From Protein Structure to Function with Bioinformatics 2nd ed

This book is about protein structural bioinformatics and how it can help understand and predict protein function. It covers structure-based methods that can assign and explain protein function based on overall folds, characteristics of protein surfaces, occurrence of small 3D motifs, protein-protein interactions and on dynamic properties. Such methods help extract maximum value from new experimental structures, but can often be applied to protein models. The book also, therefore, provides comprehensive coverage of methods for predicting or inferring protein structure, covering all structural classes from globular proteins and their membrane-resident counterparts to amyloid structures and intrinsically disordered proteins.

The book is split into two broad sections, the first covering methods to generate or infer protein structure, the second dealing with structure-based function annotation. Each chapter is written by world experts in the field. The first section covers methods ranging from traditional homology modelling and fold recognition to fragment-based ab initiomethods, and includes a chapter, new for the second edition, on structure prediction using evolutionary covariance. Membrane proteins and intrinsically disordered proteins are each assigned chapters, while two new chapters deal with amyloid structures and means to predict modes of protein-protein interaction. The second section includes chapters covering functional diversity within protein folds and means to assign function based on surface properties and recurring motifs. Further chapters cover the key roles of protein dynamics in protein function and use of automated servers for function inference. The book concludes with two chapters covering case studies of structure prediction, based respectively on crystal structures and protein models, providing numerous examples of real-world usage of the methods mentioned previously.

This book is targeted at postgraduate students and academic researchers. It is most obviously of interest to protein bioinformaticians and structural biologists, but should also serve as a guide to biologists more broadly by highlighting the insights that structural bioinformatics can provide into proteins of their interest.


Preventing Age Related Fertility Loss 1st ed. 2018 Edition

This unique book provides expert advice on all the different aspects related to fertility preservation for age related infertility. Although, there is a lot of information available on the Internet and in books about fertility preservation for cancer treatment, little information is available for young women that are confronted with a ticking biological clock. While men have been able to cryopreserve sperm since the 1950s, women have only recently gained the opportunity to preserve their gametes through the egg vitrification technique. Therefore, many women confronted with a risk of imminent fertility loss, such as chemotherapy, are now freezing their oocytes instead of embryos. Successful oocyte cryopreservation offers them a reproductive autonomy independent of men. Moreover, it now enables single women to preserve their reproductive chances.   The most important threat for female fertility is ovarian aging as it causes a progressive decline in the reproductive chances. The general trend to delay motherhood due to societal changes confronts many women and couples with a diminished fertility. This fertility problem can often not be cured by in vitro fertilization, which makes that an increasing number of women require oocyte donation as the treatment of last resort.  In the last few years, fertility centres around the world have started to offer the opportunity cryopreserve oocytes to young, often highly educated, single women.  This patient population is unique as compared to other patients in the fertility clinic as they perform a preventive treatment.  They are neither confronted with infertility nor are they undergoing a treatment that might cause an imminent treat to their fertility.


A How To Guide For Medical Students (Success in Academic Surgery) 1st ed

This book will be a ‘how to’ guide for medical students interested in pursuing a career in academic surgery.  It will discuss personal traits and rationale for going into academic surgery.  It will review accomplishments as a medical student that are key components of beginning an academic career and highlight what makes a student competitive for a surgical program.  Sections will be devoted to mentorship, research experience and personal experiences that lead to success.
The editors will also focus on  gender and work-life balance issues that often are perceived as barriers to a career in academic surgery.   It will also provide key dates and sample application information for students to use as templates.


Obesity and Lipotoxicity (Advances in Experimental Medicine and Biology) 1st ed

Due to the resultant health consequences and considerable increase in prevalence, obesity has become a major worldwide health problem. “Obesity and Lipotoxicity” is a comprehensive review of the recent researches to provide a better understanding of the lipotoxicity-related mechanisms of obesity and the potential for the development of new treatment strategies. This book overviews the biochemical pathways leading to obesity-related metabolic disorders that occur subsequent to lipotoxicity. Chapters examine the deleterious effects of nutrient excess at molecular level including the cellular and molecular aspects of breast cancer, resistance to leptin, insulin, adiponectin, and interconnection between the circadian clock and metabolic pathways during high-fat feeding. “Lipotoxicity and Obesity” will be a useful resource for clinicians and basic science researchers, such as biochemists, toxicologists, immunologists, nutritionists, adult and pediatric endocrinologists, cardiologists, as well as students who are thought in this field.


Intracytoplasmic Sperm Injection: Indications, Techniques and Applications 1st ed. 2018 Edition

This unique, comprehensive text on the male factor infertility experience centers on the current background, applications and techniques for intracytoplasmic sperm injection (ICSI), one of the more commonly utilized procedures in modern assisted reproduction for male infertility, offering insights into the rationale and indications for ICSI and providing an up-to-date discussion on male factor diagnostic tests and microsurgical techniques for ICSI itself. Topics covered include the role of reproductive genetics, the effects of paternal age, the assessment, development and selection of functional human spermatozoa (e.g., Comet assay), both naturally and in the laboratory, and the procedures by which these sperm are injected directly into an oocyte. Comparisons are made between efficacy rates of ICSI versus conventional IVF strategies, and clinical approaches to fertilization failures following ICSI are presented, and intracytoplasmic morphologically selected sperm injection (IMSI) is discussed in detail in a chapter of its own.

