Category: Infectious Diseases

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Parasitic infections such as malaria, schistosomiasis, trypanosomiasis and onchoceriasis are the scourge of the tropical countries. Many of the drugs used for the treatment of tropical parasitic infections were introduced more than 30 years ago. Most of these drugs are toxic and have complicated dosage regimens, but, because of the low economic incentive, pharmaceutical companies have shown little interest in developing new drugs to control diseases prevalent in developing countries.; However, there has been notable progress in research into parasitic diseases and a number of important drugs have been introduced for some diseases since the 1970s. Moreover, recent data on the pharmacokinetics and field evaluations of these drugs have revealed that their effectiveness can be improved and their safety increased.; This handbook is designed to provide information about the pharmacological properties and therapeutic uses of the major drugs currently employed to combat the human parasitic infections encountered in the tropics. Each of the 38 drugs covered in the book are presented under the following headings: chemical structure, physical properties, pharmacology and mechanism of action, pharmacokinetics, clinical trials, pregnancy and lactation, side effects, contraindications and precautions, dosage, preparations, and references.

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Viral infections of the nervous system are important because they are associated with high morbidity and mortality. A variety of pathogenetic mechanisms are involved in these infections and an understanding of the pathogenesis is essential in understanding the diagnostic and clinical management aspects of the disease. Specialized investigations are often necessary for definitive diagnosis, although a presumptive diagnosis should often be suspected on the basis of the clinical features. Many of the chapters in this book are written by neurologists who are experts in basic science research of their topic in addition to active clinical practice in their specialty.

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The number of diagnosed cases of primary immunodeficiency diseases (PIDs) – a group of inborn disorders of the immune system – is growing rapidly, but misdiagnosis or late diagnosis still occurs in a significant number of patients, with serious consequences. This is the second edition of a practical reference textbook on PIDs that has been widely welcomed by scientists and clinicians from around the world. The new edition has been extensively revised to reflect advances in knowledge and includes various PIDs not previously covered. For each disease, information is provided on definition, etiology, clinical manifestations, diagnosis, and management. This book will represent an ideal resource for specialists when engaging in diagnosis, clinical decision-making, and treatment planning. It will also prove invaluable for doctors in training and other physicians and nurses who wish to learn more about PIDs.

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Latest findings, practices, and strategies to detect and control nosocomial infections

Nosocomial infections, also known as hospital acquired infections, represent a growing challenge to healthcare facilities around the world. Many nosocomial pathogens are becoming more and more resistant to treatment, resulting in higher morbidity, mortality, and cost. In fact, each year it is estimated that some two million patients develop a hospital-acquired infection in the United States, representing nearly 5% of all hospitalized patients.

Molecular Techniques for the Study of Hospital Acquired Infection reviews the latest findings, practices, and strategies to support the development and implementation of effective, comprehensive programs to study and control hospital acquired infections. It focuses on the application of molecular techniques, enabling hospitals to incorporate these state-of-the-technology techniques into their infection control programs.

Key topics include:

• Characteristics of healthcare settings that allow for the development and spread of nosocomial pathogens
• Implementation of effective infection control programs
• Epidemiological methods to study nosocomial disease
• Elimination of pathogens and the development of resistance to treatment
• Molecular techniques to study hospital acquired infections and their application in characterizing important Gram-positive, Gram-negative, and fungal pathogens

Contributions come from leading international experts in nosocomial pathogen detection and control. These contributions are based on the authors’ own firsthand experience combined with a thorough review and analysis of the current literature. References at the end of each chapter enable readers to explore each individual topic in greater depth.

Molecular Techniques for the Study of Hospital Acquired Infection is highly recommended as a guide for hospital infection control programs. Moreover, it serves as a text for courses in infection control and the population biology of nosocomial infection. In particular, the book’s unique clinical perspective helps readers minimize nosocomial infections by developing a coordinated approach to infection control, laboratory methods, and clinical practices.

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From the Back Cover