Category: Pharmacology

Non-Pharmacological Management of Osteoporosis: Exercise, Nutrition, Fall and Fracture Prevention 1st ed

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This practical guide presents the most up-to-date information on the application of non-pharmacological and physical therapeutic measures, either used independently or in combination with pharmacotherapy, for the management of osteoporosis. Pharmacotherapy remains the primary treatment for osteoporosis, but to improve the biomechanical competence of bone and improve quality of life, there needs to be more comprehensive management approach involving non-pharmacological methods. The book opens with a discussion of the diagnosis, pathophysiology, complications and consequences of osteoporosis. Exercise, nutrition, orthotics, and other rehabilitation measures such as whole body vibration and electrical muscle stimulation, each described in details in chapters of their own, have had a beneficial impact on fall and fracture prevention as well as recovery post-fracture. In addition, the application of acupuncture for pain management and movement-based mind-body therapies like tai chi and the Feldenkrais method are explored.

Providing a description of independent and adjuvant techniques and practices for treatment and improving quality of life, Non-Pharmacological Management of Osteoporosis is an excellent resource for endocrinologists, bone specialists, physical therapists, occupational therapists and all clinical practitioners and staff working with osteoporosis patients.

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Pharmacology and Pathophysiology of the Control of Breathing (Lung Biology in Health and Disease)

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Exploring the functional anatomy and physiology of the ventilatory control system from the intracellular to the integrative level, this references serves as the first source to offer comprehensive coverage of the influences of various pharmacological agents on the control of breathing.

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Gamma-Hydroxybutyrate: Molecular,Functional and Clinical Aspects

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Gamma-hydroxybutyrate (GHB) has come a long way since early experiments in animals where it was found to induce a sleep-like state and from its use in general anaesthesia in human subjects. It has been found to be a naturally-occurring compound in the brain, a metabolite of GABA, the emerging ubiquitous inhibitory neurotransmitter. This has opened up a completely new line of research in an effort to establish a function for GHB.

Gamma-Hydroxybutyrate: Pharmacological and Functional Aspects has brought together the combined expertise of many of the leading authorities on the biochemistry, physiology and pharmacology of GHB in the central nervous system. Each chapter is an in-depth review of the field and the book itself will appeal to all neurobiologists interested in neurotransmitter mechanisms, as well as to clinicians and other health-care workers interested in this fascinating chemical.

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The New Drug Reimbursement Game: A Regulator’s Guide to Playing and Winning 2015th Edition

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From the Back Cover

This comprehensive text presents a rigorous framework from within which regulators can respond strategically to the claim by the pharmaceutical industry that lower drug prices today lead to a loss for the population’s future health due to less innovation. It starts with a critical review of the empirical evidence of the return to consumers on their ongoing investment into high drug prices in order to increase future innovation. The implicit, critical and unrealistic assumption inherent in these studies is identified, namely that the health budget can be expanded to purchase drugs at higher prices without an opportunity cost, for example, the foregone benefits of alternative investments in health care infrastructure.

Price effectiveness analysis (PEA), is introduced. PEA informs the question of how the innovative surplus from the new drug should be allocated between the manufacturer and the consumer so as to optimise society’s welfare. The method allows the decisions by the regulator and the firm to be analysed jointly by specifying the firm’s production and revenue functions in terms of the clinical innovation of a new drug; the incremental effect used in the summary metric of cost effectiveness analysis. An economic value of innovation that takes into account opportunity cost under conditions of economic efficiency in the health system is proposed: the health shadow price.

The limitations of the non-strategic methods that currently inform the highly contested new drug subsidy game are presented and the relative strengths of PEA are demonstrated. Health technology assessment quantifies both the clinical innovation of a new drug and its financial impact on the health system. Cost effectiveness analysis tests the relationship between the incremental cost and incremental effect of a new drug for target patients, at a given price. PEA tests the relationship between the price of a new drug and the health of the whole population, now and into the future. It achieves this by taking into account current inefficiency in both resource allocation and the displacement process, and the relationship between price and future innovation.

