Lysosomal Storage Disorders: A Practical Guide 1st Edition

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Awareness of lysomal storage disorders needs to be raised and there is very substantial pharmaceutical interest to do so. The disorders are often viewed as obscurities but in fact they are treatable. Enzyme replacement therapy is available for four of the disorders and will be available for a further three disorders in the course of the next year. Substrate reduction therapy is licensed for one of them but in the course of the next 12 months it will be licensed for two others and a new form of substrate reduction therapy is being introduced.

These diseases present to a very wide range of physicians and paediatricians. Gaucher disease may present to orthopaedic surgeons or haematologists with splenomegaly and/or skeletal disease. However, paediatricians see the childhood variants of Gaucher disease and therefore may present it to neurologists. Fabry disease typically does not present in childhood but presents to adult physicians with end organ damage (renal failrure, cardiac disease, stroke, neuropathy, gastrointestinal symptoms). A text book would draw these divergent strands together.

There is substantial scientific interest in these diseases. Gaucher is well recognised as a paradigm of a molecular illness, understood at a basic level which is treatable now with specific therapy and is likely to be treatable with gene therapy within the coming five years. New advances in small molecule therapy – e.g. chaperone treatment, modified antibiotics affecting ribosomal function – are likely to be useful for these diseases in the near future. Trials are already underway. These diseases therefore offer a fabulous platform for teaching modern clinical science from basic genetics right the way through to clinical applications.

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Integrated Endocrinology 1st Edition

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This innovative textbook provides a readable, contemporary and fully integrated introduction to endocrine glands, their hormones and how their function relates to homeostasis. It explores the pathology of endocrine disease by relating the underpinning science through a wealth of clinical scenarios and examples. The book integrates basic and clinical aspects for a range of endocrine glands and their hormones and includes a number of specialist chapters that also address areas of intense research and clinical interest including the regulation of salt, appetite and endocrine-immune interactions.

 

  • Provides a fully-integrated, scientific and clinical introduction to endocrinology.
  • Includes a wealth of colour illustrations to reinforce key concepts.
  • Introduces clinical scenarios and  leading questions to engage interest and illustrate the relevance of  the underpinning science.
  • Includes key references and suggestions for further reading at the end of each chapter.

 

Written by a highly respected and experienced author team this new textbook will prove invaluable to students needing an original, integrated introduction to the subject across a variety of disciplines including biomedical science, pharmacology , bioengineering and pre-clinical medicine.

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Internal Medicine (Cambridge Pocket Clinicians) 1 Poc Edition

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Cambridge Pocket Clinician / Internal Medicine is designed to provide the busy clinician with precisely the information needed where and when it is needed. The Associate Editors and contributors are internationally recognized authorities, and they have organized the content specifically so as to convey the essentials necessary for diagnosis, differential diagnosis, management, treatment and follow-up. Over 600 diseases and conditions are covered in detail. Cambridge Pocket Clinician / Internal Medicine can be counted on as an essential resource, particularly in this current era of shortened physician patient encounters and the need for rapid clinical decision-making.

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NMS Medicine Casebook (National Medical Series for Independent Study) 1 Pap/Psc Edition

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Organized by subspecialty, this case-based review covers all the information students are expected to learn during their internal medicine clerkship. Each topic begins with a brief patient history and a question about the most likely diagnosis or next step in management followed by a discussion of alternative diagnoses and management strategies. The user-friendly approach includes numerous algorithms, images, mnemonics, and tables.

A companion Website will offer the fully searchable text.

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Encephalitis: Diagnosis and Treatment (Neurological Disease and Therapy) Hardcover – November 28, 2007

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Inflammation of the brain, usually brought on by a viral infection, encephalitis currently poses a grave threat to patients around the world. With the migration of West Nile virus into North America, there is a greater awareness and corresponding need to understand, diagnose, and manage this illness. InEncephalitis: Diagnosis and Treatment, experts discuss advances in diagnostic tools, as well as therapeutic approaches that allow clinicians to better recognize and treat afflicted patients.

Individual chapters address the principal infectious and non-infectious causes of brain inflammation, including paraneoplastic encephalitides―an apparent autoimmune process in patients with malignancies―as well as acute disseminated encephalomyelitis, a post-infectious disorder. The book addresses etiology, epidemiology, and specific issues in diagnosis, pathology, and treatment, including various laboratory methodologies, pathologic changes seen in the different disorders, and diagnosis and management of the seizures that occur quite frequently in these disorders.

With contributions from a group of international experts, the book provides a perspective on this disorder that is both broad and in-depth.

