Infectious Diseases ⋆ Page 9 of 18 ⋆ eMEDICAL BOOKS

Primary Immunodeficiency Diseases: Definition, Diagnosis, and Management 2nd ed. 2017 Edition

November 7, 2017

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The number of diagnosed cases of primary immunodeficiency diseases (PIDs) – a group of inborn disorders of the immune system – is growing rapidly, but misdiagnosis or late diagnosis still occurs in a significant number of patients, with serious consequences. This is the second edition of a practical reference textbook on PIDs that has been widely welcomed by scientists and clinicians from around the world. The new edition has been extensively revised to reflect advances in knowledge and includes various PIDs not previously covered. For each disease, information is provided on definition, etiology, clinical manifestations, diagnosis, and management. This book will represent an ideal resource for specialists when engaging in diagnosis, clinical decision-making, and treatment planning. It will also prove invaluable for doctors in training and other physicians and nurses who wish to learn more about PIDs.

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Infectious Diseases

Molecular Techniques for the Study of Hospital Acquired Infection 1st Edition

November 7, 2017

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Latest findings, practices, and strategies to detect and control nosocomial infections

Nosocomial infections, also known as hospital acquired infections, represent a growing challenge to healthcare facilities around the world. Many nosocomial pathogens are becoming more and more resistant to treatment, resulting in higher morbidity, mortality, and cost. In fact, each year it is estimated that some two million patients develop a hospital-acquired infection in the United States, representing nearly 5% of all hospitalized patients.

Molecular Techniques for the Study of Hospital Acquired Infection reviews the latest findings, practices, and strategies to support the development and implementation of effective, comprehensive programs to study and control hospital acquired infections. It focuses on the application of molecular techniques, enabling hospitals to incorporate these state-of-the-technology techniques into their infection control programs.

Key topics include:

Characteristics of healthcare settings that allow for the development and spread of nosocomial pathogens
Implementation of effective infection control programs
Epidemiological methods to study nosocomial disease
Elimination of pathogens and the development of resistance to treatment
Molecular techniques to study hospital acquired infections and their application in characterizing important Gram-positive, Gram-negative, and fungal pathogens

Contributions come from leading international experts in nosocomial pathogen detection and control. These contributions are based on the authors’ own firsthand experience combined with a thorough review and analysis of the current literature. References at the end of each chapter enable readers to explore each individual topic in greater depth.

Molecular Techniques for the Study of Hospital Acquired Infection is highly recommended as a guide for hospital infection control programs. Moreover, it serves as a text for courses in infection control and the population biology of nosocomial infection. In particular, the book’s unique clinical perspective helps readers minimize nosocomial infections by developing a coordinated approach to infection control, laboratory methods, and clinical practices.

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Infectious Diseases

Periprosthetic Joint Infection of the Hip and Knee

November 5, 2017

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Periprosthetic Joint Infection of the Hip and Knee is a practical reference for the diagnosis and treatment of total joint infections following hip and knee arthroplasty. In addition to useful chapters presenting common tests and algorithms used for diagnosis, the book gives background on the epidemiology, risk factors, and prevention strategies of periprosthetic joint infection. Additionally, practical clinical information is given, including antibiotic treatment strategies and delivery methods and medical optimization techniques for physicians to follow for patient care and follow-up. Covering a topic that is currently underrepresented in the medical literature, Periprosthetic Joint Infection of the Hip and Knee will be useful to orthopedic surgeons, rheumatologists, and other physicians involved in the care of patients with hip and knee prosthetic implants.

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Use of Biocidal Surfaces for Reduction of Healthcare Acquired Infections

November 5, 2017

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“This book focuses primarily on a relatively novel approach to reducing HAIs through the use of biocidal surfaces in healthcare facilities. … This book may be of interest to infection preventionists, hospital epidemiologists, quality management personnel, or any other members of the healthcare team, including hospital administrators, whose decisions may impact the rate of HAIs.” (Farrin A. Manian, Doody’s Book Reviews, February, 2015)

From the Back Cover

The notion that contaminated environments in hospital settings significantly contribute to the risk of an individual acquiring an infection while hospitalized is continuously gaining recognition by the medical community. There is a clear correlation between the environmental bioburden present in a clinical setting and the risk of patients acquiring an infection. Thus using self-disinfecting surfaces can be a very important adjunct in the fight against nosocomial pathogens.

