Category: Pharmacology

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With potentially high specificity and low toxicity, biologicals offer promising alternatives to small-molecule drugs. Peptide therapeutics have again become the focus of innovative drug development efforts backed up by a resurgence of venture funds and small biotechnology companies.

 

What does it take to develop a peptide-based medicine? What are the key challenges and how are they overcome? What are emerging therapeutics for peptide modalities? This book answers these questions with a holistic story from molecules to medicine, combining the themes of design, synthesis and clinical applications of peptide-based therapeutics and biomarkers. Chapters are written and edited by leaders in the field from industry and academia and they cover the pharmacokinetics of peptide therapeutics, attributes necessary for commercially successful metabolic peptides, medicinal chemistry strategies for the design of peptidase-resistant peptide analogues, disease classes for which peptide therapeutic are most relevant, and regulatory issues and guidelines.

 

The critical themes covered provide essential background information on what it takes to develop peptide-based medicine from a chemistry perspective and views on the future of peptide drugs. This book will be a valuable resource not only as a reference book for the researcher engaged in academic and pharmaceutical setting, from basic research to manufacturing and from organic chemistry to biotechnology, but also a valuable resource to graduate students to understand discovery and development process for peptide-based medicine.

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Protozoan infections that are endemic in countries with limited economic resources pose a significant public health challenge to affected communities and some of these diseases are categorized as neglected tropical diseases by the World Health Organization. At the moment, there is an urgent need to identify and develop new antiprotozoal drugs. Antiprotozoal Drug Discovery: A Challenge That Remains brings together research from all scientists (including parasitologists, chemists, biologists among others) involved in the field of antiprotozoal experimental pharmacology, drug design and natural product research. The monograph is a compilation of review chapters written by experts on medical parasitology and pharmacology that covers a wide range of topics such as general characteristics of protozoan diseases (malaria, toxoplasmosis, Chagas’ disease, leishmaniasis, trichomoniasis) prophylaxis, treatments, natural products and rational drug design. The contents of this book are useful to medical microbiologists and pharmaceutical scientists seeking to update their knowledge about antiprotozoal drug design.

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This third volume in a four-volume set offers new theories and applications for the diagnosis and treatment of mental disorders. Having laid the groundwork in the first two volumes, the authors now embark on significant, real-life scenarios that apply their philosophy to mental disorder treatments. The goal of the project is to take the industry toward sustainability, not just in terms of the chemical engineering used to create medicines, but also environmentally, economically, and personally. Their unique approach uses a more holistic and philosophically cohesive method for treating mental disorders, making the industry “greener” and the patient healthier.

The four volumes in “The Greening of Pharmaceutical Engineering” are:

• Volume 1: Practice, Analysis, and Methodology
• Volume 2: Theories and Solutions
• Volume 3: Applications for Mental Disorder Treatments
• Volume 4: Applications for Physical Disorder Treatments

This ground-breaking set of books is a unique and state-of-the-art study that only appears here, within these pages.  A fascinating study for the engineer, scientist, and pharmacist working in the pharmaceutical industry and interested in sustainability, it is also a valuable textbook for students and faculty studying these subjects.

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The work of dope testers is constantly being obstructed by the development of ever harder-to-trace new forms of banned substances. Organisations such as the World Anti-Doping Association and the United States Anti-Doping Agency are pioneering cutting-edge techniques designed to keep competition at the highest level fair and safe, and must ensure that their drug testing laboratories adhere to the highest scientific standards. In Pharmacology, Doping and Sports these techniques and procedures are explained by the anti-doping experts who practice them.

Broad-ranging in scope, this book examines the effects of performance-enhancing substances on the athlete’s health; the role of anti-doping procedures as an ethical question, and explains the background to, and the emergence of, the anti-doping movement. The book also offers in-depth analysis of key scientific matters, such as:

• standard analytical and diagnostic tests for sports doping
• regulatory standards for laboratory proficiency
• common performance-enhancing techniques such as anabolic and designer steroids, blood doping, growth hormones, and gene doping
• carbon-isotope ratio testing.

Written by some of the world’s leading authorities on the science of sports doping, Pharmacology, Doping and Sportsprovides an invaluable study of up-to-the-minute anti-doping techniques. This book is essential reading for all sports scientists, coaches, policy-makers, students and athletes interested in the science or ethics of doping in sport.

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Although there are over 400,000 people each year in the United States alone who suffer from traumatic injury to the central nervous system (CNS), no phar­ macological treatment is currently available. Considering the enormity of the problem in terms of human tragedy as well as the economic burden to families and societies alike, it is surprising that so little effort is being made to develop treatments for these disorders. Although no one can become inured to the victims of brain or spinal cord injuries, one reason that insufficient time and effort have been devoted to research on recovery is that it is a generally held medical belief that nervous system injuries are simply not amenable to treatment. At best, current therapies are aimed at providing symptomatic relief or focus on re­ habilitative measures and the teaching of alternative behavioral strategies to help patients cope with their impairments, with only marginal results in many cases. Only within the last decade have neuroscientists begun to make serious inroads into understanding and examining the inherent “plasticity” found in the adult CNS. Ten years or so ago, very few researchers or clinicians would have thought that damaged central neurons could sprout new terminals or that intact nerve fibers in a damaged pathway could proliferate to replace inputs from neurons that died as a result of injury.

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More than 150 patient cases teach you how to apply the principles of pharmacotherapy to real-world clinical practice

The essential study companion to DiPiro’s Pharmacotherapy: A Pathophysiologic Approach, Tenth Edition

Pharmacotherapy Casebook: A Patient-Focused Approach uses 157 patient cases to help you develop the skills necessary to identify and resolve the most common drug therapy problems encountered in daily clinical practice. The case chapters are organized into organ system sections that correspond to those of the companion textbook. This proven effective case-based approach makes the book perfect for PharmD, Nursing, Nurse Practitioner, and other allied health courses

Sharpen your ability to:

• Identify actual or potential drug therapy problems
• Determine the desired therapeutic outcome
• Evaluate therapeutic alternatives
• Design an optimal individualized pharmacotherapeutic plan
• Develop methods to evaluate the therapeutic outcome
• Provide patient education
• Communicate and the implement the pharmacotherapeutic plan

Develop expertise in pharmacotherapy decision making with:

• Realistic patient presentations that include medical history, physical examination, and laboratory data, followed by a series of questions using a systematic, problem-solving approach
• A compelling range of cases – from a single disease state to multiple disease states and drug-related problems
• Expert coverage that integrates the biomedical and pharmaceutical sciences with therapeutics
• Appendices containing valuable information on medical abbreviations, laboratory tests, mathematical conversion factors, and anthropometrics

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The 2015 edition of the most accessible, comprehensive and affordable guide to prescription and nonprescription drugs.

The classic guide to all major prescription and nonprescription drugs, featuring revised, up to date FDA information and an A-Z list of illnesses for easy reference. Includes coverage of dosage and length of time before drug takes effect; side effects, special precautions; interactions with other food and drugs; standards for use by different age groups, and more

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