Oncologic Imaging: Spine and Spinal Cord Tumors 1st ed. 2017 Edition

This book is a detailed guide to image interpretation in patients with spine and spinal cord tumors that will enable clinicians and residents to improve their diagnostic abilities. The book opens by introducing basic concepts in the imaging of spinal tumors, namely the compartmental approach and the histologic basis for the different imaging appearances. These concepts are explained with the aid of representative cases and schematic illustrations. The second part of the book represents a “training step” in which various spinal tumors are described in detail, focusing on the imaging findings. Representative cases are presented with radiographic, CT, and MR images; in addition, schematic illustrations and pathologic or operative images are included in selected cases. The third part is a “practice step” describing tips for correct imaging diagnosis. Individual chapters in this part focus on incidence-, age-, location-, and imaging pattern-based approaches to bone, extradural, intradural extramedullary, intramedullary, and pediatric spinal tumors. The presented cases will enhance the reader’s understanding of the different tumor patterns and assist in solving diagnostic problems that may be encountered in daily practice.

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Breast Cancer: Recent Advances in Biology, Imaging and Therapeutics

This book considers breast cancer from many novel and exciting perspectives. New insights into the basic biology of breast cancer are discussed together with high throughput approaches to molecular profiling. Innovative strategies for diagnosis and imaging are presented as well as emerging perspectives on breast cancer treatment.

Each of the topics in this volume is addressed by respected experts in their fields and it is hoped that readers will be stimulated and challenged by the contents.

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Breast Cancer: From Biology to Medicine

This volume thoroughly examines breast cancer from basic definitions, to cellular and molecular biology, to diagnosis and treatment. This book also has some additional focus on preclinical and clinical results in diagnosis and treatment of breast cancer.

The book begins with introduction on epidemiology and pathophysiology of breast cancer in Section 1.
In Section 2, the subsequent chapters introduce molecular and cellular biology of breast cancer with some particular signaling pathways, the gene expression, as well as the gene methylation and genomic imprinting, especially the existence of breast cancer stem cells. In Section 3, some new diagnostic methods and updated therapies from surgery, chemotherapy, hormone therapy, immunotherapy, radiotherapy, and some complementary therapies are discussed.
This book provides a succinct yet comprehensive overview of breast cancer for advanced students, graduate students, and researchers as well as those working with breast cancer in a clinical setting.

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Atlas of Procedures in Surgical Oncology with Critical, Evidence-based Commentary Notes (With DVD-ROM) Har/Dvdr Edition

This unique book presents a series of concisely written technical notes on common procedures in surgical oncology. Each operation is illustrated with pictures framing precise technical points. The book is accompanied by a DVD-ROM that includes video clips of the procedures.

Written by top European experts, this volume will provide an invaluable resource for young surgical oncologists to familiarize with technical details, develop a critical approach and expand their surgical skills. It will also be a useful source of reference for medical oncologists, radiologists, radiotherapists and nurses, as well as final-year medical students.

Readership: Oncologists, surgeons, radiotherapists, surgical oncologists, nurses and final-year medical students

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Squamous cell Carcinoma: Molecular Therapeutic Targets 1st ed. 2017 Edition

This edited volume is about novel targeted therapies for the treatment of advanced neoplasms of the head and neck (HNSCC) with particular reference to oral squamous cell carcinomas and covers specific fields of cancer genetics and genomics for personalized medicine.

The landmark studies from the HNSCC Cancer Genome Anatomy (TCGA) and the cancer Genome Atlas 2015 have revealed the multiplicity and diversity of genetic alterations in HNSCC. This remarkable body of information has elucidated novel druggable targets (eg. EGFR, mTOR, p53, survivin and aberrant microRNA) for therapeutic interventions in head and neck cancer.

Readers will discover the importance of the biology and pathology of squamous cell carcinomas, the role of cancer stem cells and other factors that contribute to resistance to curative therapies such as hypoxia. We present an in-depth analysis of the HNSCC oncogenome describing the distinct molecular alterations in squamous cell carcinomas, which participate in specific molecular pathways whose dysregulation may contribute to most HNSCC cases. Final chapters of the book elucidate how these important cancer-driving molecular events and molecular pathways could be targeted to treat head and neck cancers and  their therapeutic applications for targeted therapies based on clinical trials reported worldwide.

