Phosphodiesterases: CNS Functions and Diseases (Advances in Neurobiology) 1st ed

PDEs are a family of enzymes that catalyze the hydrolysis of intracellular cyclic nucleotides. They are implicated in a number of disorders and dysfunctions and PDE inhibitors have already proven to be effective therapies for erectile dysfunction, COPD, and psoriatic arthritis.  This family of enzymes also plays a role in diseases and disorders of the CNS such as depression, anxiety, schizophrenia, and Alzheimer’s Disease. Unfortunately no effective PDE inhibitors have been developed for the treatment of these diseases.  The proposed book will be a comprehensive overview of the current state of basic and translational research on PDE inhibitors written by internationally recognized experts. Authors will also discuss potential PDE subtypes and splice variants in the hopes that this will spur more creative approaches to PDE targeting drugs.


Neuroimaging Diagnosis for Alzheimer’s Disease and Other Dementias 1st ed.

This book describes the latest modalities such as tau PET imaging for diagnosis of Alzheimer’s disease and other dementias, and also provides information on handling and analyzing imaging data that is not found in other books. In addition, it introduces routine imaging studies in the management of dementia in Japan. The prevalence of dementia has increased over the past few decades, either because of greater awareness and more accurate diagnosis, or because increased longevity has created a larger population of the elderly, the age group most commonly affected. Although only clinical assessment can lead to a diagnosis of dementia, neuroimaging in dementia is recommended by most clinical guidelines, and its adjunct role has traditionally been to exclude a mass lesion rather than to support a specific diagnosis. Neuroimaging may be also helpful for developing new strategies to achieve diagnoses as early as possible for therapies aimed at slowing the progression of neurodegenerative diseases manifesting dementia. Under these conditions, all clinicians and researchers who are involved in neuroimaging for dementia should decide which patients to scan, when imaging patients is most useful, which modality to use, how to handle imaging data from many institutions, and which analytical tool to use. This edition comprises contributions from leading Japanese experts in their fields.


Handbook of Neuroendovascular Techniques 1st ed

This handbook provides step-by-step instructions enabling even a novice in the field of interventional neuroradiology/endovascular neurosurgery to perform a procedure. It covers the breadth of mainstream endovascular techniques. This manual provides lucid, readily accessible and pertinent hands-on information. It focuses on practicalities such as technique, choice of equipment and rationale, contrast agents, medications, precise pre- and post-procedure management and management of complications. It does not elaborate on theoretical aspects of disease e.g., etiology, pathogenesis, statistics, etc. In essence, it provides the necessary information to enable performance of a procedure.  Handbook of Neuroendovascular Techniques will be a great resource for a whole range of physicians from residents, to those just embarking on their own independent practice to established experts reviewing methodology of a technique. The authors have a depth of experience and are highly qualified, ensuring objective, pertinent, authoritative and competent coverage of subject matter.


Brain Metastases: Advanced Neuroimaging 1st ed. 2018 Edition

This book describes the role of advanced neuroimaging techniques in characterizing the changes in tissue structure in patients with brain metastases. On a large number of newly recognized CT, MRI, and PET characteristics of brain metastases from different primary tumors are highlighted, thereby elucidating the potential differential diagnostic role of CT perfusion imaging, MR spectroscopy, MR diffusion-weighted imaging, MR susceptibility-weighted imaging, and PET with different radiopharmaceuticals. For example, the different manifestations of metastases of melanoma, renal cell carcinoma, and ovarian cancer on MRI and CT perfusion imaging are described, and the role of MR susceptibility-weighted imaging in the differential diagnosis of glioblastoma multiforme and metastatic tumors is clarified. Metastases of colon cancer have shown a special manifestation on T2 weighted images. The book also presents novel findings regarding pathogenesis and tumor biology and describes qualitative and quantitative changes in tumor tissue and alterations in brain white matter due to surrounding tumor growth.

Neuroradiologists and others, including neurosurgeons, neurologists, and nuclear medicine physicians, will find that this book offers a fascinating insight into the ways in which newly available data on structural, hemodynamic, and metabolic changes are enriching the neuroimaging of brain metastases.


Consultation in Neurourology: A Practical Evidence-Based Guide 1st ed. 2018 Edition

This book is aimed to bring the reader into the heart of the action of any health professional consulted for a patient with a neurogenic bladder (NB). Extensive textbooks of the NB exist but there is a lack of an actual practical guide for diagnosis and management of patients suffering from NB. This book provides a single source of information on consultation in neurourology.  The text covers both urinary incontinence and retention resulting from NB dysfunction. The book also discusses complications of NB which include urinary tract infections, hydronephrosis, renal failure or autonomic dysreflexia. Sections  address these clinical issues faced by physicians. This book provides a useful guide with comprehensive and practical instructions for all practitioners dealing with NB in their day-to-day clinical practice. It will serve as a valuable resource for those with a special interest in NB.  The book reviews new data about diagnostic and management options. It also provides a concise yet comprehensive summary of the current NB guidelines from different societies. All chapters include the most up to date scientific and clinical information with the relevant level of clinical evidence and grade of recommendation.


