Pathology and Biology of Human Germ Cell Tumors 1st ed

This book provides, for the first time, a detailed, up-to-date, holistic approach to the pathology and biology of germ cell tumors. The main focus is the complex histopathology of these tumors, but special considerations are also given to their morphologic variations in relation to age, gender and organ. Critical updates are provided on terminology and classification; the discussion of biology and pathogenesis includes references to many molecular genetic and immunohistochemical findings from recent stem cell research. Individual chapters are devoted to germ cell tumors at different anatomic locations, including not only the ovaries and testes but also the mediastinum and central nervous system, and pediatric tumors. All of the contributing authors are opinion leaders from universities of excellence in Europe and the United States. This monograph will be of wide interest to practitioners and researchers in many fields of medicine, including pathology, gynecology, urology, and pediatrics, as well as stem cell scientists.


Pathogenesis of Idiopathic Scoliosis 1st ed. 2018 Edition

This book provides comprehensive coverage of current topics in idiopathic scoliosis (IS). A three-dimensional deformity of the spine, the condition is characterized by lateral curvature combined with vertebral rotation. The primary lesion, however, lies in the median sagittal plane, taking the form of a lordosis. Although the clinical manifestations of scoliosis have been well documented, its cause and pathogenesis have not yet been determined. Research into what causes IS has focused on the structural elements of the spine, spinal musculature, collagenous structures, the endocrine system, the central nervous system, and genetics. Results of these studies have brought about a new perception of IS epiphenomena, but the main cause of IS remains unknown. Recently, several investigators have produced new hypotheses regarding the cause of IS using the developing techniques of genetics, biochemistry, and neurology. This book is a review of the various causative factors thus far proposed for IS and an introduction to the directions in which research is heading to determine the primary cause of IS.


Molecular Pathology in Cancer Research 1st ed

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About the Author

Desquamative gingivitis – A clinico-pathologic study: Erythematous Gingiva, Incisional biopsy, Histopathology of Muco-cutaneous disorders

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Gingival Desquamation is a clinical manifestation in many inflammatory and immunological disorders. Although, Oral lichen planus, pemphigus vulgaris and mucous membrane pemphigoid accounts for majority of cases of gingival desquamation, but rare case such as Linear Ig A disease, Plasma cell gingivitis, tuberculosis and chronic ulcerative stomatitis should also be taken into consideration. Gingival Desquamation may present as the only manifestation in some cases, while, it may be associated with other oral and extra oral manifestations, like wickham’s striae in lichen planus, Nikolsky’s sign in pemphigus vulgaris, Ocular involvement in mucous membrane pemphigoid which help in diagnosis. In such cases, the patient should be referred to the concerned specialists for extra oral lesions. Cases where gingival desquamation is the only presenting feature,should be carefully taken care of, as they can mimic plaque induced gingivitis.Thus, familiarisation of various clinical presentation of gingival desquamation is essential for early diagnosis and treatment planning.This book, deals in detail the various causes for gingival desquamation, along with the histopathological features.


Pathology for Surgeons in Training 3rd Edition

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Previous editions of this book have proved indispensable for trainee surgeons preparing for the MRCS and AFRCS examinations.
This extensively revised new edition is presented in a compelling new style and in a larger format. Beginning with a ‘route-map’ showing ‘how to use this book’, the text offers concise accounts of the core topics in pathology required of surgeons in training. There is particular emphasis on tissue pathology but full account is taken of relevant aspects of microbiology, haematology, immunology and clinical chemistry. Tables of normal laboratory values are included.

Each major disorder is examined from the point of view of Cause, Structure, and Behaviour. Genetics, molecular biology and imaging receive balanced attention as do transfusion, telepathology and audit. The use of computers is outlined and suggestions given on access to Internet sources for learning purposes. The needs of trainees in countries outside Europe have been considered carefully.

Illustrations have been selected to provide a clear, pictorial account of complex points. The inclusion of biographies of surgical pioneers adds interest and enables candidates to put their knowledge into context. A special feature is a series of marginal ‘signposts’ in the form ‘Now Read’ that take candidates to interrelated topics quickly and easily. There is extensive cross-referencing and a comprehensive index.


