Comprised exclusively of clinical cases presenting injuries to and management of the rotator cuff, this concise, practical casebook will provide orthopedic surgeons with the best real-world strategies to properly manage the various kinds of cuff injury they may encounter. Each chapter is a case that opens with a unique clinical presentation, followed by a description of the diagnosis, assessment and management techniques used to treat it, as well as the case outcome, literature review and clinical pearls and pitfalls. Cases included illustrate different management strategies for rotator cuff surgery, including arthroscopic repair for tendonitis and tears, open and mini-open repair for severe tears, latissimus dorsi and pectoralis tendon transfer, arthroscopic debridement, hemiarthroplasty and total reverse arthroplasty, biological augmentation, and revision repair after retear and infection.
al Casebook is an excellent resource for orthopedic surgeons and sports medicine specialists confronted with both common and complex injuries to the rotator cuff.
Patrick J. McMahon, MD, Adjunct Associate Professor, University of Pittsburgh, Department of Bioengineering, McMahon Orthopedics and Rehabilitation (MORe), Pittsburgh, PA, USA
MRI Atlas of Prostate Cancer analyses high-resolution MRI scanning and dynamic contrast-enhanced (DCE) MRI. This combination improves the diagnosis and staging of prostate cancer and may soon replace PSA testing and digital rectal examination. The first two chapters focus on normal anatomy, anatomic variations, benign disease and intraprostatic tumors. The subsequent chapters on MRI of extracapsular disease create a useful atlas of pathologic anatomy. This is the first text of its kind to show color-coded DCE-MRI scans of prostate cancer and to correlate these imaging findings with tumor grading. The chapters on the post-treatment prostate clearly display the increasing incidence of post-therapy recurrences. This book is intended for internists, radiologists, radiotherapists, oncologists, urologists, family practitioners, and general surgeons. Ultrasound, MRI, and radiotherapy technicians will find it extremely useful as a reference guide.
This volume provides an integrated account of our current understanding of the functions of D-type cyclins during development and tumorigenesis, with special emphasis on the kinase-independent functions of these proteins. The volume will provide a thorough review of the latest discoveries on the new functions and interacting partners of mammalian cyclin Ds crucial to explain their oncogenic and differentiation properties in different cellular contexts. The volume begins with a historical perspective of how D-type cyclins were first discovered and eventually cloned from cancer tissues, followed by an account on the canonical functions of cyclin Ds during the G1-S transition of the cell cycle. Several chapters will be devoted to review the functions of D-type cyclins as transcriptional regulators and the mechanisms through which these novel functions could impact the tumorigenic process. Also discussed is emerging evidence that points to a role of D-type cyclins, particularly cyclin D1, as a cytoplasmic regulator of various cellular functions. This property, in human cells at least, is traceable to certain splice isoforms with novel oncogenic implications. Finally, a chapter is devoted to recent efforts to revise the canonical view of the “retinoblastoma pathway” to incorporate new evidence that suggests that cyclin D1’s role in G1 is to singly-phosphorylate the retinoblastoma protein (pRb) for discrimination of target protein interactions. This work represents a significant departure from the view of cyclin D1 as a negative regulator of pRb and may have critical implications for understanding the function of antineoplastic agents that target the cyclin D1-associated kinases.
Philip W. Hinds is Professor and Chair of the Department of Developmental, Molecular and Chemical Biology at Tufts University School of Medicine. He is also the Deputy Director of Tufts Medical Cancer Center. Dr. Hinds is an expert in cell cycle control and its dysregulation in cancer cells. He participates in several journal editorial boards including the Journal of Biological Chemistry, the Chinese Journal of Cancer, and Cancer Research to name a few.
Nelson E. Brown is currently Associate Professor at the University of Talca School of Medicine in Chile. He is also Director of the Center for Medical Research at the University of Talca. His current work focuses on the role of cyclin D1-associated kinase activity in senescence and tumorigenesis
Hepatocellular carcinoma (HCC) is the third most common cause of cancer related death in the United States. Treatment options are limited. Viral hepatitis is one of the major risk factors for HCC, which represents a typical “inflammation-induced” cancer.Immune-based treatment approaches have revolutionized oncology in recent years. Various treatment strategies have received FDA approval including dendritic cell vaccination, for prostate cancer as well as immune checkpoint inhibition targeting the CTLA4 or the PD1/PDL1 axis in melanoma, lung, and kidney cancer. Additionally, cell based therapies (adoptive T cell therapy, CAR T cells and TCR transduced T cells) have demonstrated significant efficacy in patients with B cell malignancies and melanoma. Immune checkpoint inhibitors in particular have generated enormous excitement across the entire field of oncology, providing a significant benefit to a minority of patients.
Professor Tim F. Greten has received his training in Gastroenterology, Hepatology and Medical Oncology. He has been treating patients with hepatocellular carcinoma (HCC) for many years has been leading a number of clinical trials. Apart from his clinical expertise Professor Greten has been interested in the immunological aspects of HCC for more than 20 years. He is conducting basic research studies, which he published in the very top scientific journals including Nature, and Cancer Cell and is also a pioneer in immunotherapy studies in HCC. He published a number of different clinical trials testing different immune based approaches in HCC. Based on this medical and basic science background is considered on the world leaders in tumor immunology and immunotherapy of HCC.