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Opioid Dependence: A Clinical and Epidemiologic Approach 1st ed. 2018 Edition

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This unique and timely title offers a comprehensive assessment of the previously underappreciated risks and potentially overstated benefits of chronic opioid therapy.  It does so by approaching the rampant problem of opioid abuse and addiction – currently labeled an epidemic in the United States — from a public health/epidemiologic perspective.  That is, following a thorough overview in Part 1 that compares (and contrasts) classic infectious disease epidemiology concepts with the epidemic, the book categorizes our current understanding of basic science and best clinical practices in opioid therapy in terms of Agent (opioid), Vector (prescriber) and Host (patient) factors.  The majority of the book, which includes a plethora of instructional case studies, is organized according to these three arenas. Opioid Dependence: A Clinical and Epidemiologic Approach is designed to update all clinicians on opioid basic science, current areas of drug improvement research and development, alternatives to opioid therapy, evidence-based indications for opioid therapy, and clinical strategies for preventing and overcoming opioid dependence.  Importantly, an overview of clinical practice guidelines from the American Society of Addiction Medicine, with its biopsychosocial-spiritual “multidimensional assessment” focus is provided, along with a discussion of medication-assisted treatment, organized by the three currently FDA-approved pharmacotherapeutics (methadone, buprenorphine and naltrexone).  Developed for practitioners at every level, this ground-breaking title offers a fresh and novel approach to improving the care and outcomes of patients receiving opioid therapy.

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Pharmacotherapeutics for Advanced Practice Third Edition

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Established in its first two editions as the standard advanced pharmacotherapeutics text for nurse practitioners, students, and physician assistants this completely revised and updated new edition offers guidelines on prescribing drugs for over 50 common diseases and disorders. Organized by disorder rather than drug class this new edition includes algorithms and case studies that illustrate critical thinking aspects of prescribing, such as drug selection, lifespan considerations, therapeutic drug monitoring, adverse reactions, unexpected outcomes, and when to change therapy. The third edition includes coverage of pharmacogenomics and travel medicine.  The section on Depressive Disorders discusses weaning patients from SSRIs and changing from one medication to another.  Switching from brand names to generics is dicussed in various chapters.

Make the right drug choices for your patients. 
Quick-access format, organized by body system rather than drug class, helps you locate and identify the best drug for a range of common conditions.

Selecting the Most Appropriate Agent sections in each chapter contain information on first-line, second-line, and third-line therapies, with rationales and an algorithm to help you choose the right agent.

Practical case studies, food–drug interactions, and concerns related to the geriatric client enhance your clinical judgment and promote safe and effective prescribing choices.

Current national treatment protocols and other guidelines help you refine drug selection, treat patients across the lifespan, accurately monitor drug therapy, avoid adverse reactions, and know what to do when front-line therapy fails to produce results.

NEW to the Third Edition . . . 
Chapter on Pharmacogenomics that discusses the promises and pitfalls of this burgeoning area of study, from potential research and clinical applications to the importance of protecting patients’ genetic information from misuse

Travel Medicine chapter that includes information on vaccinations, altitude sickness, and jet lag; advice for travelers with diabetes, those with cardiovascular or pulmonary conditions, and pregnant travelers; information about bedbugs, traveler’s diarrhea, malaria, and yellow fever; and more

Reorganization of contents to group chapters concerning women’s health issues into a new Women’s Health section

New focus on switching from brand-name to generic drugs in various chapters

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A Case Approach to Perioperative Drug-Drug Interactions 1st ed

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The occurrence of deleterious or even fatal drug-drug interactions (DDIs) in the perioperative period is no longer a theoretical concern but a harrowing reality. A Case Approach to Perioperative Drug-Drug Interactions addresses the complex realm of pharmacokinetic drug interactions in an easy-to-read volume that functions as both a comprehensive clinical reference and a casebook.  The book presents a summary of the core concepts of drug interactions; an organized, annotated presentation of the drug interactions most relevant to the perioperative clinician; and approximately 200 case scenarios that highlight specific drug interactions. This book fills a real void in the clinical literature and is invaluable to anesthesiologists and surgeons, as well as trainees  in both specialties; intensive care staff, including physicians, physician’s assistants, and nurses; and nurse practitioners who staff preoperative evaluation clinics.

