Breast Cancer: Carcinogenesis, Cell Growth and Signalling Pathways

This book discusses various aspects of breast cancer carcinogenesis from clinics to its hormone-based as well as genetic-based etiologies for this deadly cancer. The book will contribute to the development of novel diagnostic as well as therapeutic approaches.

Part 1 Signaling Pathways (EGFR)
1 EGFR-Ligand Signaling in Breast Cancer Metastasis: Recurring Developmental Themes
2 EGF Regulation of HRPAP20: A Role for Calmodulin and Protein Kinase C in Breast Cancer Cells
3 Endocytic Trafficking of the Epidermal Growth Factor Receptor in Transformed Cells
4 HER-2 Signaling in Human Breast Cancer
5 Brain Metastases Progression of Breast Cancer
6 Signal Transduction Pathways in Breast Cancer – Drug Targets and Challenges
7 ErbB2/HER2: Its Contribution to Basic Cancer Biology and the Development of Molecular Targeted Therapy
8 Trastuzumab-Resistance and Breast Cancer
9 Targeting HER-2 Signaling Network: Implication in Radiation Response
Part 2 Estrogen Receptors
10 The Importance of ERa/ERp Ratio in Breast Cancer: Mitochondrial Function and Oxidative Stress
11 Heterogeneity of Phenotype in Breast Cancer Cell Lines
12 Metabolomics and Transcriptional Responses in Estrogen Receptor Positive Breast Cancer Cells
13 ER-Alpha36 Mediates Non-Genomic Estrogen and Anti-Estrogen Signaling in Breast Cancer Cells
14 Estrogen-Related Receptors and Breast Cancer: A Mini Review
15 The Role of MicroRNAs in Estrogen Receptor α-Positive Human Breast Cancer
Part 3 Cell Growth Regulation, Carcinogenesis
16 Roles of SWI/SNF Complex Genes in Breast Cancer
17 p53, p63 and p73 Network in Breast Cancers
18 Role of ING Family Tumor Suppressors in Breast Cancer
19 Lipid Rafts as Master Regulators of Breast Cancer Cell Function
20 Differences in Membrane Composition and Organization of Crucial Molecules Define the Invasive Properties of MCF-7 Breast Cancer Cells
21 Adipose Tissue and Desmoplastic Response in Breast Cancer
22 Cross-Talk of Breast Cancer Cells with the Immune System
23 Engineering Transcription Factors in Breast Cancer Stem Cells
24 Breast Cancer Stem Cells – A Review
25 Potential Roles of miR-106a in Breast Cancer
26 Scleroderma and Breast Cancer
Part 4 Signaling Pathways (Others)
27 FZD7 in Triple Negative Breast Cancer Cells
28 Dysregulation of Wnt Signaling in Breast Cancer
29 Interactions of STAP-2 with BRK and STAT3/5 in Breast Cancer Cells
30 Histamine and Breast Cancer: A New Role for a Well Known Amine
31 1,25(OH)2D3 and Cyclooxygenase-2: Possible Targets for Breast Cancer?
32 Calcium, Ca2+-Sensing Receptor and Breast Cancer
33 Signal Transduction Pathways Mediated by Unsaturated Free Fatty Acids in Breast Cancer Cells
34 Adrenoceptors and Breast Cancer: Review Article
35 Steroid Receptor Coactivators and Their Expression, Regulation and Functional Role in Endocrine Responsive and Resistant Breast Cancer


Targeted Therapy in Translational Cancer Research (Translational Oncology) 1st Edition

Targeted Therapy in Translational Cancer Research for the Translational Oncology series provides a comprehensive overview of recent developments in our understanding of tumor biology, elucidates the roles of targets and pathways involved in carcinogenesis, and describes current state-of-the-art anticancer therapy, as well as the most promising areas of translational research and targeted therapy.

  • Introduces cutting-edge ‘bench to bedside and back’ breakthroughs which have transformed the diagnosis, prognosis, and treatment of cancer
  • Covers basic principles of targeted therapy, including immunotherapy and the roles of cancer stem cells, the microenvironment, angiogenesis, epigenetics, microRNAs, and functional imaging in precision medicine
  • Summarises major advances in therapeutic management of hematologic malignancies and solid tumors using conventional therapy, targeted therapy, immunotherapy, or novel treatment modalities


Esophageal Cancer and Barrett’s Esophagus 3rd Edition

Esophageal Cancer and Barrett’s Esophagus, 3E, focuses on these two common and key conditions that affect the esophagus, providing expert guidance to their pathogenesis, cause, prevention, diagnosis and clinical management.

