Litt’s Drug Eruption and Reaction Manual, 22nd Edition 22nd Edition

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Internationally relied upon by medical practitioners for its unparalleled focus on adverse effects and cutaneous reactions, Litt’s Drug Eruption & Reaction Manual is a succinct clinical reference and essential drug-safety tool for patient care. The new edition has been comprehensively revised and updated, featuring an enlarged section of tables for class reactions and new entries for recently licensed drugs. It has been comprehensively revised and updated throughout to act as a quick reference, and each entry includes:

  • Summaries of numbers of reports and incidence for reactions
  • Clinically important and potentially hazardous drug–drug interactions
  • Categories of adverse drug reactions, eruptions, and cutaneous reaction patterns
  • Essential reference information on prescription and over-the-counter drugs as well as biologics and supplements

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Get ahead! Medicine: 150 EMQs for Finals, Second Edition 2nd Edition

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The new edition of Get ahead! Medicine: 150 EMQs for Finals has been completely updated by two junior doctors who have achieved recent success in their finals, overseen by the book’s experienced author team. The 150 EMQ themes, each with five stems, are arranged as 10 practice papers, each containing 15 themes. All the main conditions are included as well as more detailed knowledge suitable for candidates aiming at the higher deciles.

The questions are written to follow the house style of the Medical Schools Council Assessment Alliance EMQs and are therefore of a similar format to those you can expect in your exams. All the questions are accompanied by explanatory answers, including a succinct summary of the key features of each condition. Whether you work through the practice papers systematically or dip in and out by topic, this bestselling revision guide will offer a life rope for anyone preparing for undergraduate finals.

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Adverse Drug Interactions: A Handbook for Prescribers, Second Edition 2nd Edition

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Adverse Drug Interactions: A Handbook for Prescribers assists clinicians by providing key information on potential adverse effects that can result from prescribing two or more drugs for simultaneous use.

Interactions that are likely to give rise to life-threatening conditions, and which must therefore be completely avoided, are clearly highlighted. Less threatening but nonetheless important interactions necessitating practical measures, such as frequent monitoring and advice to patients, are also discussed.

Presented in a user-friendly format, the book is organised by drug class and provides a brief summary of the mechanism underlying a particular interaction, alternative drugs lacking the same reactions that may be considered, and instructions for monitoring patients when adverse effects occur.

All interactions listed in the previous edition have been reviewed and updated using the latest information available. The clinical reality of the widespread use of potent medicines, whether allopathic, herbal or traditional, has led to the inclusion of a chapter specifically addressing over-the-counter drugs and remedies.

Importantly, the increasing relevance of drug interactions due to genetic polymorphisms of metabolizing enzymes and drug transporters and the associated influence of these in ethnic groups is discussed. Also discussed is the risk of interactions in many vulnerable population groups (e.g. infancy, pregnancy, infections, liver and kidney disease).

This quick and easy reference guide brings together the current evidence base with a broad range of practical prescribing experience to produce a source of advice that can be used in the clinic, pharmacy, or at the patient’s bedside.

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Textbook of Drug Design and Discovery, Fifth Edition 5th Edition

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Building on the success of the previous editions, the Textbook of Drug Design and Discovery, Fifth Edition, has been thoroughly revised and updated to provide a complete source of information on all facets of drug design and discovery for students of chemistry, pharmacy, pharmacology, biochemistry, and medicine. The information is presented in an up-to-date review form with an underlying and fundamental focus on the educational aspects.

Beginning with an introduction to drug design and discovery, the first eight chapters cover molecular recognition, ligand-based drug design, and biostructure-based drug design. The authors also discuss drug-like properties and decision making in medicinal chemistry, chemical biology, natural products in drug discovery, and in vivo imaging in drug discovery.

The middle six chapters provide an overview of peptide and protein drug design, prodrugs in drug design and development, and enzyme inhibitors. The authors also go through receptors (structure, function, and pharmacology), ion channels (structure and function), and neurotransmitter transporters (structure, function, and drug binding).

The following chapters address important neurotransmitter systems, GABA and glutamic acid receptors and transporter ligands, acetylcholine, histamine, dopamine and serotonin, and opioid and cannabinoid receptors. The book concludes with an examination of neglected diseases, anticancer agents, tyrosine kinase receptors, and antibiotics.

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Human Drug Targets: A Compendium for Pharmaceutical Discovery 1st Edition

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The identification of drug targets in a given disease has been central to pharmaceutical research from the latter half of the 20th century right up to the modern genomics era. Human Drug Targets provides an essential guide to one of the most important aspects of drug discovery – the identification of suitable protein and RNA targets prior to the creation of drug development candidates.

