Innate Antiviral Immunity: Methods and Protocols (Methods in Molecular Biology) 1st ed. 2017 Edition

This book explores methods to study the complex and evolving interplay between a virus and its host that range from model systems to the detection of chemical molecules. The collection starts with the application of humanized mice and zebrafish as model organisms to study virus-host interactions and induction of innate immune responses. Subsequent chapters outline diverse methods to detect small interfering RNAs, microRNAs, and virus-derived dsRNA from a variety of cells, tissues, and organisms, as well as to interrogating the cytosolic RNA and DNA sensing pathways, including using RNA PAMPs as molecular tools, purification of cGAMP from virus particles and infected cells, and mechanisms to visualize the subcellular localization and activation of the adaptor proteins MAVS and STING. Cutting-edge methods, including high-throughput and genome-wide CRISPR/Cas9 screens, chromosome conformation capture, and whole-exome sequencing, are described to identify novel mediators, pathways, and variants underlying host susceptibility. Given the importance of studying these pathways and players under physiologic conditions, methods describing the isolation of primary mouse sensory neurons and group 2 innate lymphoid cells are also provided. Finally, this collection comes full circle back to the whole organism level and concludes with epidemiological methods to investigate virus-host interactions and the induction of innate immunity. Written for the Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Authoritative and practical, Innate Antiviral Immunity: Methods and Protocols spans a diverse array of approaches to study and elucidate the intricacies of this vital area of study.

DOWNLOAD THIS BOOK FREE HERE

http://upsto.re/F6RsCF3

HIV/AIDS: A Very Short Introduction (Very Short Introductions) 1st Edition

HIV/AIDS is without doubt the worst epidemic to hit humankind since the Black Death. As of 2004 an estimated 40 million people were living with the disease, and about 20 million had died. Despite rapid scientific advances there is still no cure and the drugs are expensive and toxic. In the developing world, especially in parts of Africa, life expectancy has plummeted to below 35 years, causing a serious decline in economic growth, a sharp increase in orphans, and the imminent collapse of health care systems. The news is not all bleak though. There have been unprecedented breakthroughs in understanding diseases and developing drugs. Because the disease is so closely linked to sexual activity and drug use, the need to understand and change behavior has caused us to reassess what it means to be human and how we should operate in the globalizing world. This Very Short Introduction tackles the science, the international and local politics, the fascinating demographics, and the devastating consequences of the disease, and suggests how we must respond.

About the Series: Oxford’s Very Short Introductions offers concise and original introductions to a wide range of subjects–from Islam to Sociology, Politics to Classics, and Literary Theory to History. Not simply a textbook of definitions, each volume provides trenchant and provocative–yet always balanced and complete–discussions of the central issues in a given topic. Every Very Short Introduction gives a readable evolution of the subject in question, demonstrating how it has developed and influenced society. Whatever the area of study, whatever the topic that fascinates the reader, the series has a handy and affordable guide that will likely prove indispensable.

DOWNLOAD THIS BOOK FREE HERE

http://upsto.re/FtkKTTU

Human Virology in Latin America: From Biology to Control 1st ed. 2017 Edition

This book is a compilation of some of the most remarkable contributions made by scientists currently working in Latin America to the understanding of virus biology, the pathogenesis of virus-related diseases, virus epidemiology, vaccine trials and antivirals development. In addition to recognizing the many fine virologists working in Latin America, Human Virology in Latin America also discusses both the state-of-the-art research and the current challenges that are being faced in the region, in hopes of inspiring young scientists worldwide to become eminent virologists.

DOWNLOAD THIS BOOK FREE HERE

http://upsto.re/F2AnonB

Pediatric Practice Infectious Diseases 1st Edition

The most practice-oriented guide to diagnosing and managing infectious diseases in children

“…will serve as a valuable resource for medical students, residents, pediatricians, family physicians, emergency department physicians, pediatric nurses, and pediatric infectious disease specialists….I will put it in my library where I practice and will use it especially when I am looking for an algorithm for diagnosis or treatment or seeking photographs or illustrations of a specific disease. I will use other sections for teaching hospital residents about specific infections. It is reasonably priced and covers a large amount of clinical care applicable to adults and children.”–JAMA

Part of the Pediatric Practice series, Pediatric Practice: Infectious Diseases is filled with practical, clinically relevant guidance for successful infectious disease management. The care of the patient forms the core of this indispensable resource, which also provides perspectives on epidemiology, pathophysiology, and diagnosis that every pediatrician, infectious disease specialist, and pediatric nurse needs to know.

The book’s high-yield coverage includes detailed, yet precise overviews of specific infections and their etiology, along with proven diagnostic and management strategies that you can incorporate into your practice right away.

