Drug Design: Principles and Applications 1st ed. 2017 Edition

This book offers an in-depth discussion of the latest strategies in the field of drug design and their applications in various disorders, in order to encourage readers to undertake their own projects.It also includes the contemporary application of drug-designing methodologies to inspire others to further expand the utility of this field in other diseases.It is intended for advanced undergraduate and graduate students, postdocs, researchers, lecturers and professors in bioinformatics, computational biology, medicine, pharmaceutics and other related fields.

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Privileged Structures in Drug Discovery: Medicinal Chemistry and Synthesis 1st Edition

A comprehensive guide to privileged structures and their application in the discovery of new drugs 

The use of privileged structures is a viable strategy in the discovery of new medicines at the lead optimization stages of the drug discovery process.  Privileged Structures in Drug Discovery offers a comprehensive text that reviews privileged structures from the point of view of medicinal chemistry and contains the synthetic routes to these structures. In this text, the author—a noted expert in the field—includes an historical perspective on the topic, presents a practical compendium to privileged structures, and offers an informed perspective on the future direction for the field.

The book describes the up-to-date and state-of-the-art methods of organic synthesis that describe the use of privileged structures that are of most interest. Chapters included information on benzodiazepines, 1,4-dihydropyridines, biaryls, 4-(hetero)arylpiperidines, spiropiperidines, 2-aminopyrimidines, 2-aminothiazoles, 2-(hetero)arylindoles, tetrahydroisoquinolines,  2,2-dimethylbenzopyrans, hydroxamates, and bicyclic pyridines containing ring-junction nitrogen as privileged scaffolds in medicinal chemistry. Numerous, illustrative case studies document the current use of the privileged structures in the discovery of drugs. This important volume:

  • Describes the drug compounds that have successfully made it to the marketplace and the chemistry associated with them
  • Offers the experience from an author who has worked in many therapeutic areas of medicinal chemistry
  • Details many of the recent developments in organic chemistry that prepare target molecules
  • Includes a wealth of medicinal chemistry case studies that clearly illustrate the use of privileged structures

Designed for use by industrial medicinal chemists and process chemists, academic organic and medicinal chemists, as well as chemistry students and faculty, Privileged Structures in Drug Discovery offers a current guide to organic synthesis methods to access the privileged structures of interest, and contains medicinal chemistry case studies that document their application.

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Drugs and Social Context: Social Perspectives on the Use of Alcohol and Other Drugs 1st ed. 2018 Edition

This book goes beyond the traditional approaches to drug use and discusses the issue from a societal perspective, integrating contributions from different disciplines such as psychology, public health, anthropology, law, public policies and sociology to address specifically the social aspects of the phenomenon. Given its complexity, drug use demands a multidisciplinary approach from many different perspectives, but despite the vast literature about the topic, the majority of the books are restricted either to a purely medical perspective (focused mainly on treatment techniques) or to a criminological perspective (focused mainly on drug trafficking and organized crime).

The social approach adopted in this volume challenges this dichotomy and analyzes both the social contexts to which drug use is related and the social and political consequences of the attitudes and policies adopted by governments and other social groups towards drug users, addressing topics such as:

  • Drugs and poverty
  • Drugs and gender
  • Drugs and race
  • Drugs and territory
  • Stigmatization of drug use
  • Prohibitionism

Given its broad and innovative approach, Drugs and Social Context – Social Perspectives on the Use of Alcohol and Other Drugs will be of interest for researchers, clinicians and other health professionals, since the study of the social aspects of drug use is central to everyone who deals with the issue.

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Drug Discovery for Leishmaniasis 1st Edition

For human health, leishmaniasis is among the most important protozoan diseases, superseded only by malaria. Globally, 10 to 12 million people are infected with 1.5 million new cases every year. The development of cheaper new drugs is urgently needed for this neglected disease that is developing resistance to current treatments. Chemotherapy remains the only treatment option for the bulk of patients. However, this is largely unaffordable for most. In the past three years numerous advances in drug discovery have been made for treating this disease by exploiting diverging metabolic pathways between the Leishmania enzymes and their hosts, using nanotechnology to target the immune cell phagolysosomes where Leishmania resides.

 

Drug Discovery for Leishmaniasis aims to provide a perspective of the current treatments and their challenges, blended with the emerging strategies and methodologies that will drive new target appraisals and drug developments, as well as addressing the molecular basis of resistance in Leishmania.

 

Recent studies have shown that leishmaniasis affects some of the poorest people in the world, with 95% of fatal cases occurring in only 6 countries. With the WHO goal of eliminating this public health problem in the South-east Asia Region by 2020, this book will be important for anyone who is interested in neglected tropical diseases.

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Pharmacology of Mitochondria (Handbook of Experimental Pharmacology) 1st ed. 2017 Edition

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This special book is conceived to highlight mitochondrial structural and functional integrity and how they are associated with several human diseases such as cardiovascular, cancer, renal, neurological disorder, and genetic disorders. The chapters contributed by leading mitochondrial researchers in the handbook will take us through the novel pharmacological strategies via mitochondria to understand their physiological and pathological role as well as present them as therapeutic targets.

