Penile Cancer: Diagnosis and Treatment (Current Clinical Urology) 2013th Edition

Penile Cancer: Diagnosis and Management provides a comprehensive overview of penile cancer for medical and surgical urologists oncologists, and other healthcare professionals. This book highlights many of the significant advances made in this field, which include a discussion of penile-sparing surgical and radiotherapeutic approaches to select primary penile tumors typically of lower stage and grade as well as advances in our understanding of the epidemiology, risk factors, and pathophysiology of penile cancer. The book also addresses many of the novel diagnostic and therapeutic surgical approaches to inguinal lymph nodes, including dynamic sentinel node biopsy and minimally invasive surgery. The authors also discuss many of the clinical pearls and surgical considerations that can optimize treatment outcomes while minimizing the morbidity and inherent risk of complications in patients undergoing an open inguinal lymph node dissection. Lastly, the volume presents a discussion of the paradigm shift in the management of bulky inguinal lymph node metastases from penile cancer consisting of neoadjuvant systemic chemotherapy followed by consolidative surgical resection, which can offer an improved likelihood of survival as shown in a recent phase 3 clinical trial.

Penile Cancer: Diagnosis and Management will serve as a resource for clinicians and researchers seeking an overview on the current state of knowledge in penile cancer. The editor has gathered leading worldwide experts in this field who have written a very practical and useful textbook for clinicians in an attempt to optimize patient outcomes and promote the pivotal scientific advances made in recent years.

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Holland-Frei Cancer Medicine 9th Edition

Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients.

  • A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease
  • An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies
  • Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics
  • Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs
  • Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

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The DNA Damage Response: Implications on Cancer Formation and Treatment 2009th Edition

The ?eld of cellular responses to DNA damage has attained widespread recognition and interest in recent years commensurate with its fundamental role in the ma- tenance of genomic stability. These responses, which are essential to preventing cellular death or malignant transformation, are organized into a sophisticated s- tem designated the “DNA damage response”. This system operates in all living organisms to maintain genomic stability in the face of constant attacks on the DNA from a variety of endogenous by-products of normal metabolism, as well as exogenous agents such as radiation and toxic chemicals in the environment. The response repairs DNA damage via an intricate cellular signal transduction network that coordinates with various processes such as regulation of DNA replication, tr- scriptional responses, and temporary cell cycle arrest to allow the repair to take place. Defects in this system result in severe genetic disorders involving tissue degeneration, sensitivity to speci?c damaging agents, immunode?ciency, genomic instability, cancer predisposition and premature aging. The ?nding that many of the crucial players involved in DNA damage response are structurally and functionally conserved in different species spurred discoveries of new players through similar analyses in yeast and mammals. We now understand the chain of events that leads to instantaneous activation of the massive cellular responses to DNA lesions. This book summarizes several new concepts in this rapidly evolving ?eld, and the advances in our understanding of the complex network of processes that respond to DNA damage.

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The Mayo Clinic Breast Cancer Book

The Mayo Clinic Breast Cancer Book is the trusted resource for anyone wanting reliable information about this dreaded disease. Mayo Clinic set out to provide comprehensive and up-to-date facts in easy-to-understand language. They’ve succeeded in this handbook for those who’ve been diagnosed, or for those who want to give sensitive and helpful support to someone with breast cancer. The Mayo Clinic Breast Cancer Book stands out for its tone of companionship, as well as for the many patient stories that appear throughout the book.

This straightforward yet approachable resource will empower all who are affected by breast cancer. Here are facts about the disease, but also suggestions and inspiration for working effectively with one’s doctors and caregivers. This volume offers solid tools for coping with the many uncertainties and decisions that need to be made when one is diagnosed.

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Textbook of Penile Cancer

Textbook of Penile Cancer reports accurately on recent developments in the management of penile cancer, whilst also covering the fundamentals of the disease, to provide a comprehensive, stand-alone and up-to-date volume on the subject.

The surgical management of penile cancer is shifting towards increasingly refined methods, as it is believed that a proportion of patients undergo overtreatment for the disease. Where traditionally the management of penile cancer has involved partial or total penectomy combined with radical inguinal lymphadenectomy, over the last few years the treatment   involves conservative penile reconstructive surgery  such that sexual function and phallic length is preserved. Furthermore, the increasing utilization of sentinel lymph node biopsy rather than  radical inguinal lymphadenectomy prevents the unnecessary removal of lymph nodes in patients where  lymph node  metastases has not occurred. There is also likely to be a change in the role of chemotherapy and radiotherapy for  advanced disease.

Textbook of Penile Cancer covers the epidemiology, molecular biology, radiological imaging, as well as the  latest surgical advances  in the treatment of this disease. This book is a valuable reference tool for Urological Surgeons, Genitourinary Physicians, Trainee Surgeons, Plastic Surgeons, Oncologists, Dermatologists and Sexual Health Physicians.

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Drug Therapy and Interactions in Pediatric Oncology: A Pocket Guide 1st ed. 2017 Edition

There are few publications about drug interactions in chemotherapy and even less about pediatric oncology treatment. For this reason, the present book is intended to offer guidelines about drug interactions for physicians, pharmacists and the other healthcare professionals involved in the chemotherapy of pediatric patients. In this book the reader will have access to a primary introduction for the major diseases in pediatric oncology, followed by the major therapeutic protocols. Following that, the most important drug interactions in pediatric oncology treatment are presented and discussed in detail. Finally, important topics such as Drug-Food Interactions are addressed.
Drug Therapy and Interactions in Pediatric Oncology focuses in great detail on the drug interactions in Pediatric Oncohematology and will be an indispensable resource in daily practice for a wide range of health providers.