This book reviews the increasing evidence that contaminated non-intrusive soft and hard surfaces located in the clinical surroundings are a source of nosocomial pathogens and focuses on the utility of copper containing materials in reducing bioburden and fighting hospital acquired infections. It also reviews other biocidal surface alternatives and the economics of using biocidal surfaces in a hospital environment. Finally, it discusses the pros and cons of existent disinfection modalities other than biocidal surfaces.

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Infectious Diseases

Infectious Diseases in Critical Care Medicine, Third Edition (Infectious Disease and Therapy) 3rd Edition

November 2, 2017

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A clinically focused overview of infectious disease and critical care medicine.

The Third Edition of Infectious Disease in Critical Care Medicine presents clear diagnostic methods, strategies, and knowledge on antimicrobials crucial to avoiding complications and ensuring patient recovery in the CCU.

Comprehensive yet succinct, this source discusses all clinical infectious diseases from pneumonia and empyema to central nervous system and antibiotic-related infections.

Highlights include:

the latest research on MRSA and VRE
100 high quality illustrations
four new chapters on:
- military TB
- infections related to immunosuppressive immunomodulating agents
- therapy for MRSA and VRE
- therapy for MDR klebsiella, pseudomonas, and aceinetobacter

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Atlas of Sexually Transmitted Diseases: Clinical Aspects and Differential Diagnosis 1st ed. 2018 Edition

October 27, 2017

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The Atlas of Sexually Transmitted Diseases and Differential Diagnosis is a complete course through the most important sexual diseases. Counting with about 1000 figures, this atlas focuses on the peculiar characteristics of each of these diseases and in the relevant aspects for a proper differential diagnosis. It is authored by MDs with a deep knowledge in the field, providing a very comprehensive casuistry. Throughout the book the reader will have access to hundreds of pictures discussing about the most important sexually transmitted diseases. Each chapter will approach a different disease, providing a broad sort of images, since a microscopic perspective until the most classical genital lesions and characteristics, considering also systemic manifestations. Every figure is presented with a descriptive and instructive legend, providing the reader with all possible related information. Additionally, every chapter begins with an explanatory and introductory text disclosing about key aspects of the disease, such as etiopathogenesis; clinical manifestation; clinical, laboratorial and differential diagnosis; treatment and prevention.

About the Author

Dr. Mauro Romero Leal Passos is an MD, with a Masters in Gynecology Medicine and a PhD in Microbiology from the Federal University of Rio de Janeiro, Brazil. He is currently Professor and Chief of the Department of Sexually Transmissible Diseases of the Department of Microbiology and Parasitology at the same university. Dr. Mauro was one of the founders of the Brazilian STD Society and current editor-in-chief of the Brazilian Journal of STD (open access), since its launch in 1989. Has experience in the areas of genital infectious diseases and medical microbiology, with special emphasis on sexually transmitted diseases, syphilis, HPV and HIV.

In 2013, on Rio de Janeiro’s Copacabana Beach, along with hundreds of Brazilian citizens, he organized the Vaccine March, an action that charged the Federal Government of Brazil the free availability of HPV vaccine. Two months after the popular activity led by Dr. Mauro Romero, the Brazilian Ministry of Health announced the introduction in the National Immunization Program schedule of vaccination for girls aged 9 – 13 years with the quadrivalent vaccine against HPV 6, 11, 16, 18. In 2004, Dr. Romero authored the Document of Niterói to Combat Acquired and Congenital Syphilis. On March 9, 2017, the Federal Law was approved creating the National Day to Combat Syphilis, to be celebrated on the third Saturday of October of each year.

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Sphingosine-1-Phosphate Signaling in Immunology and Infectious Diseases (Current Topics in Microbiology and Immunology)

October 27, 2017

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This volume focuses on the role of sphingosine-1-phosphate (S1P) and its analogs in the induced sequestration of lymphocytes in secondary lymphoid organs or in the microenvironment of tissues involved in infection or autoimmune disease. Initial chapters define the pathways to understand S1P signaling. They cover the organization of signaling systems, the structural biology of the S1P1 receptor, and the chemical and genetic tools that are available and useful to explore this area of research and therapeutics. The later chapters highlight S1P and endothelial integrity, lymphocyte migration in the spleen, and S1P agonist in controlling immunopathologic manifestations of acute respiratory influenza virus infection (in the lung), and its accompanying cytokine storm as well as immunopathologic disease of the central nervous system, including the beginning of treatments in multiple sclerosis. One chapter reveals the possible involvement of other lipid molecules, their use for better understanding lipid signaling, and their potential in the modulation of immune responses.