This book is aimed at a broad audience, including scientists, physicians, surgeons, and post graduate students engaged in oncology and provide the readers with an up-to-date, interdisciplinary knowledge and tools to better understand the evolving areas of targeted gene therapy and the key concept of personalized medicine in head and neck cancer.

About the Author

Professor Saman Warnakulasuriya OBE has extensive experience in conducting international collaborative research projects including clinical trials and a strong expertise of managing Head and Neck cancers.  He has championed ways to relocate his clinical follow up studies and experimental data from the laboratory into the real-world. His contributions as the Director of World Health Organization Collaborating Centre for Oral Cancer has over a decade catalysed a global collaborative effort to improve adherence to high standards of clinical care in his speciality around the world.

His experimental studies have reported on clinical adjunctive aids and novel ways of stratifying patients at high risk and reported on several biomarkers for the prediction of risk of malignant transformation from precancer to cancer. He has published over 260 peer reviewed papers mostly on oral cancer and premalignancy and several systematic reviews and book chapters. He is the recipient of several key scientific awards as a distinguished scientist and for his distinguished service to King’s College London for over 25 years.

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Current Concepts in Endometrial Cancer 1st ed. 2017 Edition

This book comprehensively covers endometrial carcinoma, a type of gynecological cancer that is often overlooked but of great interest. Although the incidence of the disease is rapidly increasing, both per se and as part of familial cancer syndromes, there is a great deal of controversy regarding its diagnosis, evaluation and management.
This book underlines the significance of endometrial carcinoma, highlights key prevention measures, charts its evaluation, and addresses the stage-by-stage management of this malignancy, with particular attention to the role of minimally invasive surgery. Further, it includes a chapter on future perspectives including robotics, targeted therapies and other developments in the offing.
Overall, the book provides a comprehensive guide to endometrial cancer, which if approached properly, can have an excellent prognosis, thus saving many lives and/or achieving substantially improved quality of life.>

About the Author

Dr. Ranu Patni is a prominent gynecologic oncologist with more than fifteen years of experience in ‘Gynecologic Oncology’. After postgraduate work in Obstetrics and Gynecology, her quest for clinical, surgical and academic excellence led her to constantly upgrade her skills through trainings from reputed international and national institutions, including King George V Hospital (Sydney, Australia) and Tata Memorial Hospital (Mumbai). She has been a pioneer in establishing the concept of ‘Gynecological Oncology’ and ‘Menopausal Medicine’ in the state of Rajasthan, India.
Her surgical skills are backed not only by a large number of gynecological cancer surgeries including those on many challenging endometrial cancer patients, but also by very competitive long-term results. She is well known for her age-appropriate approach to individual patients and routinely adopts evidence-based fertility preservation techniques and hormonal conservation measures.

She also has a keen interest in research and dissemination of knowledge among the medical fraternity as well as the public. She has organized and participated in numerous national and international conferences / workshops, contributed chapters to books of national repute, published papers in national and international journals, edited and peer-reviewed papers for prominent journals, is an active member of many academic societies and has been a Principal investigator in large multicentric clinical trials on ‘Postmenopausal Osteoporosis’.

A unique feature of Dr. Patni’s career is her passion for public health education. Over the past twenty years, she has repeatedly engaged in efforts to educate the public, especially women, about the preventive and therapeutic aspects of various health issues.

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Husband and Reznek’s Imaging in Oncology, 3rd edition (2 Vol Set) 3rd Edition

In recent years there has been recognition of the central role of imaging in the management of patients with cancer. The third edition of this widely acclaimed book builds on the foundations laid down by the first edition, the 1998 winner of the Royal Society’s award for the Multi-author Textbook of the Year, and the second (2004). The core of the book deals with the application of imaging in all tumours. An extensively referenced, evidence-based analysis is given of the role of imaging in planning treatment. Experienced opinion is provided as to the advantages and limitations of all relevant imaging modalities including ultrasound, CT, MRI, PET/CT and other nuclear medicine techniques.

Imaging in the recognition of metastatic disease is covered in detail with chapters detailing the range of appearances of deposits in each organ. Much attention is given to the differential diagnosis of focal pathology in each organ in patients with underlying malignancy and useful protocols for the performance of the study provided.