About the Author

Carolina Witchmichen Penteado Schmidt: Oncology Pharmacist with extensive experience with Pediatric Oncohematology and Chemotherapy in Children. Oncological Hospital Pharmacy Specialist; Planning and Business Management Specialist. Extensive experience in hospitals and clinics, with Pharmacy, Drug Interactions, Pediatrics, Oncology, Hematology, Neonatology, Intensive Health Care and Infectology. Academic experience in the following fields: Pharmacy, Pediatrics, Oncology and Hematology.

Fabiana Gatti de Menezes: Graduated in Pharmacy and Biochemistry, University of São Paulo, Brazil. Master in Pharmacology, Faculty of Medical Sciences, State University of Campinas, Brazil; PhD in Pharmacology, Institute of Biomedical Sciences of University of São Paulo, Brazil; Specialization in Clinical Pharmacy at Hospital Israelita Albert Einstein, Brazil. Professor and researcher in the following areas: Clinical Pharmacy, Pharmacoepidemiology and Pharmaceutical Care. Professor of Pharmacotherapy, Clinical Research Pharmacy and Clinical Pharmacy at postgraduate courses: Hospital Pharmacy (Oswaldo Cruz College, Brazil); Hospital and Clinical Pharmacology (Gama Filho University, Brazil); Oncological Hospital Pharmacy (AC Camargo Cancer Center, Brazil). Experience in Clinical Pharmacy: Pharmaceutical Care, Pharmacoepidemiology, Pharmacovigilance, Pharmacoeconomics, Hospital Pharmacy, Drug Interactions, and Industry.

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Management of Prostate Cancer: A Multidisciplinary Approach 2nd ed. 2017 Edition

This book, now in an extensively revised second edition, provides an exhaustive review of the state of the art in the management of prostate cancer, from screening to treatment, with emphasis on a multidisciplinary approach. The editors are very excited about the outstanding new or updated contributions from the different expert authors.

The opening chapters address basic aspects including epidemiology, pathology, biology, genetics, and chemoprevention. The role of individual and mass screening is carefully appraised, and extensive attention is devoted to diagnosis and clinical work-up by means of recently implemented investigations such as multiparametric MRI and choline PET-CT.

The use of active surveillance is examined in detail. Subsequent chapters discuss the different therapies that may be employed: open and minimally invasive, including robot-assisted, radical prostatectomy, the various forms of radiation treatment, high-intensity focused ultrasound, cryotherapy, hormonal manipulations, chemotherapy, targeted therapies, and immunotherapy. Up-to-date results from practice-changing phase III randomized clinical trials are included and special insights are provided into the interpretation of results and the patient’s perspective.

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Asymmetric Cell Division in Development, Differentiation and Cancer (Results and Problems in Cell Differentiation) 1st ed. 2017 Edition

This book provides readers with an overview of the frequent occurrence of asymmetric cell division. Employing a broad range of examples, it highlights how this mode of cell division constitutes the basis of multicellular organism development and how its misregulation can lead to cancer.

To underline such developmental correlations, readers will for example gain insights into stem cell fate and tumor growth. In turn, subsequent chapters include descriptions of asymmetric cell division from unicellular organisms to humans in both physiological and pathological conditions. The book also illustrates the importance of this process for evolution and our need to understand the background mechanisms, offering a valuable guide not only for students in the field of developmental biology but also for experienced researchers from neighboring fields.

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Multidisciplinary Management of Liver Metastases in Colorectal Cancer: Early Diagnosis and Treatment 1st ed. 2017 Edition

This book focuses on early diagnosis and multidisciplinary treatment, which is the key to preventing the occurrence of the liver metastases in colorectal cancer, and to increasing the resection rate of the liver metastasis foci and the 5-year survival after surgery.

This book is divided into five parts: the introduction, basics, diagnosis, treatment and prevention. It has 20 chapters in total, covering the latest advances in colorectal cancer liver metastases epidemiology, pathogenesis, molecular diagnostics, marker screening, imaging technology, surgery, chemotherapy and prevention, etc. It provides professionals with up-to-date and comprehensive information on colorectal liver metastases. This book is relevant for senior surgeons and physicians working in oncology, general surgery, chemotherapy, digestive medicine, liver medicine and hepatic surgery.

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Molecular Targeted Therapy of Lung Cancer 1st ed. 2017 Edition

This book discusses the latest molecular targeted therapy of lung cancer including its evaluation and future directions. It clearly illustrates the initial dramatic effectiveness of molecular targeted therapy, recurrence of the disease, overcoming the wide variety of resistance mechanisms using new-generation molecular targeted agents and potential novel approaches. It also outlines the increasing necessity for new diagnostic technology and strategies for managing different adverse effects and novel methods for evaluating effectiveness and safety.
Edited and authored by opinion leaders, Molecular Targeted Therapy of Lung Cancer provides a comprehensive overview of the disease and its treatments. It is a valuable resource for graduate students, post-doctoral fellows and faculty staff, as well as researchers involved in clinical and translational research on lung cancer, helping promote new ideas for further advances.

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