invaluable and enlightening clinical tool.

 

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Primary Central Nervous System Tumors: Pathogenesis and Therapy

Primary Central Nervous System Tumors: Pathogenesis and Therapy

This comprehensive, yet practical, text is a ready collection of the most up-to-date information on primary CNS tumors. Authored by a carefully selected group of the world’s leading clinicians and scientists, the book is divided into three sections. The opening chapters cover general principles, including epidemiology, pathogenesis, tumor stem cells, supportive care, complications of therapy, and quality of life. The remaining two sections are comprised of treatment-oriented chapters covering the spectrum of gliomas and rarer tumor types. Each of these chapters presents multi-disciplinary therapeutic approaches and addresses specific disease concerns. Throughout, the authors incorporate the cutting-edge advances in molecular biology and genomics that are revolutionizing neuro-oncology. The result is an important clinical resource which provides evidence-based data and interpretation essential to intelligent therapeutic decision making.

 

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Traumatic Brain Injury: Rehabilitation, Treatment, and Case Management, Fourth Edition 4th Edition

Traumatic Brain Injury: Rehabilitation, Treatment, and Case Management, Fourth Edition 4th Edition

In the last decade neuroscience has matured at a remarkable pace, shedding a far more exacting light on mechanisms of neurophysiology, pathophysiology of injury, neuroendocrinology, neuro-immunology, neuroplasticity, neuropharmacology and neurodegenerative processes. Individuals with acquired brain injury are treated earlier and now achieve far better recovery than in the past.

The fourth edition of this text constitutes a continuation of 20 years of coverage of traumatic brain injury, and broadens the discussion of acquired brain injury. Within TBI, the paradigm shift from an injury occurring at a point in time to a disease entity of a chronic nature is changing the discussion of diagnosis, management, treatment and outcome assessment. Disease specification that differentiates TBIs by the mechanism of injury, the exact nature of the injury, the extent of injury, presence of co-morbidities and their exact nature, gender, age, race, and genome are emerging as crucial. There was a time when cancer was an undifferentiated disease. Disease differentiation has consequently impacted diagnosis, treatment and outcome.

This text is intended to serve as a ready reference tool, contributing to the professional growth of each reader, and stimulating innovation and research. It also promotes the continued refinement in the management of diseases of acquired brain injury.

 

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Cervical Spine Surgery: Standard and Advanced Techniques: Cervical Spine Research Society

Cervical Spine Surgery: Standard and Advanced Techniques: Cervical Spine Research Society

This comprehensive, up-to-date textbook of modern cervical spine surgery describes the standard and advanced techniques recommended by the Cervical Spine Research Society – European Section (CSRS-E) with a view to enabling both young and experienced surgeons to further develop their skills and improve their surgical outcomes. Success in cervical spine surgery depends on the surgeon’s awareness of the main challenges posed by distinct cervical spine diseases, theoretical understanding of treatment concepts, and knowledge of technical options and the related potential for complications. It is the surgeon who has to merge theory and practice to achieve the desired outcome, in each case appraising the details of surgical anatomy and weighing the challenges and complications associated with a surgical technique against the skills that he or she possesses. This excellently illustrated book, written by key opinion makers from the CSRS-E with affiliated surgeons as co-authors, presents the full range of approaches and techniques and clearly identifies indications, precautions, and pitfalls. It will be a superb technical reference for all cervical spine surgeons, whether orthopaedic surgeons or neurosurgeons.

 

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Cerebral Ischemic Reperfusion Injuries (CIRI): Bench Research and Clinical Implications

Cerebral Ischemic Reperfusion Injuries (CIRI): Bench Research and Clinical Implications

This volume is focused on subjects related to cerebral ischemia and reperfusion injuries after acute stroke. All chapters are selected from the Sixth Elite Stroke meeting named Pangu Stroke Conference and written by members of world leading laboratories of stroke studies. The contents cover both clinical and bench studies, from basic components of cerebral arterial system to clinical reperfusion injury cases, from reperfusion caused programmed cell death and astrocyte activation to oxidative stress and nitric oxide after reperfusion, from extracellular matrix and inflammation to a role of diabetes after reperfusion, from small artery disorders to collateral circulation and blood pressure control after reperfusion.

 

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Non-Neuronal Mechanisms of Brain Damage and Repair After Stroke

Non-Neuronal Mechanisms of Brain Damage and Repair After Stroke

This book provides a comprehensive overview of the latest research in the role of non-neuronal cells – astrocytes, oligodendrocytes, endothelial cells, pericytes, microglia, and other immune cells in ischemic brain injury and long-term recovery. In these cases, neurodegeneration and brain repair are controlled in a sophisticated system, incorporating interactions between different cell types and cellular systems. Also explored are the therapeutic strategies that target non-neuronal responses after stroke and their translational potentials.

 

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Cerebral Venous System in Acute and Chronic Brain Injuries

Cerebral Venous System in Acute and Chronic Brain Injuries

Provides important information from anatomy to pathophysiology and covers most neurological disorders that involve venous circulation. Venous circulation has not been extensively studied and we know relatively little about cerebral venous circulation. Venous circulation contributes to half of the brain circulation and about 70% of the blood in the brain is venous blood. Veins and venules play extremely important roles in brain circulation especially during pathologies such as brain edema, BBB disruption, elevation of intracranial pressure during and after ischemic and hemorrhagic stroke events, traumatic brain injury, neurodegerative disorders, in adults and newborns. Occlusion of veins or sinuses by thrombus, compression of veins and venules by tumor and edematous tissues, elevation of venous pressure during cranial hypertension, all lead to fatal insults such as venous infarction and hemorrhage.

 

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Therapeutic Intranasal Delivery for Stroke and Neurological Disorders

Therapeutic Intranasal Delivery for Stroke and Neurological Disorders

The blood-brain-barrier serves to encapsulate and protect the central nervous system, but it also presents a major barricade to therapeutic drug delivery. Poor penetration is the most common hurdle to translating a promising experimental therapy that uses invasive delivery methods to a clinically useful application. In the last 10 years, intranasal delivery of various therapeutic compounds including small chemicals, large proteins, and even stem cells has proven to be very effective in bypassing the blood-brain-barrier and has led to some important advances in translational research for stroke and other neurological diseases. The proposed book will bring together reports from various labs around the world who have had successes in pre-clinical studies of intranasal therapies for various diseases including adult and perinatal stroke, Alzheimer’s, Parkinson’s, and others.

 

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Tumors of the Pediatric Central Nervous System 2nd Edition

Tumors of the Pediatric Central Nervous System 2nd Edition

Tumors of the Pediatric Central Nervous System, Second Edition, provides readers with both medical management and surgical perspectives on the clinical, pathological, and radiological diagnoses and treatment of pediatric CNS tumors. It includes complete coverage of the latest diagnostic and management techniques, state-of-the-art technologies, and trends in the surgical treatment of pediatric tumors.

Highlights of the Second Edition:

  • Contains 19 new chapters on such topics as recent advances in the cytogenetics and molecular biology of pediatric brain tumors, gangliogliomas and miscellaneous spinal cord tumors in children, post-chemotherapy morbidity, and many more
  • Addresses the important issues of long-term chronic treatment of pediatric tumor patients and related outcome measures
  • Includes summary boxes and tables that distill large amounts of information for quick review
  • Written by editors and contributors who are world-renowned experts in the field of pediatric neurosurgery and oncology

Neurosurgeons, neurologists, oncologists, radiation oncologists, and pediatricians caring for patients with tumors of the central nervous system will find this book to be an essential resource that they will repeatedly consult as they strive to enhance patient care.

 

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