Features:

  • Tips that tell you what you must know–and what you must do–at every stage of care
  • Diagnostic and treatment algorithms
  • Signs/Symptoms and Differential Diagnosis boxes
  • “When to Refer” boxes, which examine all the relevant clinical considerations
  • Diagnostic Tests–with a realistic emphasis on the rights tests to order
  • Medical Treatment coverage that includes drugs, dosages, and administration in an easy-to-read tabular format
  • Convenient icons and a templated chapter design
  • Numerous clinical color photos and didactic diagrams

DOWNLOAD THIS BOOK FREE HERE

http://upsto.re/Fd8UL7t

The Springer Index of Viruses (Springer Reference)

The continuous growth of knowledege makes it very difficult for scientists to retrieve comprehensive and accurate data on viruses. The desired information is often dispersed in a variety of books, journals and online resources. This encyclopedia presents the latest facts about all known viruses in a standardized form created by hundreds of the world’s leading virologists.

Virus taxonomy represents the basic framework that allows an understanding of the complex evolutionary process that continuously takes place among viruses and their hosts. Each of the 300 taxonomically ordered chapters includes detailed information on individual genus members, historical events, the hosts they can affect (animal, man or plant), virion morphology, genome properties, replication strategy, properties of individual transcripts and proteins, sequence accession numbers, biological properties, diseases, recombinant vector constructs, vaccine strains, key references, as well as a high-resolution particle image and a drawing of the genome organization. Its high content of easily accessible detailed information makes this Encyclopedia an indispensable tool for both researchers and lecturers. The new edition includes the recent discoveries made in this field as well as new viruses which have been discovered.

DOWNLOAD THIS BOOK FREE HERE

http://upsto.re/FCMXzmF

Infectious Diseases in Pediatric Otolaryngology: A Practical Guide 1st ed. 2016 Edition

​This quick reference on pediatric infectious diseases of the ear, nose, and throat provides reliable assistance in decision-making and management. To this end, numerous diagnostic and treatment algorithms are included. Practicing pediatricians, primary care practitioners, and otolaryngologists will all find the book to be an invaluable aid.

This book helps the otolaryngologist who is uncertain of the best antibiotic or duration of treatment for a particular condition and instruct the pediatrician on when to refer to an otolaryngologist for surgical management. The approach is multidisciplinary, with contributions from both pediatric otolaryngologists and pediatric infectious disease physicians.

DOWNLOAD THIS BOOK FREE HERE

http://upsto.re/FFBLUC9

CNS Infections: A Clinical Approach 2014th Edition

This clinically oriented book covers selected infections of the central nervous system which are of considerable current interest. Aspects that are less well documented, such as spinal cord infections, central nervous system infections in patients with cancer, tropical infections, healthcare-associated ventriculitis or meningitis and immunological problems in the international traveler are also discussed, as these are all problems relevant to daily practice.

CNS Infections: A Clinical Approach is of value to the busy clinician; the neurological international community as well as all primary care doctors, internal medicine specialists and residents who take care of patients with suspected neurological infections.

DOWNLOAD THIS BOOK FREE HERE

http://upsto.re/FQLaVQi

Clinical Virology Manual 4th Edition

A comprehensive and updated volume for the clinical virologist.

  • Details laboratory procedures for detecting and handling viruses, from specimen requirements and quality assurance to virus detection and identification, from the fundamentals through the latest molecular methods.
  • Presents the most current knowledge on the wide range of specific viral pathogens.
  • Includes information on services provided by federal and state public health virology laboratories.
  • Provides essential information for clinicians and laboratory virologists.

DOWNLOAD THIS BOOK FREE HERE

http://upsto.re/AVo4ytH

Tuberculosis of the Central Nervous System: Pathogenesis, Imaging, and Management 1st ed. 2017 Edition

Written and edited by leading international authorities in the field, this book provides an in-depth review of knowledge of tuberculosis of the central nervous system, with emphasis on clinical, diagnostics, and therapeutic features. Tuberculosis, one of the most lethal diseases in human history, still poses a serious threat in the world together with economic and social problems, although a great progress in the fight against this infectious disease in the last century. It covers the full range of tuberculosis of central nervous system and the chapters are organized into six sections: (1) the cranial; (2) the spinal; and (3) the peripheral portions of the nervous system; followed by (4) a section on the laboratory studies in tuberculosis; (5) a section on medical and surgical therapy; and (6) further insights into tuberculosis. This comprehensive reference book will be an ideal source for neurosurgeons, neurologists and specialists upon infectious diseases seeking both basic and more sophisticated information and surgical procedures relating to the complications associated with tuberculosis involving the spine, brain and peripheral nerves.

DOWNLOAD THIS BOOK FREE HERE

http://upsto.re/Aohdkom