Top international names in the field examine each of the many issues involved, using the very latest evidence-based research, and clear, didactic advice allows the reader to understand the best methods of diagnosis and clinical management of each condition – whether early or late stage.

Well-illustrated and fully revised to include the latest in ACG/ASG/UEGW guidelines, it is the perfect consultation tool for gastroenterologists and oncologists managing patients with cancer of the esophagus.  It is also ideal for teaching residents and fellows optimum patient management, and for identifying areas requiring future research.


Pediatric Cancer in Africa: A Case-Based Guide to Diagnosis and Management 1st ed. 2017 Edition

This text is the only book of its kind to provide specific guidance applicable to limited resource settings and builds up from the foundation of general practitioner or general pediatrician competence. Written and edited by leaders in the field, this manual educates physicians on the essential components of the discipline, filtered through the experience of specialists from developing countries, with immediate applicability in the specific healthcare environment in these countries. Typically, manuals of pediatric hematology-oncology are written by specialists from high-income countries, and usually target an audience with a sub-specialist level of training, often assisted by cutting-edge diagnostic and treatment facilities. However, approximately 80% of new cases of cancer in children appear in mid- and low-income countries. Almost invariably, general practitioners or general pediatricians without special training in oncology will look after children with malignancies who enter the health care system in these countries. The diagnostic facilities are usually limited, as are the treatment options. The survival figures in these conditions are somewhere below 20%, while in high-income countries they are in the range of 80% for many childhood cancers. This book includes simplified therapy protocols, pain therapy and palliation, as well as ward procedures such as bone marrow aspiration/biopsies, intravenous therapy and chemotherapy drugs mixing. It provides an overview of pediatric cancer epidemiology, cancer registration and organizing support networks and features the management of cancers with associated pathology like AIDS, malnutrition, malaria and tuberculosis.


Dying and Death in Oncology 1st ed. 2017 Edition

This book brings together in one volume many important topics about death and dying, including the pathophysiology of death, the causes of death among cancer patients, the ethics of death, the legal aspects of death for the physician and for the patient and caregivers, the economics of death, the medical management of the dying patient, including pain and dyspnea, the prediction of death, and the spiritual management of the dying patient. It also discusses other medical and humanistic aspects of death and dying, such as the historical definition of death and various cultures’ and religions’ viewpoints on death and the afterlife.   Everybody, including every patient with cancer, will die, and every physician will have to assist dying patients. Oncologists face this prospect more often than many physicians. And yet to date there has been no comprehensive textbook on Thanatology, the academic discipline studying death and dying, to assist oncologists in this difficult task. This book will help the physician to understand his or her own relationship with death and to communicate about death and dying with the patient and the patient’s caregivers.

About the Author

Lawrence Berk, a radiation oncologist, completed a PhD in Physical Chemistry from Yale University studying the high field conductivity of aqueous solutions and then researched batteries and fuel cells for Westinghouse Electric Corporation. He then studied medicine at the University of Pittsburgh and completed his residency in radiation oncology at the University of Pennsylvania. He has worked in private practice and in academics, and he is currently Professor and Chief of Radiation Oncology at the Morsani School of Medicine of the University of South Florida. His research has been in palliative care and symptom management. He has led national trials studying brain metastases, cancer cachexia and radiation esophagitis.

Dr. Berk is board certified in both Radiation Oncology and Palliative Medicine. He has previously served as Vice Chair of the US National Cancer Institute-funded cooperative research organization the Radiation Therapy Oncology Group and as the Chair of the Symptom Management Committee of the Radiation Therapy Oncology Group. He also served on the National Cancer Institute’s PDQ Board for Complementary and Alternative Medicine. He has published numerous articles in areas ranging from the polio vaccine trials in 1935, to the epidemiology of toilet training and to preventing side effects of radiation therapy and the palliative treatment of cancer patients.