Bringing together the latest evidence and written by international leaders in the field, Intracytoplasmic Sperm Injection: Indications, Techniques and Applications is a unique and accessible resource for reproductive endocrinologists, andrologists, geneticists and infertility practitioners and researchers alike.


The Milan System for Reporting Salivary Gland Cytopathology 1st ed. 2018 Edition

This volume describes a uniform international approach for classifying and reporting salivary gland FNA samples. The new reporting system is evidence-based using data from the literature as well as upon the experience of a multi-disciplinary group of leading experts involved in the field of salivary gland cytopathology. Each diagnostic category of this novel salivary gland reporting system includes detailed descriptions of the cytologic criteria as well as a comprehensive set of photomicrographs demonstrating all of the key microscopic features along with annotated descriptions for each image.


Designed as a practical book with easy readability, The Milan System for Reporting Salivary Gland Cytopathology combines the high-quality images of an atlas with a logical approach described in concise text-form and in line-drawing algorithms. It presents for the first time, an international cytologic reporting system for salivary gland lesions designed and endorsed by a panel of experts in the field.


Biomedical Applications of Metals 1st ed. 2018 Edition

Focused more specifically on the recent advances in applications of various metals and their complexes used in biomedicine, particularly in the diagnosis and treatment of chronic diseases. The editors give equal importance to other key aspects such as toxicological issues and safety concerns. The application of metals in the biomedical field is highly interdisciplinary and has a broad appeal across all biomedical specialties. Biomedical Applications of Metals is particularly focused on covering the role of metals in medicine and the development of novel therapeutic products and solutions in the form of alternative medicines, and some topics on Indian traditional medicine i.e., “Ayurveda”. In Section I, the book discusses the role of metals in medicines and include chapters on nanoparticles, noble metals, medical devices, copper. selenium, silver, and microbial pathogens; while Section II includes topics on metals toxicity including heavy metals, carcinogens, cancer therapy, Bhasma’s and chelating agents used in Ayurveda, and biochemical and molecular targets including actions of metals. These new and emerging concepts of applications of metals in medicine, their crucial role in management of microbial resistance, and their use in the treatment of various chronic diseases is essential information for toxicologists, and clinical and biomedical researchers.


Flexible and Stretchable Medical Devices 1st Edition

The book introduces flexible and stretchable wearable electronic systems and covers in detail the technologies and materials required for healthcare and medical applications. A team of excellent authors gives an overview of currently available flexible devices and thoroughly describes their physical mechanisms that enable sensing human conditions.
In dedicated chapters, crucial components needed to realize flexible and wearable devices are discussed which include transistors and sensors and deal with memory, data handling and display. Additionally, suitable power sources based on photovoltaics, thermoelectric energy and supercapacitors are reviewed. A special chapter treats implantable flexible sensors for neural recording.
The book editor concludes with a perspective on this rapidly developing field which is expected to have a great impact on healthcare in the 21st century.


The Power of Posture

Forewords by Hema Malini & Dr. K.H. Sancheti Mindful Alignment for a Pain-Free Life Do you suffer from back, neck and shoulder pains? Are you unable to lose weight? Do you have a weak core and flabby muscles? Chances are you’ve been seeking expert advice, getting countless x-rays done, downing protein shakes and raising a mountain in medical and fitness bills. But the solution to your woes may lie in something as simple as your posture. Unbelievable? It is true! Posture is not just about sitting straight – it is intelligent awareness of your body’s framework and balance, and it can be used to banish the aches and pains associated with age and modern lifestyles. The Power of Posture is your one-stop guide to successfully resolving your body’s issues and replenish your health and vitality. Here you will find: answers to weight loss issues ways to boost flexibility and metabolism corrections for muscle imbalance from over-exercising solutions to aching neck, shoulders and back the key to pain-free legs and knee joints …and much more. With Yoga and Pilates therapies and more than 100 images to show postures and techniques, you will only wish you had known the Power of Posture earlier. Dr. Renu Mahtani, MD, is a practicing physician who runs the Param Yoga centre in Pune. Her holistic approach towards health and lifestyle incorporates customised breath therapy, yoga and pilate techniques, not just for aches and pains but also for chronic diseases, low immune conditions, anxiety and depression.


Mesenchymal Stem Cells and Immunomodulation (Stem Cell Biology and Regenerative Medicine) 1st ed

This essential volume explores mesenchymal stem cells (MSCs) and their potential to suppress immune-mediated inflammation. The chapters examine applications in autoimmune diseases such as lupus, rheumatoid arthritis and multiple sclerosis; blood cancers such as leukemia and lymphoma; and reproductive complications, specifically pre-term labor and use of MSCs in vitro and in animal models to discover methods of suppressing the causal inflammatory response. It also further defines the methodologies required to develop research on MSCs in vitro into established preclinical animal models including those which are proven replicas of autoimmunity and pre-term labor, to name but two.
Mesenchymal Stem Cells and Immunomodulation, part of Springer’s Stem Cell Biology and Regenerative Medicine,is an invaluable resource for researchers and clinicians working with stem cells, autoimmune disease, oncology, and reproductive medicine.
1 2 3 44