The first part of the book consists of introductory chapters that provide the background to drug target discovery and highlight the way in which these targets have been organised into online databases. It also includes a user’s guide to the list of entries that forms the bulk of the book.

Since this is not designed to be a compendium of drugs, the emphasis will be on the known (or speculated) biological role of the targets and not on the issues associated with pharmaceutical development. The objective is to provide just enough information to be informative and prompt further searches, while keeping the amount of text for each of the many entries to a minimum.

Human Drug Targets will prove invaluable to those drug discovery professionals, in both industry and academia, who need to make some sense of the bewildering array of online information sources on current and potential human drug targets. As well as creating order out of a complex target landscape, the book will act as an ideas generator for potentially novel targets that might form the basis of future discovery projects.

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Systems Pharmacology and Pharmacodynamics (AAPS Advances in the Pharmaceutical Sciences Series) 1st ed. 2016 Edition

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While systems biology and pharmacodynamics have evolved in parallel, there are significant interrelationships that can enhance drug discovery and enable optimized therapy for each patient. Systems pharmacology is the relatively new discipline that is the interface between these two methods. This book is the first to cover the expertise from systems biology and pharmacodynamics researchers, describing how systems pharmacology may be developed and refined further to show practical applications in drug development. There is a growing awareness that pharmaceutical companies should reduce the high attrition in the pipeline due to insufficient efficacy or toxicity found in proof-of-concept and/or Phase II studies. Systems Pharmacology and Pharmacodynamics discusses the framework for integrating information obtained from understanding physiological/pathological pathways (normal body function system vs. perturbed system due to disease) and pharmacological targets in order to predict clinical efficacy and adverse events through iterations between mathematical modeling and experimentation.

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Re-inventing Drug Development 1st Edition

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The biopharmaceutical industry has entered an era of unprecedented change and challenge, characterized by increasing pricing pressures, rising rates of attrition in the product development lifecycle, and decreasing scientific innovation. The most successful products are losing patent protection, and pipelines have been unable to fill the gap. This book explores the evolving definition of innovation in therapeutic product development and begins to examine its effects on the life sciences R&D industry.

Historically, scientific innovation alone was sufficient to maintain ROI and deliver on unmet medical needs. However, with many forces now conspiring to increase pressures on the commoditization of drug development, industry support for truly novel, often high-risk development has eroded. This calls for a drastic redefinition of what “innovation” is. While innovation in the pharmaceutical R&D industry has historically been applied to major advances in therapy and unmet medical needs, we now need to see innovation increasingly defined in terms of financial, marketing (e.g. branded generics and emerging markets), pharmacoeconomic, and operational innovation.

In this book, contributors drawn from the executive ranks of clinical development practitioners and stakeholders―from biopharmaceutical companies, clinical research organizations, academia, the financial community, and the patient perspective―have all come together to provide their expertise and visions. Their goal is to start a dialogue about ways to radically improve therapeutics development and get more and better medicines to the patients who need them, as fast as possible, in the most cost-efficient manner.

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Principles of Immunopharmacology

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The rapid developments in immunology in recent immunomodulatory drugs can be distinguished years have dramatically expanded our knowledge of from their beneficial therapeutic effects. mammalian host defence mechanisms. The molecu- Currently,it is only possible to obtain an overview lar mechanisms of cellular interactions during of these various aspects of immunopharmacology immune responses have been unravelled,the intra- by reading a range of immunological,pharmacol- cellular responses involved in signal transduction ical,diagnostic and toxicological literature. Good delineated and an ever-increasing number of soluble immunological textbooks are available, while mediators of immune and inflammatory reponses immunopharmacology is covered mainly in terms of have been discovered. the inflammatory response. Principles of Immuno- The initial result of this explosion of knowledge pharmacology is intended to provide for the first time has been to provide the researcher and the clinician in a single volume a basic understanding of with an arsenal of diagnostic tools with which the immunological mechanisms,a review of important immunological bases of disease processes can be immunodiagnostic tools and a description of the investigated. This has made disease diagnosis much main pharmacological agents which modify the more precise,enabling the physician to tailor therapy immune response,together with an introduction to much more closely to the individual patient’s needs. immunotoxicology. As such we hope that it will be However,better understanding of disease processes useful as a reference text for physicians,researchers only provides a gradual improvement in therapy. This and students with a rudimentary knowledge of is because the new molecular targets that have been immunology.

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Biomedical and Pharmaceutical Applications of Electrochemistry (Modern Aspects of Electrochemistry) 1st ed. 2016 Edition

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This volume of Modern Aspects of Electrochemistry reviews the latest developments in electrochemical science and technology related to biomedical and pharmaceutical applications.
In particular, this book discusses electrochemical applications to medical devices, implants, antimicrobially active materials, and drug delivery systems.

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