Nanoscale Insights into Ion-Beam Cancer Therapy 1st ed. 2017 Edition

This book provides a unique and comprehensive overview of state-of-the-art understanding of the molecular and nano-scale processes that play significant roles in ion-beam cancer therapy. It covers experimental design and methodology, and reviews the theoretical understanding of the processes involved. It offers the reader an opportunity to learn from a coherent approach about the physics, chemistry and biology relevant to ion-beam cancer therapy, a growing field of important medical application worldwide.

The book describes phenomena occurring on different time and energy scales relevant to the radiation damage of biological targets and ion-beam cancer therapy from the molecular (nano) scale up to the macroscopic level. It illustrates how ion-beam therapy offers the possibility of excellent dose localization for treatment of malignant tumours, minimizing radiation damage in normal tissue whilst maximizing cell-killing within the tumour, offering a significant development in cancer therapy. The full potential of such therapy can only be realized by better understanding the physical, chemical and biological mechanisms, on a range of time and space scales that lead to cell death under ion irradiation. This book describes how, using a multiscale approach, experimental and theoretical expertise available can lead to greater insight at the nanoscopic and molecular level into radiation damage of biological targets induced by ion impact.

The book is intended for advanced students and specialists in the areas of physics, chemistry, biology and medicine related to ion-beam therapy, radiation protection, biophysics, radiation nanophysics and chemistry, atomic and molecular physics, condensed matter physics, and the physics of interaction of charged particles with matter. One of the most important features of the book is the inclusive multiscale approach to the understanding of complex and highly interdisciplinary processes behind ion-beam cancer therapy, which stretches from the atomistic level up to the biological scale and is demonstrated to be in excellent agreement with experimental observations.


Cardio-Oncology: The Clinical Overlap of Cancer and Heart Disease 1st ed. 2017 Edition

Co-edited and written by an interdisciplinary team of experts in oncology and cardiology, this book is a clinically useful resource on these overlapping topics:

• Cardiac complications in patients receiving cancer therapy

• The treatment of cancer in patients with cardiovascular disease

• The treatment of cardiovascular disease in patients with cancer

When relevant to medical practice, epidemiology and basic science are also included in the discussion and each chapter is written by an oncologist and a cardiologist. Additionally, the chapters follow a similar format to make the book truly interdisciplinary, user-friendly, and clinically applicable to specialists and non-specialists who care for patients with both cancer and cardiovascular disease.


Integrative Medicine for Breast Cancer: An Evidence-Based Assessment 1st ed. 2016 Edition

This book is designed to capture and clinically review the comprehensive database of clinical research articles that support and do not support the utilization of a variety of dietary supplements and other complementary medicines that physicians are exposed to in their daily practice. The growing list of CAM products that could interfere with surgery (anesthesia, bleeding, outcomes…) and/or conventional medicines is very large and is provided in each section of the book. Additionally, the list of dietary supplements that could be utilized to improve quality of life for breast cancer patients is also emphasized. The various sub-specialty groups in breast are adequately represented, which allows for a physician to rapidly and thoroughly investigate their topic of interest regardless of whether the topic is prevention, treatment, or a specific side effect of treatment.

The practical nature of Integrative Medicine for Breast Cancer: An Evidence-Based Assessment cannot be overstated. Chapters include a general overview of the CAM agent, whether or not it has data in medicine and oncology, and a list of potential drug interactions and specific clinical scenarios where it can be utilized or discouraged in the specialty. Thus, this book will become the gold standard evidence based text for use in teaching, not only for the students interested in oncology and breast cancer, but for all current oncology health providers.


Laparoscopic Colorectal Cancer Surgery: Operative Procedures Based on the Embryological Anatomy of the Fascial Composition 1st ed. 2017 Edition

This unique guide describes colorectal surgery procedures using medical terminology and anatomical terms originating from embryology.

In the last decade, laparoscopic procedures in gastrointestinal surgery have been enhanced and their safety has significantly improved. With the number of cases of colorectal cancer surgery increasing and laparoscopic surgery no longer considered a specialized surgery, the recognition of the correct anatomy is vital in these procedures. Unfortunately, however, the understanding of clinical anatomy is frequently separate from that of basic surgical concepts. Initially, the dissecting layer should be presumed to derive from the fascial anatomy based on embryological recognition. Furthermore, the techniques currently being used by surgeons should be described in sufficient detail and the appropriate anatomical terms should always be used. In view of this, this valuable monograph benefits gastrointestinal surgeons and general surgeons who are involved in the treatment of colorectal cancer.