While including a section on new horizons in cancer imaging, such as the imaging of angiogenesis, MR lymphography and the rapidly evolving field of molecular imaging, the editors have not neglected the more traditional general principles of cancer behaviour and imaging. Hence, an outline of cancer surgery, chemotherapy and radiotherapy is provided by experts. As therapy becomes more successful, increasingly important issues for the radiologist such as the assessment of response, the effect of treatment on normal tissues, the complications of treatment, and the risk of second malignancies are presented.

There are several outstanding features to this book: the colour diagrams of the staging systems are exquisite and allow the often complex systems to be understood easily and memorized; the organization of the book into different, clearly defined sections allow it to be used not only as a reliable reference text, but also to be read easily; key points and summaries in point form are provided throughout for quick revision.

This comprehensive book will not only be essential reading for all radiologists, but also important for all members of a multidisciplinary team looking after patients with cancer.

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Pathology and Biology of Human Germ Cell Tumors 1st ed. 2017 Edition

This book provides, for the first time, a detailed, up-to-date, holistic approach to the pathology and biology of germ cell tumors. The main focus is the complex histopathology of these tumors, but special considerations are also given to their morphologic variations in relation to age, gender and organ. Critical updates are provided on terminology and classification; the discussion of biology and pathogenesis includes references to many molecular genetic and immunohistochemical findings from recent stem cell research. Individual chapters are devoted to germ cell tumors at different anatomic locations, including not only the ovaries and testes but also the mediastinum and central nervous system, and pediatric tumors. All of the contributing authors are opinion leaders from universities of excellence in Europe and the United States. This monograph will be of wide interest to practitioners and researchers in many fields of medicine, including pathology, gynecology, urology, and pediatrics, as well as stem cell scientists.

From the Back Cover

This book provides, for the first time, a detailed, up-to-date, holistic approach to the pathology and biology of germ cell tumors. The main focus is the complex histopathology of these tumors, but special considerations are also given to their morphologic variations in relation to age, gender and organ. Critical updates are provided on terminology and classification; the discussion of biology and pathogenesis includes references to many molecular genetic and immunohistochemical findings from recent stem cell research. Individual chapters are devoted to germ cell tumors at different anatomic locations, including not only the ovaries and testes but also the mediastinum and central nervous system, and pediatric tumors. All of the contributing authors are opinion leaders from universities of excellence in Europe and the United States. This monograph will be of wide interest to practitioners and researchers in many fields of medicine, including pathology, gynecology, urology, and pediatrics, as well as stem cell scientists.

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Assessing and Improving Value in Cancer Care: Workshop Summary 1st Edition

Unlike many other areas in health care, the practice of oncology presents unique challenges that make assessing and improving value especially complex. First, patients and professionals feel a well-justified sense of urgency to treat for cure, and if cure is not possible, to extend life and reduce the burden of disease. Second, treatments are often both life sparing and highly toxic. Third, distinctive payment structures for cancer medicines are intertwined with practice. Fourth, providers often face tremendous pressure to apply the newest technologies to patients who fail to respond to established treatments, even when the evidence supporting those technologies is incomplete or uncertain, and providers may be reluctant to stop toxic treatments and move to palliation, even at the end of life. Finally, the newest and most novel treatments in oncology are among the most costly in medicine.

This volume summarizes the results of a workshop that addressed these issues from multiple perspectives, including those of patients and patient advocates, providers, insurers, health care researchers, federal agencies, and industry. Its broad goal was to describe value in oncology in a complete and nuanced way, to better inform decisions regarding developing, evaluating, prescribing, and paying for cancer therapeutics.

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Management of Thyroid Nodules and Differentiated Thyroid Cancer: A Practical Guide 1st ed. 2017 Edition

This book provides a comprehensive, state-of-the art review of this field, and will serve as a valuable resource for clinicians and researchers with an interest in the management of thyroid nodules and cancer, including both surgeons and endocrinologists.  The book reviews new data about risk factors for nodular disease and cancer, details the management of toxic and non-toxic benign thyroid nodular disease, discusses controversies in the management of indeterminate thyroid nodules and cancer, and reviews the latest data on use of molecular testing for diagnosis and prognosis.  Lastly, the book reviews the management of difficult-to-treat thyroid cancers.
Management of Thyroid Nodules and Differentiated Thyroid Cancer: A Practical Guide will serve as a useful resource for physicians and researchers dealing with, and interested in thyroid nodular disease and cancer.  It will provide a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts.  All chapters are written by experts in their fields and include the most up to date scientific and clinical information.

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