This book examines a range of contemporary ideas and arguments concerning the core yet unsettled clinical issues. Important aspects of pulmonary disorders are tackled such as occupational and environmental respiratory health hazards, the role of vitamin D supplementation in airway allergy, or nutritional aspects of care for lung cancer patients. Metabolic disorders affecting the processes of atherogenesis and systemic inflammation also are tackled. Attention is directed to rare but severe pediatric disease entities. Articles give readers practice at analyzing clinical data. The practical insights emphasize the role of science in transforming biomedical knowledge and care. This volume will be essential reading for clinicians, researchers, and other healthcare professionals engaged in effective patient care and therapy.
Periprosthetic joint infection (PJI) is among the most serious complications in the field of endoprosthetics. The number of PJIs is increasing worldwide and poses a real interdisciplinary challenge for everyone involved. For the patient concerned, it is necessary to promptly work out an adequate therapy solution to fight off the infection. Both the clinical experience of the surgeon and the proper diagnostic processes are prerequisite for the reliable detection and identification of an infection. The microbiologist is responsible for identifying the causative germs by screening the patient’s synovial fluid and tissue samples. Based on the findings and subsequent resistance testing, the infectious disease specialist can recommend the appropriate antibiotic therapy. Furthermore, the clinical pharmacist is consulted regularly throughout the therapy to discuss the risk of potential drug interactions. The surgeon will proceed with the revision surgery, following defined algorithms. Adequate radical debridement of infected and necrotic surrounding tissue is the most important step towards a successful cure of the infection. Accompanying the surgery, anti-infective agents are given systemically and locally. While systemic application of anti-infectives mainly reduces the number of haematogenic-spreading planktonic germs, local application immediately forms a colonization barrier and protects the implant from sessile biofilm formation. Concurrently, antibiotics are actively released from the implant, resulting in local germ reduction. Thus, local agents are embedded in the concept of surgical PJI treatment as a reliable adjuvant measure and they sustainably support the successful outcome. In one-stage procedures, local agents are released from specialized antibiotic-loaded bone cements, while in two- or multi-stage procedures, local agents are released from corresponding temporary spacers (interim prostheses). Even from an economic standpoint, the combination of systemic and local agent application is meaningful. Furthermore, there are some interesting trends towards the coating of metallic implants to protect against biofilm formation on the implant surface.
On the basis of their personal experience, specialists from all over the world present, explain and discuss preventive approaches, appropriate diagnostic strategies for detection, reproducible effective surgical treatments as well as the economic impact of PJI. The reader can use this book as a solid platform for comparing their own approach to PJI treatment with the specialists’ recommendations.
Orthopaedic Manual Therapy Diagnosis is a comprehensive and easily-accessible compendium of theory and technique related to orthopaedic manual therapy (OMT). This essential resource covers key topics such as spinal anatomy, biomechanics, arthrology, general functional aspects of the spine, definitions, theories, and examination. This text combines a comprehensive discussion of both the pathophysiologic rationale and the applied evidence base with regard to OMT diagnosis. It demonstrates numerous diagnostic techniques used in the clinical practice of manual medicine. Providing an up-to-date analysis of spinal examination, this is an ideal textbook for courses in OMT. It also serves as a reference for all manual medicine practitioners including physical therapists, chiropractors, osteopaths, and medical physicians.
How to Succeed at the Medical Interview provides candidates with a competitive edge. It reduces the likelihood of unexpected questions or situations and helps improve confidence before and during the medical interview.
This new second edition includes updated content on changes to the structure of healthcare and how this affects both the application and interview process. It details the types of questions that will be asked at medical interviews and also provides improved guidance for overseas doctors and healthcare professionals and for those seeking to practice abroad.
How to Succeed at the Medical Interview is the ideal guide for Foundation Programme trainees, Specialist Registrars and General Practitioner trainees. It is also valuable for healthcare professionals facing competitive medical interviews at any stage of their career.
Body MR Imaging at 3.0 Tesla is a practical text enabling radiologists to maximise the benefits of high field 3T MR systems in a range of body applications. It explains the physical principles of MR imaging using 3T magnets, and the differences between 1.5T and 3T when applied extracranially. The book’s organ-based approach focuses on optimized techniques, providing recommended protocols for the main vendors of 3T MRI systems. All major thoracic and abdominal organs are covered, including breast, heart, liver, pancreas, the GI tract, kidneys, prostate and female pelvic organs. Abdominal and pelvic MR angiography and MRCP are also discussed. Protocol optimization, appearance of artifacts and novel applications using 3T are emphasized. Written and edited by experts in the field, Body MR Imaging at 3.0 Tesla guides radiologists in optimizing imaging protocols for 3T MR systems, reducing artifacts and identifying the advantages of using 3T in body applications.