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Remington: An Introduction to Pharmacy 1st Edition

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Remington: An Introduction to Pharmacy is an easy-to-use introductory pharmacy textbook. It provides undergraduate students with a comprehensive overview of the content that will be covered on their pharmacy course. The content is hand-picked from Remington: The Science and Practice of Pharmacy, and serves as a user-friendly textbook to complement the larger reference work. With each section condensed to a single chapter, it enables pharmacy students to fully grasp the scope of pharmacy practice and choose their career direction early on in the curriculum. Remington: An Introduction to Pharmacy covers contemporary issues in the field in a highly readable format, with specific information for pharmacy students.

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Pharmacotherapy: A Pathophysiologic Approach, Tenth Edition 10th Edition

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The most comprehensive text available on the use of evidence-based medication therapies for optimal patient outcomes – updated with the latest breakthroughs and guidelines

A  Doody’s Core Title for 2017!

Look at all that is NEW to this edition:
• New focus on Personalized Medicine includes specific recommendations on the personalization of treatment and guidelines for integration of pharmacogenomic testing and implementation in practice
• New chapter on Travel Health
• Extensively revised chapter on pulmonary arterial hypertension reflect the latest drugs and guidelines
• Monthly updates on AccessPharmacy, keeps the content fresh and current
• More than 20 online-only chapters, in addition to print
• New interior design, keeps information flowing and makes chapters concise and to the point
•  Companion Handbook is ranked #1 in Chemotherapy on Amazon, and includes clearly-stated goals of therapy; the new Tenth Edition Casebook, includes 150 + revised and updated cases

Pharmacotherapy: A Pathophysiologic Approach is written to help you advance the quality of patient care through evidence-based medication therapy derived from sound pharmacotherapeutic principles. The scope of this trusted classic goes beyond drug indications and dosages to include the initial selection, proper administration, and monitoring of drugs. You will find everything you need to provide safe, effective drug therapy across the full range of therapeutic categories.

Presented in full-color, the Tenth Edition is enriched by more than 300 expert contributors, and every chapter has been updated to reflect the latest in evidence-based information and recommendations.  This sweeping updates include tables, charts, algorithms, and practice guidelines. This edition is also enhanced by a timely all-new chapter on Travel Health.

Here’s why this is the perfect learning tool for students,  patient-focused pharmacists, and other health care providers:

  • All chapters have been updatedto provide the most current, reliable, and relevant information possible
    • Key Concepts at the beginning of each chapter
    • Clinical Presentation Tables summarize disease signs and symptoms
    • Clinical Controversies Boxes examine the complicated issues faced by students and clinicians in providing drug therapy
    • Color coded diagnostic flow diagram, treatment algorithms, dosing recommendations, and monitoring approaches clearly distinguish treatment pathways
    • Most disease-oriented chapters include updated evidence-based treatment guidelines that often include ratings of the level of evidence to support the key therapeutic approaches

Edition after trusted edition, Pharmacotherapy: A Pathophysiologic Approach has been unmatched in its ability to clearly and impartially impart core pathophysiological and therapeutic elements that students and practitioners must be familiar with.

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Pharmacology of Mitochondria (Handbook of Experimental Pharmacology) 1st ed. 2017 Edition

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This special book is conceived to highlight mitochondrial structural and functional integrity and how they are associated with several human diseases such as cardiovascular, cancer, renal, neurological disorder, and genetic disorders. The chapters contributed by leading mitochondrial researchers in the handbook will take us through the novel pharmacological strategies via mitochondria to understand their physiological and pathological role as well as present them as therapeutic targets.

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