Category: Miscellaneous Medical Books

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This book is about protein structural bioinformatics and how it can help understand and predict protein function. It covers structure-based methods that can assign and explain protein function based on overall folds, characteristics of protein surfaces, occurrence of small 3D motifs, protein-protein interactions and on dynamic properties. Such methods help extract maximum value from new experimental structures, but can often be applied to protein models. The book also, therefore, provides comprehensive coverage of methods for predicting or inferring protein structure, covering all structural classes from globular proteins and their membrane-resident counterparts to amyloid structures and intrinsically disordered proteins.

The book is split into two broad sections, the first covering methods to generate or infer protein structure, the second dealing with structure-based function annotation. Each chapter is written by world experts in the field. The first section covers methods ranging from traditional homology modelling and fold recognition to fragment-based ab initiomethods, and includes a chapter, new for the second edition, on structure prediction using evolutionary covariance. Membrane proteins and intrinsically disordered proteins are each assigned chapters, while two new chapters deal with amyloid structures and means to predict modes of protein-protein interaction. The second section includes chapters covering functional diversity within protein folds and means to assign function based on surface properties and recurring motifs. Further chapters cover the key roles of protein dynamics in protein function and use of automated servers for function inference. The book concludes with two chapters covering case studies of structure prediction, based respectively on crystal structures and protein models, providing numerous examples of real-world usage of the methods mentioned previously.

This book is targeted at postgraduate students and academic researchers. It is most obviously of interest to protein bioinformaticians and structural biologists, but should also serve as a guide to biologists more broadly by highlighting the insights that structural bioinformatics can provide into proteins of their interest.

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This unique book provides expert advice on all the different aspects related to fertility preservation for age related infertility. Although, there is a lot of information available on the Internet and in books about fertility preservation for cancer treatment, little information is available for young women that are confronted with a ticking biological clock. While men have been able to cryopreserve sperm since the 1950s, women have only recently gained the opportunity to preserve their gametes through the egg vitrification technique. Therefore, many women confronted with a risk of imminent fertility loss, such as chemotherapy, are now freezing their oocytes instead of embryos. Successful oocyte cryopreservation offers them a reproductive autonomy independent of men. Moreover, it now enables single women to preserve their reproductive chances.   The most important threat for female fertility is ovarian aging as it causes a progressive decline in the reproductive chances. The general trend to delay motherhood due to societal changes confronts many women and couples with a diminished fertility. This fertility problem can often not be cured by in vitro fertilization, which makes that an increasing number of women require oocyte donation as the treatment of last resort.  In the last few years, fertility centres around the world have started to offer the opportunity cryopreserve oocytes to young, often highly educated, single women.  This patient population is unique as compared to other patients in the fertility clinic as they perform a preventive treatment.  They are neither confronted with infertility nor are they undergoing a treatment that might cause an imminent treat to their fertility.

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This book will be a ‘how to’ guide for medical students interested in pursuing a career in academic surgery.  It will discuss personal traits and rationale for going into academic surgery.  It will review accomplishments as a medical student that are key components of beginning an academic career and highlight what makes a student competitive for a surgical program.  Sections will be devoted to mentorship, research experience and personal experiences that lead to success.
The editors will also focus on  gender and work-life balance issues that often are perceived as barriers to a career in academic surgery.   It will also provide key dates and sample application information for students to use as templates.

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Due to the resultant health consequences and considerable increase in prevalence, obesity has become a major worldwide health problem. “Obesity and Lipotoxicity” is a comprehensive review of the recent researches to provide a better understanding of the lipotoxicity-related mechanisms of obesity and the potential for the development of new treatment strategies. This book overviews the biochemical pathways leading to obesity-related metabolic disorders that occur subsequent to lipotoxicity. Chapters examine the deleterious effects of nutrient excess at molecular level including the cellular and molecular aspects of breast cancer, resistance to leptin, insulin, adiponectin, and interconnection between the circadian clock and metabolic pathways during high-fat feeding. “Lipotoxicity and Obesity” will be a useful resource for clinicians and basic science researchers, such as biochemists, toxicologists, immunologists, nutritionists, adult and pediatric endocrinologists, cardiologists, as well as students who are thought in this field.

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This unique, comprehensive text on the male factor infertility experience centers on the current background, applications and techniques for intracytoplasmic sperm injection (ICSI), one of the more commonly utilized procedures in modern assisted reproduction for male infertility, offering insights into the rationale and indications for ICSI and providing an up-to-date discussion on male factor diagnostic tests and microsurgical techniques for ICSI itself. Topics covered include the role of reproductive genetics, the effects of paternal age, the assessment, development and selection of functional human spermatozoa (e.g., Comet assay), both naturally and in the laboratory, and the procedures by which these sperm are injected directly into an oocyte. Comparisons are made between efficacy rates of ICSI versus conventional IVF strategies, and clinical approaches to fertilization failures following ICSI are presented, and intracytoplasmic morphologically selected sperm injection (IMSI) is discussed in detail in a chapter of its own.

Bringing together the latest evidence and written by international leaders in the field, Intracytoplasmic Sperm Injection: Indications, Techniques and Applications is a unique and accessible resource for reproductive endocrinologists, andrologists, geneticists and infertility practitioners and researchers alike.

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