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Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism

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EDITOR–IN–CHIEF: Clifford J. Rosen , M.D., Maine Medical Center Research Institute, Scarborough, Maine SENIOR ASSOCIATE EDITORS: Juliet E. Compston , M.D., FRCP, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom Jane B. Lian , Ph.D., University of Massachusetts Medical School, Worcester, Massachusetts This comprehensive yet concise handbook is an indispensable reference for the many clinicians who see patients with disorders of bone formation, metabolic bone diseases, or disorders of stone formation. It is also a crucial tool for researchers, students, and all other professionals working in the bone field. In a format designed for quick reference, it provides complete information on the symptoms, pathophysiology, diagnosis, and treatment of all common and rare bone and mineral disorders. New in this edition: detailed coverage of osteonecrosis of the jaw, more in–depth coverage of cancer and bone including new approaches to pathogenesis, diagnosis, and treatment; new approaches to anabolic therapy of osteoporosis; the latest research on Vitamin D; expanded coverage of international topics; more on the genetics of bone mass; and newer imaging techniques for the skeleton. In addition, this edition features a free, online–only appendix of medicines used to treat bone disorders and their availability around the world.

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Diagnosis: A System-Based Approach in Internal Medicine 1st Edition

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Diagnosis: A Symptom-based Approach in Internal Medicine is a concise guide to diagnosis various conditions, based on the symptoms presented. The book discusses in detail, both common and uncommon symptoms and their interpretation, to help practitioners achieve an accurate diagnosis and prescribe appropriate treatment. With the help of illustrations and images, the text also guides students and clinicians through possible red flags’, helping them not to mis-diagnose certain disorders.

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The Johns Hopkins Internal Medicine Board Review: Certification and Recertification, 5e 5th Edition

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Don’t gamble on the most important exam of your career… ace the boards with The Johns Hopkins Internal Medicine Board Review! Brought to you from the birthplace of Internal Medicine and regarded as the most effective review tool in the specialty, it will ensure you’re as equipped as possible on your way to certificationor recertification. From internists to primary care physicians, this no-nonsense book is a must-have companion for everyone in the field.

  • Respected experts summarize just the imperative information you need to know for certification or recertification.
  • Comprehensive review text, bolded key information, and helpful tables and algorithms equip you with all the core knowledge you need.
  • Exam-taking tips and tricks allow you to go into the exam with confidence.

 

  • Expert Consult eBook version included with purchase. This enhanced eBook experience allows you totest your skills and simulate the exam experience with over 1,000 additional exam questions in study and test modes.
  • Features full-color clinical images covering all the image types you’ll see on the boards, including x-rays, common skin findings, peripheral blood smears, ophthalmology findings, and CT and MR images.

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The Cleveland Clinic Foundation Intensive Review of Internal Medicine Sixth Edition

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Succeed on internal medicine board certification and recertification exams with Cleveland Clinic Intensive Board Review of Internal Medicine, 6e! The new edition contains ancillary and online exclusive content, drawing from the expertise of the distinguished Cleveland Clinic faculty. Taking a more clinical approach than other review texts, this practical resource includes a unique and well-structured set of exercises that offer a challenge at the end of each chapter.

Master essential concepts of the major subspecialty areas in internal medicine with expert information, clinical       vignettes, and coverage of crucial clinical points in each chapter. Streamline your study with the book’s emphasis on the facts and scenarios most likely to be encountered in internal medicine boards. Build your confidence, competence, and test-taking skills through online board exam simulations that integrate relevant clinical cases, pathology, and imaging studies. Assess your areas of personal strength and fill in any gaps in knowledge with concise, focused guidance from distinguished Cleveland Clinic faculty. Test your knowledge and skills using the book’s more than 700 board-review style questions and answers in print. Quickly access the facts you need through the book’s combination of prose and bulleted lists. Focus your review time on specific clinical areas using the fully searchable text online, organized by topic and packed with clinical pearls and vignettes.

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Master the Wards: Internal Medicine Handbook, Third Edition 3rd Edition

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Master the Wards: Internal Medicine Handbook improves your confidence so you can survive the clerkship and ace the shelf. With this in hand, you can arrive prepared on day 1 of your medicine rotation. Written by a residency director who has been a clerkship director–and once, long ago, a med student just like you!–this handbook presents a core set of diseases and disorders from the point of view of how patients present, and teaches you how to assess patients beginning with their chief complaints.

Special features help you look like a rock star and improve patient safety:

  • Organized by chief complaint
  • Round-Saver tips help you delivery quality care
  • How NOT to Kill Your Patient boxes point you to critical “don’t miss” diagnoses and things to look out for
  • Things You Will Be Asked On Rounds boxes prep you for attendings’ questions

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