Pathology of the Bile Duct 1st ed

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This book provides a comprehensive overview of the research on bile duct pathology, from basic theory to practical aspects, and presents the latest advances. The contributing authors extensively discuss the topics from different perspectives, including the pathogenesis of conditions such as cellular senescence and innate immunity as well as diseases such as IgG4-related sclerosing cholangitis and intraductal papillary neoplasm.

Pathology of the Bile Duct is a valuable resource not only for clinicians in various disciplines, such as internal medicine, surgery, pediatrics and radiology, but also for pathologists. Further, it allows practitioners and researchers at all levels to broaden their understanding of the subject and to explore the latest findings in bile duct pathology.


Precision Molecular Pathology of Lung Cancer (Molecular Pathology Library) 2nd ed. 2018 Edition

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This new edition provides the latest information and insights into the molecular basis for lung cancer. Since the publication of the previous edition of this volume, dramatic changes have occurred with the classification of lung cancer, biomarker testing, and molecular therapy. The book covers these changes, providing updates and new insights on the background of lung cancer, testing methods, and the molecular pathology of specific cell types, including adenocarcinoma, squamous cell carcinoma, small cell carcinoma, and precursor and preinvasive lesions.
Authored by experts in the field, Precision Molecular Pathology of Lung Cancer, Second Edition remains one of the few books that comprehensively covers the new molecular pathology of lung cancer and is a valuable resource for pathologists, medical oncologists, radiation oncologists, thoracic surgeons, and thoracic radiologists.


Unhappiness, Sadness and ‘Depression’: Antidepressants and the Mental Disorder Epidemic 1st ed

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This book examines existing treatments, legislation and research methodology of depression and exposes their limitations, championing psycho-social support as an alternative. Depression, affecting 350 million people according to the World Health Organisation, is almost invariably diagnosed by the criteria of the American Psychiatric Association – a definition which encompasses those with normal emotional responses to stressful life events.

Tullio Giraldi discusses recent developments in popular and academic dialogue related to the use of antidepressants and recent increases in depression diagnosis and laments the rise in prescribing antidepressants despite their links to suicide and unfulfilled promises of efficacy and safety. He argues that psychotherapy is a cost effective treatment devoid of drugs’ adverse effects. This work presents psycho-social support as an alternative to antidepressants, particularly for less severe cases, and as a more effective strategy for coping with the emotional challenges of today’s global reality. Patients, students of medicine and psychology, and professionals of mental health will find this work valuable.


Nicotine Psychopharmacology (Handbook of Experimental Pharmacology)

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The fact that tobacco ingestion can affect how people feel and think has been known for millennia, placing the plant among those used spiritually, honori?cally, and habitually (Corti 1931; Wilbert 1987). However, the conclusion that nicotine – counted for many of these psychopharmacological effects did not emerge until the nineteenth century (Langley 1905). This was elegantly described by Lewin in 1931 as follows: “The decisive factor in the effects of tobacco, desired or undesired, is nicotine. . . ”(Lewin 1998). The use of nicotine as a pharmacological probe to und- stand physiological functioning at the dawn of the twentieth century was a landmark in the birth of modern neuropharmacology (Limbird 2004; Halliwell 2007), and led the pioneering researcher John Langley to conclude that there must exist some “- ceptive substance” to explain the diverse actions of various substances, including nicotine, when applied to muscle tissue (Langley 1905). Research on tobacco and nicotine progressed throughout the twentieth century, but much of this was from a general pharmacological and toxicological rather than a psychopharmacological perspective (Larson et al. 1961). There was some attention to the effects related to addiction, such as euphoria (Johnston 1941), tolerance (Lewin 1931), and withdrawal (Finnegan et al. 1945), but outside of research supported by the tobacco industry, addiction and psychopharmacology were not major foci for research (Slade et al. 1995; Hurt and Robertson 1998; Henning?eld et al. 2006; Henning?eld and Hartel 1999; Larson et al. 1961).


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