Intracranial Pressure & Neuromonitoring XVI (Acta Neurochirurgica Supplement) 1st ed. 2018 Edition

This book introduces the latest advances relating to the pathophysiology, biophysics, monitoring and treatment of traumatic brain injury, hydrocephalus, and stroke presented at the 16th International Conference on Intracranial Pressure and Neuromonitoring (the “ICP Conference”), held in Cambridge, Massachusetts, in June 2016 in conjunction with the 6th Annual Meeting of the Cerebral Autoregulation Research Network. Additionally, the conference held special sessions on neurocritical care informatics and cerebrovascular autoregulation. The peer-reviewed papers included were written by leading experts in neurosurgery, neurointensive care, anesthesiology, physiology, clinical engineering, clinical informatics and mathematics who have made important contributions in this translational area of research, and their focus ranges from the latest research findings and developments to clinical trials and experimental studies. The book continues the proud tradition of publishing key work from the ICP Conferences and is a must-read for anyone wishing to stay abreast of recent advances in the field.


Handbook of Cerebrovascular Disease and Neurointerventional Technique (Contemporary Medical Imaging) 3rd ed. 2018 Edition

This book offers a practical guide to endovascular treatment of cerebrovascular disease and provides a concise reference for the related neurovascular anatomy and the various disorders that affect the vascular system. Fully revised and updated, the information is accessible and easy to read. It discusses fundamental principles underlying cerebral and spinal angiography; interventional techniques, devices, and practice guidelines; and commonly encountered cerebrovascular disorders for which interventional and endovascular methods are appropriate. New topics and features include: intracerebral and intraventricular hemorrhage; intracranial tumor embolization; vasculitis work-up and management; percutaneous carotid artery puncture technique; and pediatric aspects of neurointerventional techniques and disease states. Handbook of Cerebrovascular Disease and Neurointerventional Technique, 3rd Edition, is a portable and concise resource for interventional neuroradiologists, neurologi

sts, neurosurgeons, cardiologists, and vascular surgeons.


Cell Therapy for Perinatal Brain Injury 1st ed. 2018 Edition

This book provides a wealth of insights, advances and new perspectives on cell therapy for different types of neonatal ischemic disease, such as Hypoxic-Ischemic Encephalopathy (HIE), Periventricular Leukomalacia (PVL) and neonatal infarction.

These diseases pose serious challenges for neonatologists and neurologists, because the severe sequelae lead to decreasing QOL for patients and their families. Accordingly, new treatments for neonatal ischemic diseases are needed all over the world.

The book develops new effective therapies combined with hypothermia therapy, an established treatment for HIE. After reviewing past approaches, it presents cutting-edge topics in cell therapy, one of the most promising candidates for treating neonatal ischemic disease. Cell Therapy for Neonatal Ischemic Disease will offer readers a better understanding of the current state of the art in this field from bench to bedside, and inspire researchers and physicians to further explore this evolving therapy.


Autonomic Nervous System: Basic and Clinical Aspects 1st ed. 2018 Edition

A traditional view of the Autonomic Nervous System (ANS) considers only its peripheral part: the sympathetic and parasympathetic systems. However, this view misses to consider the most important ANS function: the maintenance of homeostasis. This term is used today to define not only the strategies that allow the body proper response to changes in the environment (reactive homeostasis), but also temporal mechanisms that allow the body to predict the most likely timing of environmental stimuli (predictive homeostasis based on biological rhythms).

This book discusses the ANS from both an enlarged and a timed perspective. First, it presents how the organization of the ANS is hierarchical into different levels. Following that, the book discusses how the ANS changes functionally in the three-body configurations (wakefulness, slow sleep, rapid eye movement sleep) found in a 24-hour cycle. Finally, the most important clinical implications of this enlarged and timed vision of ANS will be discussed.

Autonomic Nervous System – Basic and Clinical Aspects is a comprehensive text intended for medical students and health professionals who are interested in a deeper approach to this important part of the nervous system. It provides a detailed and complete understanding of the neuroscience behind the ANS, allowing a proper clinical applicability of this knowledge.


Neuroendocrinology of Leptin (Frontiers of Hormone Research, Vol. 26) 1st Edition

The discovery of the adipostatic hormone leptin has transformed our understanding of the neurobiology of appetite control and has helped to establish the biological basis of obesity. In recent years there has been a wealth of publications relating to the physiology of this peptide. This volume sets out to draw together key features of the central effects of leptin. Contributions from leading authorities in the field include reviews of leptin’s actions on hypothalamic peptides, the role of leptin in fasting, its effects on reproductive function, and evidence supporting endogenous brain production of the peptide. Endocrinologists, diabetologists, obesity specialists and Neurobiologists will be interested in this succint and timely review of the effects of the adipostatic hormone leptin on neuroendocrine function.


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