About the Author

Michael B.A. Oldstone has been a successful series editor, volume editor and author of Current Topics in Microbiology and Immunology for several decades. He is a professor based at The Scripps Research Institute, La Jolla, CA, and a member of the National Academy of Sciences. Hugh Rosen is a professor at The Scripps Research Institute, La Jolla, CA, USA.

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Infections in the Adult Intensive Care Unit

October 27, 2017

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“This small book is devoted to the basic science and general epidemiology of infections that may complicate critical care practice. … Infectious disease consultants and laboratory staff supporting infection control programs are an appropriate audience for this work, written by three specialists from the U.K. … It emphasizes epidemiology and a scientific approach to infection in an effective presentation.” (David J. Dries, Doody’s Book Reviews, May, 2013)

From the Back Cover

Infections in critically ill patients are more common than in most other parts of the hospital, and are often the most complicated to manage. Underlying disease and the reasons for admission make the diagnosis, management and prevention of infection challenging. Developments in technology, the treatment of previously untreatable malignancies, complex surgery procedures, and an increasing age profile result in more patients vulnerable to infection and a greater number of patients needing critical care support.

Infections in the Adult Intensive Care Unit is designed to help trainee and practicising physician, surgeon or other medical professional manage the acutely ill patient in the critical care unit, before transfer from the emergency department, or on the hospital ward where effective management may avoid admission to the critical care unit. It has been co-authored by a clinical microbiologist, intensivist and clinical infectious diseases physician to cover some of the major infections presenting in the adult critical care unit. It provides broad principles to be used based on the latest evidence combined with common sense and the results of many years of combined experience.

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Human Respiratory Viral Infections 1st Edition

October 20, 2017

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Using a multidisciplinary approach, Human Respiratory Viral Infections is set at the level between the definitive reference work and an essential clinical manual. Exploring recent advances in human respiratory viral research, the text builds on the basic sciences of epidemiology, virology, molecular biology, and immunology to cover clinical diagnosis, mechanism of pathogenesis, manifestations of disease, impact, treatment, and management strategies.

Provides a comprehensive review of all the major human respiratory viral infections
Supplies a detailed description of the anatomy of the respiratory system
Discusses the salient features of specific viruses
Examines the latest diagnostic tools
Covers risk factors associated with incidence of respiratory viral infections in children and adults in different occupational and environmental settings

Presenting the latest knowledge in human respiratory viral infections, this text will be immensely valuable for pulmonologists, biomedical scientists, research scholars, virologists, vaccinologists, immunologists, clinicians, pharmacologists, and public health specialists.

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Management of Periprosthetic Joint Infection: A global perspective on diagnosis, treatment options, prevention strategies and their economic impact 1st ed. 2018 Edition

October 18, 2017

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Periprosthetic joint infection (PJI) is among the most serious complications in the field of endoprosthetics. The number of PJIs is increasing worldwide and poses a real interdisciplinary challenge for everyone involved. For the patient concerned, it is necessary to promptly work out an adequate therapy solution to fight off the infection. Both the clinical experience of the surgeon and the proper diagnostic processes are prerequisite for the reliable detection and identification of an infection. The microbiologist is responsible for identifying the causative germs by screening the patient’s synovial fluid and tissue samples. Based on the findings and subsequent resistance testing, the infectious disease specialist can recommend the appropriate antibiotic therapy. Furthermore, the clinical pharmacist is consulted regularly throughout the therapy to discuss the risk of potential drug interactions. The surgeon will proceed with the revision surgery, following defined algorithms. Adequate radical debridement of infected and necrotic surrounding tissue is the most important step towards a successful cure of the infection. Accompanying the surgery, anti-infective agents are given systemically and locally. While systemic application of anti-infectives mainly reduces the number of haematogenic-spreading planktonic germs, local application immediately forms a colonization barrier and protects the implant from sessile biofilm formation. Concurrently, antibiotics are actively released from the implant, resulting in local germ reduction. Thus, local agents are embedded in the concept of surgical PJI treatment as a reliable adjuvant measure and they sustainably support the successful outcome. In one-stage procedures, local agents are released from specialized antibiotic-loaded bone cements, while in two- or multi-stage procedures, local agents are released from corresponding temporary spacers (interim prostheses). Even from an economic standpoint, the combination of systemic and local agent application is meaningful. Furthermore, there are some interesting trends towards the coating of metallic implants to protect against biofilm formation on the implant surface.

On the basis of their personal experience, specialists from all over the world present, explain and discuss preventive approaches, appropriate diagnostic strategies for detection, reproducible effective surgical treatments as well as the economic impact of PJI. The reader can use this book as a solid platform for comparing their own approach to PJI treatment with the specialists’ recommendations.

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