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Handbook of Pharmaceutical Excipients 8th Revised edition Edition

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The Handbook of Pharmaceutical Excipients collects together essential data on the physical properties of excipients as well as providing information on their safe use and applications. All of the 400+ monographs are also thoroughly cross-referenced and indexed to allow their identification by chemical, non-proprietary or trade names.   It is internationally recognised as the authoritative source of information on pharmaceutical excipients and a comprehensive guide to uses, properties and safety.

Monographs benefit from a standardized, easy-to-use template and include:

  • Pharmacopeial information from the UK, Europe, Japan and the United States where relevant
  • Non-proprietary names and synonyms
  • Chemical name, CAS Registry number, empirical formula, molecular weight
  • Functional category, applications and incompatibilities
  • Material description and typical properties
  • Safety, stability, storage and handling information
  • Method of manufacture
  • Related substances
  • Primary references
  • Editorial comments
  • Authors details and revision date

Changes to this new edition:

  • Contains revised and updated monographs
  • 20 + new monographs including amino acids Arginine, Proline and Asparagine
  • Includes newly added Raman spectra for many excipients
  • New chapter content including information on excipients in oral solid dose formulations, and pediatric formulations

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Clarke’s Analysis of Drugs and Poisons, 4th Edition (Book + 1-Year Online Access Package) 4 Revised Edition

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Clarke’s Analysis of Drugs and Poisons, 4th Edition is now being offered solely as a print and online package. It is a full book & digital package, consisting of the two volume reference book in a slip case, plus one year’s individual access to the online version of Clarke’s via MedicinesComplete, with all the attendant benefits, including updating annually.

(A secure code will be included in the package enabling the end-user to access MedicinesComplete and setup their account and their 1-Year subscription)

MedicinesComplete is produced and updated by Pharmaceutical Press.

Clarke’s Analysis of Drugs and Poisons is the definitive source of analytical data for drugs and poisons. Written by over 40 international experts, the resource also boasts an editorial advisory board of over 45 world renowned scientists.

This reference work has been completely revised and updated for the new edition, and comprises two volumes.

The book is essential for all forensic and clinical toxicologists, pathologists, hospital pharmacists, pharmaceutical analysts, clinical pharmacologists, clinical and forensic laboratories, and poison information centers.

From the reviews of the previous edition

‘Some things in life are worth the wait and truly this 3rd edition of Clarke’s Analysis of Drugs and Poisons falls into this category…the quality is superb’ Australian Journal of Forensic Sciences

‘Clarke has gained an international reputation as a reliable source of information for the analyses of drugs, and this new highly-expanded edition is the 21st century’s successor.’ Veterinary and Human Toxicology

‘The content is comprehensive, absorbing and layout is well planned and executed. Without doubt, this volume will be a much well thumbed institution in any serious analytical laboratory and will assist generations of scientists in years to come.’ Pharmacy Education

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Pharmacometrics: The Science of Quantitative Pharmacology 1st Edition

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Pharmacometrics is the science of interpreting and describing pharmacology in a quantitative fashion. The pharmaceutical industry is integrating pharmacometrics into its drug development program, but there is a lack of and need for experienced pharmacometricians since fewer and fewer academic programs exist to train them. Pharmacometrics: The Science of Quantitative Pharmacology lays out the science of pharmacometrics and its application to drug development, evaluation, and patient pharmacotherapy, providing a comprehensive set of tools for the training and development of pharmacometricians.

Edited and written by key leaders in the field, this flagship text on pharmacometrics:

  • Integrates theory and practice to let the reader apply principles and concepts.
  • Provides a comprehensive set of tools for training and developing expertise in the pharmacometric field.
  • Is unique in including computer code information with the examples.

This volume is an invaluable resource for all pharmacometricians, statisticians, teachers, graduate and undergraduate students in academia, industry, and regulatory agencies.

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LWW’s Foundations in Sterile Products for Pharmacy Technicians (LWW’s Foundations Series) 1st Edition

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Designed specifically for pharmacy technician students, LWW’s Foundations in Sterile Products for Pharmacy Technicians is the comprehensive resource for understanding the role of sterile products in a pharmacy setting. Successful pharmacy technicians must follow USP 797 regulations on sterile products and aseptic technique; this textbook is the comprehensive resource to guarantee a working understanding of these regulations. Designed to be concise and accessible, students using this text will be knowledgeable, confident, and prepared for professional success.

A comprehensive supplement package includes an electronic Quiz Bank and full text online. Pharmacy technician program instructors can access PowerPoint Presentations, an Image Bank, and a Brownstone Test Generator online at thePoint™.

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Nanotechnology Applied To Pharmaceutical Technology 1st ed. 2017 Edition

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