Asthma: Targeted Biological Therapies 1st ed

This book focuses on the fundamentals of the use of biologics in asthma, describing the rationale, principles, mechanisms of action, and indications. It offers an excellent balance between basic science and the analysis of clinical trials, updating readers with new developments that are changing the global scenario for targeted biological anti-asthma therapies, especially with regard to more severe disease. A range of therapies are considered, from the humanized monoclonal anti-IgE antibody omalizumab, widely approved as add-on treatment for inadequately controlled disease, through to emerging biologics for which evidence supportive of efficacy is accumulating, including anti-IL-5, anti-IL-4, and anti-IL-13 therapies. One aspect to emerge is the variability in individual response, which suggests a need for characterization of different asthma subtypes to permit the effective implementation of phenotype-targeted treatments. This book will be of interest for pulmonologists, clinical immunologists, and physicians seeking sound information on these therapies, but also for scientists and pharmacologists wishing to enhance their knowledge of the therapeutic implications of the cellular and molecular mechanisms that underlie severe, uncontrolled asthma.


Male Infertility: A Clinical Approach 1st ed

The book aims to bring into focus the current understanding of male reproduction and the pathological basis of failure to reproduce in men. Infertility in men is a common disorder. However, attempts at scientific study of male infertility are of very recent origin. Many questions about the physiology and pathophysiology of male reproduction are still not clear. The chapters are written by authorities in the field with great clinical experience. The primary focus would be on clinical perspective; however emphasis would also be placed on basic research and molecular biology.


Chronic Illness Care: Principles and Practice 1st ed. 2018 Edition

This book offers a comprehensive overview to chronic illness care, which is the coordinated, comprehensive, and sustained response to chronic diseases and conditions by a range of health care providers, formal and informal caregivers, healthcare systems, and community-based resources. Using an ecological framework, which looks at the interdependent influences between individuals and their larger environment, this unique text examines chronic illness care at multiple levels and includes  sections on the individual influences on chronic illness, the role of family and social networks, and how chronic care is provided across the spectrum of health care settings; from home to clinic to the emergency department to hospital and residential care facilities.  The book describes the organizational frameworks and strategies that are needed to provide quality care for chronically ill patients, including behavioral health, care management, transitions of care, and health information technology. The book also addresses the changing workforce needs in health care, and the fiscal models and policies that will be required to meet the needs of this population, with a focus on sustaining the ongoing transformation in health care.  This book acts as a major reference for practitioners and students in medicine, nursing, social work, allied health, and behavioral medicine, as well as stakeholders in public health, health policy, and population health.


Multiple Choice Questions in Pain Management 1st ed. 2018 Edition

This book presents current clinical knowledge relating to key topics in acute and chronic pain in a multiple choice question (MCQ) format. Individual chapters are devoted to subjects such as the anatomy of pain pathways, pain processing, evaluation of pain, different pain syndromes and pain involving different regions of the body, pharmacologic and physical pain management, neural blockade, and special procedures. Each of the MCQs has four or five answer options in true/false format, and the answers are discussed in detail with provision of suitable references whenever appropriate. Multiple Choice Questions in Pain Management will be especially valuable for those who are sitting anesthesia board exams anywhere in the world. It will, for example, meet the needs of candidates for the FRCA examination (in which 20–25% of MCQs relate to pain management) or the FFPMRCA examination (Fellowship of the Faculty of Pain Medicine of the Royal College of Anaesthetists). In addition, the book will be useful for pain fellows and for all clinicians who are seeking to improve their knowledge of pain management.


The Bethesda System for Reporting Thyroid Cytopathology: Definitions, Criteria, and Explanatory Notes 2nd ed. 2018 Edition

  The first edition of The Bethesda System for Reporting Thyroid Cytopathology was published in 2010 and has greatly influenced the practice of thyroid cytopathology. The terminology proposed and illustrated in this text has been widely adopted not only in the U.S. but also abroad. It has become an essential text for pathology trainees and practicing pathologists examining thyroid fine needle aspiration (FNA) specimens.
  Since 2010, there have been a number of important advances in the management of patients with nodular thyroid disease and in the understanding of the biology of thyroid cancer. This new edition includes these advances that impact terminology for reporting thyroid cytopathology. In particular, it incorporates a discussion of the recently implemented and now widespread use of molecular testing of thyroid FNA samples, which has transformed the management of patients with nodular thyroid disease in the U.S.. In addition, this edition accommodates the recent changes to the classification of thyroid cancer, most notably the introduction of a new thyroid diagnosis, that of “non-invasive follicular tumor with papillary-like nuclear features (NIFTP)”.
  Thoroughly revised and updated, The Bethesda System for Reporting Thyroid Cytopathology, Second Edition will provide the reader with a unified approach to diagnosing and reporting thyroid FNA interpretations. It serves as a reference guide not just for pathologists, but also endocrinologists, surgeons, and radiologists.

Interventional Treatment of Wounds: A Modern Approach for Better Outcomes 1st ed. 2018 Edition


Dennis Orgill, MD, PhD, is the Vice Chair for Quality Improvement in the Department of Surgery at Brigham and Women’s Hospital, a professor of surgery at Harvard Medical School, and the Director of the Brigham and Women’s Hospital Wound Care Center. Dr. Orgill holds a doctoral degree in medical engineering from the Massachusetts Institute of Technology and a medical degree from Harvard University and completed additional training in reconstructive plastic surgery. He is also board certified in plastic surgery with membership in American Society og Plastic Surgeons (ASPS), American Association of Plastic Surgeons (AAPS), American College of Surgeons (ACOS), American Society for Reconstrucitve Microsurgery (ASRM), Association of Academic Chairmen of Plastic Surgery (AACPS), Massachusetts Medical Society, Plastic Surgery Education Foundation (PSEF), Plastic Sugery Rsearch Council (PSRC), and Wound Healing Society.

Head of a research team: The Orgill laboratory focuses on tissue engineering and wound healing, aiming to develop better technologies to treat wounds. The laboratory performs research on artificial skin, micromechanical forces, platelets, and stem cells. Dr. Orgill has consulted for several medical device and start-up companies, and holds several patents.


Sleep Disorders Medicine: Basic Science, Technical Considerations and Clinical Aspects 4th ed

Since publication of the first edition in 1994, the second edition in 1999, and the third edition in 2009, many new advances in sleep medicine have been made and warrant a fourth edition.  This comprehensive text features 19 additional chapters and covers basic science, technical and laboratory aspects and clinical and therapeutic advances in sleep medicine for beginners and seasoned practitioners.
With the discovery of new entities, many new techniques and therapies, and evolving basic science understanding of sleep, Sleep Disorders Medicine, Fourth Edition brings old and new knowledge about sleep medicine together succinctly in one place for a deeper understanding of the topic.  Neurologists, internists, family physicians, pediatricians, psychiatrists, psychologists, otolaryngologists, dentists, neurosurgeons, neuroscientists, intensivists, as well as those interested in advancing their knowledge in sleep and its disorders, will find this edition to be an invaluable resource to this bourgeoning field.

Disease Control Priorities, Third Edition (Volume 5): Cardiovascular, Respiratory, and Related Disorders 3rd Edition

Cardiovascular, respiratory, and related conditions cause more than 40 percent of all deaths globally, and their substantial burden is rising, particularly in low- and middle-income countries (LMICs). Their burden extends well beyond health effects to include significant economic and societal consequences. Most of these conditions are related, share risk factors, and have common control measures at the clinical, population, and policy levels. Lives can be extended and improved when these diseases are prevented, detected, and managed.

This volume summarizes current knowledge and presents evidence-based interventions that are effective, cost-effective, and scalable in LMICs.


Braunwald’s Heart Disease: A Textbook of Cardiovascular Medicine, 2-Volume Set, 11e 11th Edition

Trusted by generations of cardiologists for the latest, most reliable guidance in the field, Braunwald’s Heart Disease, 11th Edition, remains your #1 source of information on rapidly changing clinical science, clinical and translational research, and evidence-based medicine. This award-winning text has been completely updated, providing a superior multimedia reference for every aspect of this fast-changing field, including new material about almost every topic in cardiology.

    • unique update program by Dr. Braunwald creates a “living textbook” by featuring weekly Hot off the Press, periodic Late-Breaking Clinical Trials (including links to authors’ presentation slides), and monthly Focused Reviews.


    • More than a dozen new chapters cover Chronic Lung Disorders and Cardiovascular Disease; Transcatheter Treatment of Congenital Heart Disease; Approach to the Patient with Valvular Heart Disease; Obesity and Cardiometabolic Disease; Environmental Exposures and CVD; Approach to the Patient with Cardiac Arrhythmias; Cardio-oncology, Precision Medicine, and more.


    • New information on clinical cardiovascular genetics; MR PET; MR device compatibility; fibrosis; fusion imaging; OCT; IVUS; left atrial appendage exclusion approaches and other topics.


    • Many new videos that elucidate coronary, peripheral, valvular, congenital heart diseases and other cardiovascular diseases.


  • Expert Consult™ eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.


Sleep and Dreaming: Scientific Advances and Reconsiderations 1st Edition

From the study of brainstem-based models of sleep cycle control, current research is moving toward combined brainstem/forebrain models of sleep cognition. The book presents five papers by contemporary leading scientists, and more than seventy-five commentaries on those papers by nearly all of the other distinguished authorities in the field. Topics include mechanisms of dreaming and REM sleep, memory consolidation in REM sleep, and an evolutionary hypothesis of the function of dreaming. The papers and commentaries, together with the authors’ rejoinders, represent significant advances in the understanding of the sleeping and dreaming brain.


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